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Protein

Protein translocase subunit SecE

Gene

secE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecEUniRule annotation
Gene namesi
Name:secEUniRule annotation
Ordered Locus Names:TTHA0249
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicAdd BLAST31
Transmembranei32 – 52HelicalAdd BLAST21
Topological domaini53 – 60Extracellular8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001041891 – 60Protein translocase subunit SecEAdd BLAST60

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA0249.

Structurei

Secondary structure

160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 17Combined sources16
Helixi24 – 59Combined sources36

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20E1-60[»]
2ZQPX-ray6.00E1-60[»]
5AWWX-ray2.72E1-60[»]
5CH4X-ray3.64E1-60[»]
SMRiP38383.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38383.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410683Z. Bacteria.
ENOG410XUXP. LUCA.
HOGENOMiHOG000219149.
KOiK03073.
OMAiLIQYFRD.

Family and domain databases

HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARLIRYFQ EARAELARVT WPTREQVVEG TQAILLFTLA FMVILGLYDT
60
VFRFLIGLLR
Length:60
Mass (Da):7,065
Last modified:March 29, 2005 - v2
Checksum:i0B7BEA730CB3ADBD
GO

Sequence cautioni

The sequence L10348 differs from that shown. Reason: Frameshift at position 15.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44I → Y in L10348 (PubMed:1447157).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10348 Genomic DNA. No translation available.
AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqiWP_008630510.1. NC_006461.1.
YP_143515.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70072; BAD70072; BAD70072.
GeneIDi3168489.
KEGGittj:TTHA0249.
PATRICi23955445. VBITheThe93045_0249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10348 Genomic DNA. No translation available.
AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqiWP_008630510.1. NC_006461.1.
YP_143515.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20E1-60[»]
2ZQPX-ray6.00E1-60[»]
5AWWX-ray2.72E1-60[»]
5CH4X-ray3.64E1-60[»]
SMRiP38383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70072; BAD70072; BAD70072.
GeneIDi3168489.
KEGGittj:TTHA0249.
PATRICi23955445. VBITheThe93045_0249.

Phylogenomic databases

eggNOGiENOG410683Z. Bacteria.
ENOG410XUXP. LUCA.
HOGENOMiHOG000219149.
KOiK03073.
OMAiLIQYFRD.

Miscellaneous databases

EvolutionaryTraceiP38383.

Family and domain databases

HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECE_THET8
AccessioniPrimary (citable) accession number: P38383
Secondary accession number(s): Q5SLP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 29, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.