P38192 (RRT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative regulator of rDNA transcription protein 1

Gene names

Name:	RRT1
Ordered Locus Names:	YBL048W
ORF Names:	YBL0519

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	103 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Identified in a screen for mutants with decreased levels of rDNA transcription.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By the zinc-responsive transcription factor ZAP1 in response to zinc deficiency and by mild heat stress. Ref.4 Ref.5
Caution	Product of a dubious gene prediction.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 103	103	Putative regulator of rDNA transcription protein 1		PRO_0000202456
Regions
	Transmembrane	9 – 33	25	Helical; Potential
	Transmembrane	40 – 57	18	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P38192 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: 43264FBB6BE4A0C3	FASTA	103	12,447
	10 20 30 40 50 60 MILFKNLVFL PSILIGYISI RVSLLVWVNW VLVWSSCFQV AFIFSLWYFI LSIYTFFYSK 70 80 90 100 KIKQIISYEP SYFVFSYRAI DLCPERVLLY FFCIFNNVVF PML

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes." Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F. Yeast 9:1355-1371(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast." Lyons T.J., Gasch A.P., Gaither L.A., Botstein D., Brown P.O., Eide D.J. Proc. Natl. Acad. Sci. U.S.A. 97:7957-7962(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[5]	"Response of genes associated with mitochondrial function to mild heat stress in yeast Saccharomyces cerevisiae." Sakaki K., Tashiro K., Kuhara S., Mihara K. J. Biochem. 134:373-384(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae." Hontz R.D., Niederer R.O., Johnson J.M., Smith J.S. Genetics 182:105-119(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z23261 Genomic DNA. No translation available. Z35809 Genomic DNA. Translation: CAA84868.1. AY693312 Genomic DNA. Translation: AAT93331.1.
PIR	S45783.
3D structure databases
ProteinModelPortal	P38192.
ModBase	Search...
Protein-protein interaction databases
IntAct	P38192. 1 interaction.
MINT	MINT-2493123.
STRING	4932.YBL048W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBL048W; YBL048W; YBL048W.
Organism-specific databases
CYGD	YBL048w.
SGD	S000000144. RRT1.
Gene expression databases
Genevestigator	P38192.
GermOnline	YBL048W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

RRT1_YEAST

Accession

Primary (citable) accession number: P38192

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program