UniProtKB - P38383 (SECE_THET8)
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Protein
Protein translocase subunit SecE
Gene
secE
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Functioni
Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
GO - Molecular functioni
GO - Biological processi
- protein secretion Source: InterPro
- protein targeting Source: InterPro
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein translocase subunit SecEUniRule annotation |
Gene namesi | Name:secEUniRule annotation Ordered Locus Names:TTHA0249 |
Organismi | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
Taxonomic identifieri | 300852 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation1 Publication; Single-pass membrane protein UniRule annotation1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | CytoplasmicAdd BLAST | 31 | |
Transmembranei | 32 – 52 | HelicalAdd BLAST | 21 | |
Topological domaini | 53 – 60 | Extracellular | 8 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- intracellular Source: GOC
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000104189 | 1 – 60 | Protein translocase subunit SecEAdd BLAST | 60 |
Interactioni
Subunit structurei
Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.1 Publication
Protein-protein interaction databases
STRINGi | 300852.TTHA0249. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 2 – 17 | Combined sources | 16 | |
Helixi | 24 – 59 | Combined sources | 36 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZJS | X-ray | 3.20 | E | 1-60 | [»] | |
2ZQP | X-ray | 6.00 | E | 1-60 | [»] | |
5AWW | X-ray | 2.72 | E | 1-60 | [»] | |
5CH4 | X-ray | 3.64 | E | 1-60 | [»] | |
SMRi | P38383. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P38383. |
Family & Domainsi
Sequence similaritiesi
Belongs to the SecE/SEC61-gamma family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410683Z. Bacteria. ENOG410XUXP. LUCA. |
HOGENOMi | HOG000219149. |
KOi | K03073. |
OMAi | MNLIQYF. |
Family and domain databases
Gene3Di | 1.20.5.1030. 1 hit. |
HAMAPi | MF_00422. SecE. 1 hit. |
InterProi | View protein in InterPro IPR022943. SecE. IPR005807. SecE_bac. IPR038379. SecE_sf. IPR001901. Translocase_SecE/Sec61-g. |
PANTHERi | PTHR33910. PTHR33910. 1 hit. |
Pfami | View protein in Pfam PF00584. SecE. 1 hit. |
TIGRFAMsi | TIGR00964. secE_bact. 1 hit. |
PROSITEi | View protein in PROSITE PS01067. SECE_SEC61G. 1 hit. |
i Sequence
Sequence statusi: Complete.
P38383-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFARLIRYFQ EARAELARVT WPTREQVVEG TQAILLFTLA FMVILGLYDT
60
VFRFLIGLLR
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | I → Y in L10348 (PubMed:1447157).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10348 Genomic DNA. No translation available. AP008226 Genomic DNA. Translation: BAD70072.1. |
RefSeqi | WP_008630510.1. NC_006461.1. YP_143515.1. NC_006461.1. |
Genome annotation databases
EnsemblBacteriai | BAD70072; BAD70072; BAD70072. |
GeneIDi | 3168489. |
KEGGi | ttj:TTHA0249. |
Similar proteinsi
Entry informationi
Entry namei | SECE_THET8 | |
Accessioni | P38383Primary (citable) accession number: P38383 Secondary accession number(s): Q5SLP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | March 29, 2005 | |
Last modified: | March 28, 2018 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |