Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GCR1-dependent translation factor 1

Gene

GDT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in ribosome biogenesis. Has also been proposed to play a role in calcium homeostasis (PubMed:23569283).1 Publication

GO - Molecular functioni

  • calcium ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • calcium ion transmembrane transport Source: SGD
  • cellular calcium ion homeostasis Source: UniProtKB
  • Golgi calcium ion homeostasis Source: SGD
  • Golgi calcium ion transport Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29130-MONOMER.

Protein family/group databases

TCDBi2.A.106.2.3. the ca(2+):h(+) antiporter-2 (caca2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
GCR1-dependent translation factor 1
Gene namesi
Name:GDT1
Ordered Locus Names:YBR187W
ORF Names:YBR1310
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR187W.
SGDiS000000391. GDT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 45VacuolarSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Topological domaini67 – 71CytoplasmicSequence analysis5
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 104VacuolarSequence analysisAdd BLAST12
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 183CytoplasmicSequence analysisAdd BLAST58
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 222VacuolarSequence analysisAdd BLAST18
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 255CytoplasmicSequence analysisAdd BLAST12
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 280VacuolarSequence analysis4

GO - Cellular componenti

  • cis-Golgi network Source: SGD
  • fungal-type vacuole Source: SGD
  • Golgi apparatus Source: UniProtKB
  • Golgi medial cisterna Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Vacuole

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71R → C or H: Loss of function in calcium homeostasis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124671 – 280GCR1-dependent translation factor 1Add BLAST280

Proteomic databases

MaxQBiP38301.
PRIDEiP38301.

Expressioni

Inductioni

Expressin is GCR1-dependent. Promoter is also bound by the RAP1 transcription factor.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi32885. 19 interactors.
DIPiDIP-3804N.
IntActiP38301. 2 interactors.
MINTiMINT-474384.

Structurei

3D structure databases

ProteinModelPortaliP38301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005261.
InParanoidiP38301.
OMAiIVGHSIC.
OrthoDBiEOG092C49P4.

Family and domain databases

InterProiIPR001727. Gdt1.
[Graphical view]
PANTHERiPTHR12608. PTHR12608. 1 hit.
PfamiPF01169. UPF0016. 2 hits.
[Graphical view]
PROSITEiPS01214. UPF0016. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38301-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNMIKKASL IALLPLFTAA AAAATDAETS MESGSSSHLK SFLMSVSMIG
60 70 80 90 100
LSEIGDKTFL IAALMAMRHK RVLVFSAAAT SLAIMTILSG VVGHSAVAFL
110 120 130 140 150
SERYTAFFAG ILFLVFGYKL TMEGLEMSKD AGVEEEMAEV EEEIAIKDMN
160 170 180 190 200
QDMDDVEKGG DTAYDKQLKN ASIGKKIVHR IRELASFMFS PVWVQIFLMV
210 220 230 240 250
FLGELGDRSQ ISIIAMATDS DYWYVIAGAV IGHAICSGLA VVGGKLLATR
260 270 280
ISIRTITLAS SLLFFIFALM YIYQAFTTQD
Length:280
Mass (Da):30,341
Last modified:October 1, 1994 - v1
Checksum:i34CDAE95E13169FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158K → E in AAS56893 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02073 Genomic DNA. Translation: AAB60282.1.
Z36056 Genomic DNA. Translation: CAA85148.1.
Z36057 Genomic DNA. Translation: CAA85150.1.
AY558567 Genomic DNA. Translation: AAS56893.1.
BK006936 Genomic DNA. Translation: DAA07302.1.
PIRiS46059.
RefSeqiNP_009746.1. NM_001178535.1.

Genome annotation databases

EnsemblFungiiYBR187W; YBR187W; YBR187W.
GeneIDi852485.
KEGGisce:YBR187W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02073 Genomic DNA. Translation: AAB60282.1.
Z36056 Genomic DNA. Translation: CAA85148.1.
Z36057 Genomic DNA. Translation: CAA85150.1.
AY558567 Genomic DNA. Translation: AAS56893.1.
BK006936 Genomic DNA. Translation: DAA07302.1.
PIRiS46059.
RefSeqiNP_009746.1. NM_001178535.1.

3D structure databases

ProteinModelPortaliP38301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32885. 19 interactors.
DIPiDIP-3804N.
IntActiP38301. 2 interactors.
MINTiMINT-474384.

Protein family/group databases

TCDBi2.A.106.2.3. the ca(2+):h(+) antiporter-2 (caca2) family.

Proteomic databases

MaxQBiP38301.
PRIDEiP38301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR187W; YBR187W; YBR187W.
GeneIDi852485.
KEGGisce:YBR187W.

Organism-specific databases

EuPathDBiFungiDB:YBR187W.
SGDiS000000391. GDT1.

Phylogenomic databases

GeneTreeiENSGT00390000005261.
InParanoidiP38301.
OMAiIVGHSIC.
OrthoDBiEOG092C49P4.

Enzyme and pathway databases

BioCyciYEAST:G3O-29130-MONOMER.

Miscellaneous databases

PROiP38301.

Family and domain databases

InterProiIPR001727. Gdt1.
[Graphical view]
PANTHERiPTHR12608. PTHR12608. 1 hit.
PfamiPF01169. UPF0016. 2 hits.
[Graphical view]
PROSITEiPS01214. UPF0016. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGDT1_YEAST
AccessioniPrimary (citable) accession number: P38301
Secondary accession number(s): D6VQI2, E9PAD4, Q6Q545
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2170 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.