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P38227

- QDR3_YEAST

UniProt

P38227 - QDR3_YEAST

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Protein

Quinidine resistance protein 3

Gene

QDR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).1 Publication

GO - Molecular functioni

  1. drug transmembrane transporter activity Source: SGD
  2. polyamine transmembrane transporter activity Source: SGD

GO - Biological processi

  1. ascospore wall assembly Source: SGD
  2. drug transmembrane transport Source: SGD
  3. polyamine homeostasis Source: SGD
  4. polyamine transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29016-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.43. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 3
Alternative name(s):
Acids quinidine resistance protein 2
Gene namesi
Name:QDR3
Synonyms:AQR2
Ordered Locus Names:YBR043C
ORF Names:YBR0413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR043c.
SGDiS000000247. QDR3.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Quinidine resistance protein 3PRO_0000173437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei436 – 4361Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38227.
PaxDbiP38227.

Expressioni

Gene expression databases

GenevestigatoriP38227.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HXT3P324661EBI-21433,EBI-8770
HXT7P390041EBI-21433,EBI-8790
PDR12Q027851EBI-21433,EBI-13065
PMP2P409751EBI-21433,EBI-2043041
YHR146WP388451EBI-21433,EBI-24770

Protein-protein interaction databases

BioGridi32744. 13 interactions.
DIPiDIP-797N.
IntActiP38227. 2 interactions.
MINTiMINT-486852.
STRINGi4932.YBR043C.

Structurei

3D structure databases

ProteinModelPortaliP38227.
SMRiP38227. Positions 120-286.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108ExtracellularSequence AnalysisAdd
BLAST
Topological domaini132 – 1398CytoplasmicSequence Analysis
Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini194 – 23542CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini257 – 2659ExtracellularSequence Analysis
Topological domaini284 – 475192CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini494 – 51017ExtracellularSequence AnalysisAdd
BLAST
Topological domaini533 – 55826CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini578 – 5869ExtracellularSequence Analysis
Topological domaini610 – 62415CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini643 – 6486ExtracellularSequence Analysis
Topological domaini669 – 68921CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei109 – 13123HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 16324HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19318HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28318HelicalSequence AnalysisAdd
BLAST
Transmembranei476 – 49318HelicalSequence AnalysisAdd
BLAST
Transmembranei511 – 53222HelicalSequence AnalysisAdd
BLAST
Transmembranei559 – 57719HelicalSequence AnalysisAdd
BLAST
Transmembranei587 – 60923HelicalSequence AnalysisAdd
BLAST
Transmembranei625 – 64218HelicalSequence AnalysisAdd
BLAST
Transmembranei649 – 66820HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00620000088227.
InParanoidiP38227.
OMAiRLRENAW.
OrthoDBiEOG7K6Q4M.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38227-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT
60 70 80 90 100
NLESTASNSR EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD
110 120 130 140 150
YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA INSITTEFKT SVIMVNVSIG
160 170 180 190 200
VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS ALAPDINSFI
210 220 230 240 250
ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI
260 270 280 290 300
FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL
310 320 330 340 350
AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ
360 370 380 390 400
DSLDLESHSS PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ
410 420 430 440 450
VTRIRSTDPK LARSIRENSL RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV
460 470 480 490 500
RKVWDTFFVY FIKPLKSLHF LEYPPVALAI TFSAISFSTV YFVNMTVEYK
510 520 530 540 550
YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK RYKEKYGILA
560 570 580 590 600
PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT
610 620 630 640 650
IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA
660 670 680
FTMLAFIVLG ASSVLIILKK HGDYWRENYD LQKLYDKID
Length:689
Mass (Da):77,287
Last modified:July 27, 2011 - v2
Checksum:iAA2C5D2D7175F176
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371S → T in CAA84985. (PubMed:7813418)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35912 Genomic DNA. Translation: CAA84985.1.
BK006936 Genomic DNA. Translation: DAA07163.2.
PIRiS45901.
RefSeqiNP_009599.2. NM_001178391.2.

Genome annotation databases

EnsemblFungiiYBR043C; YBR043C; YBR043C.
GeneIDi852331.
KEGGisce:YBR043C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35912 Genomic DNA. Translation: CAA84985.1 .
BK006936 Genomic DNA. Translation: DAA07163.2 .
PIRi S45901.
RefSeqi NP_009599.2. NM_001178391.2.

3D structure databases

ProteinModelPortali P38227.
SMRi P38227. Positions 120-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32744. 13 interactions.
DIPi DIP-797N.
IntActi P38227. 2 interactions.
MINTi MINT-486852.
STRINGi 4932.YBR043C.

Protein family/group databases

TCDBi 2.A.1.2.43. the major facilitator superfamily (mfs).

Proteomic databases

MaxQBi P38227.
PaxDbi P38227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR043C ; YBR043C ; YBR043C .
GeneIDi 852331.
KEGGi sce:YBR043C.

Organism-specific databases

CYGDi YBR043c.
SGDi S000000247. QDR3.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00620000088227.
InParanoidi P38227.
OMAi RLRENAW.
OrthoDBi EOG7K6Q4M.

Enzyme and pathway databases

BioCyci YEAST:G3O-29016-MONOMER.

Miscellaneous databases

NextBioi 971047.

Gene expression databases

Genevestigatori P38227.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 37.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin."
    Tenreiro S., Vargas R.C., Teixeira M.C., Magnani C., Sa-Correia I.
    Biochem. Biophys. Res. Commun. 327:952-959(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQDR3_YEAST
AccessioniPrimary (citable) accession number: P38227
Secondary accession number(s): D6VQ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3