secE

Functionⁱ

Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

GO - Molecular functionⁱ

P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein secretion Source: InterPro
protein targeting Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Translocation, Transport

Biological process

Protein transport, Translocation, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein translocase subunit SecEUniRule annotation
Gene namesⁱ	Name:secEUniRule annotation Ordered Locus Names:TTHA0249
Organismⁱ	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifierⁱ	300852 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus
Proteomesⁱ	UP000000532 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00422
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Conformational transition of Sec machinery inferred from bacterial SecYE structures."
  Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D.G., Ito K., Nureki O.
  Nature 455:988-991(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 3-434 OF THE SECYE COMPLEX WITH A PARTIALLY OPEN LATERAL GATE, SUBUNIT, SUBCELLULAR LOCATION.
; Single-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00422
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Conformational transition of Sec machinery inferred from bacterial SecYE structures."
  Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D.G., Ito K., Nureki O.
  Nature 455:988-991(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 3-434 OF THE SECYE COMPLEX WITH A PARTIALLY OPEN LATERAL GATE, SUBUNIT, SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 31	CytoplasmicAdd BLAST	31
Transmembraneⁱ	32 – 52	HelicalAdd BLAST	21
Topological domainⁱ	53 – 60	Extracellular	8

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
intracellular Source: GOC
plasma membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000104189	1 – 60	Protein translocase subunit SecEAdd BLAST		60

Interactionⁱ

Subunit structureⁱ

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.1 Publication

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0249.

STRINGⁱ

300852.TTHA0249.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	2 – 17	Combined sources		16
Helixⁱ	24 – 59	Combined sources		36

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZJS	X-ray	3.20	E	1-60	[»]
	2ZQP	X-ray	6.00	E	1-60	[»]
	5AWW	X-ray	2.72	E	1-60	[»]
	5CH4	X-ray	3.64	E	1-60	[»]
SMRⁱ	P38383.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P38383.

EvolutionaryTraceⁱ

P38383.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SecE/SEC61-gamma family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410683Z. Bacteria. ENOG410XUXP. LUCA.
HOGENOMⁱ	HOG000219149.
KEGG Orthology (KO) More...KOⁱ	K03073.
OMAⁱ	MNLIQYF.

Family and domain databases

Gene3Dⁱ	1.20.5.1030. 1 hit.
HAMAPⁱ	MF_00422. SecE. 1 hit.
InterProⁱ	View protein in InterPro IPR022943. SecE. IPR005807. SecE_bac. IPR038379. SecE_sf. IPR001901. Translocase_SecE/Sec61-g.
PANTHERⁱ	PTHR33910. PTHR33910. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00584. SecE. 1 hit.
TIGRFAMsⁱ	TIGR00964. secE_bact. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01067. SECE_SEC61G. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P38383-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFARLIRYFQ EARAELARVT WPTREQVVEG TQAILLFTLA FMVILGLYDT 
        60
VFRFLIGLLR

Length:60

Mass (Da):7,065

Last modified:March 29, 2005 - v2

Checksum:ⁱ0B7BEA730CB3ADBD

GO

Sequence cautionⁱ

The sequence L10348 differs from that shown. Reason: Frameshift at position 15.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	44	I → Y in L10348 (PubMed:1447157).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10348 Genomic DNA. No translation available. AP008226 Genomic DNA. Translation: BAD70072.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_008630510.1. NC_006461.1. YP_143515.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaⁱ	BAD70072; BAD70072; BAD70072.
GeneIDⁱ	3168489.
KEGGⁱ	ttj:TTHA0249.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P38383	Q8KZP4 H7GDF7 Q72GW2 G1UBI3 H9ZP03	Thermus thermophilus Thermus parvatiensis Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) Thermus thermophilus (strain SG0.5JP17-16) Thermus thermophilus JL-18	60	UniRef100_P38383	Cluster: Protein translocase subunit SecE	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P38383	Q8KZP4 H7GDF7 Q72GW2 G1UBI3 H9ZP03	Thermus thermophilus Thermus parvatiensis Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) Thermus thermophilus (strain SG0.5JP17-16) Thermus thermophilus JL-18	60	UniRef90_P38383	Cluster: Protein translocase subunit SecE	6

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P38383	Q8KZP4 H7GDF7 Q72GW2 G1UBI3 H9ZP03 UPI00056EC0CF A0A1J0LU28 A0A0N1KPZ5 E8PJW6 W2U774 +20	Thermus thermophilus Thermus parvatiensis Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) Thermus thermophilus (strain SG0.5JP17-16) Thermus thermophilus JL-18 Thermus tengchongensis Thermus brockianus Thermus scotoductus Thermus scotoductus (strain ATCC 700910 / SA-01) Thermus sp. NMX2.A1 And more	60	UniRef50_P38383	Cluster: Protein translocase subunit SecE	31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10348 Genomic DNA. No translation available. AP008226 Genomic DNA. Translation: BAD70072.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_008630510.1. NC_006461.1. YP_143515.1. NC_006461.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ZJS	X-ray	3.20	E	1-60	[»]
	2ZQP	X-ray	6.00	E	1-60	[»]
	5AWW	X-ray	2.72	E	1-60	[»]
	5CH4	X-ray	3.64	E	1-60	[»]
SMRⁱ	P38383.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0249.

STRINGⁱ

300852.TTHA0249.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAD70072; BAD70072; BAD70072.
GeneIDⁱ	3168489.
KEGGⁱ	ttj:TTHA0249.

Phylogenomic databases

eggNOGⁱ	ENOG410683Z. Bacteria. ENOG410XUXP. LUCA.
HOGENOMⁱ	HOG000219149.
KEGG Orthology (KO) More...KOⁱ	K03073.
OMAⁱ	MNLIQYF.

Miscellaneous databases

EvolutionaryTraceⁱ	P38383.

EvolutionaryTraceⁱ

P38383.

Family and domain databases

Gene3Dⁱ	1.20.5.1030. 1 hit.
HAMAPⁱ	MF_00422. SecE. 1 hit.
InterProⁱ	View protein in InterPro IPR022943. SecE. IPR005807. SecE_bac. IPR038379. SecE_sf. IPR001901. Translocase_SecE/Sec61-g.
PANTHERⁱ	PTHR33910. PTHR33910. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00584. SecE. 1 hit.
TIGRFAMsⁱ	TIGR00964. secE_bact. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01067. SECE_SEC61G. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SECE_THET8
Accessionⁱ	P38383Primary (citable) accession number: P38383 Secondary accession number(s): Q5SLP4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	March 29, 2005
	Last modified:	March 28, 2018
	This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P38383 (SECE_THET8)

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Protein translocase subunit SecE

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ