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P38305

- AIM4_YEAST

UniProt

P38305 - AIM4_YEAST

Protein

Altered inheritance of mitochondria protein 4

Gene

AIM4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29136-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Altered inheritance of mitochondria protein 4
    Alternative name(s):
    Synthetic with old yellow enzyme protein 1
    Gene namesi
    Name:AIM4
    Synonyms:SOY1
    Ordered Locus Names:YBR194W
    ORF Names:YBR1404
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR194w.
    SGDiS000000398. AIM4.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    Increases frequency of mitochondrial genome loss and sensitivity to freeze-thaw stress and high concentrations of glucose.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 123123Altered inheritance of mitochondria protein 4PRO_0000202507Add
    BLAST

    Proteomic databases

    MaxQBiP38305.
    PaxDbiP38305.

    Expressioni

    Gene expression databases

    GenevestigatoriP38305.

    Interactioni

    Subunit structurei

    May interact with the nuclear pore complex.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    URN1Q065256EBI-20939,EBI-35138

    Protein-protein interaction databases

    BioGridi32891. 286 interactions.
    DIPiDIP-2018N.
    IntActiP38305. 67 interactions.
    MINTiMINT-401723.
    STRINGi4932.YBR194W.

    Structurei

    3D structure databases

    ProteinModelPortaliP38305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIM4 family.Curated

    Phylogenomic databases

    eggNOGiNOG80026.
    OrthoDBiEOG7KWSWG.

    Sequencei

    Sequence statusi: Complete.

    P38305-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKKDPSNN LTERRVSKVQ RPNKKKVRNQ VESLSRNLER NKEGQLLQTV    50
    SKGHLEADSG HSLGREKENG ELGIRSIFYD KDWNPRGTAP SHYRNIPYNP 100
    ATFKRRTEVQ ARLGNLENIK IPK 123
    Length:123
    Mass (Da):14,234
    Last modified:October 1, 1994 - v1
    Checksum:iAF25FE81D22D4C8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21487 Genomic DNA. Translation: CAA79681.1.
    Z36063 Genomic DNA. Translation: CAA85156.1.
    AY692669 Genomic DNA. Translation: AAT92688.1.
    BK006936 Genomic DNA. Translation: DAA07308.1.
    PIRiS34019.
    RefSeqiNP_009753.3. NM_001178542.3.

    Genome annotation databases

    EnsemblFungiiYBR194W; YBR194W; YBR194W.
    GeneIDi852493.
    KEGGisce:YBR194W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21487 Genomic DNA. Translation: CAA79681.1 .
    Z36063 Genomic DNA. Translation: CAA85156.1 .
    AY692669 Genomic DNA. Translation: AAT92688.1 .
    BK006936 Genomic DNA. Translation: DAA07308.1 .
    PIRi S34019.
    RefSeqi NP_009753.3. NM_001178542.3.

    3D structure databases

    ProteinModelPortali P38305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32891. 286 interactions.
    DIPi DIP-2018N.
    IntActi P38305. 67 interactions.
    MINTi MINT-401723.
    STRINGi 4932.YBR194W.

    Proteomic databases

    MaxQBi P38305.
    PaxDbi P38305.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR194W ; YBR194W ; YBR194W .
    GeneIDi 852493.
    KEGGi sce:YBR194W.

    Organism-specific databases

    CYGDi YBR194w.
    SGDi S000000398. AIM4.

    Phylogenomic databases

    eggNOGi NOG80026.
    OrthoDBi EOG7KWSWG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29136-MONOMER.

    Miscellaneous databases

    NextBioi 971483.

    Gene expression databases

    Genevestigatori P38305.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif."
      Demolis N., Mallet L., Bussereau F., Jacquet M.
      Yeast 9:645-659(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "The yeast nuclear pore complex: composition, architecture, and transport mechanism."
      Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.
      J. Cell Biol. 148:635-651(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION WITH THE NUCLEAR PORE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    6. "Identification and classification of genes required for tolerance to freeze-thaw stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains."
      Ando A., Nakamura T., Murata Y., Takagi H., Shima J.
      FEMS Yeast Res. 7:244-253(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
      Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
      PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    8. "Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach."
      Teixeira M.C., Raposo L.R., Palma M., Sa-Correia I.
      OMICS 14:201-210(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAIM4_YEAST
    AccessioniPrimary (citable) accession number: P38305
    Secondary accession number(s): D6VQI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3