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Protein

Sulfate permease 1

Gene

SUL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity uptake of sulfate into the cell.

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • chloride transmembrane transport Source: GO_Central
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29212-MONOMER.
ReactomeiR-SCE-427601. Multifunctional anion exchangers.

Protein family/group databases

TCDBi2.A.53.1.1. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate permease 1
Alternative name(s):
High-affinity sulfate transporter 1
Gene namesi
Name:SUL1
Synonyms:SFP2
Ordered Locus Names:YBR294W
ORF Names:YBR2110
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR294W.
SGDiS000000498. SUL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801841 – 859Sulfate permease 1Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi358N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Glycosylationi653N-linked (GlcNAc...)Sequence analysis1
Glycosylationi718N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP38359.

Interactioni

Protein-protein interaction databases

BioGridi32987. 49 interactors.

Structurei

3D structure databases

ProteinModelPortaliP38359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini630 – 808STASPROSITE-ProRule annotationAdd BLAST179

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132388.
HOGENOMiHOG000210988.
InParanoidiP38359.
KOiK14708.
OMAiDNPYPGI.
OrthoDBiEOG092C0HLP.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKSSTEYV HNQEDADIEV FESEYRTYRE SEAAENRDGL HNGDEENWKV
60 70 80 90 100
NSSKQKFGVT KNELSDVLYD SIPAYEESTV TLKEYYDHSI KNNLTAKSAG
110 120 130 140 150
SYLVSLFPII KWFPHYNFTW GYADLVAGIT VGCVLVPQSM SYAQIASLSP
160 170 180 190 200
EYGLYSSFIG AFIYSLFATS KDVCIGPVAV MSLQTAKVIA EVLKKYPEDQ
210 220 230 240 250
TEVTAPIIAT TLCLLCGIVA TGLGILRLGF LVELISLNAV AGFMTGSAFN
260 270 280 290 300
IIWGQIPALM GYNSLVNTRE ATYKVVINTL KHLPNTKLDA VFGLIPLVIL
310 320 330 340 350
YVWKWWCGTF GITLADRYYR NQPKVANRLK SFYFYAQAMR NAVVIVVFTA
360 370 380 390 400
ISWSITRNKS SKDRPISILG TVPSGLNEVG VMKIPDGLLS NMSSEIPASI
410 420 430 440 450
IVLVLEHIAI SKSFGRINDY KVVPDQELIA IGVTNLIGTF FHSYPATGSF
460 470 480 490 500
SRSALKAKCN VRTPFSGVFT GGCVLLALYC LTDAFFFIPK ATLSAVIIHA
510 520 530 540 550
VSDLLTSYKT TWTFWKTNPL DCISFIVTVF ITVFSSIENG IYFAMCWSCA
560 570 580 590 600
MLLLKQAFPA GKFLGRVEVA EVLNPTVQED IDAVISSNEL PNELNKQVKS
610 620 630 640 650
TVEVLPAPEY KFSVKWVPFD HGYSRELNIN TTVRPPPPGV IVYRLGDSFT
660 670 680 690 700
YVNCSRHYDI IFDRIKEETR RGQLITLRKK SDRPWNDPGE WKMPDSLKSL
710 720 730 740 750
FKFKRHSATT NSDLPISNGS SNGETYEKPL LKVVCLDFSQ VAQVDSTAVQ
760 770 780 790 800
SLVDLRKAVN RYADRQVEFH FAGIISPWIK RSLLSVKFGT TNEEYSDDSI
810 820 830 840 850
IAGHSSFHVA KVLKDDVDYT DEDSRISTSY SNYETLCAAT GTNLPFFHID

IPDFSKWDV
Length:859
Mass (Da):95,951
Last modified:July 15, 1998 - v2
Checksum:iA026DF572AF1FB53
GO

Sequence cautioni

The sequence CAA84506 differs from that shown. Reason: Frameshift at position 488.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87D → H in CAA84506 (PubMed:7677785).Curated1
Sequence conflicti457A → T in CAA84506 (PubMed:7677785).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36163 Genomic DNA. Translation: CAA85259.1.
X82013 mRNA. Translation: CAA57540.1.
AY693178 Genomic DNA. Translation: AAT93197.1.
Z35134 Genomic DNA. Translation: CAA84506.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07408.1.
PIRiS46176.
RefSeqiNP_009853.3. NM_001178642.3.

Genome annotation databases

EnsemblFungiiYBR294W; YBR294W; YBR294W.
GeneIDi852597.
KEGGisce:YBR294W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36163 Genomic DNA. Translation: CAA85259.1.
X82013 mRNA. Translation: CAA57540.1.
AY693178 Genomic DNA. Translation: AAT93197.1.
Z35134 Genomic DNA. Translation: CAA84506.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07408.1.
PIRiS46176.
RefSeqiNP_009853.3. NM_001178642.3.

3D structure databases

ProteinModelPortaliP38359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32987. 49 interactors.

Protein family/group databases

TCDBi2.A.53.1.1. the sulfate permease (sulp) family.

Proteomic databases

PRIDEiP38359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR294W; YBR294W; YBR294W.
GeneIDi852597.
KEGGisce:YBR294W.

Organism-specific databases

EuPathDBiFungiDB:YBR294W.
SGDiS000000498. SUL1.

Phylogenomic databases

GeneTreeiENSGT00850000132388.
HOGENOMiHOG000210988.
InParanoidiP38359.
KOiK14708.
OMAiDNPYPGI.
OrthoDBiEOG092C0HLP.

Enzyme and pathway databases

BioCyciYEAST:G3O-29212-MONOMER.
ReactomeiR-SCE-427601. Multifunctional anion exchangers.

Miscellaneous databases

PROiP38359.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUL1_YEAST
AccessioniPrimary (citable) accession number: P38359
Secondary accession number(s): D6VQT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.