P38341 (AIM5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 5, mitochondrial

Alternative name(s):
Found in mitochondrial proteome protein 51

Gene names

Name:	AIM5
Synonyms:	FMP51
Ordered Locus Names:	YBR262C
ORF Names:	YBR1731

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology. Ref.9 Ref.10
Subunit structure	Component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2. Interacts with OM45 and POR1. Ref.10
Subcellular location	Mitochondrion inner membrane; Single-pass membrane protein Ref.5 Ref.7 Ref.9 Ref.10.
Disruption phenotype	Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. Ref.8 Ref.9 Ref.10
Miscellaneous	Present with 2550 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the AIM5 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cristae formation Inferred from mutant phenotype Ref.9Ref.10PubMed 22009199. Source: SGD
Cellular_component	integral to mitochondrial inner membrane Inferred from direct assay Ref.9Ref.10PubMed 22009199. Source: SGD mitochondrial crista junction Inferred from direct assay PubMed 22009199. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Altered inheritance of mitochondria protein 5, mitochondrial		PRO_0000202527
Regions
	Transmembrane	11 – 27	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P38341 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 357863592C1E92CF	FASTA	106	12,388
	10 20 30 40 50 60 MSKLGPLARS VKWTLSVGVI GSVFYLYRYS NNGYFYDHDA TWLKQDHQVQ DLVDRKEVVP 70 80 90 100 GETRNRKLVV TDDGTAWSRT MGESIKDIWN EQIRNSVDWI YSWGKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete sequence of a 19,482 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae." Doignon F., Biteau N., Crouzet M., Aigle M. Yeast 9:189-199(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[8]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[9]	"Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis." von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A., Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C. , Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N., Chacinska A., van der Laan M. Dev. Cell 21:694-707(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[10]	"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria." Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J. J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, INTERACTION WITH OM45 AND POR1, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70529 Genomic DNA. Translation: CAA49928.1. Z36131 Genomic DNA. Translation: CAA85225.1. AY558435 Genomic DNA. Translation: AAS56761.1. BK006936 Genomic DNA. Translation: DAA07379.1.
PIR	S32964.
RefSeq	NP_009821.3. NM_001178610.3.
3D structure databases
ProteinModelPortal	P38341.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4886N.
MINT	MINT-502759.
STRING	4932.YBR262C.
Proteomic databases
PaxDb	P38341.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR262C; YBR262C; YBR262C.
GeneID	852566.
KEGG	sce:YBR262C. sce:YBR267W.
Organism-specific databases
CYGD	YBR262c.
SGD	S000000466. AIM5.
Phylogenomic databases
eggNOG	NOG71034.
KO	K14816.
OrthoDB	EOG48D458.
Gene expression databases
Genevestigator	P38341.
GermOnline	YBR262C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	971685.

Entry information

Entry name

AIM5_YEAST

Accession

Primary (citable) accession number: P38341
Secondary accession number(s): D6VQQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program