Reviewed, UniProtKB/Swiss-Prot P38266 (YBV8_YEAST)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein YBR108W

Gene names

Ordered Locus Names:	YBR108W
ORF Names:	YBR0901

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	947 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with RVS167. Ref.4
Sequence caution	The sequence CAA55611.1 differs from that shown. Reason: Frameshift at position 841. The sequence CAA85063.1 differs from that shown. Reason: Frameshift at position 841.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LSB1	P53281	1	EBI-21584,EBI-23329
LSB3	P43603	2	EBI-21584,EBI-22980
RVS167	P39743	3	EBI-21584,EBI-14500
YSC84	P32793	2	EBI-21584,EBI-24460

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 947	947	Uncharacterized protein YBR108W		PRO_0000202486
Regions
	Compositional bias	95 – 398	304	Gln-rich
	Compositional bias	371 – 447	77	Pro-rich
	Compositional bias	862 – 907	46	Pro-rich
Amino acid modifications
	Modified residue	57	1	Phosphoserine Ref.8
	Modified residue	58	1	Phosphoserine Ref.8
	Modified residue	64	1	Phosphoserine Ref.8
	Modified residue	476	1	Phosphoserine Ref.8
	Modified residue	669	1	Phosphoserine Ref.7
	Modified residue	729	1	Phosphothreonine Ref.8 Ref.6
	Modified residue	805	1	Phosphothreonine Ref.7 Ref.5
	Modified residue	826	1	Phosphothreonine Ref.6
	Modified residue	842	1	Phosphoserine Ref.8 Ref.7
	Modified residue	843	1	Phosphoserine Ref.8 Ref.7
	Modified residue	847	1	Phosphoserine Ref.8
	Modified residue	861	1	Phosphothreonine Ref.8
	Modified residue	914	1	Phosphotyrosine Ref.8
	Modified residue	915	1	Phosphoserine Ref.8 Ref.5
	Modified residue	919	1	Phosphoserine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P38266-1 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: AB58F141D3E14BB7	FASTA	947	103,835
	10 20 30 40 50 60 MGFWENNKDS ITSGLKSAGK YGYQGTKYVA KTGYKASKKH YNNSKARRER KSGKKNSSDE 70 80 90 100 110 120 EYDSEDEMEY ERKPTDIRSL KDPKSFPPPP LKPGQKTYTG QQQQQMPNGQ ASYAFQGAYQ 130 140 150 160 170 180 GQPGAGSTEQ SQYAQPQYNQ YPQQQLQQGV MPQQQQLQQG VVPQQPPIYG EQVPPYGSNS 190 200 210 220 230 240 NATSYQSLPQ QNQPQNAIPS QVSLNSASQQ STGFVSQNLQ YGTQSSNPAP SPSFQNGLQC 250 260 270 280 290 300 HQQPQYVSHG STNLGQSQFP SGQQQQPTTQ FGQQVLPSPA QPQQQQQGQP LPPPRGQVIL 310 320 330 340 350 360 PAPGEPLSNG FGQQQQQQQQ QQQPLNQNNA LLPQMNVEGV SGMAAVQPVY GQAMSSTTNM 370 380 390 400 410 420 QDSNPSYGAS PMQGQPPVGG QPPVPVRMQP QPPQPMQQGN IYPIEPSLDS TGSTPHFEVT 430 440 450 460 470 480 PFDPDAPAPK PKIDIPTVDV SSLPPPPTHR DRGAVVHQEP APSGKIQPNT TSSAASLPAK 490 500 510 520 530 540 HSRTTTADNE RNSGNKENDE STSKSSILGH YDVDANIMPP PKPFRHGLDS VPSEHTTKNA 550 560 570 580 590 600 PERAVPILPP RNNVEPPPPP SRGNFERTES VLSTNAANVQ EDPISNFLPP PKPFRHTETK 610 620 630 640 650 660 QNQNSKASPV EMKGEVLPGH PSEEDRNVEP SLVPQSKPQS QSQFRRAHME TQPIQNFQPP 670 680 690 700 710 720 PKPFRRSQSS NSSDSSYTID GPEANHGRGR GRIAKHHDGD EYNPKSENST ENGRLGDAPN 730 740 750 760 770 780 SFIRKRAPTP PAPSRSEKLH EGTITSEVDS SKDANKYEKS IPPVTSSIQA QQSTKKAPPP 790 800 810 820 830 840 VVKPKPRNFS LKANEYPKEL TREATGQDEV LNSITNELSH IKLRKTNVNL EKLGGSKKVK 850 860 870 880 890 900 DSSPVPSDLD EKYVSASGSI TPPRPPPSRS SPKKVPPVVP KKNDNLKKKP PVVPKKKPLL 910 920 930 940 KSLEPRPIEM ERAYSGDISA ADDNLNPFER YKRNVVPQED DRLHKLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a 70 kb region on the right arm of yeast chromosome II." Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H. Yeast 10:1363-1381(1994) [PubMed: 7900426] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed: 12748633] [Abstract] Cited for: IDENTIFICATION OF FRAMESHIFT.
[4]	"Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p." Germann M., Swain E., Bergman L., Nickels J.T. Jr. J. Biol. Chem. 280:4270-4278(2005) [PubMed: 15561700] [Abstract] Cited for: INTERACTION WITH RVS167.
[5]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed: 15665377] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-805 AND SER-915, MASS SPECTROMETRY.
[6]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed: 17287358] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-729 AND THR-826, MASS SPECTROMETRY.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-669; THR-805; SER-842 AND SER-843, MASS SPECTROMETRY.
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-58; SER-64; SER-476; THR-729; SER-842; SER-843; SER-847; THR-861; TYR-914; SER-915 AND SER-919, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X78993 Genomic DNA. Translation: CAA55611.1. Frameshift. Z35977 Genomic DNA. Translation: CAA85063.1. Frameshift.
PIR	S48273.
RefSeq	NP_009666.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1602N.
IntAct	P38266. 6 interactions.
Proteomic databases
PeptideAtlas	P38266.
Genome annotation databases
Ensembl	YBR108W. Saccharomyces cerevisiae. [Contig view]
GeneID	852405.
GenomeReviews	Gene locus YBR108W in contig Y13134_GR.
KEGG	sce:YBR108W.
NMPDR	fig|4932.3.peg.365.
Organism-specific databases
CYGD	YBR108w.
SGD	S000000312. YBR108W.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38266.
OMA	P38266. PPKPFRR.
Gene expression databases
ArrayExpress	P38266.
GermOnline	YBR108W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	971246.

Entry information

Entry name

YBV8_YEAST

Accession

Primary (citable) accession number: P38266

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)