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P38196

- FUI1_YEAST

UniProt

P38196 - FUI1_YEAST

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Protein
Uridine permease
Gene
FUI1, YBL042C, YBL0406
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

High-affinity transport of uridine.

GO - Molecular functioni

  1. nucleobase transmembrane transporter activity Source: InterPro
  2. uridine transmembrane transporter activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. transmembrane transport Source: SGD
  2. uridine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28943-MONOMER.

Protein family/group databases

TCDBi2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine permease
Gene namesi
Name:FUI1
Ordered Locus Names:YBL042C
ORF Names:YBL0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBL042c.
SGDiS000000138. FUI1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 162162Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei163 – 18018Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 20020Extracellular Reviewed prediction
Add
BLAST
Transmembranei201 – 22525Helical; Reviewed prediction
Add
BLAST
Topological domaini226 – 25934Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei260 – 27617Helical; Reviewed prediction
Add
BLAST
Topological domaini277 – 2837Extracellular Reviewed prediction
Transmembranei284 – 30522Helical; Reviewed prediction
Add
BLAST
Topological domaini306 – 36762Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei368 – 39225Helical; Reviewed prediction
Add
BLAST
Topological domaini393 – 41624Extracellular Reviewed prediction
Add
BLAST
Transmembranei417 – 43519Helical; Reviewed prediction
Add
BLAST
Topological domaini436 – 46025Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei461 – 47717Helical; Reviewed prediction
Add
BLAST
Topological domaini478 – 4836Extracellular Reviewed prediction
Transmembranei484 – 50724Helical; Reviewed prediction
Add
BLAST
Topological domaini508 – 53730Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei538 – 56225Helical; Reviewed prediction
Add
BLAST
Topological domaini563 – 57210Extracellular Reviewed prediction
Transmembranei573 – 59018Helical; Reviewed prediction
Add
BLAST
Topological domaini591 – 63949Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Uridine permease
PRO_0000197923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541Phosphothreonine1 Publication
Modified residuei56 – 561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38196.
PaxDbiP38196.

Expressioni

Gene expression databases

GenevestigatoriP38196.

Interactioni

Protein-protein interaction databases

BioGridi32655. 24 interactions.
DIPiDIP-1321N.
IntActiP38196. 6 interactions.
MINTiMINT-401263.
STRINGi4932.YBL042C.

Structurei

3D structure databases

ProteinModelPortaliP38196.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1953.
GeneTreeiENSGT00530000065049.
HOGENOMiHOG000202588.
OMAiAICPWDL.
OrthoDBiEOG75B8F6.

Family and domain databases

InterProiIPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

P38196-1 [UniParc]FASTAAdd to Basket

« Hide

MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE    50
KKDTDSENNI TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF 100
KDLQESLRST YLYNTDLRPV EAKRRTWTWK QYIFFWISGS FNVNTWQISA 150
TGLQLGLNWW QTWICIWVGY TFVAFFLILG SKVGNNYHIS FPISSRVSFG 200
IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT NLNTRIKDTI 250
KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL 300
IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA 350
PDFTRFGKTY KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP 400
LDILNRYLDN YTSGNRAGVF LISFIFAFDQ LGANLSGNSI PAGTDLTALL 450
PKFINIRRGS YICALISLAI CPWDLLSSSS KFTTALAAYA VFLSAIAGVI 500
SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA YIFGIAPNFA 550
GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK 600
ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI 639
Length:639
Mass (Da):72,165
Last modified:October 1, 1994 - v1
Checksum:i757325DEF4100399
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78214 Genomic DNA. Translation: CAA55059.1.
Z35803 Genomic DNA. Translation: CAA84862.1.
BK006936 Genomic DNA. Translation: DAA07076.1.
PIRiS45776.
RefSeqiNP_009511.1. NM_001178282.1.

Genome annotation databases

EnsemblFungiiYBL042C; YBL042C; YBL042C.
GeneIDi852238.
KEGGisce:YBL042C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78214 Genomic DNA. Translation: CAA55059.1 .
Z35803 Genomic DNA. Translation: CAA84862.1 .
BK006936 Genomic DNA. Translation: DAA07076.1 .
PIRi S45776.
RefSeqi NP_009511.1. NM_001178282.1.

3D structure databases

ProteinModelPortali P38196.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32655. 24 interactions.
DIPi DIP-1321N.
IntActi P38196. 6 interactions.
MINTi MINT-401263.
STRINGi 4932.YBL042C.

Protein family/group databases

TCDBi 2.A.39.3.3. the nucleobase:cation symporter-1 (ncs1) family.

Proteomic databases

MaxQBi P38196.
PaxDbi P38196.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL042C ; YBL042C ; YBL042C .
GeneIDi 852238.
KEGGi sce:YBL042C.

Organism-specific databases

CYGDi YBL042c.
SGDi S000000138. FUI1.

Phylogenomic databases

eggNOGi COG1953.
GeneTreei ENSGT00530000065049.
HOGENOMi HOG000202588.
OMAi AICPWDL.
OrthoDBi EOG75B8F6.

Enzyme and pathway databases

BioCyci YEAST:G3O-28943-MONOMER.

Miscellaneous databases

NextBioi 970784.

Gene expression databases

Genevestigatori P38196.

Family and domain databases

InterProi IPR001248. Cyt_pur_permease.
IPR012681. NCS1.
[Graphical view ]
Pfami PF02133. Transp_cyt_pur. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00800. ncs1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein."
    de Wergifosse P., Jacques B., Jonniaux J.-L., Purnelle B., Skala J., Goffeau A.
    Yeast 10:1489-1496(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease."
    Wagner R., de Montigny J., de Wergifosse P., Souciet J.-L., Potier S.
    FEMS Microbiol. Lett. 159:69-75(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. "Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes."
    Vickers M.F., Yao S.Y., Baldwin S.A., Young J.D., Cass C.E.
    J. Biol. Chem. 275:25931-25938(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54 AND SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFUI1_YEAST
AccessioniPrimary (citable) accession number: P38196
Secondary accession number(s): D6VPV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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