Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P38196

- FUI1_YEAST

UniProt

P38196 - FUI1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Uridine permease

Gene

FUI1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

High-affinity transport of uridine.

GO - Molecular functioni

  1. nucleobase transmembrane transporter activity Source: InterPro
  2. uridine transmembrane transporter activity Source: SGD

GO - Biological processi

  1. transmembrane transport Source: SGD
  2. uridine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28943-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine permease
Gene namesi
Name:FUI1
Ordered Locus Names:YBL042C
ORF Names:YBL0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBL042c.
SGDiS000000138. FUI1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Uridine permeasePRO_0000197923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541Phosphothreonine1 Publication
Modified residuei56 – 561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38196.
PaxDbiP38196.

Expressioni

Gene expression databases

GenevestigatoriP38196.

Interactioni

Protein-protein interaction databases

BioGridi32655. 24 interactions.
DIPiDIP-1321N.
IntActiP38196. 6 interactions.
MINTiMINT-401263.
STRINGi4932.YBL042C.

Structurei

3D structure databases

ProteinModelPortaliP38196.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 162162CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini181 – 20020ExtracellularSequence AnalysisAdd
BLAST
Topological domaini226 – 25934CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini277 – 2837ExtracellularSequence Analysis
Topological domaini306 – 36762CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini393 – 41624ExtracellularSequence AnalysisAdd
BLAST
Topological domaini436 – 46025CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini478 – 4836ExtracellularSequence Analysis
Topological domaini508 – 53730CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini563 – 57210ExtracellularSequence Analysis
Topological domaini591 – 63949CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei163 – 18018HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22525HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 27617HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30522HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 39225HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43519HelicalSequence AnalysisAdd
BLAST
Transmembranei461 – 47717HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50724HelicalSequence AnalysisAdd
BLAST
Transmembranei538 – 56225HelicalSequence AnalysisAdd
BLAST
Transmembranei573 – 59018HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the purine-cytosine permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
InParanoidiP38196.
OMAiAICPWDL.
OrthoDBiEOG75B8F6.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P38196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE
60 70 80 90 100
KKDTDSENNI TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF
110 120 130 140 150
KDLQESLRST YLYNTDLRPV EAKRRTWTWK QYIFFWISGS FNVNTWQISA
160 170 180 190 200
TGLQLGLNWW QTWICIWVGY TFVAFFLILG SKVGNNYHIS FPISSRVSFG
210 220 230 240 250
IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT NLNTRIKDTI
260 270 280 290 300
KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL
310 320 330 340 350
IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA
360 370 380 390 400
PDFTRFGKTY KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP
410 420 430 440 450
LDILNRYLDN YTSGNRAGVF LISFIFAFDQ LGANLSGNSI PAGTDLTALL
460 470 480 490 500
PKFINIRRGS YICALISLAI CPWDLLSSSS KFTTALAAYA VFLSAIAGVI
510 520 530 540 550
SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA YIFGIAPNFA
560 570 580 590 600
GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK
610 620 630
ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI
Length:639
Mass (Da):72,165
Last modified:October 1, 1994 - v1
Checksum:i757325DEF4100399
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78214 Genomic DNA. Translation: CAA55059.1.
Z35803 Genomic DNA. Translation: CAA84862.1.
BK006936 Genomic DNA. Translation: DAA07076.1.
PIRiS45776.
RefSeqiNP_009511.1. NM_001178282.1.

Genome annotation databases

EnsemblFungiiYBL042C; YBL042C; YBL042C.
GeneIDi852238.
KEGGisce:YBL042C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78214 Genomic DNA. Translation: CAA55059.1 .
Z35803 Genomic DNA. Translation: CAA84862.1 .
BK006936 Genomic DNA. Translation: DAA07076.1 .
PIRi S45776.
RefSeqi NP_009511.1. NM_001178282.1.

3D structure databases

ProteinModelPortali P38196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32655. 24 interactions.
DIPi DIP-1321N.
IntActi P38196. 6 interactions.
MINTi MINT-401263.
STRINGi 4932.YBL042C.

Protein family/group databases

TCDBi 2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

MaxQBi P38196.
PaxDbi P38196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL042C ; YBL042C ; YBL042C .
GeneIDi 852238.
KEGGi sce:YBL042C.

Organism-specific databases

CYGDi YBL042c.
SGDi S000000138. FUI1.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000202588.
InParanoidi P38196.
OMAi AICPWDL.
OrthoDBi EOG75B8F6.

Enzyme and pathway databases

BioCyci YEAST:G3O-28943-MONOMER.

Miscellaneous databases

NextBioi 970784.

Gene expression databases

Genevestigatori P38196.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein."
    de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J., Goffeau A.
    Yeast 10:1489-1496(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease."
    Wagner R., de Montigny J., de Wergifosse P., Souciet J.-L., Potier S.
    FEMS Microbiol. Lett. 159:69-75(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
    Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
    J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54 AND SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFUI1_YEAST
AccessioniPrimary (citable) accession number: P38196
Secondary accession number(s): D6VPV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3