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P38419

- LOXC1_ORYSJ

UniProt

P38419 - LOXC1_ORYSJ

Protein

Lipoxygenase 7, chloroplastic

Gene

CM-LOX1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This lipoxygenase introduces molecular oxygen exclusively into the C-13 position of linoleic and linolenic acids.1 Publication

    Catalytic activityi

    Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
    Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

    Cofactori

    Binds 1 iron ion per subunit. Iron is tightly bound By similarity.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi581 – 5811Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi586 – 5861Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi773 – 7731Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi777 – 7771Iron; catalyticPROSITE-ProRule annotation
    Metal bindingi924 – 9241Iron; via carboxylate; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC
    3. phytoene dehydrogenase activity Source: Gramene

    GO - Biological processi

    1. lipid oxidation Source: EnsemblPlants/Gramene
    2. oxylipin biosynthetic process Source: UniProtKB-UniPathway
    3. response to other organism Source: Gramene
    4. response to wounding Source: Gramene

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-16718.
    UniPathwayiUPA00382.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoxygenase 7, chloroplastic (EC:1.13.11.12)
    Gene namesi
    Name:CM-LOX1
    Synonyms:LOX2.1
    Ordered Locus Names:Os08g0508800, LOC_Os08g39840
    ORF Names:B1168A08.24
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 8

    Organism-specific databases

    GrameneiP38419.

    Subcellular locationi

    Plastidchloroplast Curated

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell
    2. plasma membrane Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6161ChloroplastSequence AnalysisAdd
    BLAST
    Chaini62 – 924863Lipoxygenase 7, chloroplasticPRO_0000018327Add
    BLAST

    Proteomic databases

    PRIDEiP38419.

    Expressioni

    Inductioni

    By fungal infection.

    Structurei

    3D structure databases

    ProteinModelPortaliP38419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 218131PLATPROSITE-ProRule annotationAdd
    BLAST
    Domaini225 – 924700LipoxygenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lipoxygenase family.Curated
    Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG69653.
    HOGENOMiHOG000230469.
    KOiK00454.
    OMAiIARNKMP.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProiIPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11771. PTHR11771. 1 hit.
    PfamiPF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PRINTSiPR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P38419-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRPQLNPSS HTTTTSSSSS TQLFASSSCI ASLRRPSSSS SSVVAAARRT    50
    RGQGSSRVVV VCASSSATAS RGDSSSDMAA AAAVRVKAVA TIKVTVGELI 100
    NRSIDIRDLI GRSLSLELVS SELDAKTGKE KATVRSYAHN VDDDDHSVVT 150
    YEADFDVPSG FGPIGAIIVT NELRQEMFLE DINLTASDGA GNSTVLPIRC 200
    NSWVQPKSVG DEGTPSKRIF FANKTYLPGQ TPAGLRSYRK NDLQQKRGDG 250
    TGEREADDRV YDYDVYNDLG NPDSNGDLAR PVLGGNKQFP YPRRCRTGRP 300
    PSKKDPKSET RKGNVYVPRD EEFSPEKEDY FLRKTVGSVL QAAVPAAQSL 350
    LLDKLKWNLP FPSFFVIDKL FEDGVELPGV DKLNFLESVV PRLLEHLRDT 400
    PAEKILRFET PANIQKDKFA WLRDEEFARE TLAGINPYAI ELVREFPLKS 450
    KLDPAVYGPA ESAITADLLE EQMRRVMTVE EAISQKRLFM LDFHDLFLPY 500
    VHKIRSLDHT TMYGSRTVFF LTDDGTLQLL AIELTRPASP SQPQWRQVFT 550
    PSTDATMSWL WRMAKAHVRA HDAGHHELIT HWLRTHCAVE PYIIAANRQL 600
    SEMHPIYQLL RPHFRYTMRI NARARSALIS AGGIIERSFS PQKYSMELSS 650
    VAYDKLWRFD TEALPADLVR RGMAEEDPTA EHGLKLAIED YPFANDGLLI 700
    WDAIKTWVQA YVARFYPDAD SVAGDEELQA FWTEVRTKGH GDKKDAPWWP 750
    KLDSPESLAH TLTTIVWVAA AHHAAVNFGQ YDFGGYFPNR PSIARTVMPV 800
    EEPVDGAAME RFLDNPDQAL RECFPSQVQA TVVMAVLDVL SSHSTDEEYL 850
    GGEQTRPWNS DAAVQAAYDG FAARLKEIEG VIDGRNKDRK LKNRCGAGIL 900
    PYQLMKPFSD SGVTGMGIPN STSI 924
    Length:924
    Mass (Da):102,819
    Last modified:August 30, 2005 - v2
    Checksum:iE2142F9775751FEB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti143 – 1431D → E in AAD39093. (PubMed:7508918)Curated
    Sequence conflicti342 – 3432AA → P in AAD39093. (PubMed:7508918)Curated
    Sequence conflicti350 – 3523LLL → CSS in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti450 – 4501S → T in AAD39093. (PubMed:7508918)Curated
    Sequence conflicti484 – 4841S → N in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti540 – 5401P → L in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti625 – 6284RSAL → ARV in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti682 – 6821H → Q in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti764 – 7641T → N in BAA03102. (PubMed:7508918)Curated
    Sequence conflicti819 – 8191A → R in AAD39093. (PubMed:7508918)Curated
    Sequence conflicti858 – 8647WNSDAAV → GTATRRL in BAA03102. (PubMed:7508918)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14000 mRNA. Translation: BAA03102.1.
    AF095895 mRNA. Translation: AAD39093.1.
    AP005816 Genomic DNA. Translation: BAD10665.1.
    RefSeqiNP_001062199.1. NM_001068734.1.
    UniGeneiOs.4416.

    Genome annotation databases

    EnsemblPlantsiOS08T0508800-01; OS08T0508800-01; OS08G0508800.
    GeneIDi4345993.
    KEGGiosa:4345993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14000 mRNA. Translation: BAA03102.1 .
    AF095895 mRNA. Translation: AAD39093.1 .
    AP005816 Genomic DNA. Translation: BAD10665.1 .
    RefSeqi NP_001062199.1. NM_001068734.1.
    UniGenei Os.4416.

    3D structure databases

    ProteinModelPortali P38419.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P38419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS08T0508800-01 ; OS08T0508800-01 ; OS08G0508800 .
    GeneIDi 4345993.
    KEGGi osa:4345993.

    Organism-specific databases

    Gramenei P38419.

    Phylogenomic databases

    eggNOGi NOG69653.
    HOGENOMi HOG000230469.
    KOi K00454.
    OMAi IARNKMP.

    Enzyme and pathway databases

    UniPathwayi UPA00382 .
    BioCyci MetaCyc:MONOMER-16718.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    4.10.372.10. 1 hit.
    InterProi IPR008976. Lipase_LipOase.
    IPR000907. LipOase.
    IPR013819. LipOase_C.
    IPR020834. LipOase_CS.
    IPR020833. LipOase_Fe_BS.
    IPR001246. LipOase_pln.
    IPR027433. Lipoxygenase_domain_3.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11771. PTHR11771. 1 hit.
    Pfami PF00305. Lipoxygenase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PRINTSi PR00087. LIPOXYGENASE.
    PR00468. PLTLPOXGNASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48484. SSF48484. 1 hit.
    SSF49723. SSF49723. 1 hit.
    PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
    PS00081. LIPOXYGENASE_2. 1 hit.
    PS51393. LIPOXYGENASE_3. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus."
      Peng Y.L., Shirano Y., Ohta H., Hibino T., Tanaka K., Shibata D.
      J. Biol. Chem. 269:3755-3761(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: cv. Aichiasahi.
      Tissue: Leaf.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiLOXC1_ORYSJ
    AccessioniPrimary (citable) accession number: P38419
    Secondary accession number(s): Q6YVT0, Q9XHM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3