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P38419

- LOXC1_ORYSJ

UniProt

P38419 - LOXC1_ORYSJ

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Protein

Lipoxygenase 7, chloroplastic

Gene

CM-LOX1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This lipoxygenase introduces molecular oxygen exclusively into the C-13 position of linoleic and linolenic acids.1 Publication

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi581 – 5811Iron; catalyticPROSITE-ProRule annotation
Metal bindingi586 – 5861Iron; catalyticPROSITE-ProRule annotation
Metal bindingi773 – 7731Iron; catalyticPROSITE-ProRule annotation
Metal bindingi777 – 7771Iron; catalyticPROSITE-ProRule annotation
Metal bindingi924 – 9241Iron; via carboxylate; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC
  3. phytoene dehydrogenase activity Source: Gramene

GO - Biological processi

  1. oxylipin biosynthetic process Source: UniProtKB-UniPathway
  2. response to other organism Source: Gramene
  3. response to wounding Source: Gramene
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16718.
ReactomeiREACT_220543. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_245113. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_254799. Synthesis of Hepoxilins (HX) and Trioxilins (TrX).
REACT_256153. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_261475. Synthesis of Lipoxins (LX).
UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 7, chloroplastic (EC:1.13.11.12)
Gene namesi
Name:CM-LOX1
Synonyms:LOX2.1
Ordered Locus Names:Os08g0508800, LOC_Os08g39840
ORF Names:B1168A08.24
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 8

Organism-specific databases

GrameneiP38419.

Subcellular locationi

Plastidchloroplast Curated

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6161ChloroplastSequence AnalysisAdd
BLAST
Chaini62 – 924863Lipoxygenase 7, chloroplasticPRO_0000018327Add
BLAST

Proteomic databases

PRIDEiP38419.

Expressioni

Inductioni

By fungal infection.

Gene expression databases

ExpressionAtlasiP38419. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP38419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 218131PLATPROSITE-ProRule annotationAdd
BLAST
Domaini225 – 924700LipoxygenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated
Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
Contains 1 PLAT domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG69653.
HOGENOMiHOG000230469.
InParanoidiP38419.
KOiK00454.
OMAiIARNKMP.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38419-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRPQLNPSS HTTTTSSSSS TQLFASSSCI ASLRRPSSSS SSVVAAARRT
60 70 80 90 100
RGQGSSRVVV VCASSSATAS RGDSSSDMAA AAAVRVKAVA TIKVTVGELI
110 120 130 140 150
NRSIDIRDLI GRSLSLELVS SELDAKTGKE KATVRSYAHN VDDDDHSVVT
160 170 180 190 200
YEADFDVPSG FGPIGAIIVT NELRQEMFLE DINLTASDGA GNSTVLPIRC
210 220 230 240 250
NSWVQPKSVG DEGTPSKRIF FANKTYLPGQ TPAGLRSYRK NDLQQKRGDG
260 270 280 290 300
TGEREADDRV YDYDVYNDLG NPDSNGDLAR PVLGGNKQFP YPRRCRTGRP
310 320 330 340 350
PSKKDPKSET RKGNVYVPRD EEFSPEKEDY FLRKTVGSVL QAAVPAAQSL
360 370 380 390 400
LLDKLKWNLP FPSFFVIDKL FEDGVELPGV DKLNFLESVV PRLLEHLRDT
410 420 430 440 450
PAEKILRFET PANIQKDKFA WLRDEEFARE TLAGINPYAI ELVREFPLKS
460 470 480 490 500
KLDPAVYGPA ESAITADLLE EQMRRVMTVE EAISQKRLFM LDFHDLFLPY
510 520 530 540 550
VHKIRSLDHT TMYGSRTVFF LTDDGTLQLL AIELTRPASP SQPQWRQVFT
560 570 580 590 600
PSTDATMSWL WRMAKAHVRA HDAGHHELIT HWLRTHCAVE PYIIAANRQL
610 620 630 640 650
SEMHPIYQLL RPHFRYTMRI NARARSALIS AGGIIERSFS PQKYSMELSS
660 670 680 690 700
VAYDKLWRFD TEALPADLVR RGMAEEDPTA EHGLKLAIED YPFANDGLLI
710 720 730 740 750
WDAIKTWVQA YVARFYPDAD SVAGDEELQA FWTEVRTKGH GDKKDAPWWP
760 770 780 790 800
KLDSPESLAH TLTTIVWVAA AHHAAVNFGQ YDFGGYFPNR PSIARTVMPV
810 820 830 840 850
EEPVDGAAME RFLDNPDQAL RECFPSQVQA TVVMAVLDVL SSHSTDEEYL
860 870 880 890 900
GGEQTRPWNS DAAVQAAYDG FAARLKEIEG VIDGRNKDRK LKNRCGAGIL
910 920
PYQLMKPFSD SGVTGMGIPN STSI
Length:924
Mass (Da):102,819
Last modified:August 30, 2005 - v2
Checksum:iE2142F9775751FEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431D → E in AAD39093. (PubMed:7508918)Curated
Sequence conflicti342 – 3432AA → P in AAD39093. (PubMed:7508918)Curated
Sequence conflicti350 – 3523LLL → CSS in BAA03102. (PubMed:7508918)Curated
Sequence conflicti450 – 4501S → T in AAD39093. (PubMed:7508918)Curated
Sequence conflicti484 – 4841S → N in BAA03102. (PubMed:7508918)Curated
Sequence conflicti540 – 5401P → L in BAA03102. (PubMed:7508918)Curated
Sequence conflicti625 – 6284RSAL → ARV in BAA03102. (PubMed:7508918)Curated
Sequence conflicti682 – 6821H → Q in BAA03102. (PubMed:7508918)Curated
Sequence conflicti764 – 7641T → N in BAA03102. (PubMed:7508918)Curated
Sequence conflicti819 – 8191A → R in AAD39093. (PubMed:7508918)Curated
Sequence conflicti858 – 8647WNSDAAV → GTATRRL in BAA03102. (PubMed:7508918)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14000 mRNA. Translation: BAA03102.1.
AF095895 mRNA. Translation: AAD39093.1.
AP005816 Genomic DNA. Translation: BAD10665.1.
RefSeqiNP_001062199.1. NM_001068734.1.
UniGeneiOs.4416.

Genome annotation databases

EnsemblPlantsiOS08T0508800-01; OS08T0508800-01; OS08G0508800.
GeneIDi4345993.
KEGGiosa:4345993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14000 mRNA. Translation: BAA03102.1 .
AF095895 mRNA. Translation: AAD39093.1 .
AP005816 Genomic DNA. Translation: BAD10665.1 .
RefSeqi NP_001062199.1. NM_001068734.1.
UniGenei Os.4416.

3D structure databases

ProteinModelPortali P38419.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P38419.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS08T0508800-01 ; OS08T0508800-01 ; OS08G0508800 .
GeneIDi 4345993.
KEGGi osa:4345993.

Organism-specific databases

Gramenei P38419.

Phylogenomic databases

eggNOGi NOG69653.
HOGENOMi HOG000230469.
InParanoidi P38419.
KOi K00454.
OMAi IARNKMP.

Enzyme and pathway databases

UniPathwayi UPA00382 .
BioCyci MetaCyc:MONOMER-16718.
Reactomei REACT_220543. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_245113. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_254799. Synthesis of Hepoxilins (HX) and Trioxilins (TrX).
REACT_256153. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_261475. Synthesis of Lipoxins (LX).

Gene expression databases

ExpressionAtlasi P38419. baseline and differential.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus."
    Peng Y.L., Shirano Y., Ohta H., Hibino T., Tanaka K., Shibata D.
    J. Biol. Chem. 269:3755-3761(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Aichiasahi.
    Tissue: Leaf.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiLOXC1_ORYSJ
AccessioniPrimary (citable) accession number: P38419
Secondary accession number(s): Q6YVT0, Q9XHM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3