P38305 (AIM4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 4

Alternative name(s):
Synthetic with old yellow enzyme protein 1

Gene names

Name:	AIM4
Synonyms:	SOY1
Ordered Locus Names:	YBR194W
ORF Names:	YBR1404

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	123 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May interact with the nuclear pore complex.
Subcellular location	Cytoplasm Ref.5.
Disruption phenotype	Increases frequency of mitochondrial genome loss and sensitivity to freeze-thaw stress and high concentrations of glucose. Ref.6 Ref.7 Ref.8
Sequence similarities	Belongs to the AIM4 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
URN1	Q06525	6	EBI-20939,EBI-35138

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 123	123	Altered inheritance of mitochondria protein 4		PRO_0000202507

Sequences

	Sequence		Length	Mass (Da)
	P38305 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: AF25FE81D22D4C8C	FASTA	123	14,234
	10 20 30 40 50 60 MDQKKDPSNN LTERRVSKVQ RPNKKKVRNQ VESLSRNLER NKEGQLLQTV SKGHLEADSG 70 80 90 100 110 120 HSLGREKENG ELGIRSIFYD KDWNPRGTAP SHYRNIPYNP ATFKRRTEVQ ARLGNLENIK IPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif." Demolis N., Mallet L., Bussereau F., Jacquet M. Yeast 9:645-659(1993) [PubMed: 8346681] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"The yeast nuclear pore complex: composition, architecture, and transport mechanism." Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T. J. Cell Biol. 148:635-651(2000) [PubMed: 10684247] [Abstract] Cited for: ASSOCIATION WITH THE NUCLAR PORE COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[6]	"Identification and classification of genes required for tolerance to freeze-thaw stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains." Ando A., Nakamura T., Murata Y., Takagi H., Shima J. FEMS Yeast Res. 7:244-253(2007) [PubMed: 16989656] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[7]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed: 19300474] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[8]	"Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach." Teixeira M.C., Raposo L.R., Palma M., Sa-Correia I. OMICS 14:201-210(2010) [PubMed: 20210661] [Abstract] Cited for: DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z21487 Genomic DNA. Translation: CAA79681.1. Z36063 Genomic DNA. Translation: CAA85156.1. AY692669 Genomic DNA. Translation: AAT92688.1. BK006936 Genomic DNA. Translation: DAA07308.1.
PIR	S34019.
RefSeq	NP_009753.1. NM_001178542.1.
3D structure databases
ProteinModelPortal	P38305.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2018N.
IntAct	P38305. 67 interactions.
MINT	MINT-401723.
STRING	P38305.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR194W; YBR194W; YBR194W.
GeneID	852493.
KEGG	sce:YBR194W.
NMPDR	fig|4932.3.peg.461.
Organism-specific databases
CYGD	YBR194w.
SGD	S000000398. AIM4.
Phylogenomic databases
eggNOG	fuNOG12963.
HOGENOM	HBG512096.
OMA	ANQTSSA.
OrthoDB	EOG4CNV21.
Gene expression databases
ArrayExpress	P38305.
Genevestigator	P38305.
GermOnline	YBR194W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	971483.

Entry information

Entry name

AIM4_YEAST

Accession

Primary (citable) accession number: P38305
Secondary accession number(s): D6VQI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program