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Protein

Uridine permease

Gene

FUI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity transport of uridine.

GO - Molecular functioni

GO - Biological processi

  • nucleobase transport Source: GO_Central
  • transmembrane transport Source: SGD
  • uridine transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-28943-MONOMER

Protein family/group databases

TCDBi2.A.39.3.3 the nucleobase:cation symporter-1 (ncs1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine permease
Gene namesi
Name:FUI1
Ordered Locus Names:YBL042C
ORF Names:YBL0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL042C
SGDiS000000138 FUI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 162CytoplasmicSequence analysisAdd BLAST162
Transmembranei163 – 180HelicalSequence analysisAdd BLAST18
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 225HelicalSequence analysisAdd BLAST25
Topological domaini226 – 259CytoplasmicSequence analysisAdd BLAST34
Transmembranei260 – 276HelicalSequence analysisAdd BLAST17
Topological domaini277 – 283ExtracellularSequence analysis7
Transmembranei284 – 305HelicalSequence analysisAdd BLAST22
Topological domaini306 – 367CytoplasmicSequence analysisAdd BLAST62
Transmembranei368 – 392HelicalSequence analysisAdd BLAST25
Topological domaini393 – 416ExtracellularSequence analysisAdd BLAST24
Transmembranei417 – 435HelicalSequence analysisAdd BLAST19
Topological domaini436 – 460CytoplasmicSequence analysisAdd BLAST25
Transmembranei461 – 477HelicalSequence analysisAdd BLAST17
Topological domaini478 – 483ExtracellularSequence analysis6
Transmembranei484 – 507HelicalSequence analysisAdd BLAST24
Topological domaini508 – 537CytoplasmicSequence analysisAdd BLAST30
Transmembranei538 – 562HelicalSequence analysisAdd BLAST25
Topological domaini563 – 572ExtracellularSequence analysis10
Transmembranei573 – 590HelicalSequence analysisAdd BLAST18
Topological domaini591 – 639CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979231 – 639Uridine permeaseAdd BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphothreonineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Cross-linki635Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38196
PaxDbiP38196
PRIDEiP38196

PTM databases

iPTMnetiP38196

Interactioni

Protein-protein interaction databases

BioGridi32655, 51 interactors
DIPiDIP-1321N
IntActiP38196, 6 interactors
MINTiP38196
STRINGi4932.YBL042C

Structurei

3D structure databases

ProteinModelPortaliP38196
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049
HOGENOMiHOG000202588
InParanoidiP38196
OMAiNTWQISA
OrthoDBiEOG092C1JZY

Family and domain databases

Gene3Di1.10.4160.10, 1 hit
InterProiView protein in InterPro
IPR012681 NCS1
IPR001248 Pur-cyt_permease
IPR038271 Pur-cyt_permease_sf
PfamiView protein in Pfam
PF02133 Transp_cyt_pur, 1 hit
TIGRFAMsiTIGR00800 ncs1, 1 hit

Sequencei

Sequence statusi: Complete.

P38196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE
60 70 80 90 100
KKDTDSENNI TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF
110 120 130 140 150
KDLQESLRST YLYNTDLRPV EAKRRTWTWK QYIFFWISGS FNVNTWQISA
160 170 180 190 200
TGLQLGLNWW QTWICIWVGY TFVAFFLILG SKVGNNYHIS FPISSRVSFG
210 220 230 240 250
IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT NLNTRIKDTI
260 270 280 290 300
KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL
310 320 330 340 350
IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA
360 370 380 390 400
PDFTRFGKTY KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP
410 420 430 440 450
LDILNRYLDN YTSGNRAGVF LISFIFAFDQ LGANLSGNSI PAGTDLTALL
460 470 480 490 500
PKFINIRRGS YICALISLAI CPWDLLSSSS KFTTALAAYA VFLSAIAGVI
510 520 530 540 550
SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA YIFGIAPNFA
560 570 580 590 600
GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK
610 620 630
ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI
Length:639
Mass (Da):72,165
Last modified:October 1, 1994 - v1
Checksum:i757325DEF4100399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78214 Genomic DNA Translation: CAA55059.1
Z35803 Genomic DNA Translation: CAA84862.1
BK006936 Genomic DNA Translation: DAA07076.1
PIRiS45776
RefSeqiNP_009511.1, NM_001178282.1

Genome annotation databases

EnsemblFungiiYBL042C; YBL042C; YBL042C
GeneIDi852238
KEGGisce:YBL042C

Similar proteinsi

Entry informationi

Entry nameiFUI1_YEAST
AccessioniPrimary (citable) accession number: P38196
Secondary accession number(s): D6VPV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health