Ribonucleases P/MRP protein subunit POP7 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Contribute

Send feedback

Read comments (?) or add your own

P38291 (POP7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ribonucleases P/MRP protein subunit POP7
EC=3.1.26.5

Alternative name(s):
RNA-processing protein POP7
RNases P/MRP 15.8 kDa subunit

Gene names

Name:	POP7
Synonyms:	RPP2
Ordered Locus Names:	YBR167C
ORF Names:	YBR1219

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences. Ref.1 Ref.5
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subunit structure	Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. Ref.5 Ref.7
Subcellular location	Nucleus Ref.6.
Sequence similarities	Belongs to the histone-like Alba family.

Ontologies

Keywords
Biological process	rRNA processing tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intronic box C/D snoRNA processing Inferred from direct assay PubMed 18713869. Source: SGD mRNA cleavage Inferred from physical interaction PubMed 14729943. Source: SGD rRNA processing Traceable author statement Ref.5. Source: SGD tRNA processing Traceable author statement Ref.5. Source: SGD
Cellular_component	nucleolar ribonuclease P complex Inferred from direct assay Ref.5. Source: SGD ribonuclease MRP complex Inferred from direct assay Ref.5. Source: SGD
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 140

140

Ribonucleases P/MRP protein subunit POP7

PRO_0000058519

Amino acid modifications

Modified residue

115

Phosphoserine Ref.8

Experimental info

Sequence conflict

V → I in AAT92849. Ref.4

Secondary structure

140

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P38291 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: B507BFDC7ED9C95C
Show »

FASTA

140

15,814

        10         20         30         40         50         60 
MALKKNTHNK STKRVTKHPS LKTLTHKQIH TTIFVKSTTP YVSALKRINK FLDSVHKQGS 

        70         80         90        100        110        120 
SYVAVLGMGK AVEKTLALGC HFQDQKNKKI EVYTKTIEVL DEVITEGQAD IDMESDVEDD 

       130        140 
DKETQLKKRA VSGVELRIYV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae." Stolc V., Katz A., Altman S. Proc. Natl. Acad. Sci. U.S.A. 95:6716-6721(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP." Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R. Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component." Salinas K., Wierzbicki S., Zhou L., Schmitt M.E. J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF055991 Genomic DNA. Translation: AAC24226.1.
Z36036 Genomic DNA. Translation: CAA85128.1.
AY692830 Genomic DNA. Translation: AAT92849.1.
BK006936 Genomic DNA. Translation: DAA07283.1.

PIR

S46038.

RefSeq

NP_009726.3. NM_001178515.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IAB	X-ray	2.70	B	1-140	[»]

ProteinModelPortal

P38291.

SMR

P38291. Positions 14-140.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5462N.

IntAct

P38291. 9 interactions.

MINT

MINT-570982.

STRING

4932.YBR167C.

Proteomic databases

PaxDb

P38291.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YBR167C; YBR167C; YBR167C.

GeneID

852465.

KEGG

sce:YBR167C.

Organism-specific databases

CYGD

YBR167c.

SGD

S000000371. POP7.

Phylogenomic databases

eggNOG

NOG45117.

HOGENOM

HOG000248080.

K14526.

OMA

YITVKGM.

OrthoDB

EOG483HFC.

Enzyme and pathway databases

BioCyc

YEAST:YBR167C-MONOMER.

Gene expression databases

Genevestigator

P38291.

GermOnline

YBR167C. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR020241. RNase_P/MRP_POP7.
[Graphical view]

ProDom

PD085500. Ribonuclease_P/MRP_su_POP7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

Search...

Other

EvolutionaryTrace

P38291.

NextBio

971411.

Entry information

Entry name

POP7_YEAST

Accession

Primary (citable) accession number: P38291
Secondary accession number(s): D6VQG3, E9P8X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	May 29, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents