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Protein

Alkaline ceramidase YPC1

Gene

YPC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide.

GO - Molecular functioni

  • phytoceramidase activity Source: SGD
  • sphingosine N-acyltransferase activity Source: SGD

GO - Biological processi

  • ceramide biosynthetic process Source: SGD
  • ceramide catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciMetaCyc:YBR183W-MONOMER.
YEAST:YBR183W-MONOMER.
ReactomeiR-SCE-1660661. Sphingolipid de novo biosynthesis.

Chemistry

SwissLipidsiSLP:000000372.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline ceramidase YPC1 (EC:3.5.1.-)
Gene namesi
Name:YPC1
Ordered Locus Names:YBR183W
ORF Names:YBR1305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR183W.
SGDiS000000387. YPC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6868CytoplasmicSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 934LumenalSequence analysis
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 13521CytoplasmicSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Topological domaini157 – 1604LumenalSequence analysis
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST
Topological domaini182 – 19514CytoplasmicSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 22812LumenalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Topological domaini250 – 31667CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cortical endoplasmic reticulum Source: SGD
  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Alkaline ceramidase YPC1PRO_0000212466Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi32881. 68 interactions.
DIPiDIP-7405N.
IntActiP38298. 30 interactions.
MINTiMINT-1354145.

Structurei

3D structure databases

ProteinModelPortaliP38298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline ceramidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111189.
HOGENOMiHOG000192011.
InParanoidiP38298.
KOiK05848.
OMAiCEAKEAL.
OrthoDBiEOG092C405I.

Family and domain databases

InterProiIPR008901. Ceramidase.
[Graphical view]
PfamiPF05875. Ceramidase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFRWNYPE SSVPGVWGET TSTIDWCEEN YVVSPYIAEW SNTLTNSVFI
60 70 80 90 100
LSAIYTTYSA YKNKLEKRFL LIGFGYGLVG VGSWLFHMTL KYRFQLLDEL
110 120 130 140 150
PMIYAMCIPT WSLVCEAKEA LLNGDNHKKV PLFEQIFIGV IIGLAVTTAS
160 170 180 190 200
ILYVIYKNVD IHQILFGVQI VVVAATAGSL TYRYVHDPLA KRNLKASMAL
210 220 230 240 250
GAILFLSGYI SWLLDIHYCS FWVHVRRSIL ALPLGVLLEP HGWWHILTGM
260 270 280 290 300
GIYFYIVSLE HLRVITLNVS CNYQFIWRWK VFPELIWKGR KPSTRYSLEL
310
FGPYVEDQSI EVKKEK
Length:316
Mass (Da):36,420
Last modified:October 1, 1994 - v1
Checksum:i90DD942A4522508F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191745 Genomic DNA. Translation: AAF43604.1.
U02073 Genomic DNA. Translation: AAB60277.1.
Z36052 Genomic DNA. Translation: CAA85144.1.
BK006936 Genomic DNA. Translation: DAA07298.1.
PIRiS46055.
RefSeqiNP_009742.1. NM_001178531.1.

Genome annotation databases

EnsemblFungiiYBR183W; YBR183W; YBR183W.
GeneIDi852481.
KEGGisce:YBR183W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191745 Genomic DNA. Translation: AAF43604.1.
U02073 Genomic DNA. Translation: AAB60277.1.
Z36052 Genomic DNA. Translation: CAA85144.1.
BK006936 Genomic DNA. Translation: DAA07298.1.
PIRiS46055.
RefSeqiNP_009742.1. NM_001178531.1.

3D structure databases

ProteinModelPortaliP38298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32881. 68 interactions.
DIPiDIP-7405N.
IntActiP38298. 30 interactions.
MINTiMINT-1354145.

Chemistry

SwissLipidsiSLP:000000372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR183W; YBR183W; YBR183W.
GeneIDi852481.
KEGGisce:YBR183W.

Organism-specific databases

EuPathDBiFungiDB:YBR183W.
SGDiS000000387. YPC1.

Phylogenomic databases

GeneTreeiENSGT00730000111189.
HOGENOMiHOG000192011.
InParanoidiP38298.
KOiK05848.
OMAiCEAKEAL.
OrthoDBiEOG092C405I.

Enzyme and pathway databases

BioCyciMetaCyc:YBR183W-MONOMER.
YEAST:YBR183W-MONOMER.
ReactomeiR-SCE-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiP38298.

Family and domain databases

InterProiIPR008901. Ceramidase.
[Graphical view]
PfamiPF05875. Ceramidase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPC1_YEAST
AccessioniPrimary (citable) accession number: P38298
Secondary accession number(s): D6VQH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.