Reviewed, UniProtKB/Swiss-Prot P38289 (DEM1_YEAST)

Names and origin

Protein names

Recommended name:
    Defects in morphology protein 1, mitochondrial

Gene names

Name:	DEM1
Ordered Locus Names:	YBR163W
ORF Names:	YBR1215

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in cellular morphology. Ref.2
Subcellular location	Mitochondrion.
Miscellaneous	Present with 1420 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	Belongs to the DEM1 family.

Ontologies

Keywords
Biological process	Cell shape
Cellular component	Mitochondrion
Domain	Transit peptide
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Ref.3 Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSB3	P43603	1	EBI-20869,EBI-22980
RVS167	P39743	1	EBI-20869,EBI-14500
YSC84	P32793	1	EBI-20869,EBI-24460

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 26	26	Mitochondrion Potential
	Chain	27 – 585	559	Defects in morphology protein 1, mitochondrial		PRO_0000202501

Sequences

	Sequence		Length	Mass (Da)
	P38289-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 92DBE35B819E0AFB	FASTA	585	67,570
	10 20 30 40 50 60 MLGRALINKY GFLIHPRRFV HLNDKSLDGT FILPSKKNHM YDVPTNDPSG ILNASDIDRI 70 80 90 100 110 120 NNLPFFDNTS PTKETNTKEG ALLSEKLASV KELFGEDPEN PSFINYRFPR GLENPYFDIQ 130 140 150 160 170 180 VNQLKKKRLS VTQLCTTQNW CELRNFYDFY SQNLSNQLLN LKFQVQKGKK IHKSLEDETH 190 200 210 220 230 240 PELNQYKSFT HNFLALTKLS MDIDNDMDAL LDNWFNSINR LVSLFTKGDG HAREIVCHGF 250 260 270 280 290 300 INLEDGKLVE HLLNSDSKTK ENVIISGVID HLTLRNRHNH QVQKGAAHLD TEYQSWGNIL 310 320 330 340 350 360 TNLLSNLKEL KSNNEIVISD IKTRSVPKIP SIESVIESSK LQTMYYKFFF SHLSQDMTQT 370 380 390 400 410 420 YHSFLINAQR RGLDVDAPIN PTKILTFILT NPLFANDVKN LLYGLPINHS AFDNDAKGSN 430 440 450 460 470 480 TFDMTAFNDL LDRGPTSFNV PIEQDEDSSE STKCVSLRDY GHFYTKWKTP LTLKYFAARL 490 500 510 520 530 540 SQIYFIVGNL VSNDLMIEYY YHNDNFHNII FPYDPLKLGT HAHDSAMVWF GGRDMHPIEP 550 560 570 580 TQKNFNTYCK FCDYRHVCSW KNKNELKLID LGKELKKIIL ESSMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach." Entian K.-D., Schuster T., Hegemann J.H., Becher D., Feldmann H., Gueldener U., Goetz R., Hansen M., Hollenberg C.P., Jansen G., Kramer W., Klein S., Koetter P., Kricke J., Launhardt H., Mannhaupt G., Maierl A., Meyer P. , Mewes W., Munder T., Niedenthal R.K., Ramezani Rad M., Roehmer A., Roemer A., Rose M., Schaefer B., Siegler M.-L., Vetter J., Wilhelm N., Wolf K., Zimmermann F.K., Zollner A., Hinnen A. Mol. Gen. Genet. 262:683-702(1999) [PubMed: 10628851] [Abstract] Cited for: FUNCTION.
[3]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z36032 Genomic DNA. Translation: CAA85123.1.
PIR	S46034.
RefSeq	NP_009722.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P38289. 3 interactions.
STRING	P38289.
Genome annotation databases
Ensembl	YBR163W; YBR163W; YBR163W; Saccharomyces cerevisiae. [Genome view]
GeneID	852461.
KEGG	sce:YBR163W.
NMPDR	fig|4932.3.peg.428.
Organism-specific databases
CYGD	YBR163w.
SGD	S000000367. DEM1.
Phylogenomic databases
OMA	TDVKTRS
OrthoDB	EOG98PP2P
Gene expression databases
ArrayExpress	P38289.
Genevestigator	P38289.
GermOnline	YBR163W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016610. Defects_morphology_1. IPR019190. Defects_morphology_1-like. [Graphical view]
Pfam	PF09810. Morph_protein1. 1 hit. [Graphical view]
PIRSF	PIRSF013220. UCP013220. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	971399.

Entry information

Entry name

DEM1_YEAST

Accession

Primary (citable) accession number: P38289

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)