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P38291

- POP7_YEAST

UniProt

P38291 - POP7_YEAST

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Protein
Ribonucleases P/MRP protein subunit POP7
Gene
POP7, RPP2, YBR167C, YBR1219
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.2 Publications

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. RNA phosphodiester bond hydrolysis Source: GOC
  2. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  3. intronic box C/D snoRNA processing Source: SGD
  4. mRNA cleavage Source: SGD
  5. rRNA processing Source: SGD
  6. tRNA processing Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

rRNA processing, tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YBR167C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleases P/MRP protein subunit POP7 (EC:3.1.26.5)
Alternative name(s):
RNA-processing protein POP7
RNases P/MRP 15.8 kDa subunit
Gene namesi
Name:POP7
Synonyms:RPP2
Ordered Locus Names:YBR167C
ORF Names:YBR1219
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR167c.
SGDiS000000371. POP7.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleolar ribonuclease P complex Source: SGD
  2. ribonuclease MRP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonucleases P/MRP protein subunit POP7
PRO_0000058519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38291.
PaxDbiP38291.

Expressioni

Gene expression databases

GenevestigatoriP38291.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POP6P532183EBI-13670,EBI-13662

Protein-protein interaction databases

BioGridi32867. 109 interactions.
DIPiDIP-5462N.
IntActiP38291. 9 interactions.
MINTiMINT-570982.
STRINGi4932.YBR167C.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 294
Beta strandi32 – 343
Helixi41 – 5818
Beta strandi61 – 688
Helixi69 – 713
Helixi72 – 8413
Beta strandi90 – 10213
Beta strandi126 – 13914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IABX-ray2.70B1-140[»]
ProteinModelPortaliP38291.
SMRiP38291. Positions 14-140.

Miscellaneous databases

EvolutionaryTraceiP38291.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.

Phylogenomic databases

eggNOGiNOG45117.
HOGENOMiHOG000248080.
KOiK14526.
OMAiMVSYVEL.
OrthoDBiEOG7PGF3J.

Family and domain databases

InterProiIPR020241. RNase_P/MRP_POP7.
[Graphical view]
ProDomiPD085500. Ribonuclease_P/MRP_su_POP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P38291-1 [UniParc]FASTAAdd to Basket

« Hide

MALKKNTHNK STKRVTKHPS LKTLTHKQIH TTIFVKSTTP YVSALKRINK    50
FLDSVHKQGS SYVAVLGMGK AVEKTLALGC HFQDQKNKKI EVYTKTIEVL 100
DEVITEGQAD IDMESDVEDD DKETQLKKRA VSGVELRIYV 140
Length:140
Mass (Da):15,814
Last modified:October 1, 1994 - v1
Checksum:iB507BFDC7ED9C95C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921V → I in AAT92849. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055991 Genomic DNA. Translation: AAC24226.1.
Z36036 Genomic DNA. Translation: CAA85128.1.
AY692830 Genomic DNA. Translation: AAT92849.1.
BK006936 Genomic DNA. Translation: DAA07283.1.
PIRiS46038.
RefSeqiNP_009726.3. NM_001178515.3.

Genome annotation databases

EnsemblFungiiYBR167C; YBR167C; YBR167C.
GeneIDi852465.
KEGGisce:YBR167C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF055991 Genomic DNA. Translation: AAC24226.1 .
Z36036 Genomic DNA. Translation: CAA85128.1 .
AY692830 Genomic DNA. Translation: AAT92849.1 .
BK006936 Genomic DNA. Translation: DAA07283.1 .
PIRi S46038.
RefSeqi NP_009726.3. NM_001178515.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IAB X-ray 2.70 B 1-140 [» ]
ProteinModelPortali P38291.
SMRi P38291. Positions 14-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32867. 109 interactions.
DIPi DIP-5462N.
IntActi P38291. 9 interactions.
MINTi MINT-570982.
STRINGi 4932.YBR167C.

Proteomic databases

MaxQBi P38291.
PaxDbi P38291.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR167C ; YBR167C ; YBR167C .
GeneIDi 852465.
KEGGi sce:YBR167C.

Organism-specific databases

CYGDi YBR167c.
SGDi S000000371. POP7.

Phylogenomic databases

eggNOGi NOG45117.
HOGENOMi HOG000248080.
KOi K14526.
OMAi MVSYVEL.
OrthoDBi EOG7PGF3J.

Enzyme and pathway databases

BioCyci YEAST:YBR167C-MONOMER.

Miscellaneous databases

EvolutionaryTracei P38291.
NextBioi 971411.

Gene expression databases

Genevestigatori P38291.

Family and domain databases

InterProi IPR020241. RNase_P/MRP_POP7.
[Graphical view ]
ProDomi PD085500. Ribonuclease_P/MRP_su_POP7. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae."
    Stolc V., Katz A., Altman S.
    Proc. Natl. Acad. Sci. U.S.A. 95:6716-6721(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
    Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
    Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
    Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
    J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPOP7_YEAST
AccessioniPrimary (citable) accession number: P38291
Secondary accession number(s): D6VQG3, E9P8X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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