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Protein

Ribosomal lysine N-methyltransferase 3

Gene

RKM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'.2 Publications

Miscellaneous

Present with 7880 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei334S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-lysine monomethylation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-29008-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal lysine N-methyltransferase 31 Publication (EC:2.1.1.-2 Publications)
Gene namesi
Name:RKM31 Publication
Ordered Locus Names:YBR030WImported
ORF Names:YBR0314
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR030W
SGDiS000000234 RKM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024721 – 552Ribosomal lysine N-methyltransferase 3Add BLAST552

Proteomic databases

MaxQBiP38222
PaxDbiP38222
PRIDEiP38222

Interactioni

Protein-protein interaction databases

BioGridi32732, 99 interactors
IntActiP38222, 4 interactors
MINTiP38222
STRINGi4932.YBR030W

Structurei

3D structure databases

ProteinModelPortaliP38222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 335SETPROSITE-ProRule annotationAdd BLAST310

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi418 – 427Poly-Glu10

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000142026
InParanoidiP38222
OMAiFIYETTV
OrthoDBiEOG092C3CS7

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

P38222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTFKDDVH RILKFVANCN GRFEDSKCDI RESPLGGLGV FAKTDIAEGE
60 70 80 90 100
SILTLNKSSI FSASNSSIAN LLCDSSIDGM LALNIAFIYE TTVFRNSSHW
110 120 130 140 150
YPFLRTIRIR DDEGHLNLPP SFWHADAKRL LKGTSFDTLF DSLAPEEEIM
160 170 180 190 200
EGFEIAVDLA HKWNDEFGLE IPKGFLDVSE ENHEEDYNLK LEKFISVAYT
210 220 230 240 250
LSSRGFEIDA YHETALVPIA DLFNHHVSDP DLKFVSLYDV CDKCGEPDMC
260 270 280 290 300
KHLIAEEYLE AENLDKNMPK VASMETRVID EDLIKSLEND LEKEYSNVTA
310 320 330 340 350
NIEDDDGGIE NPDECVDLVL KNDVAQGQEI FNSYGELSNV FLLARYGFTV
360 370 380 390 400
PENQYDIVHL GPDFMKILKK EEKYQEKVKW WSQVGHGLFS AWYAQMRQED
410 420 430 440 450
EEDEDGQAKS DNLSDDIESE EEEEEEEGDD SLESWLSQLY IDSSGEPSPS
460 470 480 490 500
TWALANLLTL TAVQWESLFS KKATPHISDS IVNEEKLPFL AKKDNPHSKK
510 520 530 540 550
LLSNLLKEKQ LPCIKGDNSS KITSATKSML QNARTLVQSE HNILDRCLKR

LS
Length:552
Mass (Da):62,594
Last modified:October 1, 1994 - v1
Checksum:iE7460154E683D7B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35899 Genomic DNA Translation: CAA84972.1
X76078 Genomic DNA Translation: CAA53686.1
BK006936 Genomic DNA Translation: DAA07151.1
PIRiS45886
RefSeqiNP_009586.1, NM_001178378.1

Genome annotation databases

EnsemblFungiiYBR030W; YBR030W; YBR030W
GeneIDi852318
KEGGisce:YBR030W

Similar proteinsi

Entry informationi

Entry nameiRKM3_YEAST
AccessioniPrimary (citable) accession number: P38222
Secondary accession number(s): D6VQ31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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