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Protein

Protein translocase subunit SecD

Gene

secD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecDUniRule annotation
Gene namesi
Name:secDUniRule annotation
Ordered Locus Names:ML0487
ORF Names:B1177_C1_164, MLCB1259.05
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0487.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalUniRule annotationAdd
BLAST
Transmembranei383 – 40321HelicalUniRule annotationAdd
BLAST
Transmembranei408 – 42821HelicalUniRule annotationAdd
BLAST
Transmembranei439 – 45921HelicalUniRule annotationAdd
BLAST
Transmembranei487 – 50721HelicalUniRule annotationAdd
BLAST
Transmembranei512 – 53221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Protein translocase subunit SecDPRO_0000095965Add
BLAST

Interactioni

Subunit structurei

Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0487.

Structurei

3D structure databases

ProteinModelPortaliP38387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0342. LUCA.
HOGENOMiHOG000018636.
KOiK03072.
OrthoDBiEOG6N0HJT.

Family and domain databases

HAMAPiMF_01463_B. SecD_B.
InterProiIPR005791. SecD.
IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR01129. secD. 1 hit.

Sequencei

Sequence statusi: Complete.

P38387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSAPVHF GRYLSMFLVL FIGVYLLAFL TGDKRVVPRL GIDLQGGTRV
60 70 80 90 100
TLTARTPDGS RPSREALSQA QQIISSRVNG LGVSGSEVVV DGDNLVITVP
110 120 130 140 150
GNDGNEARNL GQTARLYIRP VLNSLPVQRG QDPKPGSPAG TLPNFAPMPP
160 170 180 190 200
DHPGAQPRPY LQDPTSSPSS DPMPSPVPTG AALPGEVPSV EQPAPPDPRK
210 220 230 240 250
DLAERIAEEK KWRQSTKQSI QFLALQFEST HCDKDDILAG NDDPNLPLAT
260 270 280 290 300
CSTDHNMAYL LAPSIISGDQ IQNSTSGMNQ RGVGYVVDLQ FKSAAADVWA
310 320 330 340 350
DFTAAHIGTQ TAFTLDSEVV SVPVINEAIL GGRTQISGGD PPFTAATARQ
360 370 380 390 400
LANVLKYGSL PLSFEPSEAQ TVSATLGLTS LRAGLIAGAI GLSLVLLYSL
410 420 430 440 450
LYYRVLGLLT AFSLFCSGTI IFAILVLLGR YINYTLDLAG IAGLIIGIGT
460 470 480 490 500
TADSFVVFFE RIKDEIREGR SFRSAVPRGW VRARKTIVSG NAVTFLAAAV
510 520 530 540 550
LHFLAIGQVK GFAFTLGLTT ILDLVVVFLV TWPLVYLASK SPLLARPAYN
560 570
GLGAVQQVAR ERRASAKTGR G
Length:571
Mass (Da):60,719
Last modified:May 30, 2000 - v2
Checksum:i40852F70E049B496
GO

Sequence cautioni

The sequence AAA17086.1 differs from that shown. Reason: Frameshift at position 567. Curated
The sequence CAC29995.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023591 Genomic DNA. Translation: CAA19080.1.
AL583918 Genomic DNA. Translation: CAC29995.1. Different initiation.
U00011 Genomic DNA. Translation: AAA17086.1. Frameshift.
PIRiG86969.
S72722.
RefSeqiNP_301427.2. NC_002677.1.
WP_010907751.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29995; CAC29995; CAC29995.
GeneIDi909240.
KEGGimle:ML0487.
PATRICi18051808. VBIMycLep78757_0851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023591 Genomic DNA. Translation: CAA19080.1.
AL583918 Genomic DNA. Translation: CAC29995.1. Different initiation.
U00011 Genomic DNA. Translation: AAA17086.1. Frameshift.
PIRiG86969.
S72722.
RefSeqiNP_301427.2. NC_002677.1.
WP_010907751.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP38387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29995; CAC29995; CAC29995.
GeneIDi909240.
KEGGimle:ML0487.
PATRICi18051808. VBIMycLep78757_0851.

Organism-specific databases

LepromaiML0487.

Phylogenomic databases

eggNOGiCOG0342. LUCA.
HOGENOMiHOG000018636.
KOiK03072.
OrthoDBiEOG6N0HJT.

Family and domain databases

HAMAPiMF_01463_B. SecD_B.
InterProiIPR005791. SecD.
IPR022813. SecD/SecF_arch_bac.
IPR022645. SecD/SecF_bac.
IPR022646. SecD/SecF_CS.
[Graphical view]
PfamiPF07549. Sec_GG. 1 hit.
PF02355. SecD_SecF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00916. 2A0604s01. 1 hit.
TIGR01129. secD. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.
  2. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 88-571.

Entry informationi

Entry nameiSECD_MYCLE
AccessioniPrimary (citable) accession number: P38387
Secondary accession number(s): O69485, Q9CCT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: November 11, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.