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Protein

Sec sixty-one protein homolog

Gene

SSH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.1 Publication

GO - Molecular functioni

  • protein transmembrane transporter activity Source: SGD
  • signal sequence binding Source: SGD

GO - Biological processi

  • SRP-dependent cotranslational protein targeting to membrane Source: SGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec sixty-one protein homolog
Alternative name(s):
Ssh1 complex subunit SSH1
Ssh1 complex subunit alpha
Gene namesi
Name:SSH1
Ordered Locus Names:YBR283C
ORF Names:YBR2020
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR283C.
SGDiS000000487. SSH1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 121LumenalSequence analysisAdd BLAST68
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 146CytoplasmicSequence analysis4
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 174LumenalSequence analysis7
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 242CytoplasmicSequence analysisAdd BLAST47
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 293LumenalSequence analysisAdd BLAST30
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 339CytoplasmicSequence analysisAdd BLAST25
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361LumenalSequence analysis1
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 421CytoplasmicSequence analysisAdd BLAST39
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 449LumenalSequence analysis7
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 490CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • Ssh1 translocon complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318111 – 490Sec sixty-one protein homologAdd BLAST490

Proteomic databases

MaxQBiP38353.
PRIDEiP38353.

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

Binary interactionsi

WithEntry#Exp.IntActNotes
ERV29P533373EBI-18175,EBI-23662
PHO88P382643EBI-18175,EBI-13350
SSS1P351798EBI-18175,EBI-16406

Protein-protein interaction databases

BioGridi32977. 145 interactors.
DIPiDIP-4962N.
IntActiP38353. 36 interactors.
MINTiMINT-570624.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60A1-490[»]
2WWAelectron microscopy8.90A1-490[»]
ProteinModelPortaliP38353.
SMRiP38353.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38353.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiP38353.
KOiK10956.
OMAiFAMEKGT.
OrthoDBiEOG092C1YEK.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 2 hits.
PROSITEiPS00755. SECY_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFRLIDIV KPILPILPEV ELPFEKLPFD DKIVYTIFAG LIYLFAQFPL
60 70 80 90 100
VGLPKATTPN VNDPIYFLRG VFGCEPRTLL EFGLFPNISS GLILQLLAGL
110 120 130 140 150
KVIKVNFKIQ SDRELFQSLT KVFAIVQYVI LTNIFIFAGY FGDDLSVVQI
160 170 180 190 200
GLINFQLVGA GIFTTLLAEV IDKGFGFSSG AMIINTVVIA TNLVADTFGV
210 220 230 240 250
SQIKVGEDDQ TEAQGALINL IQGLRSKHKT FIGGIISAFN RDYLPNLTTT
260 270 280 290 300
IIVLAIAIIV CYLQSVRVEL PIRSTRARGT NNVYPIKLLY TGCLSVLFSY
310 320 330 340 350
TILFYIHIFA FVLIQLVAKN EPTHIICKIM GHYENANNLL AVPTFPLSLL
360 370 380 390 400
APPTSFFKGV TQQPLTFITY SAFILVTGIW FADKWQAISG SSARDVALEF
410 420 430 440 450
KDQGITLMGR REQNVAKELN KVIPIAAVTG ASVLSLITVI GESLGLKGKA
460 470 480 490
AGIVVGIAGG FSLLEVITIE YQQSGGQSAL NQVLGVPGAM
Length:490
Mass (Da):53,312
Last modified:October 1, 1994 - v1
Checksum:i48267EEA3E0191BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05336 Genomic DNA. Translation: AAB40986.1.
X76053 Genomic DNA. Translation: CAA53646.1.
Z36152 Genomic DNA. Translation: CAA85247.1.
AY692997 Genomic DNA. Translation: AAT93016.1.
S77888 Genomic DNA. Translation: AAB21097.2. Sequence problems.
BK006936 Genomic DNA. Translation: DAA07398.1.
PIRiS44545.
RefSeqiNP_009842.1. NM_001178631.1.

Genome annotation databases

EnsemblFungiiYBR283C; YBR283C; YBR283C.
GeneIDi852586.
KEGGisce:YBR283C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05336 Genomic DNA. Translation: AAB40986.1.
X76053 Genomic DNA. Translation: CAA53646.1.
Z36152 Genomic DNA. Translation: CAA85247.1.
AY692997 Genomic DNA. Translation: AAT93016.1.
S77888 Genomic DNA. Translation: AAB21097.2. Sequence problems.
BK006936 Genomic DNA. Translation: DAA07398.1.
PIRiS44545.
RefSeqiNP_009842.1. NM_001178631.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60A1-490[»]
2WWAelectron microscopy8.90A1-490[»]
ProteinModelPortaliP38353.
SMRiP38353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32977. 145 interactors.
DIPiDIP-4962N.
IntActiP38353. 36 interactors.
MINTiMINT-570624.

Proteomic databases

MaxQBiP38353.
PRIDEiP38353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR283C; YBR283C; YBR283C.
GeneIDi852586.
KEGGisce:YBR283C.

Organism-specific databases

EuPathDBiFungiDB:YBR283C.
SGDiS000000487. SSH1.

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiP38353.
KOiK10956.
OMAiFAMEKGT.
OrthoDBiEOG092C1YEK.

Enzyme and pathway databases

BioCyciYEAST:G3O-29203-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38353.
PROiP38353.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 2 hits.
PROSITEiPS00755. SECY_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSH1_YEAST
AccessioniPrimary (citable) accession number: P38353
Secondary accession number(s): D6VQS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.