Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38225

- FAT1_YEAST

UniProt

P38225 - FAT1_YEAST

Protein

Very long-chain fatty acid transport protein

Gene

FAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

    GO - Molecular functioni

    1. long-chain fatty acid transporter activity Source: SGD
    2. very long-chain fatty acid-CoA ligase activity Source: SGD

    GO - Biological processi

    1. long-chain fatty acid transport Source: SGD
    2. very long-chain fatty acid metabolic process Source: SGD

    Keywords - Biological processi

    Lipid transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:YBR041W-MONOMER.
    BRENDAi6.2.1.3. 984.
    ReactomeiREACT_188692. Recycling of bile acids and salts.
    REACT_188984. PPARA activates gene expression.
    REACT_189233. Transport of fatty acids.

    Protein family/group databases

    TCDBi4.C.1.1.2. the proposed fatty acid transporter (fat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Very long-chain fatty acid transport protein
    Gene namesi
    Name:FAT1
    Ordered Locus Names:YBR041W
    ORF Names:YBR0411
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR041w.
    SGDiS000000245. FAT1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of membrane Source: UniProtKB-KW
    3. intrinsic component of the cytoplasmic side of the plasma membrane Source: SGD
    4. lipid particle Source: SGD
    5. peroxisome Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 669669Very long-chain fatty acid transport proteinPRO_0000193181Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP38225.
    PaxDbiP38225.
    PeptideAtlasiP38225.

    Expressioni

    Gene expression databases

    GenevestigatoriP38225.

    Interactioni

    Protein-protein interaction databases

    BioGridi32742. 101 interactions.
    DIPiDIP-5048N.
    IntActiP38225. 14 interactions.
    MINTiMINT-514313.

    Structurei

    3D structure databases

    ProteinModelPortaliP38225.
    SMRiP38225. Positions 110-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    GeneTreeiENSGT00550000074420.
    HOGENOMiHOG000044189.
    OrthoDBiEOG77WWN1.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38225-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY    50
    KEDWYIIPYF LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP 100
    MAEKGEFQLE TFTYIETYNI VLRLSHILHF DYNVQAGDYV AIDCTNKPLF 150
    VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL KISNITQVFI DPDASNPIRE 200
    SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV RTPLGLTDFK 250
    PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF 300
    HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR 350
    YLLHTPISKY EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA 400
    PFATTTFQKG DFGIGACRNY GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK 450
    GFCEVAPVGE PGEMLMRIFF PKKPETSFQG YLGNAKETKS KVVRDVFRRG 500
    DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV EDQLTASNKE 550
    QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP 600
    SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR 650
    YEVLTAADWE AIDAQTIKL 669
    Length:669
    Mass (Da):77,141
    Last modified:August 31, 2004 - v2
    Checksum:i509A5DEDDEE98823
    GO

    Sequence cautioni

    The sequence CAA84983.1 differs from that shown. Reason: Frameshift at position 620.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF065148 Genomic DNA. Translation: AAC17118.1.
    Z35910 Genomic DNA. Translation: CAA84983.1. Frameshift.
    AY260890 Genomic DNA. Translation: AAP21758.1.
    BK006936 Genomic DNA. Translation: DAA07161.1.
    PIRiS45899.
    RefSeqiNP_009597.2. NM_001178389.1.

    Genome annotation databases

    EnsemblFungiiYBR041W; YBR041W; YBR041W.
    GeneIDi852329.
    KEGGisce:YBR041W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF065148 Genomic DNA. Translation: AAC17118.1 .
    Z35910 Genomic DNA. Translation: CAA84983.1 . Frameshift.
    AY260890 Genomic DNA. Translation: AAP21758.1 .
    BK006936 Genomic DNA. Translation: DAA07161.1 .
    PIRi S45899.
    RefSeqi NP_009597.2. NM_001178389.1.

    3D structure databases

    ProteinModelPortali P38225.
    SMRi P38225. Positions 110-662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32742. 101 interactions.
    DIPi DIP-5048N.
    IntActi P38225. 14 interactions.
    MINTi MINT-514313.

    Protein family/group databases

    TCDBi 4.C.1.1.2. the proposed fatty acid transporter (fat) family.

    Proteomic databases

    MaxQBi P38225.
    PaxDbi P38225.
    PeptideAtlasi P38225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR041W ; YBR041W ; YBR041W .
    GeneIDi 852329.
    KEGGi sce:YBR041W.

    Organism-specific databases

    CYGDi YBR041w.
    SGDi S000000245. FAT1.

    Phylogenomic databases

    eggNOGi COG0318.
    GeneTreei ENSGT00550000074420.
    HOGENOMi HOG000044189.
    OrthoDBi EOG77WWN1.

    Enzyme and pathway databases

    BioCyci YEAST:YBR041W-MONOMER.
    BRENDAi 6.2.1.3. 984.
    Reactomei REACT_188692. Recycling of bile acids and salts.
    REACT_188984. PPARA activates gene expression.
    REACT_189233. Transport of fatty acids.

    Miscellaneous databases

    NextBioi 971041.

    Gene expression databases

    Genevestigatori P38225.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids."
      Faergeman N.J., Dirusso C.C., Elberger A., Knudsen J., Black P.N.
      J. Biol. Chem. 272:8531-8538(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: W303A.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Saccharomyces cerevisiae YBR041W sequence update."
      Zhang Z., Stuart L.T., Dietrich F.S.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 590-639.
      Strain: ATCC 204508 / S288c.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFAT1_YEAST
    AccessioniPrimary (citable) accession number: P38225
    Secondary accession number(s): D6VQ41, O60021, Q86ZS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 16900 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3