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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 2

Gene

PSY4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.1 Publication

Miscellaneous

Present with 1010 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • protein phosphatase regulator activity Source: SGD

GO - Biological processi

  • negative regulation of DNA damage checkpoint Source: SGD
  • protein dephosphorylation Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-28946-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Short name:
PP4R2
Gene namesi
Name:PSY4
Synonyms:HTP3
Ordered Locus Names:YBL046W
ORF Names:YBL0402
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL046W.
SGDiS000000142. PSY4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024581 – 441Serine/threonine-protein phosphatase 4 regulatory subunit 2Add BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38193.
PRIDEiP38193.

PTM databases

iPTMnetiP38193.

Interactioni

Subunit structurei

Regulatory subunit (R2) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. Interacts with SPT4 and SPT5.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32651. 59 interactors.
DIPiDIP-4295N.
IntActiP38193. 10 interactors.
MINTiMINT-553643.
STRINGi4932.YBL046W.

Structurei

3D structure databases

ProteinModelPortaliP38193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 302Asp-richAdd BLAST105

Sequence similaritiesi

Belongs to the PPP4R2 family.Curated

Phylogenomic databases

HOGENOMiHOG000115651.
InParanoidiP38193.
OMAiICELCYD.
OrthoDBiEOG092C2N2F.

Family and domain databases

InterProiView protein in InterPro
IPR015267. PPP4R2.
PANTHERiPTHR16487. PTHR16487. 1 hit.
PfamiView protein in Pfam
PF09184. PPP4R2. 1 hit.

Sequencei

Sequence statusi: Complete.

P38193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTMLDDVD NNMMGIKSIS LYELLSDVVK QGDKTRLVTA GPEQVLPDLI
60 70 80 90 100
RHITETIPFD LFINLKNEMN DARNLVTRLN WLGKFLNDNF LQNHTFPFTI
110 120 130 140 150
LRICELCYDP FKYYKINELE KFVNALEKCC MVTSSWQVFD KTHGEKQEDD
160 170 180 190 200
KEKDINFIKN QEDVSLMKIP WMTENNTREL APFIREIDSI MSVNLGYDDE
210 220 230 240 250
DEEEGFFDGD EDREMGNKSK RNVLLKDENF MVEEYYEDDC GINDDNSDNK
260 270 280 290 300
GQNCQSDVTK NNSDDEDDDD NDDDYREDGA DEDDEDDDHM GSTDDDEDDD
310 320 330 340 350
EDRQAGESTK VQNFDKKNET PRKRKPTDLD NFEYDESPSF TNMDLTTPKK
360 370 380 390 400
YKHTATGRFS IIESPSSSLL NAMDGSNEIS SSQEEEKEDA HENHEGRSEG
410 420 430 440
LLPGDELVSP SMSSSQEDKM VAIAGITYRE NISSPLGKKS R
Length:441
Mass (Da):50,655
Last modified:October 1, 1994 - v1
Checksum:i74BCA72FCF2BD9A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti374D → V in AAT92597 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78214 Genomic DNA. Translation: CAA55049.1.
Z35807 Genomic DNA. Translation: CAA84866.1.
AY692578 Genomic DNA. Translation: AAT92597.1.
BK006936 Genomic DNA. Translation: DAA07072.1.
PIRiS42499.
RefSeqiNP_009507.1. NM_001178286.1.

Genome annotation databases

EnsemblFungiiYBL046W; YBL046W; YBL046W.
GeneIDi852234.
KEGGisce:YBL046W.

Similar proteinsi

Entry informationi

Entry nameiPP4R2_YEAST
AccessioniPrimary (citable) accession number: P38193
Secondary accession number(s): D6VPV2, Q6B302
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names