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P38315

- YBP1_YEAST

UniProt

P38315 - YBP1_YEAST

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Protein
YAP1-binding protein 1
Gene
YBP1, YBR216C, YBR1505
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in oxidative stress response and redox homeostasis. Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of YAP1. Functions probably in concert with HYP1/GPX3, the actual YAP1 modifying enzyme. YBP1 is not required for HYP1/GPX3-independent, diamide-induced oxidation of YAP1.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cellular response to oxidative stress Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
YAP1-binding protein 1
Alternative name(s):
Activator of YAP1
Gene namesi
Name:YBP1
Ordered Locus Names:YBR216C
ORF Names:YBR1505
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR216c.
SGDiS000000420. YBP1.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 674674YAP1-binding protein 1
PRO_0000066150Add
BLAST

Proteomic databases

MaxQBiP38315.
PaxDbiP38315.

Expressioni

Gene expression databases

GenevestigatoriP38315.

Interactioni

Subunit structurei

Interacts with YAP1. Forms a peroxide stress induced complex with YAP1 in the cytoplasm. Systematic proteome-wide 2-hybrid interaction studies suggest that YAP1, HYR1/GPX3, and YBP1 all interact with the nuclear pore complex subunit NUP116, which is involved in nucleocytoplasmic transport.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
YAP1P198804EBI-20985,EBI-31265

Protein-protein interaction databases

BioGridi32913. 20 interactions.
DIPiDIP-4499N.
IntActiP38315. 17 interactions.
MINTiMINT-505614.
STRINGi4932.YBR216C.

Structurei

3D structure databases

ProteinModelPortaliP38315.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi613 – 6164Poly-Leu

Sequence similaritiesi

To yeast YBP2.

Phylogenomic databases

eggNOGiNOG47496.
GeneTreeiENSGT00530000068379.
HOGENOMiHOG000141987.
OMAiYEIGWDL.
OrthoDBiEOG7NKKTX.

Family and domain databases

InterProiIPR013877. YAP-bd/ALF4/Glomulin.
[Graphical view]
PfamiPF08568. Kinetochor_Ybp2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38315-1 [UniParc]FASTAAdd to Basket

« Hide

MEPIDDILFE VTDAFKTQKE DLLELVTLID IYGEQVNQEG SYEEKTRFIE    50
TLNTLLEDNP STTGEIGWDL PKGLLKFLSK DNVDVNGRLG TNMIVQGVMK 100
CFYAISIQGE PKKCLITGLE LLSSLCSKDF SKSDQQNKED FVDKKANTLP 150
PEGVIENSSN RKDFPSYGES KSSNEFFLKL KSYILFEFIG ASLKRISTLF 200
PSKYLGAAVS TIEKFVYSHA DTFEDALFLL RRVYTFCRNY IPPDPPKDIQ 250
LNEDFTREMF DKVVEEESEL QVRLLRRLCT FGISTPIKTV TTNADVKYYC 300
ALNQQKFELS AYYTEYLELF CRYYQMAFSL DVDIEGEFQN VIKECRIIYK 350
SVPQEISAVN DEAKLVLERM VYKLAYTFEV QKAAKEKNVG LDYNGVILFS 400
GIHYLETNQH LVKEMNITDA IYLYLRFTTP SLYSKVYYNV AVESVSRYWL 450
WYAITTEPLE DVKKELKNLS VFVTKTLLHV LLQKNCIQVN QQLRMITFTL 500
LTRLLCLIPE KVAFEFILDV LKTSPLPLAK TSVLCVFKDL SRRRISTKDN 550
DSETDLIVEK LSKLKVNDSN KAQQSNIRHY IQLDSSKMKA VHDCCLQTIQ 600
DSFTADAKKS DILLLLTYLN IFIVLKKTWD EDLLKIVCSK IDSNLKSVEP 650
DKLPKYKEIV DKNESLNDYF TGIK 674
Length:674
Mass (Da):77,741
Last modified:October 1, 1994 - v1
Checksum:i31F2B200CE34B32D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → L in strain: W303-1a.
Natural varianti328 – 3281F → V in strain: W303-1a.
Natural varianti343 – 3431K → E in strain: W303-1a.
Natural varianti570 – 5701N → D in strain: W303-1a.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36085 Genomic DNA. Translation: CAA85180.1.
BK006936 Genomic DNA. Translation: DAA07332.1.
PIRiS46092.
RefSeqiNP_009775.3. NM_001178564.3.

Genome annotation databases

EnsemblFungiiYBR216C; YBR216C; YBR216C.
GeneIDi852517.
KEGGisce:YBR216C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36085 Genomic DNA. Translation: CAA85180.1 .
BK006936 Genomic DNA. Translation: DAA07332.1 .
PIRi S46092.
RefSeqi NP_009775.3. NM_001178564.3.

3D structure databases

ProteinModelPortali P38315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32913. 20 interactions.
DIPi DIP-4499N.
IntActi P38315. 17 interactions.
MINTi MINT-505614.
STRINGi 4932.YBR216C.

Proteomic databases

MaxQBi P38315.
PaxDbi P38315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR216C ; YBR216C ; YBR216C .
GeneIDi 852517.
KEGGi sce:YBR216C.

Organism-specific databases

CYGDi YBR216c.
SGDi S000000420. YBP1.

Phylogenomic databases

eggNOGi NOG47496.
GeneTreei ENSGT00530000068379.
HOGENOMi HOG000141987.
OMAi YEIGWDL.
OrthoDBi EOG7NKKTX.

Enzyme and pathway databases

BioCyci YEAST:G3O-29153-MONOMER.

Miscellaneous databases

NextBioi 971547.

Gene expression databases

Genevestigatori P38315.

Family and domain databases

InterProi IPR013877. YAP-bd/ALF4/Glomulin.
[Graphical view ]
Pfami PF08568. Kinetochor_Ybp2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A comprehensive two-hybrid analysis to explore the yeast protein interactome."
    Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NUP116.
  4. "Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor."
    Veal E.A., Ross S.J., Malakasi P., Peacock E., Morgan B.A.
    J. Biol. Chem. 278:30896-30904(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, OXIDATIVE STRESS RESPONSE.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYBP1_YEAST
AccessioniPrimary (citable) accession number: P38315
Secondary accession number(s): D6VQL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3100 molecules/cell in log phase SD medium.

Caution

YBP1 encoded by the widely used laboratory strain W303-1a is only partially functional, probably due to four amino acid substitutions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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