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Protein

Ribonucleases P/MRP protein subunit POP7

Gene

POP7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.2 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  • ribonuclease P activity Source: UniProtKB-EC
  • RNA binding Source: SGD

GO - Biological processi

  • intronic box C/D snoRNA processing Source: SGD
  • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay Source: SGD
  • rRNA processing Source: SGD
  • tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

rRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YBR167C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP7 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein POP7
RNases P/MRP 15.8 kDa subunit
Gene namesi
Name:POP7
Synonyms:RPP2
Ordered Locus Names:YBR167C
ORF Names:YBR1219
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR167C.
SGDiS000000371. POP7.

Subcellular locationi

GO - Cellular componenti

  • nucleolar ribonuclease P complex Source: SGD
  • ribonuclease MRP complex Source: SGD
  • telomerase holoenzyme complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585191 – 140Ribonucleases P/MRP protein subunit POP7Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38291.
PRIDEiP38291.
TopDownProteomicsiP38291.

PTM databases

iPTMnetiP38291.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POP1P418124EBI-13670,EBI-13621
POP4P383364EBI-13670,EBI-13646
POP6P532185EBI-13670,EBI-13662

Protein-protein interaction databases

BioGridi32867. 110 interactors.
DIPiDIP-5462N.
IntActiP38291. 10 interactors.
MINTiMINT-570982.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 29Combined sources4
Beta strandi32 – 34Combined sources3
Helixi41 – 58Combined sources18
Beta strandi61 – 68Combined sources8
Helixi69 – 71Combined sources3
Helixi72 – 84Combined sources13
Beta strandi90 – 102Combined sources13
Beta strandi126 – 139Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IABX-ray2.70B1-140[»]
ProteinModelPortaliP38291.
SMRiP38291.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38291.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

HOGENOMiHOG000248080.
InParanoidiP38291.
KOiK14526.
OMAiYITVKGM.
OrthoDBiEOG092C5VPB.

Family and domain databases

InterProiIPR014612. Pop7/Rpp20.
IPR020241. RNase_P/MRP_POP7.
[Graphical view]
PfamiPF12328. Rpp20. 1 hit.
[Graphical view]
ProDomiPD085500. Ribonuclease_P/MRP_su_POP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P38291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKKNTHNK STKRVTKHPS LKTLTHKQIH TTIFVKSTTP YVSALKRINK
60 70 80 90 100
FLDSVHKQGS SYVAVLGMGK AVEKTLALGC HFQDQKNKKI EVYTKTIEVL
110 120 130 140
DEVITEGQAD IDMESDVEDD DKETQLKKRA VSGVELRIYV
Length:140
Mass (Da):15,814
Last modified:October 1, 1994 - v1
Checksum:iB507BFDC7ED9C95C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92V → I in AAT92849 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055991 Genomic DNA. Translation: AAC24226.1.
Z36036 Genomic DNA. Translation: CAA85128.1.
AY692830 Genomic DNA. Translation: AAT92849.1.
BK006936 Genomic DNA. Translation: DAA07283.1.
PIRiS46038.
RefSeqiNP_009726.3. NM_001178515.3.

Genome annotation databases

EnsemblFungiiYBR167C; YBR167C; YBR167C.
GeneIDi852465.
KEGGisce:YBR167C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055991 Genomic DNA. Translation: AAC24226.1.
Z36036 Genomic DNA. Translation: CAA85128.1.
AY692830 Genomic DNA. Translation: AAT92849.1.
BK006936 Genomic DNA. Translation: DAA07283.1.
PIRiS46038.
RefSeqiNP_009726.3. NM_001178515.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IABX-ray2.70B1-140[»]
ProteinModelPortaliP38291.
SMRiP38291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32867. 110 interactors.
DIPiDIP-5462N.
IntActiP38291. 10 interactors.
MINTiMINT-570982.

PTM databases

iPTMnetiP38291.

Proteomic databases

MaxQBiP38291.
PRIDEiP38291.
TopDownProteomicsiP38291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR167C; YBR167C; YBR167C.
GeneIDi852465.
KEGGisce:YBR167C.

Organism-specific databases

EuPathDBiFungiDB:YBR167C.
SGDiS000000371. POP7.

Phylogenomic databases

HOGENOMiHOG000248080.
InParanoidiP38291.
KOiK14526.
OMAiYITVKGM.
OrthoDBiEOG092C5VPB.

Enzyme and pathway databases

BioCyciYEAST:YBR167C-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38291.
PROiP38291.

Family and domain databases

InterProiIPR014612. Pop7/Rpp20.
IPR020241. RNase_P/MRP_POP7.
[Graphical view]
PfamiPF12328. Rpp20. 1 hit.
[Graphical view]
ProDomiPD085500. Ribonuclease_P/MRP_su_POP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiPOP7_YEAST
AccessioniPrimary (citable) accession number: P38291
Secondary accession number(s): D6VQG3, E9P8X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.