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Reviewed, UniProtKB/Swiss-Prot P38308 (CS111_YEAST)

Last modified June 16, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    F-box protein COS111
Alternative name(s):
    Ciclopirox olamine sensitivity protein 111
Gene names
Name: COS111
Ordered Locus Names: YBR203W
ORF Names: YBR1443
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length924 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent. Ref.3

Sequence similarities

Contains 1 F-box domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmodification-dependent protein catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction Ref.3

Inferred from mutant phenotype. Source: SGD

   Cellular componentmitochondrion

Inferred from direct assay. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SAM50P539691EBI-20947,EBI-28646
SKP1P522861EBI-20947,EBI-4090

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 924924F-box protein COS111
PRO_0000202509

Regions

Domain185 – 23652F-box
Compositional bias2 – 162161Ser-rich
Compositional bias354 – 475122Ser-rich

Sequences

Sequence LengthMass (Da)Tools
P38308-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: B553A2F32D89BE0D

FASTA924104,505
        10         20         30         40         50         60 
MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS SISQKSRSKQ 

        70         80         90        100        110        120 
RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR RSDDVTSLDN ETIITMNSRK 

       130        140        150        160        170        180 
SRIKKKYKSL ISTSSKKFMN KLYDHGASSD SFSIFSLKTS HSGKHENSRF EKLRKRKYHA 

       190        200        210        220        230        240 
WGKFADINDL PVEIIAKILS EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR 

       250        260        270        280        290        300 
VAQFVTSLRL HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT 

       310        320        330        340        350        360 
SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE PLYSSPLLNS 

       370        380        390        400        410        420 
FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT TSIMSSIYNT SHVSLSSTTS 

       430        440        450        460        470        480 
NTSNGNISSG SNLSRVSTAG SLKKASAKST RSSPQKAKPI SDITSSSWFR MRLSSRNRKA 

       490        500        510        520        530        540 
RTANTINLKN SKDKSDDDFK VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA 

       550        560        570        580        590        600 
PYKDLPLGYI LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS 

       610        620        630        640        650        660 
AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT DYPPPIDAQT 

       670        680        690        700        710        720 
KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG YCSLTKVKMN DIVWCRQYMV 

       730        740        750        760        770        780 
KYFVMRSWRN DLDYKSMENN SYERHLFSFR DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN 

       790        800        810        820        830        840 
LDDLGLEELF NIKSEKLYIK NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ 

       850        860        870        880        890        900 
FRLTILKTEK PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR 

       910        920 
LKELRRVDLR RNVGENSYYA GSII 

« Hide

References

« Hide 'large scale' references
[1]"A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes."
Bussereau F., Mallet L., Gaillon L., Jacquet M.
Yeast 9:797-806(1993) [PubMed: 8368014] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae."
Leem S.-H., Park J.-E., Kim I.-S., Chae J.-Y., Sugino A., Sunwoo Y.
Mol. Cells 15:55-61(2003) [PubMed: 12661761] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z21487 Genomic DNA. Translation: CAA79691.1.
Z36072 Genomic DNA. Translation: CAA85167.1.
PIRS34926.
RefSeqNP_009762.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:4943N.
IntActP38308. 5 interactions.

Genome annotation databases

EnsemblYBR203W. Saccharomyces cerevisiae. [Contig view]
GeneID852502.
GenomeReviewsGene locus YBR203W in contig Y13134_GR.
KEGGsce:YBR203W.
NMPDRfig|4932.3.peg.473.

Organism-specific databases

CYGDYBR203w.
SGDS000000407. COS111.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP38308.
OMAP38308. TSTYRVA.

Gene expression databases

ArrayExpressP38308.
GermOnlineYBR203W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001810. F-box.
[Graphical view]
PfamPF00646. F-box. 1 hit.
[Graphical view]
PROSITEPS50181. FBOX. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971510.

Entry information

Entry nameCS111_YEAST
AccessionPrimary (citable) accession number: P38308
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents