P38224 (FIG1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Factor-induced gene 1 protein

Gene names

Name:	FIG1
Ordered Locus Names:	YBR040W
ORF Names:	YBR0410

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for efficient mating.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By mating pheromones.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell morphogenesis involved in conjugation with cellular fusion Inferred from mutant phenotype PubMed 9456310. Source: SGD cytogamy Inferred from mutant phenotype PubMed 9456310. Source: SGD
Cellular_component	fungal-type cell wall Inferred from direct assay PubMed 9456310. Source: SGD integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mating projection tip Inferred from direct assay PubMed 12374868. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Factor-induced gene 1 protein		PRO_0000087242
Regions
	Transmembrane	17 – 37	21	Helical; Potential
	Transmembrane	163 – 183	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential
Amino acid modifications
	Modified residue	288	1	Phosphoserine Ref.5
	Modified residue	293	1	Phosphothreonine Ref.5
	Modified residue	296	1	Phosphoserine Ref.5
Natural variations
	Natural variant	1 – 5	5	Missing in strain: CLIB 556 haplotype Ha1 and CLIB 630.
	Natural variant	153	1	L → V in strain: CLIB 413 haplotype Ha1. Ref.1
	Natural variant	203	1	I → L in strain: CLIB 630. Ref.1
	Natural variant	204	1	V → I in strain: K1. Ref.1
	Natural variant	220	1	A → E in strain: CLIB 413 haplotype Ha2. Ref.1
	Natural variant	223	1	R → I in strain: CLIB 630. Ref.1
	Natural variant	236	1	K → N in strain: CLIB 219. Ref.1
	Natural variant	241	1	A → T in strain: CLIB 388 haplotype Ha2. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P38224 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 6C72CBA2E9C5A0D8	FASTA	298	33,776
	10 20 30 40 50 60 MVAISMIWFF TKRMPRIFAL AFNLISIFLL IFLLIGCYNP SNQSTFLVKY KFDDNSPFYT 70 80 90 100 110 120 IIEKSYEKSN TTLGLEEVII RSGYMGVCID NIPSQYSSYN NMTTFSNSIC YARKNLSSVP 130 140 150 160 170 180 LYRDLEIQLS NIASSSSKTQ SSVVLNILKL AQLTSVNVIH PYVLMATVIL TILMFLFILY 190 200 210 220 230 240 VTVPKLPFKL AVNKFLLLLS STIVLTWGIG AMWTHVGINA SYRLVPSSSM NIITVKKGKK 250 260 270 280 290 AAVMAWFSFA FLLLDSVVLW LIFLRDRKSL KDEIDNVPCA QNRYNNYSSD SSTLHSKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny." Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L. Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS 1-MET--SER-5 DEL; VAL-153; LEU-203; ILE-204; GLU-220; ILE-223; ASN-236 AND THR-241. Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae." Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P. J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; THR-293 AND SER-296, MASS SPECTROMETRY. Strain: ADR376.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ585600 Genomic DNA. Translation: CAE52120.1. AJ585601 Genomic DNA. Translation: CAE52121.1. AJ585602 Genomic DNA. Translation: CAE52122.1. AJ585603 Genomic DNA. Translation: CAE52123.1. AJ585604 Genomic DNA. Translation: CAE52124.1. AJ585605 Genomic DNA. Translation: CAE52125.1. AJ585606 Genomic DNA. Translation: CAE52126.1. AJ585607 Genomic DNA. Translation: CAE52127.1. AJ585608 Genomic DNA. Translation: CAE52128.1. AJ585609 Genomic DNA. Translation: CAE52129.1. AJ585610 Genomic DNA. Translation: CAE52130.1. AJ585611 Genomic DNA. Translation: CAE52131.1. AJ585612 Genomic DNA. Translation: CAE52132.1. AJ585613 Genomic DNA. Translation: CAE52133.1. AJ585614 Genomic DNA. Translation: CAE52134.1. AJ585615 Genomic DNA. Translation: CAE52135.1. AJ585616 Genomic DNA. Translation: CAE52136.1. AJ585617 Genomic DNA. Translation: CAE52137.1. AJ585618 Genomic DNA. Translation: CAE52138.1. AJ585619 Genomic DNA. Translation: CAE52139.1. Z35909 Genomic DNA. Translation: CAA84982.1. AY557864 Genomic DNA. Translation: AAS56190.1. BK006936 Genomic DNA. Translation: DAA07160.1.
PIR	S45898.
RefSeq	NP_009596.1. NM_001178388.1.
3D structure databases
ProteinModelPortal	P38224.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1347N.
IntAct	P38224. 1 interaction.
MINT	MINT-401479.
Protein family/group databases
TCDB	9.A.46.1.1. putative low affinity Ca2+ channel (LACC) family.
Proteomic databases
PaxDb	P38224.
PeptideAtlas	P38224.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR040W; YBR040W; YBR040W.
GeneID	852328.
KEGG	sce:YBR040W.
Organism-specific databases
CYGD	YBR040w.
SGD	S000000244. FIG1.
Phylogenomic databases
eggNOG	NOG329168.
OMA	VGYLGVC.
OrthoDB	EOG4JDMH8.
Gene expression databases
Genevestigator	P38224.
GermOnline	YBR040W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016509. M_fusion_mating_FIG1. [Graphical view]
PIRSF	PIRSF007138. FIG1. 1 hit.
ProtoNet	Search...
Other
NextBio	971038.

Entry information

Entry name

FIG1_YEAST

Accession

Primary (citable) accession number: P38224
Secondary accession number(s): D6VQ40 , Q70DD9, Q70DE0, Q70DE1, Q70DE3, Q70DE4, Q70DE5, Q70DE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program