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Protein

Hsp70 nucleotide exchange factor FES1

Gene

FES1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins.10 Publications

Miscellaneous

Present with 13100 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29063-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70 nucleotide exchange factor FES1
Alternative name(s):
Factor exchange for SSA1 protein 1
Gene namesi
Name:FES1
Ordered Locus Names:YBR101C
ORF Names:YBR0830
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR101C
SGDiS000000305 FES1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6102

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024851 – 290Hsp70 nucleotide exchange factor FES1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38260
PaxDbiP38260
PRIDEiP38260

PTM databases

iPTMnetiP38260

Interactioni

Subunit structurei

Interacts with the Hsp70 chaperones SSA1 and SSB1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32805, 101 interactors
DIPiDIP-4918N
IntActiP38260, 39 interactors
MINTiP38260
STRINGi4932.YBR101C

Structurei

3D structure databases

ProteinModelPortaliP38260
SMRiP38260
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 57ARM 1Add BLAST45
Repeati76 – 116ARM 2Add BLAST41
Repeati120 – 161ARM 3Add BLAST42
Repeati164 – 205ARM 4Add BLAST42
Repeati211 – 251ARM 5Add BLAST41
Repeati253 – 290ARM 6Add BLAST38

Sequence similaritiesi

Belongs to the FES1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000000726
InParanoidiP38260
OMAiFEMLIEN
OrthoDBiEOG092C5GYG

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013918 Nucleotide_exch_fac_Fes1
PfamiView protein in Pfam
PF08609 Fes1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

P38260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA
60 70 80 90 100
VIMNPEVDLE TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD
110 120 130 140 150
EELRAAALSI IGTAVQNNLD SQNNFMKYDN GLRSLIEIAS DKTKPLDVRT
160 170 180 190 200
KAFYALSNLI RNHKDISEKF FKLNGLDCIA PVLSDNTAKP KLKMRAIALL
210 220 230 240 250
TAYLSSVKID ENIISVLRKD GVIESTIECL SDESNLNIID RVLSFLSHLI
260 270 280 290
SSGIKFNEQE LHKLNEGYKH IEPLKDRLNE DDYLAVKYVL
Length:290
Mass (Da):32,604
Last modified:October 1, 1994 - v1
Checksum:i4A50D069625BA500
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78993 Genomic DNA Translation: CAA55604.1
Z35970 Genomic DNA Translation: CAA85056.1
AY693000 Genomic DNA Translation: AAT93019.1
BK006936 Genomic DNA Translation: DAA07220.1
PIRiS48266
RefSeqiNP_009659.3, NM_001178449.3

Genome annotation databases

EnsemblFungiiYBR101C; YBR101C; YBR101C
GeneIDi852397
KEGGisce:YBR101C

Similar proteinsi

Entry informationi

Entry nameiFES1_YEAST
AccessioniPrimary (citable) accession number: P38260
Secondary accession number(s): D6VQA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health