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P38221

- CDS1_YEAST

UniProt

P38221 - CDS1_YEAST

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Protein
Phosphatidate cytidylyltransferase
Gene
CDS1, CDG1, YBR029C, YBR0313
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Supplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: SGD

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: SGD
  2. phosphatidylinositol metabolic process Source: SGD
  3. phosphatidylserine metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciYEAST:YBR029C-MONOMER.
ReactomeiREACT_188995. Synthesis of PG.
REACT_189002. Synthesis of PI.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:CDS1
Synonyms:CDG1
Ordered Locus Names:YBR029C
ORF Names:YBR0313
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR029c.
SGDiS000000233. CDS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Transmembranei330 – 35021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi to plasma membrane transport vesicle Source: SGD
  2. endoplasmic reticulum Source: SGD
  3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  4. integral component of membrane Source: UniProtKB-KW
  5. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi102 – 1021C → Y: Reduced enzyme level. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Phosphatidate cytidylyltransferase
PRO_0000090722Add
BLAST

Proteomic databases

MaxQBiP38221.
PaxDbiP38221.
PeptideAtlasiP38221.

Expressioni

Gene expression databases

GenevestigatoriP38221.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi32731. 27 interactions.
DIPiDIP-7898N.
IntActiP38221. 3 interactions.
MINTiMINT-1360573.
STRINGi4932.YBR029C.

Structurei

3D structure databases

ProteinModelPortaliP38221.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
GeneTreeiENSGT00390000016175.
HOGENOMiHOG000209582.
KOiK00981.
OMAiVKCFQEI.
OrthoDBiEOG7XDBQH.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38221-1 [UniParc]FASTAAdd to Basket

« Hide

MSDNPEMKPH GTSKEIVESV TDATSKAIDK LQEELHKDAS ESVTPVTKES    50
TAATKESRKY NFFIRTVWTF VMISGFFITL ASGHAWCIVL ILGCQIATFK 100
ECIAVTSASG REKNLPLTKT LNWYLLFTTI YYLDGKSLFK FFQATFYEYP 150
VLNFIVTNHK FICYCLYLMG FVLFVCSLRK GFLKFQFGSL CVTHMVLLLV 200
VFQAHLIIKN VLNGLFWFLL PCGLVIVNDI FAYLCGITFG KTKLIEISPK 250
KTLEGFLGAW FFTALASIIL TRILSPYTYL TCPVEDLHTN FFSNLTCELN 300
PVFLPQVYRL PPIFFDKVQI NSITVKPIYF HALNLATFAS LFAPFGGFFA 350
SGLKRTFKVK DFGHSIPGHG GITDRVDCQF IMGSFANLYY ETFISEHRIT 400
VDTVLSTILM NLNDKQIIEL IDILIRFLSK KGIISAKNFE KLADIFNVTK 450
KSLTNHS 457
Length:457
Mass (Da):51,823
Last modified:October 1, 1994 - v1
Checksum:iF9F3613856EDE172
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53685.1.
Z35898 Genomic DNA. Translation: CAA84971.1.
AY693074 Genomic DNA. Translation: AAT93093.1.
BK006936 Genomic DNA. Translation: DAA07150.1.
PIRiS45885.
RefSeqiNP_009585.1. NM_001178377.1.

Genome annotation databases

EnsemblFungiiYBR029C; YBR029C; YBR029C.
GeneIDi852317.
KEGGisce:YBR029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76078 Genomic DNA. Translation: CAA53685.1 .
Z35898 Genomic DNA. Translation: CAA84971.1 .
AY693074 Genomic DNA. Translation: AAT93093.1 .
BK006936 Genomic DNA. Translation: DAA07150.1 .
PIRi S45885.
RefSeqi NP_009585.1. NM_001178377.1.

3D structure databases

ProteinModelPortali P38221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32731. 27 interactions.
DIPi DIP-7898N.
IntActi P38221. 3 interactions.
MINTi MINT-1360573.
STRINGi 4932.YBR029C.

Proteomic databases

MaxQBi P38221.
PaxDbi P38221.
PeptideAtlasi P38221.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR029C ; YBR029C ; YBR029C .
GeneIDi 852317.
KEGGi sce:YBR029C.

Organism-specific databases

CYGDi YBR029c.
SGDi S000000233. CDS1.

Phylogenomic databases

eggNOGi COG0575.
GeneTreei ENSGT00390000016175.
HOGENOMi HOG000209582.
KOi K00981.
OMAi VKCFQEI.
OrthoDBi EOG7XDBQH.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
BioCyci YEAST:YBR029C-MONOMER.
Reactomei REACT_188995. Synthesis of PG.
REACT_189002. Synthesis of PI.

Miscellaneous databases

NextBioi 971008.
PROi P38221.

Gene expression databases

Genevestigatori P38221.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth."
    Shen H., Heacock P.N., Clancey C.J., Dowhan W.
    J. Biol. Chem. 271:789-795(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. "The complete sequence of a 33 kb fragment on the right arm of chromosome II from Saccharomyces cerevisiae reveals 16 open reading frames, including ten new open reading frames, five previously identified genes and a homologue of the SCO1 gene."
    Smits P.H.M., de Haan M., Maat C., Grivell L.A.
    Yeast 10:S75-S80(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae."
    Shen H., Dowhan W.
    J. Biol. Chem. 271:29043-29048(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF CYS-102.

Entry informationi

Entry nameiCDS1_YEAST
AccessioniPrimary (citable) accession number: P38221
Secondary accession number(s): D6VQ30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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