Reviewed, UniProtKB/Swiss-Prot P38308 (CS111_YEAST)

Names and origin

Protein names

Recommended name:
    F-box protein COS111
Alternative name(s):
    Ciclopirox olamine sensitivity protein 111

Gene names

Name:	COS111
Ordered Locus Names:	YBR203W
ORF Names:	YBR1443

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent. Ref.3
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Ref.3 Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrion Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SAM50	P53969	1	EBI-20947,EBI-28646
SKP1	P52286	1	EBI-20947,EBI-4090

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 924	924	F-box protein COS111		PRO_0000202509
Regions
	Domain	185 – 236	52	F-box
	Compositional bias	2 – 162	161	Ser-rich
	Compositional bias	354 – 475	122	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	P38308-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: B553A2F32D89BE0D	FASTA	924	104,505
	10 20 30 40 50 60 MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS SISQKSRSKQ 70 80 90 100 110 120 RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR RSDDVTSLDN ETIITMNSRK 130 140 150 160 170 180 SRIKKKYKSL ISTSSKKFMN KLYDHGASSD SFSIFSLKTS HSGKHENSRF EKLRKRKYHA 190 200 210 220 230 240 WGKFADINDL PVEIIAKILS EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR 250 260 270 280 290 300 VAQFVTSLRL HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT 310 320 330 340 350 360 SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE PLYSSPLLNS 370 380 390 400 410 420 FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT TSIMSSIYNT SHVSLSSTTS 430 440 450 460 470 480 NTSNGNISSG SNLSRVSTAG SLKKASAKST RSSPQKAKPI SDITSSSWFR MRLSSRNRKA 490 500 510 520 530 540 RTANTINLKN SKDKSDDDFK VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA 550 560 570 580 590 600 PYKDLPLGYI LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS 610 620 630 640 650 660 AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT DYPPPIDAQT 670 680 690 700 710 720 KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG YCSLTKVKMN DIVWCRQYMV 730 740 750 760 770 780 KYFVMRSWRN DLDYKSMENN SYERHLFSFR DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN 790 800 810 820 830 840 LDDLGLEELF NIKSEKLYIK NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ 850 860 870 880 890 900 FRLTILKTEK PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR 910 920 LKELRRVDLR RNVGENSYYA GSII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes." Bussereau F., Mallet L., Gaillon L., Jacquet M. Yeast 9:797-806(1993) [PubMed: 8368014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae." Leem S.-H., Park J.-E., Kim I.-S., Chae J.-Y., Sugino A., Sunwoo Y. Mol. Cells 15:55-61(2003) [PubMed: 12661761] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z21487 Genomic DNA. Translation: CAA79691.1. Z36072 Genomic DNA. Translation: CAA85167.1.
PIR	S34926.
RefSeq	NP_009762.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:4943N.
IntAct	P38308. 5 interactions.
Genome annotation databases
Ensembl	YBR203W. Saccharomyces cerevisiae. [Contig view]
GeneID	852502.
GenomeReviews	Gene locus YBR203W in contig Y13134_GR.
KEGG	sce:YBR203W.
NMPDR	fig|4932.3.peg.473.
Organism-specific databases
CYGD	YBR203w.
SGD	S000000407. COS111.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38308.
OMA	P38308. TSTYRVA.
Gene expression databases
ArrayExpress	P38308.
GermOnline	YBR203W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001810. F-box. [Graphical view]
Pfam	PF00646. F-box. 1 hit. [Graphical view]
PROSITE	PS50181. FBOX. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	971510.

Entry information

Entry name

CS111_YEAST

Accession

Primary (citable) accession number: P38308

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)