P38281 (APD1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin patches distal protein 1

Gene names

Name:	APD1
Ordered Locus Names:	YBR151W
ORF Names:	YBR1201

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for normal localization of actin patches. Involved in tolerance to sodium ions and hydrogen peroxide. Ref.4
Subcellular location	Cytoplasm. Nucleus Ref.6.
Induction	Expression is controled by the transcription factor YRR1. Ref.5
Miscellaneous	Present with 2000 molecules/cell in log phase SD medium. Ref.7
Sequence similarities	Belongs to the APD1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay Ref.6. Source: SGD nucleus Inferred from direct assay Ref.6. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Actin patches distal protein 1		PRO_0000202497

Sequences

	Sequence		Length	Mass (Da)
	P38281 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 23A1BD4DD6C34CFC	FASTA	316	35,759
	10 20 30 40 50 60 MAFLNIFKQK RGDEASQLSA KGREEISQSI KICKSDDAAN EHSCSGDCKT EIEEGEQAFA 70 80 90 100 110 120 KLKIEHETPL LNSSKTPKIH FVVPTSQIDW QHDACLEDPK SVQYKISQWC DKNSAKFSNV 130 140 150 160 170 180 GTGKTLNCAV SSLPKDIMDI DVMRGTKNNV LILPYFIWLN DLRSDDVEAT LDGLVPDLLD 190 200 210 220 230 240 ENISREKLLE TRPNVAVARE RAFVFICSHT TRDKRCGITA PYLKKVFDSK LQEHGLYRDN 250 260 270 280 290 300 SDYRAEGVKI AFVNHVGGHK FAANVQIYLR NPNTLIWLGR VTPTIVPSIV EHLIVPEEPT 310 LPFPEKVRCI KKYQSW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach." Entian K.-D., Schuster T., Hegemann J.H., Becher D., Feldmann H., Gueldener U., Goetz R., Hansen M., Hollenberg C.P., Jansen G., Kramer W., Klein S., Koetter P., Kricke J., Launhardt H., Mannhaupt G., Maierl A., Meyer P. , Mewes W., Munder T., Niedenthal R.K., Ramezani Rad M., Roehmer A., Roemer A., Rose M., Schaefer B., Siegler M.-L., Vetter J., Wilhelm N., Wolf K., Zimmermann F.K., Zollner A., Hinnen A. Mol. Gen. Genet. 262:683-702(1999) [PubMed: 10628851] [Abstract] Cited for: FUNCTION.
[5]	"New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system." Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C. Mol. Cell. Biol. 22:2642-2649(2002) [PubMed: 11909958] [Abstract] Cited for: INDUCTION.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36020 Genomic DNA. Translation: CAA85109.1. AY693048 Genomic DNA. Translation: AAT93067.1. BK006936 Genomic DNA. Translation: DAA07266.1.
PIR	S46022.
RefSeq	NP_009709.1. NM_001178499.1.
3D structure databases
ProteinModelPortal	P38281.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38281. 6 interactions.
MINT	MINT-665782.
STRING	P38281.
Proteomic databases
PeptideAtlas	P38281.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR151W; YBR151W; YBR151W.
GeneID	852448.
KEGG	sce:YBR151W.
NMPDR	fig|4932.3.peg.415.
Organism-specific databases
CYGD	YBR151w.
SGD	S000000355. APD1.
Phylogenomic databases
eggNOG	fuNOG08005.
GeneTree	EFGT00050000000359.
HOGENOM	HBG396546.
OMA	TRDKRCG.
OrthoDB	EOG4X6GJJ.
Gene expression databases
ArrayExpress	P38281.
Genevestigator	P38281.
GermOnline	YBR151W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009737. Suc_Fer-like. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF06999. Suc_Fer-like. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
ProtoNet	Search...
Other
NextBio	971360.

Entry information

Entry name

APD1_YEAST

Accession

Primary (citable) accession number: P38281
Secondary accession number(s): D6VQE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program