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Protein

Very long-chain fatty acid transport protein

Gene

FAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in long-chain fatty acids uptake, and thus may play a pivotal role in regulating their accessibility prior to metabolic utilization. May play an important role in uptake of these hydrophobic compounds under conditions where fatty acid synthesis is compromised.

Miscellaneous

Present with 16900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • long-chain fatty acid transporter activity Source: SGD
  • very long-chain fatty acid-CoA ligase activity Source: SGD

GO - Biological processi

  • long-chain fatty acid import Source: SGD
  • very long-chain fatty acid metabolic process Source: SGD

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:YBR041W-MONOMER.
BRENDAi6.2.1.3. 984.
ReactomeiR-SCE-159418. Recycling of bile acids and salts.
R-SCE-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-SCE-193775. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
R-SCE-389599. Alpha-oxidation of phytanate.
R-SCE-6798695. Neutrophil degranulation.
R-SCE-804914. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.2. the fatty acid transporter (fat) family.

Chemistry databases

SwissLipidsiSLP:000000129.

Names & Taxonomyi

Protein namesi
Recommended name:
Very long-chain fatty acid transport protein
Gene namesi
Name:FAT1
Ordered Locus Names:YBR041W
ORF Names:YBR0411
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR041W.
SGDiS000000245. FAT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei54 – 71HelicalSequence analysisAdd BLAST18
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931811 – 669Very long-chain fatty acid transport proteinAdd BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP38225.
PRIDEiP38225.

Interactioni

Protein-protein interaction databases

BioGridi32742. 201 interactors.
DIPiDIP-5048N.
IntActiP38225. 14 interactors.
MINTiMINT-514313.
STRINGi4932.YBR041W.

Structurei

3D structure databases

ProteinModelPortaliP38225.
SMRiP38225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
InParanoidiP38225.
OMAiLTALWAY.
OrthoDBiEOG092C0XV9.

Family and domain databases

InterProiView protein in InterPro
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PROSITEiView protein in PROSITE
PS00455. AMP_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

P38225-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPIQVVVFA LSRIFLLLFR LIKLIITPIQ KSLGYLFGNY FDELDRKYRY
60 70 80 90 100
KEDWYIIPYF LKSVFCYIID VRRHRFQNWY LFIKQVQQNG DHLAISYTRP
110 120 130 140 150
MAEKGEFQLE TFTYIETYNI VLRLSHILHF DYNVQAGDYV AIDCTNKPLF
160 170 180 190 200
VFLWLSLWNI GAIPAFLNYN TKGTPLVHSL KISNITQVFI DPDASNPIRE
210 220 230 240 250
SEEEIKNALP DVKLNYLEEQ DLMHELLNSQ SPEFLQQDNV RTPLGLTDFK
260 270 280 290 300
PSMLIYTSGT TGLPKSAIMS WRKSSVGCQV FGHVLHMTNE STVFTAMPLF
310 320 330 340 350
HSTAALLGAC AILSHGGCLA LSHKFSASTF WKQVYLTGAT HIQYVGEVCR
360 370 380 390 400
YLLHTPISKY EKMHKVKVAY GNGLRPDIWQ DFRKRFNIEV IGEFYAATEA
410 420 430 440 450
PFATTTFQKG DFGIGACRNY GTIIQWFLSF QQTLVRMDPN DDSVIYRNSK
460 470 480 490 500
GFCEVAPVGE PGEMLMRIFF PKKPETSFQG YLGNAKETKS KVVRDVFRRG
510 520 530 540 550
DAWYRCGDLL KADEYGLWYF LDRMGDTFRW KSENVSTTEV EDQLTASNKE
560 570 580 590 600
QYAQVLVVGI KVPKYEGRAG FAVIKLTDNS LDITAKTKLL NDSLSRLNLP
610 620 630 640 650
SYAMPLFVKF VDEIKMTDNH KILKKVYREQ KLPKGLDGND TIFWLKNYKR
660
YEVLTAADWE AIDAQTIKL
Length:669
Mass (Da):77,141
Last modified:August 31, 2004 - v2
Checksum:i509A5DEDDEE98823
GO

Sequence cautioni

The sequence CAA84983 differs from that shown. Reason: Frameshift at position 620.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065148 Genomic DNA. Translation: AAC17118.1.
Z35910 Genomic DNA. Translation: CAA84983.1. Frameshift.
AY260890 Genomic DNA. Translation: AAP21758.1.
BK006936 Genomic DNA. Translation: DAA07161.1.
PIRiS45899.
RefSeqiNP_009597.2. NM_001178389.1.

Genome annotation databases

EnsemblFungiiYBR041W; YBR041W; YBR041W.
GeneIDi852329.
KEGGisce:YBR041W.

Similar proteinsi

Entry informationi

Entry nameiFAT1_YEAST
AccessioniPrimary (citable) accession number: P38225
Secondary accession number(s): D6VQ41, O60021, Q86ZS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: August 31, 2004
Last modified: October 25, 2017
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names