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P38328 (ARPC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-related protein 2/3 complex subunit 1
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene names
Name:ARC40
Ordered Locus Names:YBR234C
ORF Names:YBR1532
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks By similarity.

Subunit structure

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC. Ref.4

Subcellular location

Cytoplasm › cytoskeleton › actin patch.

Sequence similarities

Belongs to the WD repeat ARPC1 family.

Contains 5 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Actin-related protein 2/3 complex subunit 1
PRO_0000050859

Regions

Repeat61 – 9939WD 1
Repeat105 – 14642WD 2
Repeat151 – 19040WD 3
Repeat212 – 25140WD 4
Repeat349 – 38335WD 5

Sequences

Sequence LengthMass (Da)Tools
P38328 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: D75C6BB8EC35EEDF

FASTA38442,475
        10         20         30         40         50         60 
MSFSNSKDKS VVAVYKLVKA PIYSHCFSQD KSILAVTCET DCLVYRVSNN TPPVLFATLK 

        70         80         90        100        110        120 
DHDKTITAVD ISIHGRIVTC SQDRNAYVWE PLSDGTYKPT LVLLRINRAA TSVTWAPNGY 

       130        140        150        160        170        180 
KFAVGSSARI IAVCYYEHEN NWWVSKHIKK PIKSTINCLS WHANGVLLAA GGTDGFMRVF 

       190        200        210        220        230        240 
SGFIKGLDSK ESVAGSPWGQ KFPFGCLIRE WYQGSYIHDV EWRSQMERIA YVAHDGTLNV 

       250        260        270        280        290        300 
VDYQSPVQSV NAPEGLPYRS LVWINDHEIV CGGYSCHPVL FSEASEGWKF AKNLDKSDNN 

       310        320        330        340        350        360 
KSSALTASGN TDELSGNNDE SSTFGISALR KFKELDLKGK VSTDVQESAH ENAIVELRPF 

       370        380 
AESNGQITQV SSCGLDGKIV IYTI

« Hide

References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits."
Winter D.C., Choe E.Y., Li R.
Proc. Natl. Acad. Sci. U.S.A. 96:7288-7293(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ARP2/3 COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z36103 Genomic DNA. Translation: CAA85197.1.
AY692758 Genomic DNA. Translation: AAT92777.1.
BK006936 Genomic DNA. Translation: DAA07350.1.
PIRS46110.
RefSeqNP_009793.1. NM_001178582.1.

3D structure databases

ProteinModelPortalP38328.
SMRP38328. Positions 13-384.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2219N.
IntActP38328. 39 interactions.
MINTMINT-382482.
STRING4932.YBR234C.

Proteomic databases

PaxDbP38328.
PeptideAtlasP38328.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBR234C; YBR234C; YBR234C.
GeneID852536.
KEGGsce:YBR234C.

Organism-specific databases

CYGDYBR234c.
SGDS000000438. ARC40.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00390000008339.
HOGENOMHOG000181752.
KOK05757.
OMAFQTLCGD.
OrthoDBEOG42FWS2.

Gene expression databases

GenevestigatorP38328.
GermOnlineYBR234C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR017383. ARPC2/3_su1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR10709. PTHR10709. 1 hit.
PfamPF00400. WD40. 2 hits.
[Graphical view]
PIRSFPIRSF038093. ARP2/3_su1. 1 hit.
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. False negative.
PS50082. WD_REPEATS_2. False negative.
PS50294. WD_REPEATS_REGION. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio971595.

Entry information

Entry nameARPC1_YEAST
AccessionPrimary (citable) accession number: P38328
Secondary accession number(s): D6VQN0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 1, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

SIMILARITY comments

Index of protein domains and families

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