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Reviewed, UniProtKB/Swiss-Prot P38225 (FAT1_YEAST)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Very long-chain fatty acid transport protein
Gene names
Name: FAT1
Ordered Locus Names: YBR041W
ORF Names: YBR0411
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

Present with 16900 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence caution

The sequence CAA84983.1 differs from that shown. Reason: Frameshift at position 620.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Very long-chain fatty acid transport protein
PRO_0000193181

Regions

Transmembrane6 – 2621 Potential
Transmembrane54 – 7118 Potential
Transmembrane149 – 16921 Potential
Transmembrane293 – 31321 Potential

Amino acid modifications

Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation5341N-linked (GlcNAc...) Potential
Glycosylation5911N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
P38225-1 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: 509A5DEDDEE98823

FASTA66977,141
        10         20         30         40         50         60 
MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY KEDWYIIPYF 

        70         80         90        100        110        120 
LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP MAEKGEFQLE TFTYIETYNI 

       130        140        150        160        170        180 
VLRLSHILHF DYNVQAGDYV AIDCTNKPLF VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL 

       190        200        210        220        230        240 
KISNITQVFI DPDASNPIRE SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV 

       250        260        270        280        290        300 
RTPLGLTDFK PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF 

       310        320        330        340        350        360 
HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR YLLHTPISKY 

       370        380        390        400        410        420 
EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA PFATTTFQKG DFGIGACRNY 

       430        440        450        460        470        480 
GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK GFCEVAPVGE PGEMLMRIFF PKKPETSFQG 

       490        500        510        520        530        540 
YLGNAKETKS KVVRDVFRRG DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV 

       550        560        570        580        590        600 
EDQLTASNKE QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP 

       610        620        630        640        650        660 
SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR YEVLTAADWE 


AIDAQTIKL

« Hide

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References

« Hide 'large scale' references
[1]"Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids."
Faergeman N.J., Dirusso C.C., Elberger A., Knudsen J., Black P.N.
J. Biol. Chem. 272:8531-8538(1997) [PubMed: 9079682] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: W303A.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Saccharomyces cerevisiae YBR041W sequence update."
Zhang Z., Stuart L.T., Dietrich F.S.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 590-639.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF065148 Genomic DNA. Translation: AAC17118.1.
Z35910 Genomic DNA. Translation: CAA84983.1. Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1.
PIRS45899.
RefSeqNP_009597.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5048N.
IntActP38225. 20 interactions.

Protein family/group databases

TCDB4.C.1.1.2. proposed fatty acid transporter (FAT) family.

Proteomic databases

PeptideAtlasP38225.

Genome annotation databases

EnsemblYBR041W. Saccharomyces cerevisiae. [Contig view]
GeneID852329.
GenomeReviewsGene locus YBR041W in contig Y13134_GR.
KEGGsce:YBR041W.
NMPDRfig|4932.3.peg.292.

Organism-specific databases

CYGDYBR041w.
SGDS000000245. FAT1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMP38225.
OMAP38225. MESRPLV.

Enzyme and pathway databases

BRENDA6.2.1.3. 250.

Gene expression databases

ArrayExpressP38225.
GermOnlineYBR041W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971041.

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Entry information

Entry nameFAT1_YEAST
AccessionPrimary (citable) accession number: P38225
Secondary accession number(s): O60021, Q86ZS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 31, 2004
Last modified: June 16, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents