P38276 (YBY7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0303 protein YBR137W

Gene names

Ordered Locus Names:	YBR137W
ORF Names:	YBR1013

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.6.
Miscellaneous	Present with 1200 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the UPF0303 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	TRC complex Inferred from direct assay PubMed 20850366. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-21630,EBI-21630
NUP116	Q02630	1	EBI-21630,EBI-11703
SRP1	Q02821	1	EBI-21630,EBI-1797
TEM1	P38987	1	EBI-21630,EBI-19113

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	UPF0303 protein YBR137W		PRO_0000208926
Experimental info
	Sequence conflict	110	1	G → S in CAA53495. Ref.2
	Sequence conflict	110	1	G → S in CAA85095. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P38276 [UniParc]. Last modified July 27, 2011. Version 4. Checksum: 8CBA454492E29273	FASTA	179	20,454
	10 20 30 40 50 60 MVVLDKKLLE RLTSRKVPLE ELEDMEKRCF LSTFTYQDAF DLGTYIRNAV KENFPEKPVA 70 80 90 100 110 120 IDISLPNGHC LFRTVTYGGS ALDNDFWIQR KKKTALRFGH SSFYMGCKKG DKTPEEKFFV 130 140 150 160 170 DSKEYAFHGG AVLIQSERSD YPYACLTISG LKQEEDHLMA VSSLIAFANE SLEEDLNLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae." Kato R., Ogawa H. Nucleic Acids Res. 22:3104-3112(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The sequence of 29.7 kb from the right arm of chromosome II reveals 13 complete open reading frames, of which ten correspond to new genes." Becam A.-M., Cullin C., Grzybowska E., Lacroute F., Nasr F., Ozier-Kalogeropoulos O., Palucha A., Slonimski P.P., Zagulski M., Herbert C.J. Yeast 10:S1-S11(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	Saccharomyces Genome Database Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 110. Strain: ATCC 204508 / S288c.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D11088 Genomic DNA. Translation: BAA01861.1. X75891 Genomic DNA. Translation: CAA53495.1. Z36006 Genomic DNA. Translation: CAA85095.1. AY558187 Genomic DNA. Translation: AAS56513.1. BK006936 Genomic DNA. Translation: DAA07253.2.
PIR	S46006.
RefSeq	NP_009695.2. NM_001178485.2.
3D structure databases
ProteinModelPortal	P38276.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-2038N.
IntAct	P38276. 7 interactions.
MINT	MINT-559422.
STRING	4932.YBR137W.
Proteomic databases
PaxDb	P38276.
PeptideAtlas	P38276.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR137W; YBR137W; YBR137W.
GeneID	852434.
KEGG	sce:YBR137W.
Organism-specific databases
SGD	S000000341. YBR137W.
Phylogenomic databases
eggNOG	COG4702.
HOGENOM	HOG000244036.
OMA	SKEYAFH.
OrthoDB	EOG4N8VFC.
Gene expression databases
Genevestigator	P38276.
GermOnline	YBR137W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005624. DUF336. IPR010371. UPF0303. [Graphical view]
Pfam	PF03928. DUF336. 1 hit. [Graphical view]
PIRSF	PIRSF008757. UCP008757. 1 hit.
ProtoNet	Search...
Other
NextBio	971321.

Entry information

Entry name

YBY7_YEAST

Accession

Primary (citable) accession number: P38276
Secondary accession number(s): D6VQD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 94 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program