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P38266

- AIM3_YEAST

UniProt

P38266 - AIM3_YEAST

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Protein
Altered inheritance of mitochondria protein 3
Gene
AIM3, YBR108W, YBR0901
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. actin cortical patch assembly Source: SGD
  2. barbed-end actin filament capping Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29070-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Altered inheritance of mitochondria protein 3
Gene namesi
Name:AIM3
Ordered Locus Names:YBR108W
ORF Names:YBR0901
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR108w.
SGDiS000000312. AIM3.

Subcellular locationi

Membrane raft; Peripheral membrane protein
Note: Localize within detergent-insoluble glycolipid-enriched membranes.1 Publication

GO - Cellular componenti

  1. actin cortical patch Source: SGD
  2. membrane raft Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 947947Altered inheritance of mitochondria protein 3
PRO_0000202486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei57 – 571Phosphoserine1 Publication
Modified residuei58 – 581Phosphoserine1 Publication
Modified residuei64 – 641Phosphoserine1 Publication
Modified residuei476 – 4761Phosphoserine1 Publication
Modified residuei729 – 7291Phosphothreonine2 Publications
Modified residuei861 – 8611Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38266.
PaxDbiP38266.
PeptideAtlasiP38266.

Expressioni

Gene expression databases

GenevestigatoriP38266.

Interactioni

Subunit structurei

Interacts with RVS167.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BZZ1P388222EBI-21584,EBI-3889
LSB1P532813EBI-21584,EBI-23329
LSB3P436034EBI-21584,EBI-22980
RVS167P397436EBI-21584,EBI-14500
YSC84P327935EBI-21584,EBI-24460

Protein-protein interaction databases

BioGridi32812. 151 interactions.
DIPiDIP-1602N.
IntActiP38266. 16 interactions.
MINTiMINT-385431.
STRINGi4932.YBR108W.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 398304Gln-rich
Add
BLAST
Compositional biasi371 – 44777Pro-rich
Add
BLAST
Compositional biasi862 – 90746Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the AIM3 family.

Phylogenomic databases

eggNOGiNOG12793.
OMAiPPKPFRH.
OrthoDBiEOG712V4W.

Sequencei

Sequence statusi: Complete.

P38266-1 [UniParc]FASTAAdd to Basket

« Hide

MGFWENNKDS ITSGLKSAGK YGYQGTKYVA KTGYKASKKH YNNSKARRER    50
KSGKKNSSDE EYDSEDEMEY ERKPTDIRSL KDPKSFPPPP LKPGQKTYTG 100
QQQQQMPNGQ ASYAFQGAYQ GQPGAGSTEQ SQYAQPQYNQ YPQQQLQQGV 150
MPQQQQLQQG VVPQQPPIYG EQVPPYGSNS NATSYQSLPQ QNQPQNAIPS 200
QVSLNSASQQ STGFVSQNLQ YGTQSSNPAP SPSFQNGLQC HQQPQYVSHG 250
STNLGQSQFP SGQQQQPTTQ FGQQVLPSPA QPQQQQQGQP LPPPRGQVIL 300
PAPGEPLSNG FGQQQQQQQQ QQQPLNQNNA LLPQMNVEGV SGMAAVQPVY 350
GQAMSSTTNM QDSNPSYGAS PMQGQPPVGG QPPVPVRMQP QPPQPMQQGN 400
IYPIEPSLDS TGSTPHFEVT PFDPDAPAPK PKIDIPTVDV SSLPPPPTHR 450
DRGAVVHQEP APSGKIQPNT TSSAASLPAK HSRTTTADNE RNSGNKENDE 500
STSKSSILGH YDVDVNIMPP PKPFRHGLDS VPSEHTTKNA PERAVPILPP 550
RNNVEPPPPP SRGNFERTES VLSTNAANVQ EDPISNFLPP PKPFRHTETK 600
QNQNSKASPV EMKGEVLPGH PSEEDRNVEP SLVPQSKPQS QSQFRRAHME 650
TQPIQNFQPP PKPFRRSQSS NSSDSSYTID GPEANHGRGR GRIAKHHDGD 700
EYNPKSENST ENGRLGDAPN SFIRKRAPTP PAPSRSEKLH EGTITSEVDS 750
SKDANKYEKS IPPVTSSIQA QQSTKKAPPP VVKPKPRNFS LKANEYPKEL 800
TREATGQDEV LNSITNELSH IKLRKTNVNL EKLGGSKKVK DSSPVPSDLD 850
EKYVSASGSI TPPRPPPSRS SPKKVPPVVP KKNDNLKKKP PVVPKKKPLL 900
KSLEPRPIEM ERAYSGDISA ADDNLNPFER YKRNVVPQED DRLHKLK 947
Length:947
Mass (Da):103,863
Last modified:July 27, 2011 - v3
Checksum:iCD624428B29DA272
GO

Sequence cautioni

The sequence CAA55611.1 differs from that shown. Reason: Frameshift at position 841.
The sequence CAA85063.1 differs from that shown. Reason: Frameshift at position 841.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti515 – 5151V → A in CAA55611. 1 Publication
Sequence conflicti515 – 5151V → A in CAA85063. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78993 Genomic DNA. Translation: CAA55611.1. Frameshift.
Z35977 Genomic DNA. Translation: CAA85063.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07227.2.
PIRiS48273.
RefSeqiNP_009666.3. NM_001178456.2.

Genome annotation databases

EnsemblFungiiYBR108W; YBR108W; YBR108W.
GeneIDi852405.
KEGGisce:YBR108W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78993 Genomic DNA. Translation: CAA55611.1 . Frameshift.
Z35977 Genomic DNA. Translation: CAA85063.1 . Frameshift.
BK006936 Genomic DNA. Translation: DAA07227.2 .
PIRi S48273.
RefSeqi NP_009666.3. NM_001178456.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32812. 151 interactions.
DIPi DIP-1602N.
IntActi P38266. 16 interactions.
MINTi MINT-385431.
STRINGi 4932.YBR108W.

Proteomic databases

MaxQBi P38266.
PaxDbi P38266.
PeptideAtlasi P38266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR108W ; YBR108W ; YBR108W .
GeneIDi 852405.
KEGGi sce:YBR108W.

Organism-specific databases

CYGDi YBR108w.
SGDi S000000312. AIM3.

Phylogenomic databases

eggNOGi NOG12793.
OMAi PPKPFRH.
OrthoDBi EOG712V4W.

Enzyme and pathway databases

BioCyci YEAST:G3O-29070-MONOMER.

Miscellaneous databases

NextBioi 971246.

Gene expression databases

Genevestigatori P38266.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
    Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
    Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 515.
    Strain: ATCC 204508 / S288c.
  4. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  5. "Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p."
    Germann M., Swain E., Bergman L., Nickels J.T. Jr.
    J. Biol. Chem. 280:4270-4278(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RVS167, SUBCELLULAR LOCATION.
  6. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  7. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-729, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476; THR-729 AND THR-861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-58 AND SER-64, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIM3_YEAST
AccessioniPrimary (citable) accession number: P38266
Secondary accession number(s): D6VQA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

Similar proteinsi