Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38208

- POP8_YEAST

UniProt

P38208 - POP8_YEAST

Protein

Ribonucleases P/MRP protein subunit POP8

Gene

POP8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.1 Publication

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. intronic box C/D snoRNA processing Source: SGD
    2. mRNA cleavage Source: SGD
    3. RNA phosphodiester bond hydrolysis Source: GOC
    4. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    5. rRNA processing Source: UniProtKB-KW
    6. tRNA processing Source: SGD

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    rRNA processing, tRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:YBL018C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleases P/MRP protein subunit POP8 (EC:3.1.26.5)
    Alternative name(s):
    RNA-processing protein POP8
    RNases P/MRP 15.5 kDa subunit
    Gene namesi
    Name:POP8
    Ordered Locus Names:YBL018C
    ORF Names:YBL0301
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBL018c.
    SGDiS000000114. POP8.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nucleolar ribonuclease P complex Source: SGD
    3. nucleus Source: SGD
    4. ribonuclease MRP complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133Ribonucleases P/MRP protein subunit POP8PRO_0000058521Add
    BLAST

    Proteomic databases

    MaxQBiP38208.
    PaxDbiP38208.
    PeptideAtlasiP38208.

    Expressioni

    Gene expression databases

    GenevestigatoriP38208.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 9 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RPP1 and RPR2. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.2 Publications

    Protein-protein interaction databases

    BioGridi32680. 114 interactions.
    DIPiDIP-2033N.
    IntActiP38208. 7 interactions.
    MINTiMINT-486880.
    STRINGi4932.YBL018C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40549.
    HOGENOMiHOG000000716.
    KOiK14528.
    OMAiALKRSHG.
    OrthoDBiEOG7W9S74.

    Family and domain databases

    InterProiIPR020347. RNase_P/MRP_POP8.
    [Graphical view]
    ProDomiPD082524. Ribonucleases_P/MRP_su_POP8. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P38208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKKTFREWQ YFKLSITSFD QDVDDAHAID QMTWRQWLNN ALKRSYGIFG    50
    EGVEYSFLHV DDKLAYIRVN HADKDTFSSS ISTYISTDEL VGSPLTVSIL 100
    QESSSLRLLE VTDDDRLWLK KVMEEEEQDC KCI 133
    Length:133
    Mass (Da):15,512
    Last modified:October 1, 1994 - v1
    Checksum:i9605CC5BD74AFA21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35779 Genomic DNA. Translation: CAA84837.1.
    BK006936 Genomic DNA. Translation: DAA07102.1.
    PIRiS45752.
    RefSeqiNP_009535.1. NM_001178258.1.

    Genome annotation databases

    EnsemblFungiiYBL018C; YBL018C; YBL018C.
    GeneIDi852263.
    KEGGisce:YBL018C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35779 Genomic DNA. Translation: CAA84837.1 .
    BK006936 Genomic DNA. Translation: DAA07102.1 .
    PIRi S45752.
    RefSeqi NP_009535.1. NM_001178258.1.

    3D structure databases

    ProteinModelPortali P38208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32680. 114 interactions.
    DIPi DIP-2033N.
    IntActi P38208. 7 interactions.
    MINTi MINT-486880.
    STRINGi 4932.YBL018C.

    Proteomic databases

    MaxQBi P38208.
    PaxDbi P38208.
    PeptideAtlasi P38208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL018C ; YBL018C ; YBL018C .
    GeneIDi 852263.
    KEGGi sce:YBL018C.

    Organism-specific databases

    CYGDi YBL018c.
    SGDi S000000114. POP8.

    Phylogenomic databases

    eggNOGi NOG40549.
    HOGENOMi HOG000000716.
    KOi K14528.
    OMAi ALKRSHG.
    OrthoDBi EOG7W9S74.

    Enzyme and pathway databases

    BioCyci YEAST:YBL018C-MONOMER.

    Miscellaneous databases

    NextBioi 970859.

    Gene expression databases

    Genevestigatori P38208.

    Family and domain databases

    InterProi IPR020347. RNase_P/MRP_POP8.
    [Graphical view ]
    ProDomi PD082524. Ribonucleases_P/MRP_su_POP8. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP."
      Chamberlain J.R., Lee Y., Lane W.S., Engelke D.R.
      Genes Dev. 12:1678-1690(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RNASE P COMPLEX BY MASS SPECTROMETRY.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
      Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
      J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPOP8_YEAST
    AccessioniPrimary (citable) accession number: P38208
    Secondary accession number(s): D6VPY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4870 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3