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P38225

- FAT1_YEAST

UniProt

P38225 - FAT1_YEAST

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Protein

Very long-chain fatty acid transport protein

Gene

FAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

GO - Molecular functioni

  1. long-chain fatty acid transporter activity Source: SGD
  2. very long-chain fatty acid-CoA ligase activity Source: SGD

GO - Biological processi

  1. long-chain fatty acid transport Source: SGD
  2. very long-chain fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YBR041W-MONOMER.
BRENDAi6.2.1.3. 984.
ReactomeiREACT_188984. PPARA activates gene expression.
REACT_189233. Transport of fatty acids.
REACT_229431. Alpha-oxidation of phytanate.
REACT_257005. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
REACT_269909. Recycling of bile acids and salts.
REACT_270728. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.

Protein family/group databases

TCDBi4.C.1.1.2. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain fatty acid transport protein
Gene namesi
Name:FAT1
Ordered Locus Names:YBR041W
ORF Names:YBR0411
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR041w.
SGDiS000000245. FAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence AnalysisAdd
BLAST
Transmembranei54 – 7118HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. intrinsic component of the cytoplasmic side of the plasma membrane Source: SGD
  4. lipid particle Source: SGD
  5. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Very long-chain fatty acid transport proteinPRO_0000193181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38225.
PaxDbiP38225.
PeptideAtlasiP38225.

Expressioni

Gene expression databases

GenevestigatoriP38225.

Interactioni

Protein-protein interaction databases

BioGridi32742. 101 interactions.
DIPiDIP-5048N.
IntActiP38225. 14 interactions.
MINTiMINT-514313.

Structurei

3D structure databases

ProteinModelPortaliP38225.
SMRiP38225. Positions 110-662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
InParanoidiP38225.
OrthoDBiEOG77WWN1.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38225-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY
60 70 80 90 100
KEDWYIIPYF LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP
110 120 130 140 150
MAEKGEFQLE TFTYIETYNI VLRLSHILHF DYNVQAGDYV AIDCTNKPLF
160 170 180 190 200
VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL KISNITQVFI DPDASNPIRE
210 220 230 240 250
SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV RTPLGLTDFK
260 270 280 290 300
PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF
310 320 330 340 350
HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR
360 370 380 390 400
YLLHTPISKY EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA
410 420 430 440 450
PFATTTFQKG DFGIGACRNY GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK
460 470 480 490 500
GFCEVAPVGE PGEMLMRIFF PKKPETSFQG YLGNAKETKS KVVRDVFRRG
510 520 530 540 550
DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV EDQLTASNKE
560 570 580 590 600
QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP
610 620 630 640 650
SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR
660
YEVLTAADWE AIDAQTIKL
Length:669
Mass (Da):77,141
Last modified:August 31, 2004 - v2
Checksum:i509A5DEDDEE98823
GO

Sequence cautioni

The sequence CAA84983.1 differs from that shown. Reason: Frameshift at position 620. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065148 Genomic DNA. Translation: AAC17118.1.
Z35910 Genomic DNA. Translation: CAA84983.1. Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1.
BK006936 Genomic DNA. Translation: DAA07161.1.
PIRiS45899.
RefSeqiNP_009597.2. NM_001178389.1.

Genome annotation databases

EnsemblFungiiYBR041W; YBR041W; YBR041W.
GeneIDi852329.
KEGGisce:YBR041W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065148 Genomic DNA. Translation: AAC17118.1 .
Z35910 Genomic DNA. Translation: CAA84983.1 . Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1 .
BK006936 Genomic DNA. Translation: DAA07161.1 .
PIRi S45899.
RefSeqi NP_009597.2. NM_001178389.1.

3D structure databases

ProteinModelPortali P38225.
SMRi P38225. Positions 110-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32742. 101 interactions.
DIPi DIP-5048N.
IntActi P38225. 14 interactions.
MINTi MINT-514313.

Protein family/group databases

TCDBi 4.C.1.1.2. the proposed fatty acid transporter (fat) family.

Proteomic databases

MaxQBi P38225.
PaxDbi P38225.
PeptideAtlasi P38225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR041W ; YBR041W ; YBR041W .
GeneIDi 852329.
KEGGi sce:YBR041W.

Organism-specific databases

CYGDi YBR041w.
SGDi S000000245. FAT1.

Phylogenomic databases

eggNOGi COG0318.
GeneTreei ENSGT00550000074420.
HOGENOMi HOG000044189.
InParanoidi P38225.
OrthoDBi EOG77WWN1.

Enzyme and pathway databases

BioCyci YEAST:YBR041W-MONOMER.
BRENDAi 6.2.1.3. 984.
Reactomei REACT_188984. PPARA activates gene expression.
REACT_189233. Transport of fatty acids.
REACT_229431. Alpha-oxidation of phytanate.
REACT_257005. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
REACT_269909. Recycling of bile acids and salts.
REACT_270728. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.

Miscellaneous databases

NextBioi 971041.

Gene expression databases

Genevestigatori P38225.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids."
    Faergeman N.J., Dirusso C.C., Elberger A., Knudsen J., Black P.N.
    J. Biol. Chem. 272:8531-8538(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: W303A.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Saccharomyces cerevisiae YBR041W sequence update."
    Zhang Z., Stuart L.T., Dietrich F.S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 590-639.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAT1_YEAST
AccessioniPrimary (citable) accession number: P38225
Secondary accession number(s): D6VQ41, O60021, Q86ZS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 31, 2004
Last modified: November 26, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 16900 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3