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P38432 (COIL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coilin
Alternative name(s):
p80
Gene names
Name:COIL
Synonyms:CLN80
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin.

Subunit structure

Interacts with ANKS1B. Ref.7

Subcellular location

Nucleus. Note: Nuclear coiled body located in the interchromatin space between the nucleolus and the nucleus.

Tissue specificity

Found in all the cell types examined.

Sequence similarities

Belongs to the coilin family.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentCajal body

Inferred from direct assay. Source: UniProtKB

nucleolus

Inferred from direct assay. Source: UniProtKB

   Molecular functionidentical protein binding

Inferred from physical interaction. Source: IntAct

protein C-terminus binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Coilin
PRO_0000058146

Regions

Repeat223 – 22641-1
Repeat268 – 27141-2
Repeat386 – 38942-1
Repeat413 – 41423-1
Repeat415 – 41623-2
Repeat417 – 41823-3
Repeat419 – 42023-4
Repeat517 – 52042-2
Region223 – 271492 X 4 AA repeats of A-R-N-S
Region386 – 5201352 X 4 AA repeats of S-L-P-A
Region413 – 42084 X 2 AA tandem repeats of R-G
Compositional bias181 – 20121Lys-rich (basic)
Compositional bias243 – 25210Ser/Thr-rich
Compositional bias310 – 32011Ser/Thr-rich

Amino acid modifications

Modified residue1221Phosphothreonine Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14
Modified residue2711Phosphoserine Ref.13 Ref.14
Modified residue2901Phosphothreonine Ref.13
Modified residue3011Phosphoserine Ref.13
Modified residue3031Phosphothreonine Ref.8 Ref.13 Ref.14
Modified residue4561Phosphothreonine Ref.14
Modified residue4871Phosphoserine Ref.14
Modified residue4891Phosphoserine Ref.10 Ref.13 Ref.14
Modified residue5661Phosphoserine Ref.14
Modified residue5681Phosphoserine Ref.14

Sequences

Sequence LengthMass (Da)Tools
P38432 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 879702B590F16849

FASTA57662,608
        10         20         30         40         50         60 
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG FSSGAFLGLY 

        70         80         90        100        110        120 
LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG DINLSLRKAK KRAFQLEEGE 

       130        140        150        160        170        180 
ETEPDCKYSK KHWKSRENNN NNEKVLDLEP KAVTDQTVSK KNKRKNKATC GTVGDDNEEA 

       190        200        210        220        230        240 
KRKSPKKKEK CEYKKKAKNP KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS 

       250        260        270        280        290        300 
KESPSSSSES ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF 

       310        320        330        340        350        360 
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR GRPGPGLSSQ 

       370        380        390        400        410        420 
TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN LFSWKGAKGR GMRGRGRGRG 

       430        440        450        460        470        480 
HPVSCVVNRS TDNQRQQQLN DVVKNSSTII QNPVETPKKD YSLLPLLAAA PQVGEKIAFK 

       490        500        510        520        530        540 
LLELTSSYSP DVSDYKEGRI LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV 

       550        560        570 
EYAVTQESKI TVFWKELIDP RLIIESPSNT SSTEPA

« Hide

References

« Hide 'large scale' references
[1]"Structure, expression and chromosomal localization of human p80-coilin gene."
Chan E.K.L., Takano S., Andrade L.E.C., Hamel J.C., Matera A.G.
Nucleic Acids Res. 22:4462-4469(1994) [PubMed: 7971277] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin."
Andrade L.E.C., Chan E.K.L., Raska I., Peebles C.L., Roos G., Tan E.M.
J. Exp. Med. 173:1407-1419(1991) [PubMed: 2033369] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-576.
Tissue: Liver.
[6]"Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure."
Carmo-Fonseca M., Ferreira J., Lamond A.I.
J. Cell Biol. 120:841-852(1993) [PubMed: 7679389] [Abstract]
Cited for: CHARACTERIZATION.
[7]"A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin."
Xu H., Hebert M.D.
BMC Cell Biol. 6:23-23(2005) [PubMed: 15862129] [Abstract]
Cited for: INTERACTION WITH ANKS1B.
[8]"Large-scale characterization of HeLa cell nuclear phosphoproteins."
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-303, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[10]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122 AND SER-489, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[11]"Phosphoproteome analysis of the human mitotic spindle."
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006) [PubMed: 16565220] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, MASS SPECTROMETRY.
Tissue: Cervix adenocarcinoma.
[12]"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry."
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[13]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122; SER-271; THR-290; SER-301; THR-303 AND SER-489, MASS SPECTROMETRY.
Tissue: Cervix carcinoma.
[14]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122; SER-271; THR-303; THR-456; SER-487; SER-489; SER-566 AND SER-568, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
[15]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M58411 mRNA. Translation: AAA36412.1.
AK313616 mRNA. Translation: BAG36378.1.
CH471109 Genomic DNA. Translation: EAW94522.1.
BC010385 mRNA. Translation: AAH10385.1.
U06632 mRNA. Translation: AAB81550.1.
IPIIPI00006442.
PIRS50113.
RefSeqNP_004636.1. NM_004645.2.
UniGeneHs.532795.

3D structure databases

ProteinModelPortalP38432.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-38503N.
IntActP38432. 58 interactions.
MINTMINT-2855441.
STRINGP38432.

PTM databases

PhosphoSiteP38432.

Polymorphism databases

DMDM585632.

Proteomic databases

PeptideAtlasP38432.
PRIDEP38432.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000240316; ENSP00000240316; ENSG00000121058.
GeneID8161.
KEGGhsa:8161.
UCSCuc002iuu.1. human.

Organism-specific databases

CTD8161.
GeneCardsGC17M055015.
H-InvDBHIX0202484.
HGNCHGNC:2184. COIL.
HPACAB017524.
MIM600272. gene.
neXtProtNX_P38432.
PharmGKBPA26700.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18140.
GeneTreeENSGT00390000004832.
HOGENOMHBG278407.
HOVERGENHBG007989.
InParanoidP38432.
OMARQRFGFS.
OrthoDBEOG4W3SNX.
PhylomeDBP38432.

Gene expression databases

ArrayExpressP38432.
BgeeP38432.
CleanExHS_COIL.
GenevestigatorP38432.
GermOnlineENSG00000121058. Homo sapiens.

Family and domain databases

InterProIPR024822. Coilin.
[Graphical view]
KOK13150.
PANTHERPTHR15197. PTHR15197. 1 hit.
ProtoNetSearch...

Other

NextBio30832.
SOURCESearch...

Entry information

Entry nameCOIL_HUMAN
AccessionPrimary (citable) accession number: P38432
Secondary accession number(s): B2R931
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: January 25, 2012
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents