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Protein

Altered inheritance of mitochondria protein 4

Gene

AIM4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-29136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Altered inheritance of mitochondria protein 4
Alternative name(s):
Synthetic with old yellow enzyme protein 1
Gene namesi
Name:AIM4
Synonyms:SOY1
Ordered Locus Names:YBR194W
ORF Names:YBR1404
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome II

Organism-specific databases

CYGDiYBR194w.
SGDiS000000398. AIM4.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss and sensitivity to freeze-thaw stress and high concentrations of glucose.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 123123Altered inheritance of mitochondria protein 4PRO_0000202507Add
BLAST

Proteomic databases

MaxQBiP38305.
PaxDbiP38305.

Expressioni

Gene expression databases

GenevestigatoriP38305.

Interactioni

Subunit structurei

May interact with the nuclear pore complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
URN1Q065256EBI-20939,EBI-35138

Protein-protein interaction databases

BioGridi32891. 286 interactions.
DIPiDIP-2018N.
IntActiP38305. 67 interactions.
MINTiMINT-401723.
STRINGi4932.YBR194W.

Structurei

3D structure databases

ProteinModelPortaliP38305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIM4 family.Curated

Phylogenomic databases

eggNOGiNOG80026.
InParanoidiP38305.
OMAiQEDSAYM.
OrthoDBiEOG7KWSWG.

Sequencei

Sequence statusi: Complete.

P38305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQKKDPSNN LTERRVSKVQ RPNKKKVRNQ VESLSRNLER NKEGQLLQTV
60 70 80 90 100
SKGHLEADSG HSLGREKENG ELGIRSIFYD KDWNPRGTAP SHYRNIPYNP
110 120
ATFKRRTEVQ ARLGNLENIK IPK
Length:123
Mass (Da):14,234
Last modified:September 30, 1994 - v1
Checksum:iAF25FE81D22D4C8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA. Translation: CAA79681.1.
Z36063 Genomic DNA. Translation: CAA85156.1.
AY692669 Genomic DNA. Translation: AAT92688.1.
BK006936 Genomic DNA. Translation: DAA07308.1.
PIRiS34019.
RefSeqiNP_009753.3. NM_001178542.3.

Genome annotation databases

EnsemblFungiiYBR194W; YBR194W; YBR194W.
GeneIDi852493.
KEGGisce:YBR194W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21487 Genomic DNA. Translation: CAA79681.1.
Z36063 Genomic DNA. Translation: CAA85156.1.
AY692669 Genomic DNA. Translation: AAT92688.1.
BK006936 Genomic DNA. Translation: DAA07308.1.
PIRiS34019.
RefSeqiNP_009753.3. NM_001178542.3.

3D structure databases

ProteinModelPortaliP38305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32891. 286 interactions.
DIPiDIP-2018N.
IntActiP38305. 67 interactions.
MINTiMINT-401723.
STRINGi4932.YBR194W.

Proteomic databases

MaxQBiP38305.
PaxDbiP38305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR194W; YBR194W; YBR194W.
GeneIDi852493.
KEGGisce:YBR194W.

Organism-specific databases

CYGDiYBR194w.
SGDiS000000398. AIM4.

Phylogenomic databases

eggNOGiNOG80026.
InParanoidiP38305.
OMAiQEDSAYM.
OrthoDBiEOG7KWSWG.

Enzyme and pathway databases

BioCyciYEAST:G3O-29136-MONOMER.

Miscellaneous databases

NextBioi971483.

Gene expression databases

GenevestigatoriP38305.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif."
    Demolis N., Mallet L., Bussereau F., Jacquet M.
    Yeast 9:645-659(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The yeast nuclear pore complex: composition, architecture, and transport mechanism."
    Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.
    J. Cell Biol. 148:635-651(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION WITH THE NUCLEAR PORE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  6. "Identification and classification of genes required for tolerance to freeze-thaw stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains."
    Ando A., Nakamura T., Murata Y., Takagi H., Shima J.
    FEMS Yeast Res. 7:244-253(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach."
    Teixeira M.C., Raposo L.R., Palma M., Sa-Correia I.
    OMICS 14:201-210(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIM4_YEAST
AccessioniPrimary (citable) accession number: P38305
Secondary accession number(s): D6VQI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 30, 1994
Last sequence update: September 30, 1994
Last modified: January 6, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.