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P38315

- YBP1_YEAST

UniProt

P38315 - YBP1_YEAST

Protein

YAP1-binding protein 1

Gene

YBP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of YAP1. Functions probably in concert with HYP1/GPX3, the actual YAP1 modifying enzyme. YBP1 is not required for HYP1/GPX3-independent, diamide-induced oxidation of YAP1.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cellular response to oxidative stress Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29153-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    YAP1-binding protein 1
    Alternative name(s):
    Activator of YAP1
    Gene namesi
    Name:YBP1
    Ordered Locus Names:YBR216C
    ORF Names:YBR1505
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR216c.
    SGDiS000000420. YBP1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 674674YAP1-binding protein 1PRO_0000066150Add
    BLAST

    Proteomic databases

    MaxQBiP38315.
    PaxDbiP38315.

    Expressioni

    Gene expression databases

    GenevestigatoriP38315.

    Interactioni

    Subunit structurei

    Interacts with YAP1. Forms a peroxide stress induced complex with YAP1 in the cytoplasm. Systematic proteome-wide 2-hybrid interaction studies suggest that YAP1, HYR1/GPX3, and YBP1 all interact with the nuclear pore complex subunit NUP116, which is involved in nucleocytoplasmic transport.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    YAP1P198804EBI-20985,EBI-31265

    Protein-protein interaction databases

    BioGridi32913. 20 interactions.
    DIPiDIP-4499N.
    IntActiP38315. 17 interactions.
    MINTiMINT-505614.
    STRINGi4932.YBR216C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38315.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi613 – 6164Poly-Leu

    Sequence similaritiesi

    To yeast YBP2.Curated

    Phylogenomic databases

    eggNOGiNOG47496.
    GeneTreeiENSGT00530000068379.
    HOGENOMiHOG000141987.
    OMAiYEIGWDL.
    OrthoDBiEOG7NKKTX.

    Family and domain databases

    InterProiIPR013877. YAP-bd/ALF4/Glomulin.
    [Graphical view]
    PfamiPF08568. Kinetochor_Ybp2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38315-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPIDDILFE VTDAFKTQKE DLLELVTLID IYGEQVNQEG SYEEKTRFIE    50
    TLNTLLEDNP STTGEIGWDL PKGLLKFLSK DNVDVNGRLG TNMIVQGVMK 100
    CFYAISIQGE PKKCLITGLE LLSSLCSKDF SKSDQQNKED FVDKKANTLP 150
    PEGVIENSSN RKDFPSYGES KSSNEFFLKL KSYILFEFIG ASLKRISTLF 200
    PSKYLGAAVS TIEKFVYSHA DTFEDALFLL RRVYTFCRNY IPPDPPKDIQ 250
    LNEDFTREMF DKVVEEESEL QVRLLRRLCT FGISTPIKTV TTNADVKYYC 300
    ALNQQKFELS AYYTEYLELF CRYYQMAFSL DVDIEGEFQN VIKECRIIYK 350
    SVPQEISAVN DEAKLVLERM VYKLAYTFEV QKAAKEKNVG LDYNGVILFS 400
    GIHYLETNQH LVKEMNITDA IYLYLRFTTP SLYSKVYYNV AVESVSRYWL 450
    WYAITTEPLE DVKKELKNLS VFVTKTLLHV LLQKNCIQVN QQLRMITFTL 500
    LTRLLCLIPE KVAFEFILDV LKTSPLPLAK TSVLCVFKDL SRRRISTKDN 550
    DSETDLIVEK LSKLKVNDSN KAQQSNIRHY IQLDSSKMKA VHDCCLQTIQ 600
    DSFTADAKKS DILLLLTYLN IFIVLKKTWD EDLLKIVCSK IDSNLKSVEP 650
    DKLPKYKEIV DKNESLNDYF TGIK 674
    Length:674
    Mass (Da):77,741
    Last modified:October 1, 1994 - v1
    Checksum:i31F2B200CE34B32D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71I → L in strain: W303-1a.
    Natural varianti328 – 3281F → V in strain: W303-1a.
    Natural varianti343 – 3431K → E in strain: W303-1a.
    Natural varianti570 – 5701N → D in strain: W303-1a.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36085 Genomic DNA. Translation: CAA85180.1.
    BK006936 Genomic DNA. Translation: DAA07332.1.
    PIRiS46092.
    RefSeqiNP_009775.3. NM_001178564.3.

    Genome annotation databases

    EnsemblFungiiYBR216C; YBR216C; YBR216C.
    GeneIDi852517.
    KEGGisce:YBR216C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36085 Genomic DNA. Translation: CAA85180.1 .
    BK006936 Genomic DNA. Translation: DAA07332.1 .
    PIRi S46092.
    RefSeqi NP_009775.3. NM_001178564.3.

    3D structure databases

    ProteinModelPortali P38315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32913. 20 interactions.
    DIPi DIP-4499N.
    IntActi P38315. 17 interactions.
    MINTi MINT-505614.
    STRINGi 4932.YBR216C.

    Proteomic databases

    MaxQBi P38315.
    PaxDbi P38315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR216C ; YBR216C ; YBR216C .
    GeneIDi 852517.
    KEGGi sce:YBR216C.

    Organism-specific databases

    CYGDi YBR216c.
    SGDi S000000420. YBP1.

    Phylogenomic databases

    eggNOGi NOG47496.
    GeneTreei ENSGT00530000068379.
    HOGENOMi HOG000141987.
    OMAi YEIGWDL.
    OrthoDBi EOG7NKKTX.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29153-MONOMER.

    Miscellaneous databases

    NextBioi 971547.

    Gene expression databases

    Genevestigatori P38315.

    Family and domain databases

    InterProi IPR013877. YAP-bd/ALF4/Glomulin.
    [Graphical view ]
    Pfami PF08568. Kinetochor_Ybp2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "A comprehensive two-hybrid analysis to explore the yeast protein interactome."
      Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
      Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NUP116.
    4. "Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor."
      Veal E.A., Ross S.J., Malakasi P., Peacock E., Morgan B.A.
      J. Biol. Chem. 278:30896-30904(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, OXIDATIVE STRESS RESPONSE.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYBP1_YEAST
    AccessioniPrimary (citable) accession number: P38315
    Secondary accession number(s): D6VQL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3100 molecules/cell in log phase SD medium.1 Publication

    Caution

    YBP1 encoded by the widely used laboratory strain W303-1a is only partially functional, probably due to four amino acid substitutions.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3