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Protein

Actin-related protein 2/3 complex subunit 1

Gene

ARC40

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • ubiquitin binding Source: SGD

GO - Biological processi

  • actin filament organization Source: SGD
  • actin nucleation Source: SGD
  • Arp2/3 complex-mediated actin nucleation Source: GO_Central

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29165-MONOMER
ReactomeiR-SCE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-SCE-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1
Alternative name(s):
Arp2/3 complex 41 kDa subunit
p41-ARC
Gene namesi
Name:ARC40
Ordered Locus Names:YBR234C
ORF Names:YBR1532
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR234C
SGDiS000000438 ARC40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508591 – 384Actin-related protein 2/3 complex subunit 1Add BLAST384

Proteomic databases

MaxQBiP38328
PaxDbiP38328
PRIDEiP38328

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARC40/p41-ARC, ARC35/p34-ARC, ARC18/p21-ARC, ARC19/p20-ARC and ARC16/p16-ARC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • ubiquitin binding Source: SGD

Protein-protein interaction databases

BioGridi32929, 168 interactors
DIPiDIP-2219N
IntActiP38328, 59 interactors
MINTiP38328
STRINGi4932.YBR234C

Structurei

3D structure databases

ProteinModelPortaliP38328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 99WD 1Add BLAST39
Repeati105 – 146WD 2Add BLAST42
Repeati151 – 190WD 3Add BLAST40
Repeati212 – 251WD 4Add BLAST40
Repeati349 – 383WD 5Add BLAST35

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000008339
HOGENOMiHOG000181752
InParanoidiP38328
KOiK05757
OMAiTVCGEYL
OrthoDBiEOG092C2XMA

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR017383 ARPC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10709 PTHR10709, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
PIRSFiPIRSF038093 ARP2/3_su1, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 2 hits

Sequencei

Sequence statusi: Complete.

P38328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSNSKDKS VVAVYKLVKA PIYSHCFSQD KSILAVTCET DCLVYRVSNN
60 70 80 90 100
TPPVLFATLK DHDKTITAVD ISIHGRIVTC SQDRNAYVWE PLSDGTYKPT
110 120 130 140 150
LVLLRINRAA TSVTWAPNGY KFAVGSSARI IAVCYYEHEN NWWVSKHIKK
160 170 180 190 200
PIKSTINCLS WHANGVLLAA GGTDGFMRVF SGFIKGLDSK ESVAGSPWGQ
210 220 230 240 250
KFPFGCLIRE WYQGSYIHDV EWRSQMERIA YVAHDGTLNV VDYQSPVQSV
260 270 280 290 300
NAPEGLPYRS LVWINDHEIV CGGYSCHPVL FSEASEGWKF AKNLDKSDNN
310 320 330 340 350
KSSALTASGN TDELSGNNDE SSTFGISALR KFKELDLKGK VSTDVQESAH
360 370 380
ENAIVELRPF AESNGQITQV SSCGLDGKIV IYTI
Length:384
Mass (Da):42,475
Last modified:October 1, 1994 - v1
Checksum:iD75C6BB8EC35EEDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36103 Genomic DNA Translation: CAA85197.1
AY692758 Genomic DNA Translation: AAT92777.1
BK006936 Genomic DNA Translation: DAA07350.1
PIRiS46110
RefSeqiNP_009793.1, NM_001178582.1

Genome annotation databases

EnsemblFungiiYBR234C; YBR234C; YBR234C
GeneIDi852536
KEGGisce:YBR234C

Similar proteinsi

Entry informationi

Entry nameiARPC1_YEAST
AccessioniPrimary (citable) accession number: P38328
Secondary accession number(s): D6VQN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health