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Protein

SWI5-dependent HO expression protein 3

Gene

SHE3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.11 Publications

Miscellaneous

Present with 1010 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mRNA binding Source: SGD
  • sequence-specific mRNA binding Source: SGD

GO - Biological processi

  • endoplasmic reticulum inheritance Source: SGD
  • intracellular mRNA localization Source: SGD
  • mating type switching Source: SGD
  • mRNA transport Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29085-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
SWI5-dependent HO expression protein 3
Gene namesi
Name:SHE3
Ordered Locus Names:YBR130C
ORF Names:YBR1005
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR130C
SGDiS000000334 SHE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi343S → E: Prevents correct localization of ASH1 mRNA; when associated with E-361. 1 Publication1
Mutagenesisi348S → E: Prevents correct localization of ASH1 mRNA. 1 Publication1
Mutagenesisi361S → E: Prevents correct localization of ASH1 mRNA; when associated with E-343. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024901 – 425SWI5-dependent HO expression protein 3Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei343PhosphoserineCombined sources1
Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38272
PaxDbiP38272
PRIDEiP38272

PTM databases

iPTMnetiP38272

Interactioni

Subunit structurei

Interacts with SHE2 and MYO4.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32831, 102 interactors
DIPiDIP-2037N
IntActiP38272, 27 interactors
MINTiP38272
STRINGi4932.YBR130C

Structurei

Secondary structure

1425
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 71Combined sources28
Helixi74 – 134Combined sources61

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LL7X-ray2.31A/B/C/D/E/F/G/H42-137[»]
4LL8X-ray3.58B/E81-311[»]
4WNLX-ray2.80E/F/G/H342-374[»]
5M0IX-ray2.41H/I/J382-405[»]
5M0JX-ray2.80A/B/C/D/G/H/I/J331-405[»]
ProteinModelPortaliP38272
SMRiP38272
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili68 – 197Sequence analysisAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi377 – 381Poly-Ser5

Sequence similaritiesi

Belongs to the SHE3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP38272
KOiK18737
OMAiNAKHEND
OrthoDBiEOG092C5AYK

Family and domain databases

InterProiView protein in InterPro
IPR031398 She3
PfamiView protein in Pfam
PF17078 SHE3, 1 hit

Sequencei

Sequence statusi: Complete.

P38272-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQDNTQTS SSKLAPHHNI FMANLESSPT KDRNTSSQNA SSSRVIESLH
60 70 80 90 100
DQIDMLTKTN LQLTTQSQNL LSKLELAQSK ESKLLENLNL LKNENENLNS
110 120 130 140 150
IFERKNKKLK ELEKDYSELS NRYNEQKEKM DQLSKLAKNS SAIEQSCSEK
160 170 180 190 200
LQNMEVNYNS LLESQNLYRD HYSDEISKLN EKIGLLELEL SNQNLNYGSD
210 220 230 240 250
TSSNSDIELN LNKFNDSVKD LKSLETEKDS KLSKIITHSL DELNLQSWLN
260 270 280 290 300
LYQTNENLIS TFAEKMDLKD VLKRNDEKIS NKGAVVQTLK KNVQTQVESN
310 320 330 340 350
NADALSSNNA QDMLPIKMVK LRKTPNTNDS SSNGNSSNNK RRSFYTASPL
360 370 380 390 400
LSSGSIPKSA SPVLPGVKRT ASVRKPSSSS SKTNVTHNND PSTSPTISVP
410 420
PGVTRTVSST HKKKGNSMVV HGAQS
Length:425
Mass (Da):47,417
Last modified:October 1, 1994 - v1
Checksum:i590404D2E140BB7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75891 Genomic DNA Translation: CAA53489.1
Z35999 Genomic DNA Translation: CAA85087.1
BK006936 Genomic DNA Translation: DAA07247.1
PIRiS45999
RefSeqiNP_009688.3, NM_001178478.3

Genome annotation databases

EnsemblFungiiYBR130C; YBR130C; YBR130C
GeneIDi852427
KEGGisce:YBR130C

Similar proteinsi

Entry informationi

Entry nameiSHE3_YEAST
AccessioniPrimary (citable) accession number: P38272
Secondary accession number(s): D6VQC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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