secE

Functionⁱ

Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein translocase subunit SecEUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00422
Gene namesⁱ	Name:secEUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00422 Ordered Locus Names:TTHA0249
Organismⁱ	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifierⁱ	300852 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus › Thermus thermophilus
Proteomesⁱ	UP000000532 Componentⁱ: Chromosome

Subcellular locationⁱ

Cell inner membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00422
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Conformational transition of Sec machinery inferred from bacterial SecYE structures."
  Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D.G., Ito K., Nureki O.
  Nature 455:988-991(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 3-434 OF THE SECYE COMPLEX WITH A PARTIALLY OPEN LATERAL GATE, SUBUNIT, SUBCELLULAR LOCATION.
; Single-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00422
1 Publication
Manual assertion based on experiment inⁱ
- Ref.3
  "Conformational transition of Sec machinery inferred from bacterial SecYE structures."
  Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D.G., Ito K., Nureki O.
  Nature 455:988-991(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 3-434 OF THE SECYE COMPLEX WITH A PARTIALLY OPEN LATERAL GATE, SUBUNIT, SUBCELLULAR LOCATION.

Topology

Feature key	Position(s)	Length	Description	Actions
Topological domainⁱ	1 – 31	31	Cytoplasmic	Add BLAST
Transmembraneⁱ	32 – 52	21	Helical	Add BLAST
Topological domainⁱ	53 – 60	8	Extracellular

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW
intracellular Source: GOC
plasma membrane Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell inner membrane, Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 60	60	Protein translocase subunit SecE		PRO_0000104189	Add BLAST

Interactionⁱ

Subunit structureⁱ

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.1 Publication

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0249.

STRINGⁱ

300852.TTHA0249.

Structureⁱ

Secondary structure

1

60

Legend: HelixTurnBeta strand

Show more details

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Helixⁱ	2 – 17	16	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:5AWW
Helixⁱ	24 – 59	36	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:5AWW

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ZJS	X-ray	3.20	E	1-60	[»]
2ZQP	X-ray	6.00	E	1-60	[»]
5AWW	X-ray	2.72	E	1-60	[»]
5CH4	X-ray	3.64	E	1-60	[»]

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P38383.

EvolutionaryTraceⁱ

P38383.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SecE/SEC61-gamma family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410683Z. Bacteria. ENOG410XUXP. LUCA.
HOGENOMⁱ	HOG000219149.
KOⁱ	K03073.
OMAⁱ	LIQYFRD.

Family and domain databases

HAMAPⁱ	MF_00422. SecE. 1 hit.
InterProⁱ	IPR022943. SecE. IPR005807. SecE_bac. IPR001901. Translocase_SecE/Sec61-g. [Graphical view]
Pfamⁱ	PF00584. SecE. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR00964. secE_bact. 1 hit.
PROSITEⁱ	PS01067. SECE_SEC61G. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

P38383-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFARLIRYFQ EARAELARVT WPTREQVVEG TQAILLFTLA FMVILGLYDT 
        60
VFRFLIGLLR

Length:60

Mass (Da):7,065

Last modified:March 29, 2005 - v2

Checksum:ⁱ0B7BEA730CB3ADBD

GO

Sequence cautionⁱ

The sequence L10348 differs from that shown. Reason: Frameshift at position 15. Curated

Experimental Info

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Sequence conflictⁱ	44 – 44	1	I → Y in L10348 (PubMed:1447157).Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10348 Genomic DNA. No translation available. AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqⁱ	WP_008630510.1. NC_006461.1. YP_143515.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaⁱ	BAD70072; BAD70072; BAD70072.
GeneIDⁱ	3168489.
KEGGⁱ	ttj:TTHA0249.
PATRICⁱ	23955445. VBITheThe93045_0249.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10348 Genomic DNA. No translation available. AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqⁱ	WP_008630510.1. NC_006461.1. YP_143515.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ZJS	X-ray	3.20	E	1-60	[»]
2ZQP	X-ray	6.00	E	1-60	[»]
5AWW	X-ray	2.72	E	1-60	[»]
5CH4	X-ray	3.64	E	1-60	[»]

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protein-protein interaction databases

STRINGⁱ	300852.TTHA0249.

STRINGⁱ

300852.TTHA0249.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	BAD70072; BAD70072; BAD70072.
GeneIDⁱ	3168489.
KEGGⁱ	ttj:TTHA0249.
PATRICⁱ	23955445. VBITheThe93045_0249.

Phylogenomic databases

eggNOGⁱ	ENOG410683Z. Bacteria. ENOG410XUXP. LUCA.
HOGENOMⁱ	HOG000219149.
KOⁱ	K03073.
OMAⁱ	LIQYFRD.

Miscellaneous databases

EvolutionaryTraceⁱ	P38383.

EvolutionaryTraceⁱ

P38383.

Family and domain databases

HAMAPⁱ	MF_00422. SecE. 1 hit.
InterProⁱ	IPR022943. SecE. IPR005807. SecE_bac. IPR001901. Translocase_SecE/Sec61-g. [Graphical view]
Pfamⁱ	PF00584. SecE. 1 hit. [Graphical view]
TIGRFAMsⁱ	TIGR00964. secE_bact. 1 hit.
PROSITEⁱ	PS01067. SECE_SEC61G. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

SECE_THET8

Accessionⁱ

Primary (citable) accession number: P38383
Secondary accession number(s): Q5SLP4

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	March 29, 2005
Last modified:	September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P38383 (SECE_THET8)

UniProt

P38383 - SECE_THET8

Your basket is currently empty.

Protein translocase subunit SecE

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

<p>Reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.</p><p><a href='../manual/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ