Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38227

- QDR3_YEAST

UniProt

P38227 - QDR3_YEAST

Protein

Quinidine resistance protein 3

Gene

QDR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).1 Publication

    GO - Molecular functioni

    1. drug transmembrane transporter activity Source: SGD
    2. polyamine transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. ascospore wall assembly Source: SGD
    2. drug transmembrane transport Source: SGD
    3. polyamine homeostasis Source: SGD
    4. polyamine transmembrane transport Source: GOC

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29016-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.2.43. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinidine resistance protein 3
    Alternative name(s):
    Acids quinidine resistance protein 2
    Gene namesi
    Name:QDR3
    Synonyms:AQR2
    Ordered Locus Names:YBR043C
    ORF Names:YBR0413
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR043c.
    SGDiS000000247. QDR3.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689Quinidine resistance protein 3PRO_0000173437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei436 – 4361Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38227.
    PaxDbiP38227.

    Expressioni

    Gene expression databases

    GenevestigatoriP38227.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HXT3P324661EBI-21433,EBI-8770
    HXT7P390041EBI-21433,EBI-8790
    PDR12Q027851EBI-21433,EBI-13065
    PMP2P409751EBI-21433,EBI-2043041
    YHR146WP388451EBI-21433,EBI-24770

    Protein-protein interaction databases

    BioGridi32744. 13 interactions.
    DIPiDIP-797N.
    IntActiP38227. 2 interactions.
    MINTiMINT-486852.
    STRINGi4932.YBR043C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38227.
    SMRiP38227. Positions 120-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 108108ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 1398CytoplasmicSequence Analysis
    Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini194 – 23542CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 2659ExtracellularSequence Analysis
    Topological domaini284 – 475192CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini494 – 51017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini533 – 55826CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini578 – 5869ExtracellularSequence Analysis
    Topological domaini610 – 62415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini643 – 6486ExtracellularSequence Analysis
    Topological domaini669 – 68921CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 13123HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16324HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei476 – 49318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei511 – 53222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei559 – 57719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei587 – 60923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei625 – 64218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei649 – 66820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00620000088227.
    OMAiRLRENAW.
    OrthoDBiEOG7K6Q4M.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38227-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT    50
    NLESTASNSR EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD 100
    YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA INSITTEFKT SVIMVNVSIG 150
    VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS ALAPDINSFI 200
    ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI 250
    FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL 300
    AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ 350
    DSLDLESHSS PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ 400
    VTRIRSTDPK LARSIRENSL RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV 450
    RKVWDTFFVY FIKPLKSLHF LEYPPVALAI TFSAISFSTV YFVNMTVEYK 500
    YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK RYKEKYGILA 550
    PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT 600
    IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA 650
    FTMLAFIVLG ASSVLIILKK HGDYWRENYD LQKLYDKID 689
    Length:689
    Mass (Da):77,287
    Last modified:July 27, 2011 - v2
    Checksum:iAA2C5D2D7175F176
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371S → T in CAA84985. (PubMed:7813418)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35912 Genomic DNA. Translation: CAA84985.1.
    BK006936 Genomic DNA. Translation: DAA07163.2.
    PIRiS45901.
    RefSeqiNP_009599.2. NM_001178391.2.

    Genome annotation databases

    EnsemblFungiiYBR043C; YBR043C; YBR043C.
    GeneIDi852331.
    KEGGisce:YBR043C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35912 Genomic DNA. Translation: CAA84985.1 .
    BK006936 Genomic DNA. Translation: DAA07163.2 .
    PIRi S45901.
    RefSeqi NP_009599.2. NM_001178391.2.

    3D structure databases

    ProteinModelPortali P38227.
    SMRi P38227. Positions 120-286.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32744. 13 interactions.
    DIPi DIP-797N.
    IntActi P38227. 2 interactions.
    MINTi MINT-486852.
    STRINGi 4932.YBR043C.

    Protein family/group databases

    TCDBi 2.A.1.2.43. the major facilitator superfamily (mfs).

    Proteomic databases

    MaxQBi P38227.
    PaxDbi P38227.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR043C ; YBR043C ; YBR043C .
    GeneIDi 852331.
    KEGGi sce:YBR043C.

    Organism-specific databases

    CYGDi YBR043c.
    SGDi S000000247. QDR3.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00620000088227.
    OMAi RLRENAW.
    OrthoDBi EOG7K6Q4M.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29016-MONOMER.

    Miscellaneous databases

    NextBioi 971047.

    Gene expression databases

    Genevestigatori P38227.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 37.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin."
      Tenreiro S., Vargas R.C., Teixeira M.C., Magnani C., Sa-Correia I.
      Biochem. Biophys. Res. Commun. 327:952-959(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiQDR3_YEAST
    AccessioniPrimary (citable) accession number: P38227
    Secondary accession number(s): D6VQ43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 279 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3