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Protein

Trehalose synthase complex regulatory subunit TSL1

Gene

TSL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex, and confer sensitivity to physiological concentrations of phosphate and to fructose 6-phosphate.1 Publication

Miscellaneous

Present with 1960 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • enzyme regulator activity Source: SGD

GO - Biological processi

  • dephosphorylation Source: GOC
  • trehalose biosynthetic process Source: SGD
  • trehalose metabolism in response to stress Source: GO_Central

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-4029
YEAST:MONOMER3O-4029

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose synthase complex regulatory subunit TSL1
Alternative name(s):
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit
Gene namesi
Name:TSL1
Ordered Locus Names:YML100W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML100W
SGDiS000004566 TSL1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225111 – 1098Trehalose synthase complex regulatory subunit TSL1Add BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei251PhosphothreonineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei815PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38427
PaxDbiP38427
PRIDEiP38427

PTM databases

iPTMnetiP38427

Expressioni

Inductioni

Repressed by glucose.

Interactioni

Subunit structurei

The trehalose synthase complex is composed of the two catalytic subunits TPS1 and TPS2, and at least one of the two regulatory subunits TPS3 or TSL1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35043, 74 interactors
DIPiDIP-753N
IntActiP38427, 15 interactors
MINTiP38427
STRINGi4932.YML100W

Structurei

3D structure databases

ProteinModelPortaliP38427
SMRiP38427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 15017
Repeati158 – 16427

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni144 – 1642 X 7 AA repeats of R-I-A-S-P-I-QAdd BLAST21
Regioni320 – 812TPS complex domainAdd BLAST493

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 45Poly-Gln4
Compositional biasi164 – 168Poly-Gln5

Domaini

C-terminal 700 AA are mainly in alpha-helices and beta-sheets.

Sequence similaritiesi

In the C-terminal section; belongs to the glycosyltransferase 20 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000075394
HOGENOMiHOG000179930
InParanoidiP38427
KOiK22337
OMAiCHEFIIA
OrthoDBiEOG092C0LDC

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR003337 Trehalose_PPase
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
PF02358 Trehalose_PPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit

Sequencei

Sequence statusi: Complete.

P38427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIVASLFL PYQPQFELDT SLPENSQVDS SLVNIQAMAN DQQQQRALSN
60 70 80 90 100
NISQESLVAP APEQGVPPAI SRSATRSPSA FNRASSTTNT ATLDDLVSSD
110 120 130 140 150
IFMENLTANA TTSHTPTSKT MLKPRKNGSV ERFFSPSSNI PTDRIASPIQ
160 170 180 190 200
HEHDSGSRIA SPIQQQQQDP TTNLLKNVNK SLLVHSLLNN TSQTSLEGPN
210 220 230 240 250
NHIVTPKSRA GNRPTSAATS LVNRTKQGSA SSGSSGSSAP PSIKRITPHL
260 270 280 290 300
TASAAKQRPL LAKQPSNLKY SELADISSSE TSSQHNESDP DDLTTAPDEE
310 320 330 340 350
YVSDLEMDDA KQDYKVPKFG GYSNKSKLKK YALLRSSQEL FSRLPWSIVP
360 370 380 390 400
SIKGNGAMKN AINTAVLENI IPHRHVKWVG TVGIPTDEIP ENILANISDS
410 420 430 440 450
LKDKYDSYPV LTDDDTFKAA YKNYCKQILW PTLHYQIPDN PNSKAFEDHS
460 470 480 490 500
WKFYRNLNQR FADAIVKIYK KGDTIWIHDY HLMLVPQMVR DVLPFAKIGF
510 520 530 540 550
TLHVSFPSSE VFRCLAQREK ILEGLTGADF VGFQTREYAR HFLQTSNRLL
560 570 580 590 600
MADVVHDEEL KYNGRVVSVR FTPVGIDAFD LQSQLKDGSV MQWRQLIRER
610 620 630 640 650
WQGKKLIVCR DQFDRIRGIH KKLLAYEKFL VENPEYVEKS TLIQICIGSS
660 670 680 690 700
KDVELERQIM IVVDRINSLS TNISISQPVV FLHQDLDFSQ YLALSSEADL
710 720 730 740 750
FVVSSLREGM NLTCHEFIVC SEDKNAPLLL SEFTGSASLL NDGAIIINPW
760 770 780 790 800
DTKNFSQAIL KGLEMPFDKR RPQWKKLMKD IINNDSTNWI KTSLQDIHIS
810 820 830 840 850
WQFNQEGSKI FKLNTKTLME DYQSSKKRMF VFNIAEPPSS RMISILNDMT
860 870 880 890 900
SKGNIVYIMN SFPKPILENL YSRVQNIGLI AENGAYVSLN GVWYNIVDQV
910 920 930 940 950
DWRNDVAKIL EDKVERLPGS YYKINESMIK FHTENAEDQD RVASVIGDAI
960 970 980 990 1000
THINTVFDHR GIHAYVYKNV VSVQQVGLSL SAAQFLFRFY NSASDPLDTS
1010 1020 1030 1040 1050
SGQITNIQTP SQQNPSDQEQ QPPASPTVSM NHIDFACVSG SSSPVLEPLF
1060 1070 1080 1090
KLVNDEASEG QVKAGHAIVY GDATSTYAKE HVNGLNELFT IISRIIED
Length:1,098
Mass (Da):123,018
Last modified:October 1, 1994 - v1
Checksum:iEA0A8A86AF178F04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72788 Genomic DNA Translation: CAA51303.1
X80835 Genomic DNA Translation: CAA56797.1
BK006946 Genomic DNA Translation: DAA09799.1
PIRiS36868
RefSeqiNP_013608.1, NM_001182460.1

Genome annotation databases

EnsemblFungiiYML100W; YML100W; YML100W
GeneIDi854872
KEGGisce:YML100W

Similar proteinsi

Entry informationi

Entry nameiTSL1_YEAST
AccessioniPrimary (citable) accession number: P38427
Secondary accession number(s): D6W0I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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