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Reviewed, UniProtKB/Swiss-Prot P38227 (YBP3_YEAST)

Last modified December 15, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uncharacterized transporter YBR043C
Gene names
Ordered Locus Names: YBR043C
ORF Names: YBR0413
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length689 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Present with 279 molecules/cell in log phase SD medium. Ref.2

Sequence similarities

Belongs to the major facilitator superfamily. CAR1 family.

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Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processmultidrug transport

Inferred from mutant phenotype. Source: SGD

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay. Source: SGD

   Molecular functionmultidrug efflux pump activity

Inferred from mutant phenotype. Source: SGD

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 689689Uncharacterized transporter YBR043C
PRO_0000173437

Regions

Topological domain1 – 108108Extracellular Potential
Transmembrane109 – 13123 Potential
Topological domain132 – 1398Cytoplasmic Potential
Transmembrane140 – 16324 Potential
Topological domain164 – 17512Extracellular Potential
Transmembrane176 – 19318 Potential
Topological domain194 – 23542Cytoplasmic Potential
Transmembrane236 – 25621 Potential
Topological domain257 – 2659Extracellular Potential
Transmembrane266 – 28318 Potential
Topological domain284 – 475192Cytoplasmic Potential
Transmembrane476 – 49318 Potential
Topological domain494 – 51017Extracellular Potential
Transmembrane511 – 53222 Potential
Topological domain533 – 55826Cytoplasmic Potential
Transmembrane559 – 57719 Potential
Topological domain578 – 5869Extracellular Potential
Transmembrane587 – 60923 Potential
Topological domain610 – 62415Cytoplasmic Potential
Transmembrane625 – 64218 Potential
Topological domain643 – 6486Extracellular Potential
Transmembrane649 – 66820 Potential
Topological domain669 – 68921Cytoplasmic Potential

Amino acid modifications

Modified residue571Phosphoserine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P38227-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 61420CBB8DB1925F

FASTA68977,301
        10         20         30         40         50         60 
MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGTPHS EHNDYSYEKT NLESTASNSR 

        70         80         90        100        110        120 
EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD YPPMMKKMIV FLIAFSSMMG 

       130        140        150        160        170        180 
PMGTSIIFPA INSITTEFKT SVIMVNVSIG VYLLSLGVFP LWWSSLSELE GRRTTYITSF 

       190        200        210        220        230        240 
ALLFAFNIGS ALAPDINSFI ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG 

       250        260        270        280        290        300 
PLLAPLLSPI FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL 

       310        320        330        340        350        360 
AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ DSLDLESHSS 

       370        380        390        400        410        420 
PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ VTRIRSTDPK LARSIRENSL 

       430        440        450        460        470        480 
RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV RKVWDTFFVY FIKPLKSLHF LEYPPVALAI 

       490        500        510        520        530        540 
TFSAISFSTV YFVNMTVEYK YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK 

       550        560        570        580        590        600 
RYKEKYGILA PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT 

       610        620        630        640        650        660 
IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA FTMLAFIVLG 

       670        680 
ASSVLIILKK HGDYWRENYD LQKLYDKID

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References

[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[3]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z35912 Genomic DNA. Translation: CAA84985.1.
PIRS45901.
RefSeqNP_009599.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-797N.
IntActP38227. 7 interactions.
STRINGP38227.

Proteomic databases

PRIDEP38227.

Genome annotation databases

EnsemblYBR043C; YBR043C; YBR043C; Saccharomyces cerevisiae. [Genome view]
GeneID852331.
KEGGsce:YBR043C.
NMPDRfig|4932.3.peg.294.

Organism-specific databases

CYGDYBR043c.
SGDS000000247. QDR3.

Phylogenomic databases

HOGENOMHBG324539.
OMAGTSIMLP.
OrthoDBEOG9W9KM2.

Gene expression databases

ArrayExpressP38227.
GenevestigatorP38227.
GermOnlineYBR043C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011701. MFS_1.
IPR016196. MFS_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971047.

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Entry information

Entry nameYBP3_YEAST
AccessionPrimary (citable) accession number: P38227
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 15, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents