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Protein

Alkaline ceramidase YPC1

Gene

YPC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes phytoceramide and also dihydroceramide into phytosphingosine or dihydrosphingosine. Prefers phytoceramide. Has also reverse hydrolysis activity, catalyzing synthesis of phytoceramide and dihydroceramide from palmitic acid and phytosphingosine or dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide.

GO - Molecular functioni

  • phytoceramidase activity Source: SGD
  • sphingosine N-acyltransferase activity Source: SGD

GO - Biological processi

  • ceramide biosynthetic process Source: SGD
  • ceramide catabolic process Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:YBR183W-MONOMER
YEAST:YBR183W-MONOMER
ReactomeiR-SCE-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsiSLP:000000372

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline ceramidase YPC1 (EC:3.5.1.-)
Gene namesi
Name:YPC1
Ordered Locus Names:YBR183W
ORF Names:YBR1305
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR183W
SGDiS000000387 YPC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 93LumenalSequence analysis4
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 135CytoplasmicSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 160LumenalSequence analysis4
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 195CytoplasmicSequence analysisAdd BLAST14
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 228LumenalSequence analysisAdd BLAST12
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 316CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124661 – 316Alkaline ceramidase YPC1Add BLAST316

Proteomic databases

PaxDbiP38298
PRIDEiP38298

Interactioni

Protein-protein interaction databases

BioGridi32881, 121 interactors
DIPiDIP-7405N
IntActiP38298, 30 interactors
MINTiP38298
STRINGi4932.YBR183W

Structurei

3D structure databases

ProteinModelPortaliP38298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline ceramidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000111189
HOGENOMiHOG000192011
InParanoidiP38298
KOiK05848
OMAiVFHQVMY
OrthoDBiEOG092C405I

Family and domain databases

InterProiView protein in InterPro
IPR008901 Ceramidase
PfamiView protein in Pfam
PF05875 Ceramidase, 1 hit

Sequencei

Sequence statusi: Complete.

P38298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFRWNYPE SSVPGVWGET TSTIDWCEEN YVVSPYIAEW SNTLTNSVFI
60 70 80 90 100
LSAIYTTYSA YKNKLEKRFL LIGFGYGLVG VGSWLFHMTL KYRFQLLDEL
110 120 130 140 150
PMIYAMCIPT WSLVCEAKEA LLNGDNHKKV PLFEQIFIGV IIGLAVTTAS
160 170 180 190 200
ILYVIYKNVD IHQILFGVQI VVVAATAGSL TYRYVHDPLA KRNLKASMAL
210 220 230 240 250
GAILFLSGYI SWLLDIHYCS FWVHVRRSIL ALPLGVLLEP HGWWHILTGM
260 270 280 290 300
GIYFYIVSLE HLRVITLNVS CNYQFIWRWK VFPELIWKGR KPSTRYSLEL
310
FGPYVEDQSI EVKKEK
Length:316
Mass (Da):36,420
Last modified:October 1, 1994 - v1
Checksum:i90DD942A4522508F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191745 Genomic DNA Translation: AAF43604.1
U02073 Genomic DNA Translation: AAB60277.1
Z36052 Genomic DNA Translation: CAA85144.1
BK006936 Genomic DNA Translation: DAA07298.1
PIRiS46055
RefSeqiNP_009742.1, NM_001178531.1

Genome annotation databases

EnsemblFungiiYBR183W; YBR183W; YBR183W
GeneIDi852481
KEGGisce:YBR183W

Similar proteinsi

Entry informationi

Entry nameiYPC1_YEAST
AccessioniPrimary (citable) accession number: P38298
Secondary accession number(s): D6VQH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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