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Protein

Trafficking protein particle complex subunit 20

Gene

TRS20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.4 Publications

Miscellaneous

Present with 1200 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • autophagy Source: UniProtKB-KW
  • cellular protein complex assembly Source: SGD
  • ER to Golgi vesicle-mediated transport Source: SGD

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29179-MONOMER.
ReactomeiR-SCE-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 20
Short name:
TRAPP subunit 20
Alternative name(s):
Transport protein particle 20 kDa subunit
Gene namesi
Name:TRS20
Ordered Locus Names:YBR254C
ORF Names:YBR1722
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR254C.
SGDiS000000458. TRS20.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115681 – 175Trafficking protein particle complex subunit 20Add BLAST175

Proteomic databases

MaxQBiP38334.
PRIDEiP38334.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32949. 506 interactors.
DIPiDIP-1711N.
IntActiP38334. 22 interactors.
MINTiMINT-407365.
STRINGi4932.YBR254C.

Structurei

3D structure databases

ProteinModelPortaliP38334.
SMRiP38334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00510000047168.
HOGENOMiHOG000214139.
InParanoidiP38334.
KOiK20301.
OMAiDKFNQWF.
OrthoDBiEOG092C5M89.

Family and domain databases

InterProiView protein in InterPro
IPR011012. Longin-like_dom_sf.
IPR006722. Sedlin.
PANTHERiPTHR12403. PTHR12403. 1 hit.
PfamiView protein in Pfam
PF04628. Sedlin_N. 1 hit.
SUPFAMiSSF64356. SSF64356. 2 hits.

Sequencei

Sequence statusi: Complete.

P38334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQYFAIIGK KDNPVYEIEF TNAENPQGFP QDLKELNPFI LHASLDIVED
60 70 80 90 100
LQWQINPTSQ LNGNGGNGSN GGGGFLRSRA VNNTDNCYLG KVDHFYGLAI
110 120 130 140 150
TAYISYSGMK FVMIHGNSAN SSVVIDDNNM RSFYQEVHEL YVKTLMNPFY
160 170
KITDPIRSPA FDSRVRTLAR KHLSK
Length:175
Mass (Da):19,700
Last modified:October 1, 1994 - v1
Checksum:i82285CAEAC2735D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70529 Genomic DNA. Translation: CAA49918.1.
Z36123 Genomic DNA. Translation: CAA85217.1.
BK006936 Genomic DNA. Translation: DAA07370.1.
PIRiS32957.
RefSeqiNP_009813.1. NM_001178602.1.

Genome annotation databases

EnsemblFungiiYBR254C; YBR254C; YBR254C.
GeneIDi852556.
KEGGisce:YBR254C.

Similar proteinsi

Entry informationi

Entry nameiTRS20_YEAST
AccessioniPrimary (citable) accession number: P38334
Secondary accession number(s): D6VQQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names