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Protein

Probable quinone oxidoreductase

Gene

ZTA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NADPH + 2 quinone = NADP+ + 2 semiquinone.

GO - Molecular functioni

  • 2-alkenal reductase [NAD(P)] activity Source: SGD
  • AU-rich element binding Source: SGD
  • NADPH:quinone reductase activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:YBR046C-MONOMER.
BRENDAi1.6.5.5. 984.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable quinone oxidoreductase (EC:1.6.5.5)
Alternative name(s):
NADPH:quinone reductase
Gene namesi
Name:ZTA1
Ordered Locus Names:YBR046C
ORF Names:YBR0421
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR046C.
SGDiS000000250. ZTA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001609121 – 334Probable quinone oxidoreductaseAdd BLAST334

Proteomic databases

MaxQBiP38230.
PRIDEiP38230.

Interactioni

Protein-protein interaction databases

BioGridi32748. 18 interactors.
IntActiP38230. 1 interactor.
MINTiMINT-4476758.

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 19Combined sources13
Helixi20 – 22Combined sources3
Beta strandi23 – 29Combined sources7
Beta strandi37 – 46Combined sources10
Helixi51 – 55Combined sources5
Beta strandi63 – 66Combined sources4
Beta strandi69 – 78Combined sources10
Beta strandi90 – 94Combined sources5
Beta strandi99 – 106Combined sources8
Beta strandi109 – 113Combined sources5
Helixi120 – 141Combined sources22
Beta strandi151 – 156Combined sources6
Helixi160 – 171Combined sources12
Beta strandi175 – 182Combined sources8
Helixi183 – 191Combined sources9
Beta strandi195 – 199Combined sources5
Turni200 – 202Combined sources3
Helixi205 – 212Combined sources8
Turni213 – 215Combined sources3
Beta strandi218 – 223Combined sources6
Helixi226 – 229Combined sources4
Helixi230 – 236Combined sources7
Beta strandi237 – 245Combined sources9
Helixi248 – 252Combined sources5
Helixi258 – 261Combined sources4
Turni262 – 265Combined sources4
Beta strandi267 – 269Combined sources3
Helixi273 – 276Combined sources4
Helixi280 – 295Combined sources16
Beta strandi303 – 308Combined sources6
Helixi309 – 311Combined sources3
Helixi312 – 320Combined sources9
Beta strandi326 – 331Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QWAX-ray2.00A/B1-334[»]
3QWBX-ray1.59A/B/C/D1-334[»]
ProteinModelPortaliP38230.
SMRiP38230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000009335.
HOGENOMiHOG000294672.
InParanoidiP38230.
KOiK00344.
OMAiDTWEEDF.
OrthoDBiEOG092C43LO.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCTIPEQQK VILIDEIGGY DVIKYEDYPV PSISEEELLI KNKYTGVNYI
60 70 80 90 100
ESYFRKGIYP CEKPYVLGRE ASGTVVAKGK GVTNFEVGDQ VAYISNSTFA
110 120 130 140 150
QYSKISSQGP VMKLPKGTSD EELKLYAAGL LQVLTALSFT NEAYHVKKGD
160 170 180 190 200
YVLLFAAAGG VGLILNQLLK MKGAHTIAVA STDEKLKIAK EYGAEYLINA
210 220 230 240 250
SKEDILRQVL KFTNGKGVDA SFDSVGKDTF EISLAALKRK GVFVSFGNAS
260 270 280 290 300
GLIPPFSITR LSPKNITLVR PQLYGYIADP EEWKYYSDEF FGLVNSKKLN
310 320 330
IKIYKTYPLR DYRTAAADIE SRKTVGKLVL EIPQ
Length:334
Mass (Da):37,019
Last modified:October 1, 1994 - v1
Checksum:i8E9D2D85D9AC518E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35915 Genomic DNA. Translation: CAA84988.1.
AY557866 Genomic DNA. Translation: AAS56192.1.
BK006936 Genomic DNA. Translation: DAA07166.1.
PIRiS45904.
RefSeqiNP_009602.1. NM_001178394.1.

Genome annotation databases

EnsemblFungiiYBR046C; YBR046C; YBR046C.
GeneIDi852335.
KEGGisce:YBR046C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35915 Genomic DNA. Translation: CAA84988.1.
AY557866 Genomic DNA. Translation: AAS56192.1.
BK006936 Genomic DNA. Translation: DAA07166.1.
PIRiS45904.
RefSeqiNP_009602.1. NM_001178394.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QWAX-ray2.00A/B1-334[»]
3QWBX-ray1.59A/B/C/D1-334[»]
ProteinModelPortaliP38230.
SMRiP38230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32748. 18 interactors.
IntActiP38230. 1 interactor.
MINTiMINT-4476758.

Proteomic databases

MaxQBiP38230.
PRIDEiP38230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR046C; YBR046C; YBR046C.
GeneIDi852335.
KEGGisce:YBR046C.

Organism-specific databases

EuPathDBiFungiDB:YBR046C.
SGDiS000000250. ZTA1.

Phylogenomic databases

GeneTreeiENSGT00390000009335.
HOGENOMiHOG000294672.
InParanoidiP38230.
KOiK00344.
OMAiDTWEEDF.
OrthoDBiEOG092C43LO.

Enzyme and pathway databases

BioCyciYEAST:YBR046C-MONOMER.
BRENDAi1.6.5.5. 984.

Miscellaneous databases

PROiP38230.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQOR_YEAST
AccessioniPrimary (citable) accession number: P38230
Secondary accession number(s): D6VQ46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.