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Protein

Coilin

Gene

COIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.1 Publication

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121058-MONOMER.
SIGNORiP38432.

Names & Taxonomyi

Protein namesi
Recommended name:
Coilin
Alternative name(s):
p80-coilin
Gene namesi
Name:COIL
Synonyms:CLN80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:2184. COIL.

Subcellular locationi

  • Nucleus 1 Publication
  • NucleusCajal body 1 Publication

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi413 – 419RGRGRGR → GGGGGGG: Impaired interaction with SMN. 1 Publication7

Organism-specific databases

DisGeNETi8161.
OpenTargetsiENSG00000121058.
PharmGKBiPA26700.

Polymorphism and mutation databases

BioMutaiCOIL.
DMDMi585632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000581461 – 576CoilinAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineCombined sources1
Modified residuei122PhosphothreonineCombined sources1
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei184Phosphoserine; by VRK1 and VRK21 Publication1
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei271PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei290PhosphothreonineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei303PhosphothreonineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei456PhosphothreonineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1

Post-translational modificationi

Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.
Phosphorylation during mitosis is associated with disassembly of CBs.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP38432.
MaxQBiP38432.
PaxDbiP38432.
PeptideAtlasiP38432.
PRIDEiP38432.

PTM databases

iPTMnetiP38432.
PhosphoSitePlusiP38432.
SwissPalmiP38432.

Expressioni

Tissue specificityi

Found in all the cell types examined.

Gene expression databases

BgeeiENSG00000121058.
CleanExiHS_COIL.
ExpressionAtlasiP38432. baseline and differential.
GenevisibleiP38432. HS.

Organism-specific databases

HPAiCAB017524.
CAB069400.
HPA027885.
HPA057480.

Interactioni

Subunit structurei

Interacts with ANKS1B. Interacts with SMN (via Tudor domain). Interacts (via C-terminus) with AK6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-945751,EBI-945751
AK6Q9Y3D85EBI-945751,EBI-2896123
ARMCX1Q9P2913EBI-945751,EBI-2843626
ATXN1P542533EBI-945751,EBI-930964
ATXN1P54253-16EBI-945751,EBI-930975
BYSLQ1389510EBI-945751,EBI-358049
CDC23Q9UJX23EBI-945751,EBI-396137
CEP70Q8NHQ13EBI-945751,EBI-739624
DRG1Q9Y2953EBI-945751,EBI-719554
FGF12P613283EBI-945751,EBI-6657662
LNX1Q8TBB12EBI-945751,EBI-739832
MFAP1P550813EBI-945751,EBI-1048159
PDE4DQ084993EBI-945751,EBI-1642831
PDLIM5Q96HC43EBI-945751,EBI-751267
PICK1Q9NRD53EBI-945751,EBI-79165
POLR2LP628753EBI-945751,EBI-359527
PSME3P612895EBI-945751,EBI-355546
PTSQ033933EBI-945751,EBI-712344
SNRPFP623065EBI-945751,EBI-356900
VRK1Q999869EBI-945751,EBI-1769146
WDR34Q96EX33EBI-945751,EBI-2556091
WDYHV1Q96HA83EBI-945751,EBI-741158
XRCC5P130106EBI-945751,EBI-357997
XRCC6P129563EBI-945751,EBI-353208
ZCCHC10Q8TBK63EBI-945751,EBI-597063
ZNF277Q8WWA63EBI-945751,EBI-10192794

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113815. 91 interactors.
DIPiDIP-38503N.
IntActiP38432. 92 interactors.
MINTiMINT-2855441.
STRINGi9606.ENSP00000240316.

Structurei

3D structure databases

ProteinModelPortaliP38432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati223 – 2261-14
Repeati268 – 2711-24
Repeati386 – 3892-14
Repeati413 – 4143-12
Repeati415 – 4163-22
Repeati417 – 4183-32
Repeati419 – 4203-42
Domaini460 – 559Tudor; atypicalAdd BLAST100
Repeati517 – 5202-24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 2712 X 4 AA repeats of A-R-N-SAdd BLAST49
Regioni386 – 5202 X 4 AA repeats of S-L-P-AAdd BLAST135
Regioni392 – 420Required for interaction with SMN1 PublicationAdd BLAST29
Regioni413 – 4204 X 2 AA tandem repeats of R-G8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 201Lys-rich (basic)Add BLAST21
Compositional biasi243 – 252Ser/Thr-rich10
Compositional biasi310 – 320Ser/Thr-richAdd BLAST11

Domaini

The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues.1 Publication

Sequence similaritiesi

Belongs to the coilin family.Curated
Contains 1 Tudor domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHAK. Eukaryota.
ENOG41121C6. LUCA.
GeneTreeiENSGT00390000004832.
HOGENOMiHOG000059586.
HOVERGENiHBG007989.
InParanoidiP38432.
KOiK13150.
OMAiQFDYPPP.
OrthoDBiEOG091G0B3V.
PhylomeDBiP38432.
TreeFamiTF331811.

Family and domain databases

InterProiIPR024822. Coilin.
IPR031722. Coilin_N.
[Graphical view]
PANTHERiPTHR15197:SF0. PTHR15197:SF0. 1 hit.
PfamiPF15862. Coilin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38432-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASETVRLR LQFDYPPPAT PHCTAFWLLV DLNRCRVVTD LISLIRQRFG
60 70 80 90 100
FSSGAFLGLY LEGGLLPPAE SARLVRDNDC LRVKLEERGV AENSVVISNG
110 120 130 140 150
DINLSLRKAK KRAFQLEEGE ETEPDCKYSK KHWKSRENNN NNEKVLDLEP
160 170 180 190 200
KAVTDQTVSK KNKRKNKATC GTVGDDNEEA KRKSPKKKEK CEYKKKAKNP
210 220 230 240 250
KSPKVQAVKD WANQRCSSPK GSARNSLVKA KRKGSVSVCS KESPSSSSES
260 270 280 290 300
ESCDESISDG PSKVTLEARN SSEKLPTELS KEEPSTKNTT ADKLAIKLGF
310 320 330 340 350
SLTPSKGKTS GTTSSSSDSS AESDDQCLMS SSTPECAAGF LKTVGLFAGR
360 370 380 390 400
GRPGPGLSSQ TAGAAGWRRS GSNGGGQAPG ASPSVSLPAS LGRGWGREEN
410 420 430 440 450
LFSWKGAKGR GMRGRGRGRG HPVSCVVNRS TDNQRQQQLN DVVKNSSTII
460 470 480 490 500
QNPVETPKKD YSLLPLLAAA PQVGEKIAFK LLELTSSYSP DVSDYKEGRI
510 520 530 540 550
LSHNPETQQV DIEILSSLPA LREPGKFDLV YHNENGAEVV EYAVTQESKI
560 570
TVFWKELIDP RLIIESPSNT SSTEPA
Length:576
Mass (Da):62,608
Last modified:October 1, 1994 - v1
Checksum:i879702B590F16849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58411 mRNA. Translation: AAA36412.1.
AK313616 mRNA. Translation: BAG36378.1.
AC004584 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94522.1.
BC010385 mRNA. Translation: AAH10385.1.
U06632 mRNA. Translation: AAB81550.1.
CCDSiCCDS11592.1.
PIRiS50113.
RefSeqiNP_004636.1. NM_004645.2.
UniGeneiHs.532795.

Genome annotation databases

EnsembliENST00000240316; ENSP00000240316; ENSG00000121058.
GeneIDi8161.
KEGGihsa:8161.
UCSCiuc002iuu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58411 mRNA. Translation: AAA36412.1.
AK313616 mRNA. Translation: BAG36378.1.
AC004584 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94522.1.
BC010385 mRNA. Translation: AAH10385.1.
U06632 mRNA. Translation: AAB81550.1.
CCDSiCCDS11592.1.
PIRiS50113.
RefSeqiNP_004636.1. NM_004645.2.
UniGeneiHs.532795.

3D structure databases

ProteinModelPortaliP38432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113815. 91 interactors.
DIPiDIP-38503N.
IntActiP38432. 92 interactors.
MINTiMINT-2855441.
STRINGi9606.ENSP00000240316.

PTM databases

iPTMnetiP38432.
PhosphoSitePlusiP38432.
SwissPalmiP38432.

Polymorphism and mutation databases

BioMutaiCOIL.
DMDMi585632.

Proteomic databases

EPDiP38432.
MaxQBiP38432.
PaxDbiP38432.
PeptideAtlasiP38432.
PRIDEiP38432.

Protocols and materials databases

DNASUi8161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240316; ENSP00000240316; ENSG00000121058.
GeneIDi8161.
KEGGihsa:8161.
UCSCiuc002iuu.4. human.

Organism-specific databases

CTDi8161.
DisGeNETi8161.
GeneCardsiCOIL.
HGNCiHGNC:2184. COIL.
HPAiCAB017524.
CAB069400.
HPA027885.
HPA057480.
MIMi600272. gene.
neXtProtiNX_P38432.
OpenTargetsiENSG00000121058.
PharmGKBiPA26700.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHAK. Eukaryota.
ENOG41121C6. LUCA.
GeneTreeiENSGT00390000004832.
HOGENOMiHOG000059586.
HOVERGENiHBG007989.
InParanoidiP38432.
KOiK13150.
OMAiQFDYPPP.
OrthoDBiEOG091G0B3V.
PhylomeDBiP38432.
TreeFamiTF331811.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121058-MONOMER.
SIGNORiP38432.

Miscellaneous databases

ChiTaRSiCOIL. human.
GeneWikiiCoilin.
GenomeRNAii8161.
PROiP38432.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121058.
CleanExiHS_COIL.
ExpressionAtlasiP38432. baseline and differential.
GenevisibleiP38432. HS.

Family and domain databases

InterProiIPR024822. Coilin.
IPR031722. Coilin_N.
[Graphical view]
PANTHERiPTHR15197:SF0. PTHR15197:SF0. 1 hit.
PfamiPF15862. Coilin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOIL_HUMAN
AccessioniPrimary (citable) accession number: P38432
Secondary accession number(s): B2R931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.