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Protein

Quinidine resistance protein 3

Gene

QDR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate).1 Publication

GO - Molecular functioni

  • drug transmembrane transporter activity Source: SGD
  • polyamine transmembrane transporter activity Source: SGD

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • drug transmembrane transport Source: SGD
  • polyamine homeostasis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29016-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.43. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Quinidine resistance protein 3
Alternative name(s):
Acids quinidine resistance protein 2
Gene namesi
Name:QDR3
Synonyms:AQR2
Ordered Locus Names:YBR043C
ORF Names:YBR0413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR043C.
SGDiS000000247. QDR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108ExtracellularSequence analysisAdd BLAST108
Transmembranei109 – 131HelicalSequence analysisAdd BLAST23
Topological domaini132 – 139CytoplasmicSequence analysis8
Transmembranei140 – 163HelicalSequence analysisAdd BLAST24
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 193HelicalSequence analysisAdd BLAST18
Topological domaini194 – 235CytoplasmicSequence analysisAdd BLAST42
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 265ExtracellularSequence analysis9
Transmembranei266 – 283HelicalSequence analysisAdd BLAST18
Topological domaini284 – 475CytoplasmicSequence analysisAdd BLAST192
Transmembranei476 – 493HelicalSequence analysisAdd BLAST18
Topological domaini494 – 510ExtracellularSequence analysisAdd BLAST17
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22
Topological domaini533 – 558CytoplasmicSequence analysisAdd BLAST26
Transmembranei559 – 577HelicalSequence analysisAdd BLAST19
Topological domaini578 – 586ExtracellularSequence analysis9
Transmembranei587 – 609HelicalSequence analysisAdd BLAST23
Topological domaini610 – 624CytoplasmicSequence analysisAdd BLAST15
Transmembranei625 – 642HelicalSequence analysisAdd BLAST18
Topological domaini643 – 648ExtracellularSequence analysis6
Transmembranei649 – 668HelicalSequence analysisAdd BLAST20
Topological domaini669 – 689CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734371 – 689Quinidine resistance protein 3Add BLAST689

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei436PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38227.
PRIDEiP38227.

PTM databases

iPTMnetiP38227.

Interactioni

Protein-protein interaction databases

BioGridi32744. 14 interactors.
DIPiDIP-797N.
IntActiP38227. 2 interactors.
MINTiMINT-486852.

Structurei

3D structure databases

ProteinModelPortaliP38227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00620000088227.
InParanoidiP38227.
OMAiHYARRTK.
OrthoDBiEOG092C2079.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGSPHS EHNDYSYEKT
60 70 80 90 100
NLESTASNSR EHRDNQLSRL KSEEYVVPKN QRRGLLPQLA IIPEFKDARD
110 120 130 140 150
YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA INSITTEFKT SVIMVNVSIG
160 170 180 190 200
VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS ALAPDINSFI
210 220 230 240 250
ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI
260 270 280 290 300
FGSLLVNRWP WRSTQWFMVI LSGCNVILLT VLLPETLRKQ DSKGAIAQIL
310 320 330 340 350
AERRIQVDNN ERGEIQEDYQ RGEDETDRIE NQVATLSTEK HNYVGEVRDQ
360 370 380 390 400
DSLDLESHSS PNTYDGRAGE TQLQRIYTEA SRSLYEYQLD DSGIDATTAQ
410 420 430 440 450
VTRIRSTDPK LARSIRENSL RKLQTNLEEQ VKKVLSSNGG EIAPKQVSAV
460 470 480 490 500
RKVWDTFFVY FIKPLKSLHF LEYPPVALAI TFSAISFSTV YFVNMTVEYK
510 520 530 540 550
YSRPPYNFKP LYIGLLYIPN SVTYFFASIY GGRWVDMLLK RYKEKYGILA
560 570 580 590 600
PEARISWNVV TSVISFPIAL LIFGWCLDKK CHWVTPLIGT ALFGYAAMMT
610 620 630 640 650
IGATLSYLVD SLPGKGATGV ALNNLIRQIL AATAVFVTTP MLNGMGTGWA
660 670 680
FTMLAFIVLG ASSVLIILKK HGDYWRENYD LQKLYDKID
Length:689
Mass (Da):77,287
Last modified:July 27, 2011 - v2
Checksum:iAA2C5D2D7175F176
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37S → T in CAA84985 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35912 Genomic DNA. Translation: CAA84985.1.
BK006936 Genomic DNA. Translation: DAA07163.2.
PIRiS45901.
RefSeqiNP_009599.2. NM_001178391.2.

Genome annotation databases

EnsemblFungiiYBR043C; YBR043C; YBR043C.
GeneIDi852331.
KEGGisce:YBR043C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35912 Genomic DNA. Translation: CAA84985.1.
BK006936 Genomic DNA. Translation: DAA07163.2.
PIRiS45901.
RefSeqiNP_009599.2. NM_001178391.2.

3D structure databases

ProteinModelPortaliP38227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32744. 14 interactors.
DIPiDIP-797N.
IntActiP38227. 2 interactors.
MINTiMINT-486852.

Protein family/group databases

TCDBi2.A.1.2.43. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP38227.

Proteomic databases

MaxQBiP38227.
PRIDEiP38227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR043C; YBR043C; YBR043C.
GeneIDi852331.
KEGGisce:YBR043C.

Organism-specific databases

EuPathDBiFungiDB:YBR043C.
SGDiS000000247. QDR3.

Phylogenomic databases

GeneTreeiENSGT00620000088227.
InParanoidiP38227.
OMAiHYARRTK.
OrthoDBiEOG092C2079.

Enzyme and pathway databases

BioCyciYEAST:G3O-29016-MONOMER.

Miscellaneous databases

PROiP38227.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQDR3_YEAST
AccessioniPrimary (citable) accession number: P38227
Secondary accession number(s): D6VQ43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.