P38308 (CS111_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: F-box protein COS111 Alternative name(s): Ciclopirox olamine sensitivity protein 111 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 924 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent. Ref.4 |
| Sequence similarities | Contains 1 F-box domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | signal transduction Inferred from mutant phenotype Ref.4. Source: SGD |
| Cellular_component | mitochondrion Inferred from direct assay PubMed 16823961. Source: SGD |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| SKP1 | P52286 | 2 | EBI-20947,EBI-4090 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 924 | 924 | F-box protein COS111 | PRO_0000202509 | |||||
Regions | |||||||||
| Domain | 185 – 236 | 52 | F-box | ||||||
| Compositional bias | 2 – 162 | 161 | Ser-rich | ||||||
| Compositional bias | 354 – 475 | 122 | Ser-rich | ||||||
Experimental info | |||||||||
| Sequence conflict | 727 – 731 | 5 | TFRQH → SWRND in CAA79691. Ref.1 | ||||||
| Sequence conflict | 727 – 731 | 5 | TFRQH → SWRND in CAA85167. Ref.2 | ||||||
| Sequence conflict | 917 | 1 | N → S in CAA79691. Ref.1 | ||||||
| Sequence conflict | 917 | 1 | N → S in CAA85167. Ref.2 | ||||||
| Sequence conflict | 921 | 1 | E → G in CAA79691. Ref.1 | ||||||
| Sequence conflict | 921 | 1 | E → G in CAA85167. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes." Bussereau F., Mallet L., Gaillon L., Jacquet M. Yeast 9:797-806(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [2] | "Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. Kleine K.EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [3] | Saccharomyces Genome Database Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 727-731; 917 AND 921. Strain: ATCC 204508 / S288c. |
| [4] | "The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae." Leem S.-H., Park J.-E., Kim I.-S., Chae J.-Y., Sugino A., Sunwoo Y. Mol. Cells 15:55-61(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z21487 Genomic DNA. Translation: CAA79691.1. Z36072 Genomic DNA. Translation: CAA85167.1. BK006936 Genomic DNA. Translation: DAA07321.2. |
| PIR | S34926. |
| RefSeq | NP_009762.2. NM_001178551.2. |
3D structure databases | |
| ProteinModelPortal | P38308. |
| SMR | P38308. Positions 184-233. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4943N. |
| IntAct | P38308. 3 interactions. |
| MINT | MINT-533883. |
| STRING | 4932.YBR203W. |
Proteomic databases | |
| PRIDE | P38308. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YBR203W; YBR203W; YBR203W. |
| GeneID | 852502. |
| KEGG | sce:YBR203W. |
Organism-specific databases | |
| CYGD | YBR203w. |
| SGD | S000000407. COS111. |
Phylogenomic databases | |
| eggNOG | NOG74611. |
| HOGENOM | HOG000112003. |
| OMA | SDSFSIF. |
| OrthoDB | EOG4SFDG2. |
Gene expression databases | |
| Genevestigator | P38308. |
| GermOnline | YBR203W. Saccharomyces cerevisiae. |
Family and domain databases | |
| PROSITE | PS50181. FBOX. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 971510. |
Entry information
| Entry name | CS111_YEAST | ||||||||
| Accession | Primary (citable) accession number: P38308 Secondary accession number(s): D6VQK1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome II Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
