Lipoxygenase 7, chloroplastic precursor - Oryza sativa subsp. japonica (Rice)

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Reviewed, UniProtKB/Swiss-Prot P38419 (LOXC1_ORYSJ)

Last modified June 16, 2009. Version 68. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Lipoxygenase 7, chloroplastic
EC=1.13.11.12

Gene names

Name:	CM-LOX1
Synonyms:	LOX2.1
Ordered Locus Names:	Os08g0508800, LOC_Os08g39840
ORF Names:	B1168A08.24

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This lipoxygenase introduces molecular oxygen exclusively into the C-13 position of linoleic and linolenic acids. Ref.1
Catalytic activity	Linoleate + O₂ = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Cofactor	Binds 1 iron ion per subunit. Iron is tightly bound By similarity.
Pathway	Lipid metabolism; oxylipin biosynthesis.
Subcellular location	Plastid › chloroplast Potential.
Induction	By fungal infection.
Sequence similarities	Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain.

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Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis Oxylipin biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW oxylipin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW response to other organism Ref.1 Inferred from direct assay. Source: Gramene response to wounding Ref.1 Inferred from direct assay. Source: Gramene
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW lipoxygenase activity Inferred from electronic annotation. Source: EC phytoene dehydrogenase activity Ref.1 Inferred from direct assay. Source: Gramene
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 61

Chloroplast Potential

Chain

62 – 924

863

Lipoxygenase 7, chloroplastic

PRO_0000018327

Regions

Domain

88 – 218

131

PLAT

Domain

225 – 924

700

Lipoxygenase

Sites

Metal binding

581

Iron; catalytic By similarity

Metal binding

586

Iron; catalytic By similarity

Metal binding

773

Iron; catalytic By similarity

Metal binding

777

Iron; catalytic By similarity

Metal binding

924

Iron; via carboxylate; catalytic By similarity

Experimental info

Sequence conflict

143

D → E in AAD39093. Ref.1

Sequence conflict

342 – 343

AA → P in AAD39093. Ref.1

Sequence conflict

350 – 352

LLL → CSS in BAA03102. Ref.1

Sequence conflict

450

S → T in AAD39093. Ref.1

Sequence conflict

484

S → N in BAA03102. Ref.1

Sequence conflict

540

P → L in BAA03102. Ref.1

Sequence conflict

625 – 628

RSAL → ARV in BAA03102. Ref.1

Sequence conflict

682

H → Q in BAA03102. Ref.1

Sequence conflict

764

T → N in BAA03102. Ref.1

Sequence conflict

819

A → R in AAD39093. Ref.1

Sequence conflict

858 – 864

WNSDAAV → GTATRRL in BAA03102. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P38419-1 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: E2142F9775751FEB
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FASTA

924

102,819

        10         20         30         40         50         60 
MLRPQLNPSS HTTTTSSSSS TQLFASSSCI ASLRRPSSSS SSVVAAARRT RGQGSSRVVV 

        70         80         90        100        110        120 
VCASSSATAS RGDSSSDMAA AAAVRVKAVA TIKVTVGELI NRSIDIRDLI GRSLSLELVS 

       130        140        150        160        170        180 
SELDAKTGKE KATVRSYAHN VDDDDHSVVT YEADFDVPSG FGPIGAIIVT NELRQEMFLE 

       190        200        210        220        230        240 
DINLTASDGA GNSTVLPIRC NSWVQPKSVG DEGTPSKRIF FANKTYLPGQ TPAGLRSYRK 

       250        260        270        280        290        300 
NDLQQKRGDG TGEREADDRV YDYDVYNDLG NPDSNGDLAR PVLGGNKQFP YPRRCRTGRP 

       310        320        330        340        350        360 
PSKKDPKSET RKGNVYVPRD EEFSPEKEDY FLRKTVGSVL QAAVPAAQSL LLDKLKWNLP 

       370        380        390        400        410        420 
FPSFFVIDKL FEDGVELPGV DKLNFLESVV PRLLEHLRDT PAEKILRFET PANIQKDKFA 

       430        440        450        460        470        480 
WLRDEEFARE TLAGINPYAI ELVREFPLKS KLDPAVYGPA ESAITADLLE EQMRRVMTVE 

       490        500        510        520        530        540 
EAISQKRLFM LDFHDLFLPY VHKIRSLDHT TMYGSRTVFF LTDDGTLQLL AIELTRPASP 

       550        560        570        580        590        600 
SQPQWRQVFT PSTDATMSWL WRMAKAHVRA HDAGHHELIT HWLRTHCAVE PYIIAANRQL 

       610        620        630        640        650        660 
SEMHPIYQLL RPHFRYTMRI NARARSALIS AGGIIERSFS PQKYSMELSS VAYDKLWRFD 

       670        680        690        700        710        720 
TEALPADLVR RGMAEEDPTA EHGLKLAIED YPFANDGLLI WDAIKTWVQA YVARFYPDAD 

       730        740        750        760        770        780 
SVAGDEELQA FWTEVRTKGH GDKKDAPWWP KLDSPESLAH TLTTIVWVAA AHHAAVNFGQ 

       790        800        810        820        830        840 
YDFGGYFPNR PSIARTVMPV EEPVDGAAME RFLDNPDQAL RECFPSQVQA TVVMAVLDVL 

       850        860        870        880        890        900 
SSHSTDEEYL GGEQTRPWNS DAAVQAAYDG FAARLKEIEG VIDGRNKDRK LKNRCGAGIL 

       910        920 
PYQLMKPFSD SGVTGMGIPN STSI

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel lipoxygenase from rice. Primary structure and specific expression upon incompatible infection with rice blast fungus." Peng Y.L., Shirano Y., Ohta H., Hibino T., Tanaka K., Shibata D. J. Biol. Chem. 269:3755-3761(1994) [PubMed: 7508918] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: cv. Aichiasahi. Tissue: Leaf.
[2]	"Oryza sativa nipponbare chromosome 8 genomic DNA sequence." The international rice genome sequencing project (IRGSP) consortium Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

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Cross-references

Sequence databases
	D14000 mRNA. Translation: BAA03102.1. AF095895 mRNA. Translation: AAD39093.1. AP005816 Genomic DNA. Translation: BAD10665.1.
RefSeq	NP_001062199.1.
UniGene	Os.4416
3D structure databases
HSSP	HSSP built from PDB template 2SBL based on UniProtKB P08170.
ModBase	Search...
Genome annotation databases
GeneID	4345993.
KEGG	osa:4345993.
Organism-specific databases
Gramene	P38419.
Family and domain databases
InterPro	IPR000907. LipOase. IPR013819. LipOase_C. IPR001024. LipOase_LH2. IPR001246. LipOase_pln. [Graphical view]
Gene3D	G3DSA:2.60.60.20. Lipase_LipOase. 1 hit.
PANTHER	PTHR11771. LipOase. 1 hit.
Pfam	PF00305. Lipoxygenase. 1 hit. PF01477. PLAT. 1 hit. [Graphical view]
PRINTS	PR00087. LIPOXYGENASE. PR00468. PLTLPOXGNASE.
SMART	SM00308. LH2. 1 hit. [Graphical view]
PROSITE	PS00711. LIPOXYGENASE_1. 1 hit. PS00081. LIPOXYGENASE_2. 1 hit. PS51393. LIPOXYGENASE_3. 1 hit. PS50095. PLAT. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

LOXC1_ORYSJ

Accession

Primary (citable) accession number: P38419
Secondary accession number(s): Q6YVT0, Q9XHM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry information

Relevant documents