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Protein

Sulfate permease 1

Gene

SUL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity uptake of sulfate into the cell.

GO - Molecular functioni

GO - Biological processi

  • bicarbonate transport Source: GO_Central
  • chloride transmembrane transport Source: GO_Central
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • sulfate transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29212-MONOMER.

Protein family/group databases

TCDBi2.A.53.1.1. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate permease 1
Alternative name(s):
High-affinity sulfate transporter 1
Gene namesi
Name:SUL1
Synonyms:SFP2
Ordered Locus Names:YBR294W
ORF Names:YBR2110
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR294W.
SGDiS000000498. SUL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Transmembranei292 – 31221HelicalSequence analysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence analysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence analysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence analysisAdd
BLAST
Transmembranei468 – 48821HelicalSequence analysisAdd
BLAST
Transmembranei525 – 54521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Sulfate permease 1PRO_0000080184Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence analysis
Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence analysis
Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi32987. 49 interactions.

Structurei

3D structure databases

ProteinModelPortaliP38359.
SMRiP38359. Positions 124-263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini630 – 808179STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119026.
HOGENOMiHOG000210988.
InParanoidiP38359.
KOiK14708.
OMAiPAVMGFM.
OrthoDBiEOG7HXD07.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKSSTEYV HNQEDADIEV FESEYRTYRE SEAAENRDGL HNGDEENWKV
60 70 80 90 100
NSSKQKFGVT KNELSDVLYD SIPAYEESTV TLKEYYDHSI KNNLTAKSAG
110 120 130 140 150
SYLVSLFPII KWFPHYNFTW GYADLVAGIT VGCVLVPQSM SYAQIASLSP
160 170 180 190 200
EYGLYSSFIG AFIYSLFATS KDVCIGPVAV MSLQTAKVIA EVLKKYPEDQ
210 220 230 240 250
TEVTAPIIAT TLCLLCGIVA TGLGILRLGF LVELISLNAV AGFMTGSAFN
260 270 280 290 300
IIWGQIPALM GYNSLVNTRE ATYKVVINTL KHLPNTKLDA VFGLIPLVIL
310 320 330 340 350
YVWKWWCGTF GITLADRYYR NQPKVANRLK SFYFYAQAMR NAVVIVVFTA
360 370 380 390 400
ISWSITRNKS SKDRPISILG TVPSGLNEVG VMKIPDGLLS NMSSEIPASI
410 420 430 440 450
IVLVLEHIAI SKSFGRINDY KVVPDQELIA IGVTNLIGTF FHSYPATGSF
460 470 480 490 500
SRSALKAKCN VRTPFSGVFT GGCVLLALYC LTDAFFFIPK ATLSAVIIHA
510 520 530 540 550
VSDLLTSYKT TWTFWKTNPL DCISFIVTVF ITVFSSIENG IYFAMCWSCA
560 570 580 590 600
MLLLKQAFPA GKFLGRVEVA EVLNPTVQED IDAVISSNEL PNELNKQVKS
610 620 630 640 650
TVEVLPAPEY KFSVKWVPFD HGYSRELNIN TTVRPPPPGV IVYRLGDSFT
660 670 680 690 700
YVNCSRHYDI IFDRIKEETR RGQLITLRKK SDRPWNDPGE WKMPDSLKSL
710 720 730 740 750
FKFKRHSATT NSDLPISNGS SNGETYEKPL LKVVCLDFSQ VAQVDSTAVQ
760 770 780 790 800
SLVDLRKAVN RYADRQVEFH FAGIISPWIK RSLLSVKFGT TNEEYSDDSI
810 820 830 840 850
IAGHSSFHVA KVLKDDVDYT DEDSRISTSY SNYETLCAAT GTNLPFFHID

IPDFSKWDV
Length:859
Mass (Da):95,951
Last modified:July 15, 1998 - v2
Checksum:iA026DF572AF1FB53
GO

Sequence cautioni

The sequence CAA84506.1 differs from that shown. Reason: Frameshift at position 488. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871D → H in CAA84506 (PubMed:7677785).Curated
Sequence conflicti457 – 4571A → T in CAA84506 (PubMed:7677785).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36163 Genomic DNA. Translation: CAA85259.1.
X82013 mRNA. Translation: CAA57540.1.
AY693178 Genomic DNA. Translation: AAT93197.1.
Z35134 Genomic DNA. Translation: CAA84506.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07408.1.
PIRiS46176.
RefSeqiNP_009853.3. NM_001178642.3.

Genome annotation databases

EnsemblFungiiYBR294W; YBR294W; YBR294W.
GeneIDi852597.
KEGGisce:YBR294W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36163 Genomic DNA. Translation: CAA85259.1.
X82013 mRNA. Translation: CAA57540.1.
AY693178 Genomic DNA. Translation: AAT93197.1.
Z35134 Genomic DNA. Translation: CAA84506.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07408.1.
PIRiS46176.
RefSeqiNP_009853.3. NM_001178642.3.

3D structure databases

ProteinModelPortaliP38359.
SMRiP38359. Positions 124-263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32987. 49 interactions.

Protein family/group databases

TCDBi2.A.53.1.1. the sulfate permease (sulp) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR294W; YBR294W; YBR294W.
GeneIDi852597.
KEGGisce:YBR294W.

Organism-specific databases

EuPathDBiFungiDB:YBR294W.
SGDiS000000498. SUL1.

Phylogenomic databases

GeneTreeiENSGT00760000119026.
HOGENOMiHOG000210988.
InParanoidiP38359.
KOiK14708.
OMAiPAVMGFM.
OrthoDBiEOG7HXD07.

Enzyme and pathway databases

BioCyciYEAST:G3O-29212-MONOMER.

Miscellaneous databases

PROiP38359.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 3 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane."
    Smith F.W., Hawkesford M.J., Prosser I.M., Clarkson D.T.
    Mol. Gen. Genet. 247:709-715(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: INVSC1.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Characterization of SFP2, a putative sulfate permease gene of Saccharomyces cerevisiae."
    Jin Y.H., Jang Y.K., Kim M.J., Rad M.R., Kirchrath L., Seong R.H., Hong S.H., Hollenberg C.P., Park S.D.
    Biochem. Biophys. Res. Commun. 214:709-715(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-585.
    Strain: ATCC 44774 / DBY747 and LP1721-1B.
  6. "Molecular characterization of two high affinity sulfate transporters in Saccharomyces cerevisiae."
    Cherest H., Davidian J.C., Thomas D., Benes V., Ansorge W., Surdin-Kerjan Y.
    Genetics 145:627-635(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiSUL1_YEAST
AccessioniPrimary (citable) accession number: P38359
Secondary accession number(s): D6VQT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: July 6, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.