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Protein

UDP-N-acetylglucosamine transferase subunit ALG14

Gene

ALG14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.2 Publications

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein membrane anchor Source: SGD

GO - Biological processi

  • dolichol-linked oligosaccharide biosynthetic process Source: SGD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-23
YEAST:MONOMER3O-23
BRENDAi2.4.1.141 984
ReactomeiR-SCE-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine transferase subunit ALG14
Alternative name(s):
Asparagine-linked glycosylation protein 14
Gene namesi
Name:ALG14
Ordered Locus Names:YBR070C
ORF Names:YBR0711
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR070C
SGDiS000000274 ALG14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7Lumenal1 Publication7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 237Cytoplasmic1 PublicationAdd BLAST209

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238181 – 237UDP-N-acetylglucosamine transferase subunit ALG14Add BLAST237

Proteomic databases

MaxQBiP38242
PaxDbiP38242
PRIDEiP38242

PTM databases

iPTMnetiP38242

Interactioni

Subunit structurei

Heterodimer with ALG13 to form a functional enzyme.

Binary interactionsi

WithEntry#Exp.IntActNotes
ALG13P531783EBI-21477,EBI-23770

GO - Molecular functioni

  • protein membrane anchor Source: SGD

Protein-protein interaction databases

BioGridi32773, 209 interactors
DIPiDIP-5670N
IntActiP38242, 5 interactors
MINTiP38242
STRINGi4932.YBR070C

Structurei

3D structure databases

ProteinModelPortaliP38242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALG14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000002579
HOGENOMiHOG000182099
InParanoidiP38242
KOiK07441
OMAiESICRVK
OrthoDBiEOG092C4P3F

Family and domain databases

InterProiView protein in InterPro
IPR013969 Oligosacch_biosynth_Alg14
PANTHERiPTHR12154 PTHR12154, 1 hit
PfamiView protein in Pfam
PF08660 Alg14, 1 hit

Sequencei

Sequence statusi: Complete.

P38242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTAYLASLV LIVSTAYVIR LIAILPFFHT QAGTEKDTKD GVNLLKIRKS
60 70 80 90 100
SKKPLKIFVF LGSGGHTGEM IRLLENYQDL LLGKSIVYLG YSDEASRQRF
110 120 130 140 150
AHFIKKFGHC KVKYYEFMKA REVKATLLQS VKTIIGTLVQ SFVHVVRIRF
160 170 180 190 200
AMCGSPHLFL LNGPGTCCII SFWLKIMELL LPLLGSSHIV YVESLARINT
210 220 230
PSLTGKILYW VVDEFIVQWQ ELRDNYLPRS KWFGILV
Length:237
Mass (Da):27,035
Last modified:October 1, 1994 - v1
Checksum:i53E2D17E18593156
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76294 Genomic DNA Translation: CAA53927.1
Z35939 Genomic DNA Translation: CAA85014.1
BK006936 Genomic DNA Translation: DAA07189.1
PIRiS45463
RefSeqiNP_009626.1, NM_001178418.1

Genome annotation databases

EnsemblFungiiYBR070C; YBR070C; YBR070C
GeneIDi852362
KEGGisce:YBR070C

Similar proteinsi

Entry informationi

Entry nameiALG14_YEAST
AccessioniPrimary (citable) accession number: P38242
Secondary accession number(s): D6VQ69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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