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Protein

Actin-related protein 2/3 complex subunit 1

Gene

ARC40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • ubiquitin binding Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • actin nucleation Source: SGD
  • Arp2/3 complex-mediated actin nucleation Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARC40
Ordered Locus Names:YBR234C
ORF Names:YBR1532
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR234C.
SGDiS000000438. ARC40.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: UniProtKB-SubCell
  • Arp2/3 protein complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508591 – 384Actin-related protein 2/3 complex subunit 1Add BLAST384

Proteomic databases

MaxQBiP38328.
PRIDEiP38328.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARC18Q059333EBI-2777,EBI-2764
ARC19P332043EBI-2777,EBI-2757
ARC35P537315EBI-2777,EBI-2770
ARP2P323814EBI-2777,EBI-2927
ARP3P471173EBI-2777,EBI-2933
LAS17Q124462EBI-2777,EBI-10022
MYO5Q044393EBI-2777,EBI-11687

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi32929. 79 interactors.
DIPiDIP-2219N.
IntActiP38328. 34 interactors.
MINTiMINT-382482.

Structurei

3D structure databases

ProteinModelPortaliP38328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 99WD 1Add BLAST39
Repeati105 – 146WD 2Add BLAST42
Repeati151 – 190WD 3Add BLAST40
Repeati212 – 251WD 4Add BLAST40
Repeati349 – 383WD 5Add BLAST35

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 5 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
InParanoidiP38328.
KOiK05757.
OMAiHGRIVTC.
OrthoDBiEOG092C2XMA.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 2 hits.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

P38328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSNSKDKS VVAVYKLVKA PIYSHCFSQD KSILAVTCET DCLVYRVSNN
60 70 80 90 100
TPPVLFATLK DHDKTITAVD ISIHGRIVTC SQDRNAYVWE PLSDGTYKPT
110 120 130 140 150
LVLLRINRAA TSVTWAPNGY KFAVGSSARI IAVCYYEHEN NWWVSKHIKK
160 170 180 190 200
PIKSTINCLS WHANGVLLAA GGTDGFMRVF SGFIKGLDSK ESVAGSPWGQ
210 220 230 240 250
KFPFGCLIRE WYQGSYIHDV EWRSQMERIA YVAHDGTLNV VDYQSPVQSV
260 270 280 290 300
NAPEGLPYRS LVWINDHEIV CGGYSCHPVL FSEASEGWKF AKNLDKSDNN
310 320 330 340 350
KSSALTASGN TDELSGNNDE SSTFGISALR KFKELDLKGK VSTDVQESAH
360 370 380
ENAIVELRPF AESNGQITQV SSCGLDGKIV IYTI
Length:384
Mass (Da):42,475
Last modified:October 1, 1994 - v1
Checksum:iD75C6BB8EC35EEDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36103 Genomic DNA. Translation: CAA85197.1.
AY692758 Genomic DNA. Translation: AAT92777.1.
BK006936 Genomic DNA. Translation: DAA07350.1.
PIRiS46110.
RefSeqiNP_009793.1. NM_001178582.1.

Genome annotation databases

EnsemblFungiiYBR234C; YBR234C; YBR234C.
GeneIDi852536.
KEGGisce:YBR234C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36103 Genomic DNA. Translation: CAA85197.1.
AY692758 Genomic DNA. Translation: AAT92777.1.
BK006936 Genomic DNA. Translation: DAA07350.1.
PIRiS46110.
RefSeqiNP_009793.1. NM_001178582.1.

3D structure databases

ProteinModelPortaliP38328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32929. 79 interactors.
DIPiDIP-2219N.
IntActiP38328. 34 interactors.
MINTiMINT-382482.

Proteomic databases

MaxQBiP38328.
PRIDEiP38328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR234C; YBR234C; YBR234C.
GeneIDi852536.
KEGGisce:YBR234C.

Organism-specific databases

EuPathDBiFungiDB:YBR234C.
SGDiS000000438. ARC40.

Phylogenomic databases

GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
InParanoidiP38328.
KOiK05757.
OMAiHGRIVTC.
OrthoDBiEOG092C2XMA.

Enzyme and pathway databases

BioCyciYEAST:G3O-29165-MONOMER.

Miscellaneous databases

PROiP38328.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 2 hits.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiARPC1_YEAST
AccessioniPrimary (citable) accession number: P38328
Secondary accession number(s): D6VQN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.