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Protein

Exocyst complex component EXO84

Gene

EXO84

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis and to the budding site. Also involved in assembly of the spliceosome.3 Publications

GO - Biological processi

  • exocyst assembly Source: SGD
  • exocyst localization Source: SGD
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • protein transport Source: UniProtKB-KW
  • spliceosomal complex assembly Source: SGD
  • vesicle tethering involved in exocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29064-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component EXO84
Alternative name(s):
Exocyst complex protein of 84 kDa
U1 SNP1-associating protein 3
Gene namesi
Name:EXO84
Synonyms:USA3
Ordered Locus Names:YBR102C
ORF Names:YBR0831
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR102C.
SGDiS000000306. EXO84.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • exocyst Source: SGD
  • incipient cellular bud site Source: SGD
  • transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189871 – 753Exocyst complex component EXO84Add BLAST753

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphothreonineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei482PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38261.
PRIDEiP38261.

PTM databases

iPTMnetiP38261.

Interactioni

Subunit structurei

Component of the exocyst complex composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84. Interacts also with SNP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC10Q062456EBI-21567,EBI-16504
SEC15P222243EBI-21567,EBI-16543
SEC5P891026EBI-21567,EBI-16865
SEC8P328555EBI-21567,EBI-16896
SNP1Q009162EBI-21567,EBI-724

Protein-protein interaction databases

BioGridi32806. 59 interactors.
DIPiDIP-2732N.
IntActiP38261. 19 interactors.
MINTiMINT-617970.

Structurei

Secondary structure

1753
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi528 – 548Combined sources21
Helixi552 – 568Combined sources17
Helixi579 – 604Combined sources26
Helixi609 – 621Combined sources13
Helixi625 – 645Combined sources21
Helixi653 – 678Combined sources26
Helixi684 – 708Combined sources25
Helixi717 – 728Combined sources12
Helixi729 – 733Combined sources5
Helixi738 – 746Combined sources9
Helixi747 – 751Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D2SX-ray2.85A523-753[»]
ProteinModelPortaliP38261.
SMRiP38261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38261.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 279Sequence analysisAdd BLAST53
Coiled coili531 – 585Sequence analysisAdd BLAST55

Sequence similaritiesi

Belongs to the EXO84 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000000727.
InParanoidiP38261.
KOiK19986.
OMAiYVYQTDR.
OrthoDBiEOG092C0RTO.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016159. Cullin_repeat-like_dom.
IPR033961. Exo84.
IPR032403. Exo84_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR21426. PTHR21426. 4 hits.
PfamiPF16528. Exo84_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF74788. SSF74788. 1 hit.

Sequencei

Sequence statusi: Complete.

P38261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEFSLKKAR NNWKHVKKSA SSPAKQKTPP SPAKPKQKTK KNPYSDLKDP
60 70 80 90 100
ATSYTLPTIN ARERSRVATS MQRRLSIHNT NYAPPTLDYS MPLPDMPNMI
110 120 130 140 150
VPNDNVDSSH NNSSFTTENE SVSSKGPSNS LNLSTADLSL NDSSYNKVPA
160 170 180 190 200
RSAMRNTVNP SGSNDPFNNS TSLRKMLANP HFNAKDFVHD KLGNASAITI
210 220 230 240 250
DKFTSNLTDL SIQVQEEVKL NINKSYNEIM TVNNDLNVAM LELKRVRANI
260 270 280 290 300
NDLNEVLDQC TKIAEKRLQL QDQIDQERQG NFNNVESHSN SPALLPPLKA
310 320 330 340 350
GQNGNLMRRD RSSVLILEKF WDTELDQLFK NVEGAQKFIN STKGRHILMN
360 370 380 390 400
SANWMELNTT TGKPLQMVQI FILNDLVLIA DKSRDKQNDF IVSQCYPLKD
410 420 430 440 450
VTVTQEEFST KRLLFKFSNS NSSLYECRDA DECSRLLDVI RKAKDDLCDI
460 470 480 490 500
FHVEEENSKR IRESFRYLQS TQQTPGRENN RSPNKNKRRS MGGSITPGRN
510 520 530 540 550
VTGAMDQYLL QNLTLSMHSR PRSRDMSSTA QRLKFLDEGV EEIDIELARL
560 570 580 590 600
RFESAVETLL DIESQLEDLS ERISDEELML LNLISLKIEQ RREAISSKLS
610 620 630 640 650
QSILSSNEIV HLKSGTENMI KLGLPEQALD LFLQNRSNFI QDLILQIGSV
660 670 680 690 700
DNPTNYLTQL AVIRFQTIKK TVEDFQDIFK ELGAKISSIL VDWCSDEVDN
710 720 730 740 750
HFKLIDKQLL NDEMLSPGSI KSSRKQIDGL KAVGLDFVYK LDEFIKKNSD

KIR
Length:753
Mass (Da):85,538
Last modified:October 1, 1994 - v1
Checksum:i1BCDE834466C3536
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA. Translation: CAA55605.1.
Z35971 Genomic DNA. Translation: CAA85057.1.
BK006936 Genomic DNA. Translation: DAA07221.1.
PIRiS48267.
RefSeqiNP_009660.1. NM_001178450.1.

Genome annotation databases

EnsemblFungiiYBR102C; YBR102C; YBR102C.
GeneIDi852398.
KEGGisce:YBR102C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA. Translation: CAA55605.1.
Z35971 Genomic DNA. Translation: CAA85057.1.
BK006936 Genomic DNA. Translation: DAA07221.1.
PIRiS48267.
RefSeqiNP_009660.1. NM_001178450.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D2SX-ray2.85A523-753[»]
ProteinModelPortaliP38261.
SMRiP38261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32806. 59 interactors.
DIPiDIP-2732N.
IntActiP38261. 19 interactors.
MINTiMINT-617970.

PTM databases

iPTMnetiP38261.

Proteomic databases

MaxQBiP38261.
PRIDEiP38261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR102C; YBR102C; YBR102C.
GeneIDi852398.
KEGGisce:YBR102C.

Organism-specific databases

EuPathDBiFungiDB:YBR102C.
SGDiS000000306. EXO84.

Phylogenomic databases

HOGENOMiHOG000000727.
InParanoidiP38261.
KOiK19986.
OMAiYVYQTDR.
OrthoDBiEOG092C0RTO.

Enzyme and pathway databases

BioCyciYEAST:G3O-29064-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38261.
PROiP38261.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016159. Cullin_repeat-like_dom.
IPR033961. Exo84.
IPR032403. Exo84_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR21426. PTHR21426. 4 hits.
PfamiPF16528. Exo84_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF74788. SSF74788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXO84_YEAST
AccessioniPrimary (citable) accession number: P38261
Secondary accession number(s): D6VQA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.