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P38196

- FUI1_YEAST

UniProt

P38196 - FUI1_YEAST

Protein

Uridine permease

Gene

FUI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
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    Functioni

    High-affinity transport of uridine.

    GO - Molecular functioni

    1. nucleobase transmembrane transporter activity Source: InterPro
    2. uridine transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. transmembrane transport Source: SGD
    2. uridine transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28943-MONOMER.

    Protein family/group databases

    TCDBi2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine permease
    Gene namesi
    Name:FUI1
    Ordered Locus Names:YBL042C
    ORF Names:YBL0406
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBL042c.
    SGDiS000000138. FUI1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 639639Uridine permeasePRO_0000197923Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541Phosphothreonine1 Publication
    Modified residuei56 – 561Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP38196.
    PaxDbiP38196.

    Expressioni

    Gene expression databases

    GenevestigatoriP38196.

    Interactioni

    Protein-protein interaction databases

    BioGridi32655. 24 interactions.
    DIPiDIP-1321N.
    IntActiP38196. 6 interactions.
    MINTiMINT-401263.
    STRINGi4932.YBL042C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38196.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 162162CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 25934CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 2837ExtracellularSequence Analysis
    Topological domaini306 – 36762CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini393 – 41624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini436 – 46025CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini478 – 4836ExtracellularSequence Analysis
    Topological domaini508 – 53730CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini563 – 57210ExtracellularSequence Analysis
    Topological domaini591 – 63949CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22525HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 27617HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 39225HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei461 – 47717HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50724HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 56225HelicalSequence AnalysisAdd
    BLAST
    Transmembranei573 – 59018HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine-cytosine permease family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1953.
    GeneTreeiENSGT00530000065049.
    HOGENOMiHOG000202588.
    OMAiAICPWDL.
    OrthoDBiEOG75B8F6.

    Family and domain databases

    InterProiIPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view]
    PfamiPF02133. Transp_cyt_pur. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00800. ncs1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P38196-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE    50
    KKDTDSENNI TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF 100
    KDLQESLRST YLYNTDLRPV EAKRRTWTWK QYIFFWISGS FNVNTWQISA 150
    TGLQLGLNWW QTWICIWVGY TFVAFFLILG SKVGNNYHIS FPISSRVSFG 200
    IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT NLNTRIKDTI 250
    KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL 300
    IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA 350
    PDFTRFGKTY KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP 400
    LDILNRYLDN YTSGNRAGVF LISFIFAFDQ LGANLSGNSI PAGTDLTALL 450
    PKFINIRRGS YICALISLAI CPWDLLSSSS KFTTALAAYA VFLSAIAGVI 500
    SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA YIFGIAPNFA 550
    GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK 600
    ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI 639
    Length:639
    Mass (Da):72,165
    Last modified:October 1, 1994 - v1
    Checksum:i757325DEF4100399
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78214 Genomic DNA. Translation: CAA55059.1.
    Z35803 Genomic DNA. Translation: CAA84862.1.
    BK006936 Genomic DNA. Translation: DAA07076.1.
    PIRiS45776.
    RefSeqiNP_009511.1. NM_001178282.1.

    Genome annotation databases

    EnsemblFungiiYBL042C; YBL042C; YBL042C.
    GeneIDi852238.
    KEGGisce:YBL042C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78214 Genomic DNA. Translation: CAA55059.1 .
    Z35803 Genomic DNA. Translation: CAA84862.1 .
    BK006936 Genomic DNA. Translation: DAA07076.1 .
    PIRi S45776.
    RefSeqi NP_009511.1. NM_001178282.1.

    3D structure databases

    ProteinModelPortali P38196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32655. 24 interactions.
    DIPi DIP-1321N.
    IntActi P38196. 6 interactions.
    MINTi MINT-401263.
    STRINGi 4932.YBL042C.

    Protein family/group databases

    TCDBi 2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

    Proteomic databases

    MaxQBi P38196.
    PaxDbi P38196.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL042C ; YBL042C ; YBL042C .
    GeneIDi 852238.
    KEGGi sce:YBL042C.

    Organism-specific databases

    CYGDi YBL042c.
    SGDi S000000138. FUI1.

    Phylogenomic databases

    eggNOGi COG1953.
    GeneTreei ENSGT00530000065049.
    HOGENOMi HOG000202588.
    OMAi AICPWDL.
    OrthoDBi EOG75B8F6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28943-MONOMER.

    Miscellaneous databases

    NextBioi 970784.

    Gene expression databases

    Genevestigatori P38196.

    Family and domain databases

    InterProi IPR001248. Cyt_pur_permease.
    IPR012681. NCS1.
    [Graphical view ]
    Pfami PF02133. Transp_cyt_pur. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00800. ncs1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein."
      de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J., Goffeau A.
      Yeast 10:1489-1496(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease."
      Wagner R., de Montigny J., de Wergifosse P., Souciet J.-L., Potier S.
      FEMS Microbiol. Lett. 159:69-75(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
      Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
      J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54 AND SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFUI1_YEAST
    AccessioniPrimary (citable) accession number: P38196
    Secondary accession number(s): D6VPV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3