Guanine nucleotide-binding protein G(olf) subunit alpha

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P38405 (GNAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(olf) subunit alpha

Alternative name(s):
Adenylate cyclase-stimulating G alpha protein, olfactory type

Gene names

Name:

GNAL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Tissue specificity	Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.
Sequence similarities	Belongs to the G-alpha family. G(s) subfamily.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Transducer
PTM	ADP-ribosylation Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity by dopamine receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome inhibition of adenylate cyclase activity by G-protein signaling pathway Traceable author statement. Source: Reactome sensory perception of smell Inferred from Biological aspect of Ancestor. Source: RefGenome synaptic transmission Traceable author statement. Source: Reactome
Cellular component	heterotrimeric G-protein complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	G-protein beta/gamma-subunit complex binding Inferred from Biological aspect of Ancestor. Source: RefGenome G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Traceable author statement. Source: Reactome adenylate cyclase activity Traceable author statement. Source: Reactome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 381

380

Guanine nucleotide-binding protein G(olf) subunit alpha

PRO_0000203732

Regions

Nucleotide binding

49 – 56

GTP By similarity

Nucleotide binding

185 – 191

GTP By similarity

Nucleotide binding

210 – 214

GTP By similarity

Nucleotide binding

279 – 282

GTP By similarity

Sites

Metal binding

Magnesium By similarity

Metal binding

191

Magnesium By similarity

Binding site

353

GTP; via amide nitrogen By similarity

Amino acid modifications

Modified residue

188

ADP-ribosylarginine; by cholera toxin By similarity

Lipidation

N-palmitoyl glycine By similarity

Lipidation

S-palmitoyl cysteine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P38405 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9A73D2982FF9C9A3
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FASTA

381

44,308

        10         20         30         40         50         60 
MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA GESGKSTIVK 

        70         80         90        100        110        120 
QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI IPPVPLANPE NQFRSDYIKS 

       130        140        150        160        170        180 
IAPITDFEYS QEFFDHVKKL WDDEGVKACF ERSNEYQLID CAQYFLERID SVSLVDYTPT 

       190        200        210        220        230        240 
DQDLLRCRVL TSGIFETRFQ VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY 

       250        260        270        280        290        300 
NMVIREDNNT NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP 

       310        320        330        340        350        360 
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF TCAVDTENIR 

       370        380 
RVFNDCRDII QRMHLKQYEL L

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system." Zigman J.M., Westermark G.T., Lamendola J., Boel E., Steiner D.F. Endocrinology 133:2508-2514(1993) [PubMed: 8243272] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Insulinoma.
[2]	"The gene for the human G protein Golf alpha." Vuoristo J.T., Berrettini W.H., Overhauser J., Prockop D.J., Ferraro T.N., Ala-Kokko L. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L10665 mRNA. Translation: AAC37535.1. U55184 , U55180, U55181, U55182, U55183 Genomic DNA. Translation: AAD00085.1. AF493893 mRNA. Translation: AAM12607.1.
IPI	IPI00006395.
PIR	I53271.
RefSeq	NP_001135811.1. NM_001142339.1. NP_002062.1. NM_002071.3.
UniGene	Hs.136295.
3D structure databases
ProteinModelPortal	P38405.
SMR	P38405. Positions 39-378.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38405. 4 interactions.
STRING	P38405.
PTM databases
PhosphoSite	P38405.
Polymorphism databases
DMDM	585178.
Proteomic databases
PRIDE	P38405.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269162; ENSP00000269162; ENSG00000141404. ENST00000423027; ENSP00000408489; ENSG00000141404.
GeneID	2774.
KEGG	hsa:2774.
UCSC	uc002kqd.1. human.
Organism-specific databases
CTD	2774.
GeneCards	GC18P011679.
H-InvDB	HIX0014341.
HGNC	HGNC:4388. GNAL.
HPA	CAB015464.
MIM	139312. gene.
neXtProt	NX_P38405.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05346.
GeneTree	ENSGT00560000077005.
HOVERGEN	HBG063184.
OMA	DYSQEFF.
OrthoDB	EOG490792.
PhylomeDB	P38405.
Enzyme and pathway databases
Pathway_Interaction_DB	endothelinpathway. Endothelins. lpa4_pathway. LPA4-mediated signaling events. er_nongenomic_pathway. Plasma membrane estrogen receptor signaling.
Reactome	REACT_111102. Signal Transduction. REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	P38405.
Bgee	P38405.
CleanEx	HS_GNAL.
Genevestigator	P38405.
GermOnline	ENSG00000141404. Homo sapiens.
Family and domain databases
InterPro	IPR000367. Gprotein_alpha_S. IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. [Graphical view]
Gene3D	G3DSA:1.10.400.10. GproteinA_insert. 1 hit.
KO	K04633.
PANTHER	PTHR10218. Gprotein_alph_bd. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00443. GPROTEINAS.
SMART	SM00275. G_alpha. 1 hit. [Graphical view]
SUPFAM	SSF47895. Transducn_insert. 1 hit.
ProtoNet	Search...
Other
NextBio	10910.
SOURCE	Search...

Entry information

Entry name

GNAL_HUMAN

Accession

Primary (citable) accession number: P38405

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 25, 2012
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents