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Protein

Protein translocase subunit SecE

Gene

secE

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecEUniRule annotation
Gene namesi
Name:secEUniRule annotation
Ordered Locus Names:TTHA0249
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131CytoplasmicAdd
BLAST
Transmembranei32 – 5221HelicalAdd
BLAST
Topological domaini53 – 608Extracellular

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Protein translocase subunit SecEPRO_0000104189Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with SecDF, and other proteins may be involved. The channel interacts with SecA via subunit SecY.1 Publication

Protein-protein interaction databases

STRINGi300852.TTHA0249.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1716Combined sources
Helixi24 – 5936Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20E1-60[»]
2ZQPX-ray6.00E1-60[»]
5AWWX-ray2.72E1-60[»]
5CH4X-ray3.64E1-60[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38383.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410683Z. Bacteria.
ENOG410XUXP. LUCA.
HOGENOMiHOG000219149.
KOiK03073.
OMAiLIQYFRD.
OrthoDBiEOG6DRPR4.

Family and domain databases

HAMAPiMF_00422. SecE.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARLIRYFQ EARAELARVT WPTREQVVEG TQAILLFTLA FMVILGLYDT
60
VFRFLIGLLR
Length:60
Mass (Da):7,065
Last modified:March 29, 2005 - v2
Checksum:i0B7BEA730CB3ADBD
GO

Sequence cautioni

The sequence L10348 differs from that shown. Reason: Frameshift at position 15. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441I → Y in L10348 (PubMed:1447157).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10348 Genomic DNA. No translation available.
AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqiWP_008630510.1. NC_006461.1.
YP_143515.1. NC_006461.1.

Genome annotation databases

EnsemblBacteriaiBAD70072; BAD70072; BAD70072.
GeneIDi3168489.
KEGGittj:TTHA0249.
PATRICi23955445. VBITheThe93045_0249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10348 Genomic DNA. No translation available.
AP008226 Genomic DNA. Translation: BAD70072.1.
RefSeqiWP_008630510.1. NC_006461.1.
YP_143515.1. NC_006461.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZJSX-ray3.20E1-60[»]
2ZQPX-ray6.00E1-60[»]
5AWWX-ray2.72E1-60[»]
5CH4X-ray3.64E1-60[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi300852.TTHA0249.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD70072; BAD70072; BAD70072.
GeneIDi3168489.
KEGGittj:TTHA0249.
PATRICi23955445. VBITheThe93045_0249.

Phylogenomic databases

eggNOGiENOG410683Z. Bacteria.
ENOG410XUXP. LUCA.
HOGENOMiHOG000219149.
KOiK03073.
OMAiLIQYFRD.
OrthoDBiEOG6DRPR4.

Miscellaneous databases

EvolutionaryTraceiP38383.

Family and domain databases

HAMAPiMF_00422. SecE.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the gene encoding transcription factor NusG of Thermus thermophilus."
    Heinrich T., Schroeder W., Erdmann V.A., Hartmann R.K.
    J. Bacteriol. 174:7859-7863(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  2. "Complete genome sequence of Thermus thermophilus HB8."
    Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB8 / ATCC 27634 / DSM 579.
  3. "Conformational transition of Sec machinery inferred from bacterial SecYE structures."
    Tsukazaki T., Mori H., Fukai S., Ishitani R., Mori T., Dohmae N., Perederina A., Sugita Y., Vassylyev D.G., Ito K., Nureki O.
    Nature 455:988-991(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 3-434 OF THE SECYE COMPLEX WITH A PARTIALLY OPEN LATERAL GATE, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSECE_THET8
AccessioniPrimary (citable) accession number: P38383
Secondary accession number(s): Q5SLP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 29, 2005
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.