Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA mismatch repair protein HSM3

Gene

HSM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).7 Publications

GO - Biological processi

  • mismatch repair Source: SGD
  • proteasome regulatory particle assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-29193-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein HSM3
Alternative name(s):
Enhanced spontaneous mutability protein 3
Gene namesi
Name:HSM3
Ordered Locus Names:YBR272C
ORF Names:YBR1740
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR272C.
SGDiS000000476. HSM3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002025321 – 480DNA mismatch repair protein HSM3Add BLAST480

Proteomic databases

MaxQBiP38348.
PRIDEiP38348.

PTM databases

iPTMnetiP38348.

Interactioni

Subunit structurei

Interacts with RPT1, RPT2, RPT3, RPT5, RPT6, RPN1 and RPN2. Part of transient complex (BP1) containing HSM3, RPT1, RPT2 and RPT5 formed during the assembly of the 26S proteasome.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NAS6P500866EBI-21152,EBI-14028
RPN14P531966EBI-21152,EBI-23691
RPN8Q087235EBI-21152,EBI-36176
RPT1P332997EBI-21152,EBI-13910
RPT5P332976EBI-21152,EBI-13920
SEM1O947422EBI-21152,EBI-31337

Protein-protein interaction databases

BioGridi32967. 64 interactors.
DIPiDIP-2748N.
IntActiP38348. 39 interactors.
MINTiMINT-545299.

Structurei

Secondary structure

1480
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 21Combined sources12
Beta strandi22 – 24Combined sources3
Helixi29 – 42Combined sources14
Helixi52 – 63Combined sources12
Helixi73 – 86Combined sources14
Helixi89 – 95Combined sources7
Helixi98 – 105Combined sources8
Helixi110 – 121Combined sources12
Helixi126 – 129Combined sources4
Helixi134 – 142Combined sources9
Helixi150 – 163Combined sources14
Helixi167 – 174Combined sources8
Turni175 – 177Combined sources3
Helixi178 – 187Combined sources10
Helixi190 – 204Combined sources15
Turni209 – 211Combined sources3
Helixi214 – 217Combined sources4
Helixi221 – 227Combined sources7
Helixi231 – 250Combined sources20
Helixi254 – 256Combined sources3
Helixi257 – 260Combined sources4
Helixi261 – 263Combined sources3
Helixi264 – 272Combined sources9
Turni274 – 276Combined sources3
Helixi278 – 283Combined sources6
Helixi285 – 295Combined sources11
Beta strandi301 – 303Combined sources3
Helixi304 – 312Combined sources9
Turni316 – 318Combined sources3
Helixi320 – 322Combined sources3
Helixi323 – 329Combined sources7
Helixi332 – 338Combined sources7
Helixi340 – 346Combined sources7
Helixi351 – 353Combined sources3
Helixi354 – 360Combined sources7
Helixi364 – 368Combined sources5
Helixi371 – 373Combined sources3
Helixi376 – 380Combined sources5
Helixi384 – 394Combined sources11
Helixi398 – 407Combined sources10
Helixi409 – 416Combined sources8
Helixi421 – 423Combined sources3
Helixi427 – 441Combined sources15
Helixi445 – 448Combined sources4
Helixi449 – 451Combined sources3
Helixi452 – 464Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VLDX-ray2.05A/B1-480[»]
3VLEX-ray2.41A/B1-480[»]
3VLFX-ray3.80A/C1-480[»]
4A3TX-ray2.10A/B2-480[»]
4A3VX-ray3.80A/C2-480[»]
4FP7X-ray2.20A/B1-480[»]
4JPOX-ray5.00A/B1-480[»]
ProteinModelPortaliP38348.
SMRiP38348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the proteasome subunit S5B/HSM3 family.Curated

Phylogenomic databases

HOGENOMiHOG000112972.
InParanoidiP38348.
OMAiNCENTIM.
OrthoDBiEOG092C27B7.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

P38348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKETNYVE NLLTQLENEL NEDNLPEDIN TLLRKCSLNL VTVVSLPDMD
60 70 80 90 100
VKPLLATIKR FLTSNVSYDS LNYDYLLDVV DKLVPMADFD DVLEVYSAED
110 120 130 140 150
LVKALRSEID PLKVAACRVI ENSQPKGLFA TSNIIDILLD ILFDEKVEND
160 170 180 190 200
KLITAIEKAL ERLSTDELIR RRLFDNNLPY LVSVKGRMET VSFVRLIDFL
210 220 230 240 250
TIEFQFISGP EFKDIIFCFT KEEILKSVED ILVFIELVNY YTKFLLEIRN
260 270 280 290 300
QDKYWALRHV KKILPVFAQL FEDTENYPDV RAFSTNCLLQ LFAEVSRIEE
310 320 330 340 350
DEYSLFKTMD KDSLKIGSEA KLITEWLELI NPQYLVKYHK DVVENYFHVS
360 370 380 390 400
GYSIGMLRNL SADEECFNAI RNKFSAEIVL RLPYLEQMQV VETLTRYEYT
410 420 430 440 450
SKFLLNEMPK VMGSLIGDGS AGAIIDLETV HYRNSALRNL LDKGEEKLSV
460 470 480
WYEPLLREYS KAVNGKNYST GSETKIADCR
Length:480
Mass (Da):55,543
Last modified:October 1, 1994 - v1
Checksum:i8B739BCC9A46A63E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36141 Genomic DNA. Translation: CAA85235.1.
AY692825 Genomic DNA. Translation: AAT92844.1.
BK006936 Genomic DNA. Translation: DAA07388.1.
PIRiS46153.
RefSeqiNP_009831.3. NM_001178620.3.

Genome annotation databases

EnsemblFungiiYBR272C; YBR272C; YBR272C.
GeneIDi852575.
KEGGisce:YBR272C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36141 Genomic DNA. Translation: CAA85235.1.
AY692825 Genomic DNA. Translation: AAT92844.1.
BK006936 Genomic DNA. Translation: DAA07388.1.
PIRiS46153.
RefSeqiNP_009831.3. NM_001178620.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VLDX-ray2.05A/B1-480[»]
3VLEX-ray2.41A/B1-480[»]
3VLFX-ray3.80A/C1-480[»]
4A3TX-ray2.10A/B2-480[»]
4A3VX-ray3.80A/C2-480[»]
4FP7X-ray2.20A/B1-480[»]
4JPOX-ray5.00A/B1-480[»]
ProteinModelPortaliP38348.
SMRiP38348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32967. 64 interactors.
DIPiDIP-2748N.
IntActiP38348. 39 interactors.
MINTiMINT-545299.

PTM databases

iPTMnetiP38348.

Proteomic databases

MaxQBiP38348.
PRIDEiP38348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR272C; YBR272C; YBR272C.
GeneIDi852575.
KEGGisce:YBR272C.

Organism-specific databases

EuPathDBiFungiDB:YBR272C.
SGDiS000000476. HSM3.

Phylogenomic databases

HOGENOMiHOG000112972.
InParanoidiP38348.
OMAiNCENTIM.
OrthoDBiEOG092C27B7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29193-MONOMER.

Miscellaneous databases

PROiP38348.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHSM3_YEAST
AccessioniPrimary (citable) accession number: P38348
Secondary accession number(s): D6VQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.