ID   SLM6_YEAST              Reviewed;         150 AA.
AC   P38343; A0A8D9PCQ2;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 3.
DT   08-NOV-2023, entry version 101.
DE   RecName: Full=Protein SLM6 {ECO:0000305};
DE   AltName: Full=Synthetic lethal with MSS4 protein 6 {ECO:0000303|PubMed:15372071};
GN   Name=SLM6 {ECO:0000303|PubMed:15372071};
GN   OrderedLocusNames=YBR266C {ECO:0000312|SGD:S000000470};
GN   ORFNames=YBR1735;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8465606; DOI=10.1002/yea.320090210;
RA   Doignon F., Biteau N., Crouzet M., Aigle M.;
RT   "The complete sequence of a 19,482 bp segment located on the right arm of
RT   chromosome II from Saccharomyces cerevisiae.";
RL   Yeast 9:189-199(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Aigle M., Baclet M.C., Barthe C., Biteau N., Crouzet M., Doignon F.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15372071; DOI=10.1038/sj.emboj.7600384;
RA   Audhya A., Loewith R., Parsons A.B., Gao L., Tabuchi M., Zhou H., Boone C.,
RA   Hall M.N., Emr S.D.;
RT   "Genome-wide lethality screen identifies new PI4,5P2 effectors that
RT   regulate the actin cytoskeleton.";
RL   EMBO J. 23:3747-3757(2004).
RN   [7]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: Synthetic lethal with MSS4.
CC       {ECO:0000269|PubMed:15372071}.
CC   -!- MISCELLANEOUS: Present with 339 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X70529; CAA49932.1; -; Genomic_DNA.
DR   EMBL; Z36135; CAA85230.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAD54803.1; -; Genomic_DNA.
DR   PIR; S32968; S32968.
DR   AlphaFoldDB; P38343; -.
DR   DIP; DIP-4955N; -.
DR   IntAct; P38343; 2.
DR   STRING; 4932.YBR266C; -.
DR   iPTMnet; P38343; -.
DR   PaxDb; 4932-YBR266C; -.
DR   EnsemblFungi; YBR266C_mRNA; YBR266C; YBR266C.
DR   AGR; SGD:S000000470; -.
DR   SGD; S000000470; SLM6.
DR   HOGENOM; CLU_1741999_0_0_1; -.
DR   InParanoid; P38343; -.
DR   PRO; PR:P38343; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38343; Protein.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006897; P:endocytosis; IMP:SGD.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..150
FT                   /note="Protein SLM6"
FT                   /id="PRO_0000202528"
FT   TOPO_DOM        1..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305|PubMed:16847258"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..104
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:16847258"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..150
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000269|PubMed:16847258"
FT   CONFLICT        31
FT                   /note="S -> T (in Ref. 1; CAA49932 and 2; CAA85230)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   150 AA;  16028 MW;  D3D02D0816B37CA1 CRC64;
     MCSRFSSTSL KCLLCSQNRH CSSGISTLLR SFSCITLSAI SSSVNCSGSS FLGSSFSLFS
     SFSCKESLLR SGVFPSWLFC MFSSILALAI SNSFFFFSSN ACFSLLFNSF LVTGFSFSAD
     LLVLAAAADT LESNVSNDIG GNCATRLFKL
//