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Reviewed, UniProtKB/Swiss-Prot P38405 (GNAL_HUMAN)

Last modified November 25, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Guanine nucleotide-binding protein G(olf) subunit alpha
Alternative name(s):
    Adenylate cyclase-stimulating G alpha protein, olfactory type
Gene names
Name: GNAL
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Tissue specificity

Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined.

Sequence similarities

Belongs to the G-alpha family. G(s) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 381380Guanine nucleotide-binding protein G(olf) subunit alpha
PRO_0000203732

Regions

Nucleotide binding49 – 568GTP By similarity
Nucleotide binding210 – 2145GTP By similarity
Nucleotide binding279 – 2824GTP By similarity

Amino acid modifications

Modified residue1881ADP-ribosylarginine; by cholera toxin By similarity
Lipidation21N-palmitoyl glycine By similarity
Lipidation31S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P38405-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 9A73D2982FF9C9A3

FASTA38144,308
        10         20         30         40         50         60 
MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA GESGKSTIVK 

        70         80         90        100        110        120 
QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI IPPVPLANPE NQFRSDYIKS 

       130        140        150        160        170        180 
IAPITDFEYS QEFFDHVKKL WDDEGVKACF ERSNEYQLID CAQYFLERID SVSLVDYTPT 

       190        200        210        220        230        240 
DQDLLRCRVL TSGIFETRFQ VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY 

       250        260        270        280        290        300 
NMVIREDNNT NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP 

       310        320        330        340        350        360 
EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF TCAVDTENIR 

       370        380 
RVFNDCRDII QRMHLKQYEL L 

« Hide

References

« Hide 'large scale' references
[1]"Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system."
Zigman J.M., Westermark G.T., Lamendola J., Boel E., Steiner D.F.
Endocrinology 133:2508-2514(1993) [PubMed: 8243272] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Insulinoma.
[2]"The gene for the human G protein Golf alpha."
Vuoristo J.T., Berrettini W.H., Overhauser J., Prockop D.J., Ferraro T.N., Ala-Kokko L.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

L10665 mRNA. Translation: AAC37535.1.
U55184 expand/collapse EMBL AC list , U55180, U55181, U55182, U55183 Genomic DNA. Translation: AAD00085.1.
AF493893 mRNA. Translation: AAM12607.1.
PIRI53271.
RefSeqNP_002062.1.
UniGeneHs.136295

3D structure databases

HSSPHSSP built from PDB template 1CJU based on UniProtKB P04896.
SMRP38405. Positions 39-378.
ModBaseSearch...

PTM databases

PhosphoSiteP38405.

Genome annotation databases

EnsemblENSG00000141404. Homo sapiens. [Contig view]
GeneID2774.
KEGGhsa:2774.

Organism-specific databases

H-InvDBHIX0017705.
HGNCHGNC:4388. GNAL.
HPACAB015464.
MIM139312. gene.
PharmGKBPA28770.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP38405.

Gene expression databases

ArrayExpressP38405.
CleanExHS_GNAL.
GermOnlineENSG00000141404. Homo sapiens.

Family and domain databases

InterProIPR001019. Gprotein_alph_bd.
IPR000367. Gprotein_alpha_S.
[Graphical view]
PANTHERPTHR10218. Gprotein_alph_bd. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00443. GPROTEINAS.
ProDomPD000281. Gprotein_alpha. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio10910.
SOURCESearch...

Entry information

Entry nameGNAL_HUMAN
AccessionPrimary (citable) accession number: P38405
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 25, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents