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Protein

Nucleoporin NUP170

Gene

NUP170

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.5 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD
  • promoter-specific chromatin binding Source: SGD
  • protein complex binding Source: SGD
  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • chromatin silencing Source: SGD
  • chromosome segregation Source: SGD
  • gene silencing Source: CACAO
  • heterochromatin assembly involved in chromatin silencing Source: SGD
  • mRNA transport Source: UniProtKB-KW
  • nuclear pore complex assembly Source: SGD
  • nucleocytoplasmic transport Source: SGD
  • nucleosome positioning Source: CACAO
  • protein import into nucleus Source: GO_Central
  • protein targeting to nuclear inner membrane Source: SGD
  • RNA export from nucleus Source: GO_Central
  • telomere tethering at nuclear periphery Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28970-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP170
Alternative name(s):
Nuclear pore protein NUP170
Gene namesi
Name:NUP170
Synonyms:NLE3
Ordered Locus Names:YBL079W
ORF Names:YBL0725
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL079W.
SGDiS000000175. NUP170.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: SGD
  • nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15021502Nucleoporin NUP170PRO_0000204854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1247 – 12471PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38181.

PTM databases

iPTMnetiP38181.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. During mitosis NUP53 changes its binding partner within the NPC from NUP170 to NIC96, exposing a high affinity binding site for the karyopherin PSE1, and retaining it in the NPC.

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP53Q037905EBI-11756,EBI-27321
SIR4P119783EBI-11756,EBI-17237
STH1P325973EBI-11756,EBI-18410

GO - Molecular functioni

  • protein complex binding Source: SGD

Protein-protein interaction databases

BioGridi32624. 179 interactions.
DIPiDIP-2450N.
IntActiP38181. 22 interactions.
MINTiMINT-2788627.

Structurei

Secondary structure

1
1502
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1001 – 101515Combined sources
Helixi1022 – 103211Combined sources
Helixi1045 – 105612Combined sources
Helixi1060 – 107516Combined sources
Helixi1079 – 10868Combined sources
Beta strandi1089 – 10935Combined sources
Helixi1095 – 111420Combined sources
Helixi1146 – 11494Combined sources
Beta strandi1150 – 11523Combined sources
Helixi1155 – 116713Combined sources
Helixi1171 – 11766Combined sources
Helixi1182 – 11887Combined sources
Helixi1196 – 12016Combined sources
Helixi1203 – 12064Combined sources
Helixi1210 – 122112Combined sources
Beta strandi1222 – 12254Combined sources
Helixi1229 – 124214Combined sources
Helixi1262 – 12643Combined sources
Helixi1265 – 128117Combined sources
Beta strandi1283 – 12853Combined sources
Helixi1287 – 129913Combined sources
Helixi1304 – 13107Combined sources
Turni1311 – 13166Combined sources
Helixi1318 – 132710Combined sources
Helixi1333 – 135018Combined sources
Helixi1357 – 137822Combined sources
Turni1382 – 13843Combined sources
Helixi1387 – 140115Combined sources
Helixi1404 – 14063Combined sources
Turni1409 – 14124Combined sources
Helixi1413 – 14197Combined sources
Helixi1423 – 143513Combined sources
Helixi1442 – 145817Combined sources
Helixi1460 – 14634Combined sources
Helixi1469 – 14724Combined sources
Turni1479 – 14813Combined sources
Helixi1483 – 14919Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5PX-ray3.20A980-1502[»]
3I5QX-ray2.20A/B1253-1502[»]
ProteinModelPortaliP38181.
SMRiP38181. Positions 98-991, 1000-1502.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38181.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni233 – 26129Leucine-zipperSequence analysisAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP38181.
KOiK14312.
OMAiPIWTERV.
OrthoDBiEOG092C06XC.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 3 hits.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQSFFHNNG PAAAGETFSD SRSYPLTNHQ EVPRNGLNEL ASSATKAQQQ
60 70 80 90 100
PTHILNSYPI TGSNPLMRAS AMGATSGSIN PNMSNMNEHI RVSGMGTSKP
110 120 130 140 150
LDLAGKYIDH LQHKDSNTPV LDERSYYNSG VDYNFSREKN GLGAFTPFEK
160 170 180 190 200
QDVFNIPDEI LHEFSTSQTK TDMGIFPELN RCWITIDNKL ILWNINNDNE
210 220 230 240 250
YQVVDDMKHT IQKVALVRPK PNTFVPAVKH LLLISTTMEL FMFAISLDKA
260 270 280 290 300
TNELSVFNTH LSVPVQGIDV IDIVSHERSG RIFFAGQASG LNIWELHYSG
310 320 330 340 350
SDDWFNSKCS KVCLTKSALL SLLPTNMLSQ IPGVDFIQAL FEDNSNGNGG
360 370 380 390 400
FSQETITQLT IDQQRGIIYS LSSKSTIRAY VITEKSLEGP MSIEPAYISR
410 420 430 440 450
IIGTTTARAA PILGPKYLKI VKISSVAPEE NNNLFLVALT VGGVRLYFNG
460 470 480 490 500
SMGRFNIEAL RLESIKFPPS SVTPEVIQQE LLHQQQEQAK RSFPFFSNLM
510 520 530 540 550
SSEPVLLKFQ KKSSVLLETT KASTIISPGI FFSAVIKSSQ QTHQQEKKEN
560 570 580 590 600
SSVTGTTATA GSKTVKQQPV TLQHKLFVSV PDYGILKTHG KYVENATFLE
610 620 630 640 650
TAGPVQQIIP LSGLFNATTK PQGFANEFAT QYTSETLRVA VLTSTSIEIY
660 670 680 690 700
KYRTPDEIFE DLIDNPLPFV LNYGAAEACS TALFVTCKSN KSEKLRSNAL
710 720 730 740 750
TFLTMGIPGV VDIKPVYNRY SVSTVSSLLS KPTLSTATTN LQQSITGFSK
760 770 780 790 800
PSPANKEDFD LDDVILSPRF YGIALLITRL LRDIWGRHVF MTFTDNRVTS
810 820 830 840 850
HAFISSSDPI TPSINNLKSD EISQNRNIIS KVSISKDCIE YYLSSINILN
860 870 880 890 900
EFFITYGDSI SQISAPYVLA NNSNGRVIDK TEEVANQAES IAINAMIKMV
910 920 930 940 950
QSIKEGLSFL NVLYEESEVE GFDNQYLGFK DIISFVSLDV QKDLVKLDFK
960 970 980 990 1000
DLFAPNDKTK SLIREILLSI INRNITKGAS IEYTATALQE RCGSFCSASD
1010 1020 1030 1040 1050
ILGFRAIEHL RRAKEIGLRN YDSLNYHLKN ATALLEQIVD DLSIEKLKEA
1060 1070 1080 1090 1100
VSMMLSVNYY PKSIEFLLNI ANSMDKGKLA CQYVANGFLE NDDRKQYYDK
1110 1120 1130 1140 1150
RILVYDLVFD TLIKVDELAE KKQSSKTQNQ ISISNDDEVK LRQKSYEAAL
1160 1170 1180 1190 1200
KYNDRLFHYH MYDWLVSQNR EEKLLDIETP FILPYLMEKA GSSLKISNIL
1210 1220 1230 1240 1250
WVYYSRRSKF FESAEILYRL ATSNFDITLF ERIEFLSRAN GFCNSVSPLS
1260 1270 1280 1290 1300
QKQRIVQLAS RIQDACEVAG IQGDILSLVY TDARIDSAIK DELIKTLDGK
1310 1320 1330 1340 1350
ILSTSELFND FAVPLSYHEI ALFIFKIADF RDHEVIMAKW DELFQSLRME
1360 1370 1380 1390 1400
FNNTGKKEDS MNFINLLSNV LIKIGKNVQD SEFIFPIFEL FPIVCNFFYE
1410 1420 1430 1440 1450
TLPKEHIVSG SIVSIFITAG VSFNKMYYIL KELIETSDSD NSVFNKEMTW
1460 1470 1480 1490 1500
LIHEWYKSDR KFRDIISYND IIHLKEYKID NDPIEKYVKN SGNNLGICFY

KE
Length:1,502
Mass (Da):169,475
Last modified:October 1, 1994 - v1
Checksum:i3BEA65DAA2A5F99A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56029.1.
Z35840 Genomic DNA. Translation: CAA84900.1.
BK006936 Genomic DNA. Translation: DAA07044.1.
PIRiS45429.
RefSeqiNP_009474.1. NM_001178319.1.

Genome annotation databases

EnsemblFungiiYBL079W; YBL079W; YBL079W.
GeneIDi852199.
KEGGisce:YBL079W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56029.1.
Z35840 Genomic DNA. Translation: CAA84900.1.
BK006936 Genomic DNA. Translation: DAA07044.1.
PIRiS45429.
RefSeqiNP_009474.1. NM_001178319.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I5PX-ray3.20A980-1502[»]
3I5QX-ray2.20A/B1253-1502[»]
ProteinModelPortaliP38181.
SMRiP38181. Positions 98-991, 1000-1502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32624. 179 interactions.
DIPiDIP-2450N.
IntActiP38181. 22 interactions.
MINTiMINT-2788627.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP38181.

Proteomic databases

MaxQBiP38181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL079W; YBL079W; YBL079W.
GeneIDi852199.
KEGGisce:YBL079W.

Organism-specific databases

EuPathDBiFungiDB:YBL079W.
SGDiS000000175. NUP170.

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP38181.
KOiK14312.
OMAiPIWTERV.
OrthoDBiEOG092C06XC.

Enzyme and pathway databases

BioCyciYEAST:G3O-28970-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38181.
PROiP38181.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 3 hits.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU170_YEAST
AccessioniPrimary (citable) accession number: P38181
Secondary accession number(s): D6VPS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.