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P38196 (FUI1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine permease
Gene names
Name:FUI1
Ordered Locus Names:YBL042C
ORF Names:YBL0406
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity transport of uridine.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the purine-cytosine permease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 639639Uridine permease
PRO_0000197923

Regions

Topological domain1 – 162162Cytoplasmic Potential
Transmembrane163 – 18018Helical; Potential
Topological domain181 – 20020Extracellular Potential
Transmembrane201 – 22525Helical; Potential
Topological domain226 – 25934Cytoplasmic Potential
Transmembrane260 – 27617Helical; Potential
Topological domain277 – 2837Extracellular Potential
Transmembrane284 – 30522Helical; Potential
Topological domain306 – 36762Cytoplasmic Potential
Transmembrane368 – 39225Helical; Potential
Topological domain393 – 41624Extracellular Potential
Transmembrane417 – 43519Helical; Potential
Topological domain436 – 46025Cytoplasmic Potential
Transmembrane461 – 47717Helical; Potential
Topological domain478 – 4836Extracellular Potential
Transmembrane484 – 50724Helical; Potential
Topological domain508 – 53730Cytoplasmic Potential
Transmembrane538 – 56225Helical; Potential
Topological domain563 – 57210Extracellular Potential
Transmembrane573 – 59018Helical; Potential
Topological domain591 – 63949Cytoplasmic Potential

Amino acid modifications

Modified residue541Phosphothreonine Ref.7
Modified residue561Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P38196 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 757325DEF4100399

FASTA63972,165
        10         20         30         40         50         60 
MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE KKDTDSENNI 

        70         80         90        100        110        120 
TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF KDLQESLRST YLYNTDLRPV 

       130        140        150        160        170        180 
EAKRRTWTWK QYIFFWISGS FNVNTWQISA TGLQLGLNWW QTWICIWVGY TFVAFFLILG 

       190        200        210        220        230        240 
SKVGNNYHIS FPISSRVSFG IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT 

       250        260        270        280        290        300 
NLNTRIKDTI KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL 

       310        320        330        340        350        360 
IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA PDFTRFGKTY 

       370        380        390        400        410        420 
KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP LDILNRYLDN YTSGNRAGVF 

       430        440        450        460        470        480 
LISFIFAFDQ LGANLSGNSI PAGTDLTALL PKFINIRRGS YICALISLAI CPWDLLSSSS 

       490        500        510        520        530        540 
KFTTALAAYA VFLSAIAGVI SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA 

       550        560        570        580        590        600 
YIFGIAPNFA GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK 

       610        620        630 
ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein."
de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J., Goffeau A.
Yeast 10:1489-1496(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease."
Wagner R., de Montigny J., de Wergifosse P., Souciet J.-L., Potier S.
FEMS Microbiol. Lett. 159:69-75(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54 AND SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78214 Genomic DNA. Translation: CAA55059.1.
Z35803 Genomic DNA. Translation: CAA84862.1.
BK006936 Genomic DNA. Translation: DAA07076.1.
PIRS45776.
RefSeqNP_009511.1. NM_001178282.1.

3D structure databases

ProteinModelPortalP38196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32655. 24 interactions.
DIPDIP-1321N.
IntActP38196. 6 interactions.
MINTMINT-401263.
STRING4932.YBL042C.

Protein family/group databases

TCDB2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

PaxDbP38196.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBL042C; YBL042C; YBL042C.
GeneID852238.
KEGGsce:YBL042C.

Organism-specific databases

CYGDYBL042c.
SGDS000000138. FUI1.

Phylogenomic databases

eggNOGCOG1953.
GeneTreeENSGT00530000065049.
HOGENOMHOG000202588.
OMAWIVINRV.
OrthoDBEOG75B8F6.

Enzyme and pathway databases

BioCycYEAST:G3O-28943-MONOMER.

Gene expression databases

GenevestigatorP38196.

Family and domain databases

InterProIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsTIGR00800. ncs1. 1 hit.
ProtoNetSearch...

Other

NextBio970784.

Entry information

Entry nameFUI1_YEAST
AccessionPrimary (citable) accession number: P38196
Secondary accession number(s): D6VPV6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families