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Protein

Protein translocase subunit SecD

Gene

secD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-539-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecDUniRule annotation
Gene namesi
Name:secDUniRule annotation
Ordered Locus Names:ML0487
ORF Names:B1177_C1_164, MLCB1259.05
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0487

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei383 – 403HelicalUniRule annotationAdd BLAST21
Transmembranei408 – 428HelicalUniRule annotationAdd BLAST21
Transmembranei439 – 459HelicalUniRule annotationAdd BLAST21
Transmembranei487 – 507HelicalUniRule annotationAdd BLAST21
Transmembranei512 – 532HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000959651 – 571Protein translocase subunit SecDAdd BLAST571

Proteomic databases

PRIDEiP38387

Interactioni

Subunit structurei

Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0487

Structurei

3D structure databases

ProteinModelPortaliP38387
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0342 LUCA
HOGENOMiHOG000018636
KOiK03072
OrthoDBiPOG091H02C5

Family and domain databases

HAMAPiMF_01463_B SecD_B, 1 hit
InterProiView protein in InterPro
IPR005791 SecD
IPR022813 SecD/SecF_arch_bac
IPR022645 SecD/SecF_bac
IPR022646 SecD/SecF_CS
PfamiView protein in Pfam
PF07549 Sec_GG, 1 hit
PF02355 SecD_SecF, 1 hit
TIGRFAMsiTIGR00916 2A0604s01, 1 hit
TIGR01129 secD, 1 hit

Sequencei

Sequence statusi: Complete.

P38387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSAPVHF GRYLSMFLVL FIGVYLLAFL TGDKRVVPRL GIDLQGGTRV
60 70 80 90 100
TLTARTPDGS RPSREALSQA QQIISSRVNG LGVSGSEVVV DGDNLVITVP
110 120 130 140 150
GNDGNEARNL GQTARLYIRP VLNSLPVQRG QDPKPGSPAG TLPNFAPMPP
160 170 180 190 200
DHPGAQPRPY LQDPTSSPSS DPMPSPVPTG AALPGEVPSV EQPAPPDPRK
210 220 230 240 250
DLAERIAEEK KWRQSTKQSI QFLALQFEST HCDKDDILAG NDDPNLPLAT
260 270 280 290 300
CSTDHNMAYL LAPSIISGDQ IQNSTSGMNQ RGVGYVVDLQ FKSAAADVWA
310 320 330 340 350
DFTAAHIGTQ TAFTLDSEVV SVPVINEAIL GGRTQISGGD PPFTAATARQ
360 370 380 390 400
LANVLKYGSL PLSFEPSEAQ TVSATLGLTS LRAGLIAGAI GLSLVLLYSL
410 420 430 440 450
LYYRVLGLLT AFSLFCSGTI IFAILVLLGR YINYTLDLAG IAGLIIGIGT
460 470 480 490 500
TADSFVVFFE RIKDEIREGR SFRSAVPRGW VRARKTIVSG NAVTFLAAAV
510 520 530 540 550
LHFLAIGQVK GFAFTLGLTT ILDLVVVFLV TWPLVYLASK SPLLARPAYN
560 570
GLGAVQQVAR ERRASAKTGR G
Length:571
Mass (Da):60,719
Last modified:May 30, 2000 - v2
Checksum:i40852F70E049B496
GO

Sequence cautioni

The sequence AAA17086 differs from that shown. Reason: Frameshift at position 567.Curated
The sequence CAC29995 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023591 Genomic DNA Translation: CAA19080.1
AL583918 Genomic DNA Translation: CAC29995.1 Different initiation.
U00011 Genomic DNA Translation: AAA17086.1 Frameshift.
PIRiG86969
S72722
RefSeqiNP_301427.2, NC_002677.1
WP_010907751.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC29995; CAC29995; CAC29995
GeneIDi909240
KEGGimle:ML0487
PATRICifig|272631.5.peg.851

Similar proteinsi

Entry informationi

Entry nameiSECD_MYCLE
AccessioniPrimary (citable) accession number: P38387
Secondary accession number(s): O69485, Q9CCT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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