Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable quinone oxidoreductase

Gene

ZTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

GO - Molecular functioni

  • 2-alkenal reductase [NAD(P)] activity Source: SGD
  • AU-rich element binding Source: SGD
  • NADPH:quinone reductase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YBR046C-MONOMER.
BRENDAi1.6.5.5. 984.
ReactomeiR-SCE-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Gene namesi
Name:ZTA1
Ordered Locus Names:YBR046C
ORF Names:YBR0421
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR046C.
SGDiS000000250. ZTA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Probable quinone oxidoreductasePRO_0000160912Add
BLAST

Proteomic databases

MaxQBiP38230.
PRIDEiP38230.

Interactioni

Protein-protein interaction databases

BioGridi32748. 18 interactions.
IntActiP38230. 1 interaction.
MINTiMINT-4476758.

Structurei

Secondary structure

1
334
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 1913Combined sources
Helixi20 – 223Combined sources
Beta strandi23 – 297Combined sources
Beta strandi37 – 4610Combined sources
Helixi51 – 555Combined sources
Beta strandi63 – 664Combined sources
Beta strandi69 – 7810Combined sources
Beta strandi90 – 945Combined sources
Beta strandi99 – 1068Combined sources
Beta strandi109 – 1135Combined sources
Helixi120 – 14122Combined sources
Beta strandi151 – 1566Combined sources
Helixi160 – 17112Combined sources
Beta strandi175 – 1828Combined sources
Helixi183 – 1919Combined sources
Beta strandi195 – 1995Combined sources
Turni200 – 2023Combined sources
Helixi205 – 2128Combined sources
Turni213 – 2153Combined sources
Beta strandi218 – 2236Combined sources
Helixi226 – 2294Combined sources
Helixi230 – 2367Combined sources
Beta strandi237 – 2459Combined sources
Helixi248 – 2525Combined sources
Helixi258 – 2614Combined sources
Turni262 – 2654Combined sources
Beta strandi267 – 2693Combined sources
Helixi273 – 2764Combined sources
Helixi280 – 29516Combined sources
Beta strandi303 – 3086Combined sources
Helixi309 – 3113Combined sources
Helixi312 – 3209Combined sources
Beta strandi326 – 3316Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QWAX-ray2.00A/B1-334[»]
3QWBX-ray1.59A/B/C/D1-334[»]
ProteinModelPortaliP38230.
SMRiP38230. Positions 3-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
InParanoidiP38230.
KOiK00344.
OMAiAHYLIES.
OrthoDBiEOG7SN8P7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCTIPEQQK VILIDEIGGY DVIKYEDYPV PSISEEELLI KNKYTGVNYI
60 70 80 90 100
ESYFRKGIYP CEKPYVLGRE ASGTVVAKGK GVTNFEVGDQ VAYISNSTFA
110 120 130 140 150
QYSKISSQGP VMKLPKGTSD EELKLYAAGL LQVLTALSFT NEAYHVKKGD
160 170 180 190 200
YVLLFAAAGG VGLILNQLLK MKGAHTIAVA STDEKLKIAK EYGAEYLINA
210 220 230 240 250
SKEDILRQVL KFTNGKGVDA SFDSVGKDTF EISLAALKRK GVFVSFGNAS
260 270 280 290 300
GLIPPFSITR LSPKNITLVR PQLYGYIADP EEWKYYSDEF FGLVNSKKLN
310 320 330
IKIYKTYPLR DYRTAAADIE SRKTVGKLVL EIPQ
Length:334
Mass (Da):37,019
Last modified:October 1, 1994 - v1
Checksum:i8E9D2D85D9AC518E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35915 Genomic DNA. Translation: CAA84988.1.
AY557866 Genomic DNA. Translation: AAS56192.1.
BK006936 Genomic DNA. Translation: DAA07166.1.
PIRiS45904.
RefSeqiNP_009602.1. NM_001178394.1.

Genome annotation databases

EnsemblFungiiYBR046C; YBR046C; YBR046C.
GeneIDi852335.
KEGGisce:YBR046C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35915 Genomic DNA. Translation: CAA84988.1.
AY557866 Genomic DNA. Translation: AAS56192.1.
BK006936 Genomic DNA. Translation: DAA07166.1.
PIRiS45904.
RefSeqiNP_009602.1. NM_001178394.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QWAX-ray2.00A/B1-334[»]
3QWBX-ray1.59A/B/C/D1-334[»]
ProteinModelPortaliP38230.
SMRiP38230. Positions 3-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32748. 18 interactions.
IntActiP38230. 1 interaction.
MINTiMINT-4476758.

Proteomic databases

MaxQBiP38230.
PRIDEiP38230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR046C; YBR046C; YBR046C.
GeneIDi852335.
KEGGisce:YBR046C.

Organism-specific databases

EuPathDBiFungiDB:YBR046C.
SGDiS000000250. ZTA1.

Phylogenomic databases

GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294672.
InParanoidiP38230.
KOiK00344.
OMAiAHYLIES.
OrthoDBiEOG7SN8P7.

Enzyme and pathway databases

BioCyciYEAST:YBR046C-MONOMER.
BRENDAi1.6.5.5. 984.
ReactomeiR-SCE-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Miscellaneous databases

PROiP38230.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiQOR_YEAST
AccessioniPrimary (citable) accession number: P38230
Secondary accession number(s): D6VQ46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.