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Protein

Pyridoxal phosphate homeostasis protein

Gene

YBL036C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.UniRule annotation

Miscellaneous

Present with 4890 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • pyridoxal phosphate binding Source: SGD

Keywordsi

LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:G3O-28938-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate homeostasis proteinUniRule annotation
Short name:
PLP homeostasis proteinUniRule annotation
Gene namesi
Ordered Locus Names:YBL036C
ORF Names:YBL0413
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL036C
SGDiS000000132 YBL036C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001632132 – 257Pyridoxal phosphate homeostasis proteinAdd BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei49N6-(pyridoxal phosphate)lysineUniRule annotation1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP38197
PaxDbiP38197
PRIDEiP38197

PTM databases

iPTMnetiP38197

Interactioni

Protein-protein interaction databases

BioGridi32661, 92 interactors
DIPiDIP-6608N
IntActiP38197, 17 interactors
MINTiP38197
STRINGi4932.YBL036C

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 31Combined sources23
Beta strandi43 – 47Combined sources5
Helixi53 – 62Combined sources10
Beta strandi66 – 69Combined sources4
Helixi72 – 81Combined sources10
Beta strandi87 – 90Combined sources4
Helixi96 – 98Combined sources3
Helixi99 – 104Combined sources6
Beta strandi108 – 114Combined sources7
Helixi117 – 130Combined sources14
Beta strandi132 – 134Combined sources3
Beta strandi137 – 143Combined sources7
Beta strandi146 – 148Combined sources3
Beta strandi151 – 154Combined sources4
Helixi157 – 168Combined sources12
Beta strandi174 – 181Combined sources8
Helixi197 – 213Combined sources17
Beta strandi218 – 220Combined sources3
Turni224 – 226Combined sources3
Helixi227 – 232Combined sources6
Beta strandi236 – 241Combined sources6
Helixi242 – 245Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B54X-ray2.10A1-257[»]
1CT5X-ray2.00A2-257[»]
ProteinModelPortaliP38197
SMRiP38197
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38197

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000004928
HOGENOMiHOG000048983
InParanoidiP38197
KOiK06997
OMAiKLMAVPN
OrthoDBiEOG092C3DQC

Family and domain databases

Gene3Di3.20.20.10, 1 hit
HAMAPiMF_02087 PLP_homeostasis, 1 hit
InterProiView protein in InterPro
IPR001608 Ala_racemase_N
IPR029066 PLP-binding_barrel
IPR011078 PyrdxlP_homeostasis
PANTHERiPTHR10146 PTHR10146, 1 hit
PfamiView protein in Pfam
PF01168 Ala_racemase_N, 1 hit
PIRSFiPIRSF004848 YBL036c_PLPDEIII, 1 hit
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00044 TIGR00044, 1 hit
PROSITEiView protein in PROSITE
PS01211 UPF0001, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P38197-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGITYDED RKTQLIAQYE SVREVVNAEA KNVHVNENAS KILLLVVSKL
60 70 80 90 100
KPASDIQILY DHGVREFGEN YVQELIEKAK LLPDDIKWHF IGGLQTNKCK
110 120 130 140 150
DLAKVPNLYS VETIDSLKKA KKLNESRAKF QPDCNPILCN VQINTSHEDQ
160 170 180 190 200
KSGLNNEAEI FEVIDFFLSE ECKYIKLNGL MTIGSWNVSH EDSKENRDFA
210 220 230 240 250
TLVEWKKKID AKFGTSLKLS MGMSADFREA IRQGTAEVRI GTDIFGARPP

KNEARII
Length:257
Mass (Da):29,123
Last modified:October 1, 1994 - v1
Checksum:i5643EE0D36B6D85A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8D → G in AAT92893 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78214 Genomic DNA Translation: CAA55058.1
Z35797 Genomic DNA Translation: CAA84856.1
AY692874 Genomic DNA Translation: AAT92893.1
BK006936 Genomic DNA Translation: DAA07083.1
PIRiS50294
RefSeqiNP_009517.1, NM_001178276.1

Genome annotation databases

EnsemblFungiiYBL036C; YBL036C; YBL036C
GeneIDi852244
KEGGisce:YBL036C

Similar proteinsi

Entry informationi

Entry nameiPLPHP_YEAST
AccessioniPrimary (citable) accession number: P38197
Secondary accession number(s): D6VPW3, Q6B256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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