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Protein

Sec sixty-one protein homolog

Gene

SSH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein endoplasmic reticulum (ER) import.1 Publication

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein transmembrane transporter activity Source: SGD
  • signal sequence binding Source: SGD

GO - Biological processi

  • SRP-dependent cotranslational protein targeting to membrane Source: SGD

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29203-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sec sixty-one protein homolog
Alternative name(s):
Ssh1 complex subunit SSH1
Ssh1 complex subunit alpha
Gene namesi
Name:SSH1
Ordered Locus Names:YBR283C
ORF Names:YBR2020
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR283C
SGDiS000000487 SSH1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 121LumenalSequence analysisAdd BLAST68
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 146CytoplasmicSequence analysis4
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 174LumenalSequence analysis7
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 242CytoplasmicSequence analysisAdd BLAST47
Transmembranei243 – 263HelicalSequence analysisAdd BLAST21
Topological domaini264 – 293LumenalSequence analysisAdd BLAST30
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 339CytoplasmicSequence analysisAdd BLAST25
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361LumenalSequence analysis1
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 421CytoplasmicSequence analysisAdd BLAST39
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 449LumenalSequence analysis7
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 490CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001318111 – 490Sec sixty-one protein homologAdd BLAST490

Proteomic databases

MaxQBiP38353
PaxDbiP38353
PRIDEiP38353

Interactioni

Subunit structurei

Component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32977, 270 interactors
DIPiDIP-4962N
IntActiP38353, 39 interactors
MINTiP38353
STRINGi4932.YBR283C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WW9electron microscopy8.60A1-490[»]
2WWAelectron microscopy8.90A1-490[»]
ProteinModelPortaliP38353
SMRiP38353
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38353

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231249
InParanoidiP38353
KOiK10956
OMAiTCLFVPL
OrthoDBiEOG092C1YEK

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
InterProiView protein in InterPro
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
IPR019561 Translocon_Sec61/SecY_plug_dom
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF10559 Plug_translocon, 1 hit
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 2 hits
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit

Sequencei

Sequence statusi: Complete.

P38353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFRLIDIV KPILPILPEV ELPFEKLPFD DKIVYTIFAG LIYLFAQFPL
60 70 80 90 100
VGLPKATTPN VNDPIYFLRG VFGCEPRTLL EFGLFPNISS GLILQLLAGL
110 120 130 140 150
KVIKVNFKIQ SDRELFQSLT KVFAIVQYVI LTNIFIFAGY FGDDLSVVQI
160 170 180 190 200
GLINFQLVGA GIFTTLLAEV IDKGFGFSSG AMIINTVVIA TNLVADTFGV
210 220 230 240 250
SQIKVGEDDQ TEAQGALINL IQGLRSKHKT FIGGIISAFN RDYLPNLTTT
260 270 280 290 300
IIVLAIAIIV CYLQSVRVEL PIRSTRARGT NNVYPIKLLY TGCLSVLFSY
310 320 330 340 350
TILFYIHIFA FVLIQLVAKN EPTHIICKIM GHYENANNLL AVPTFPLSLL
360 370 380 390 400
APPTSFFKGV TQQPLTFITY SAFILVTGIW FADKWQAISG SSARDVALEF
410 420 430 440 450
KDQGITLMGR REQNVAKELN KVIPIAAVTG ASVLSLITVI GESLGLKGKA
460 470 480 490
AGIVVGIAGG FSLLEVITIE YQQSGGQSAL NQVLGVPGAM
Length:490
Mass (Da):53,312
Last modified:October 1, 1994 - v1
Checksum:i48267EEA3E0191BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05336 Genomic DNA Translation: AAB40986.1
X76053 Genomic DNA Translation: CAA53646.1
Z36152 Genomic DNA Translation: CAA85247.1
AY692997 Genomic DNA Translation: AAT93016.1
S77888 Genomic DNA Translation: AAB21097.2 Sequence problems.
BK006936 Genomic DNA Translation: DAA07398.1
PIRiS44545
RefSeqiNP_009842.1, NM_001178631.1

Genome annotation databases

EnsemblFungiiYBR283C; YBR283C; YBR283C
GeneIDi852586
KEGGisce:YBR283C

Similar proteinsi

Entry informationi

Entry nameiSSH1_YEAST
AccessioniPrimary (citable) accession number: P38353
Secondary accession number(s): D6VQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health