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Protein

Mannosyl phosphorylinositol ceramide synthase CSH1

Gene

CSH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the synthesis of mannosyl phosphorylinositol ceramide. Catalyzes the addition of mannosyl to phosphorylinositol ceramide.1 Publication

Miscellaneous

Present with 195 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mannosyltransferase activity Source: SGD
  • transferase activity, transferring glycosyl groups Source: SGD

GO - Biological processi

  • glycosphingolipid biosynthetic process Source: SGD
  • mannosyl-inositol phosphorylceramide biosynthetic process Source: GO_Central
  • sphingolipid biosynthetic process Source: SGD

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:G3O-29111-MONOMER.
YEAST:G3O-29111-MONOMER.

Protein family/group databases

CAZyiGT32. Glycosyltransferase Family 32.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl phosphorylinositol ceramide synthase CSH1 (EC:2.-.-.-)
Alternative name(s):
CSG1/SUR1 homolog 1
Gene namesi
Name:CSH1
Ordered Locus Names:YBR161W
ORF Names:YBR1212
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR161W.
SGDiS000000365. CSH1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793951 – 376Mannosyl phosphorylinositol ceramide synthase CSH1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei354PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38287.
PRIDEiP38287.

PTM databases

iPTMnetiP38287.

Interactioni

Subunit structurei

Heterodimer of CSH1 and CSG2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CSG2P352062EBI-20861,EBI-2051140

Protein-protein interaction databases

BioGridi32860. 182 interactors.
DIPiDIP-5144N.
IntActiP38287. 3 interactors.
MINTiMINT-511838.
STRINGi4932.YBR161W.

Structurei

3D structure databases

ProteinModelPortaliP38287.
SMRiP38287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 32 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000007232.
HOGENOMiHOG000200927.
InParanoidiP38287.
OMAiMITTARH.
OrthoDBiEOG092C2XIG.

Family and domain databases

InterProiView protein in InterPro
IPR007577. GlycoTrfase_DXD_sugar-bd_CS.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF04488. Gly_transf_sug. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P38287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKELKILII ANIALLISII HYTFDLLTLC IDDTSKDALT DEQLNPPNGF
60 70 80 90 100
NSTFYESPPQ LIPKIIHQTY KTNDIPEQWV KGRQKCIDLH PDYTYILWTD
110 120 130 140 150
EMSDTFIKQE YPWFLDTFRS YEYPIERADA IRYFILSHYG GIYIDLDDGC
160 170 180 190 200
ERRLDPLLKV PAFLRKTSPT GVSNDVMGSV PRHPFFLKVI KSLKHYKKNW
210 220 230 240 250
YIPYMTIMGS TGPLFISVVW KQYKRWSNTA ENGAVRILQP ADYKMHNNSF
260 270 280 290 300
FSISKGSSWH TGDANFMKTL ENHILSCVVT GFIFGFFILY GEFTFYTWLC
310 320 330 340 350
SGPFNNKRYY IQWLSDKFKL HKWKLTSSYK NKEKRRNPTR HEYNSRGKRL
360 370
RKDSNIPYDS VFLDIEKNHA KFTDLT
Length:376
Mass (Da):44,382
Last modified:October 1, 1994 - v1
Checksum:i34D992039DA0B796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80224 Genomic DNA. Translation: CAA56510.1.
Z36030 Genomic DNA. Translation: CAA85120.1.
AY692764 Genomic DNA. Translation: AAT92783.1.
BK006936 Genomic DNA. Translation: DAA07276.1.
PIRiS46032.
RefSeqiNP_009719.3. NM_001178509.3.

Genome annotation databases

EnsemblFungiiYBR161W; YBR161W; YBR161W.
GeneIDi852458.
KEGGisce:YBR161W.

Similar proteinsi

Entry informationi

Entry nameiCSH1_YEAST
AccessioniPrimary (citable) accession number: P38287
Secondary accession number(s): D6VQF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names