P38308 (CS111_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
F-box protein COS111

Alternative name(s):
Ciclopirox olamine sensitivity protein 111

Gene names

Name:	COS111
Ordered Locus Names:	YBR203W
ORF Names:	YBR1443

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	924 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	F-box protein probably involved in ubiquitin conjugation pathway. Involved in the resistance to ciclopirox olamine (CPO), a synthetic antifungal agent. Ref.4
Sequence similarities	Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Inferred from mutant phenotype Ref.4. Source: SGD
Cellular_component	mitochondrion Inferred from direct assay PubMed 16823961. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SKP1	P52286	2	EBI-20947,EBI-4090

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 924	924	F-box protein COS111		PRO_0000202509
Regions
	Domain	185 – 236	52	F-box
	Compositional bias	2 – 162	161	Ser-rich
	Compositional bias	354 – 475	122	Ser-rich
Experimental info
	Sequence conflict	727 – 731	5	TFRQH → SWRND in CAA79691. Ref.1
	Sequence conflict	727 – 731	5	TFRQH → SWRND in CAA85167. Ref.2
	Sequence conflict	917	1	N → S in CAA79691. Ref.1
	Sequence conflict	917	1	N → S in CAA85167. Ref.2
	Sequence conflict	921	1	E → G in CAA79691. Ref.1
	Sequence conflict	921	1	E → G in CAA85167. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P38308 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 4B3C940BB8FC10DF	FASTA	924	104,615
	10 20 30 40 50 60 MSSASRLQNV NIVSNNYSRY GTSVYDKLYH SNGSGSNNAG KNSTTVGKLS SISQKSRSKQ 70 80 90 100 110 120 RHGSNCSRSM SQSPLSTFKS PLSNQNQSSA PDDLASIGQR RSDDVTSLDN ETIITMNSRK 130 140 150 160 170 180 SRIKKKYKSL ISTSSKKFMN KLYDHGASSD SFSIFSLKTS HSGKHENSRF EKLRKRKYHA 190 200 210 220 230 240 WGKFADINDL PVEIIAKILS EFELGRDQKT LVRCLYVSKK FYKATKIVLY RLPYFTSTYR 250 260 270 280 290 300 VAQFVTSLRL HPDNGAYVKV LDLSHLKPGI IGQDSKDSQG LDDDGHSRRH RRRRRRSTNT 310 320 330 340 350 360 SLNLPPATPT STISNEDDAN SGLIKDDASN GSEVEDLALA GWRDWRYRNE PLYSSPLLNS 370 380 390 400 410 420 FKLKKVVSRS SSITSTSSGN STGVHSTRRQ RSNSSVASIT TSIMSSIYNT SHVSLSSTTS 430 440 450 460 470 480 NTSNGNISSG SNLSRVSTAG SLKKASAKST RSSPQKAKPI SDITSSSWFR MRLSSRNRKA 490 500 510 520 530 540 RTANTINLKN SKDKSDDDFK VLKHDSGHPS NYRSSTLKFS IEQPFSTHHP YANKFLLKYA 550 560 570 580 590 600 PYKDLPLGYI LHMLNLCPNL VELNLSNLVI CTDFKLINQR SERRRMTSSL LPAVQESSVS 610 620 630 640 650 660 AGPEKDLEIV YMTDSGKGYE YYEGLSKKHS RSSSLGTNPS SWIGGQANWT DYPPPIDAQT 670 680 690 700 710 720 KTREEHRRNN TLNNKNVVLK KLNPFEIFEM ICNRNEEKGG YCSLTKVKMN DIVWCRQYMV 730 740 750 760 770 780 KYFVMRTFRQ HLDYKSMENN SYERHLFSFR DSGLDRNFSW ACNAKLHEFV ALMVMDHLSN 790 800 810 820 830 840 LDDLGLEELF NIKSEKLYIK NYCCRDPDIL EISNLFDIRY GAGSEADATS DSNLEAESLQ 850 860 870 880 890 900 FRLTILKTEK PTSFWLTKVS KDYVSLVVKL CVDDDIDMDK MKVGKPTLRI DSITHNLISR 910 920 LKELRRVDLR RNVGENNYYA ESII

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 12.8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1,2 gene, contains five putative new genes." Bussereau F., Mallet L., Gaillon L., Jacquet M. Yeast 9:797-806(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 727-731; 917 AND 921. Strain: ATCC 204508 / S288c.
[4]	"The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae." Leem S.-H., Park J.-E., Kim I.-S., Chae J.-Y., Sugino A., Sunwoo Y. Mol. Cells 15:55-61(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21487 Genomic DNA. Translation: CAA79691.1. Z36072 Genomic DNA. Translation: CAA85167.1. BK006936 Genomic DNA. Translation: DAA07321.2.
PIR	S34926.
RefSeq	NP_009762.2. NM_001178551.2.
3D structure databases
ProteinModelPortal	P38308.
SMR	P38308. Positions 184-233.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4943N.
IntAct	P38308. 3 interactions.
MINT	MINT-533883.
STRING	4932.YBR203W.
Proteomic databases
PRIDE	P38308.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR203W; YBR203W; YBR203W.
GeneID	852502.
KEGG	sce:YBR203W.
Organism-specific databases
CYGD	YBR203w.
SGD	S000000407. COS111.
Phylogenomic databases
eggNOG	NOG74611.
HOGENOM	HOG000112003.
OMA	SDSFSIF.
OrthoDB	EOG4SFDG2.
Gene expression databases
Genevestigator	P38308.
GermOnline	YBR203W. Saccharomyces cerevisiae.
Family and domain databases
PROSITE	PS50181. FBOX. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	971510.

Entry information

Entry name

CS111_YEAST

Accession

Primary (citable) accession number: P38308
Secondary accession number(s): D6VQK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program