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P38225

- FAT1_YEAST

UniProt

P38225 - FAT1_YEAST

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Protein
Very long-chain fatty acid transport protein
Gene
FAT1, YBR041W, YBR0411
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

GO - Molecular functioni

  1. long-chain fatty acid transporter activity Source: SGD
  2. very long-chain fatty acid-CoA ligase activity Source: SGD

GO - Biological processi

  1. long-chain fatty acid transport Source: SGD
  2. very long-chain fatty acid metabolic process Source: SGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YBR041W-MONOMER.
BRENDAi6.2.1.3. 984.
ReactomeiREACT_188692. Recycling of bile acids and salts.
REACT_188984. PPARA activates gene expression.
REACT_189233. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.2. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain fatty acid transport protein
Gene namesi
Name:FAT1
Ordered Locus Names:YBR041W
ORF Names:YBR0411
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR041w.
SGDiS000000245. FAT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Transmembranei54 – 7118Helical; Reviewed prediction
Add
BLAST
Transmembranei149 – 16921Helical; Reviewed prediction
Add
BLAST
Transmembranei293 – 31321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
  3. intrinsic component of the cytoplasmic side of the plasma membrane Source: SGD
  4. lipid particle Source: SGD
  5. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Very long-chain fatty acid transport protein
PRO_0000193181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi591 – 5911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38225.
PaxDbiP38225.
PeptideAtlasiP38225.

Expressioni

Gene expression databases

GenevestigatoriP38225.

Interactioni

Protein-protein interaction databases

BioGridi32742. 101 interactions.
DIPiDIP-5048N.
IntActiP38225. 14 interactions.
MINTiMINT-514313.

Structurei

3D structure databases

ProteinModelPortaliP38225.
SMRiP38225. Positions 110-662.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
OrthoDBiEOG77WWN1.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38225-1 [UniParc]FASTAAdd to Basket

« Hide

MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY    50
KEDWYIIPYF LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP 100
MAEKGEFQLE TFTYIETYNI VLRLSHILHF DYNVQAGDYV AIDCTNKPLF 150
VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL KISNITQVFI DPDASNPIRE 200
SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV RTPLGLTDFK 250
PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF 300
HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR 350
YLLHTPISKY EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA 400
PFATTTFQKG DFGIGACRNY GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK 450
GFCEVAPVGE PGEMLMRIFF PKKPETSFQG YLGNAKETKS KVVRDVFRRG 500
DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV EDQLTASNKE 550
QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP 600
SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR 650
YEVLTAADWE AIDAQTIKL 669
Length:669
Mass (Da):77,141
Last modified:August 31, 2004 - v2
Checksum:i509A5DEDDEE98823
GO

Sequence cautioni

The sequence CAA84983.1 differs from that shown. Reason: Frameshift at position 620.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065148 Genomic DNA. Translation: AAC17118.1.
Z35910 Genomic DNA. Translation: CAA84983.1. Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1.
BK006936 Genomic DNA. Translation: DAA07161.1.
PIRiS45899.
RefSeqiNP_009597.2. NM_001178389.1.

Genome annotation databases

EnsemblFungiiYBR041W; YBR041W; YBR041W.
GeneIDi852329.
KEGGisce:YBR041W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF065148 Genomic DNA. Translation: AAC17118.1 .
Z35910 Genomic DNA. Translation: CAA84983.1 . Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1 .
BK006936 Genomic DNA. Translation: DAA07161.1 .
PIRi S45899.
RefSeqi NP_009597.2. NM_001178389.1.

3D structure databases

ProteinModelPortali P38225.
SMRi P38225. Positions 110-662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32742. 101 interactions.
DIPi DIP-5048N.
IntActi P38225. 14 interactions.
MINTi MINT-514313.

Protein family/group databases

TCDBi 4.C.1.1.2. the proposed fatty acid transporter (fat) family.

Proteomic databases

MaxQBi P38225.
PaxDbi P38225.
PeptideAtlasi P38225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR041W ; YBR041W ; YBR041W .
GeneIDi 852329.
KEGGi sce:YBR041W.

Organism-specific databases

CYGDi YBR041w.
SGDi S000000245. FAT1.

Phylogenomic databases

eggNOGi COG0318.
GeneTreei ENSGT00550000074420.
HOGENOMi HOG000044189.
OrthoDBi EOG77WWN1.

Enzyme and pathway databases

BioCyci YEAST:YBR041W-MONOMER.
BRENDAi 6.2.1.3. 984.
Reactomei REACT_188692. Recycling of bile acids and salts.
REACT_188984. PPARA activates gene expression.
REACT_189233. Transport of fatty acids.

Miscellaneous databases

NextBioi 971041.

Gene expression databases

Genevestigatori P38225.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of the Saccharomyces cerevisiae homologue to the murine fatty acid transport protein impairs uptake and growth on long-chain fatty acids."
    Faergeman N.J., Dirusso C.C., Elberger A., Knudsen J., Black P.N.
    J. Biol. Chem. 272:8531-8538(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: W303A.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Saccharomyces cerevisiae YBR041W sequence update."
    Zhang Z., Stuart L.T., Dietrich F.S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 590-639.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFAT1_YEAST
AccessioniPrimary (citable) accession number: P38225
Secondary accession number(s): D6VQ41, O60021, Q86ZS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 16900 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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