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Protein

Nucleoporin NUP170

Gene

NUP170

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.5 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD
  • promoter-specific chromatin binding Source: SGD
  • protein complex binding Source: SGD
  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • chromatin silencing Source: SGD
  • chromosome segregation Source: SGD
  • gene silencing Source: CACAO
  • heterochromatin assembly involved in chromatin silencing Source: SGD
  • mRNA transport Source: UniProtKB-KW
  • nuclear pore complex assembly Source: SGD
  • nucleocytoplasmic transport Source: SGD
  • nucleosome positioning Source: CACAO
  • protein import into nucleus Source: GO_Central
  • protein targeting to nuclear inner membrane Source: SGD
  • RNA export from nucleus Source: GO_Central
  • telomere tethering at nuclear periphery Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-28970-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP170
Alternative name(s):
Nuclear pore protein NUP170
Gene namesi
Name:NUP170
Synonyms:NLE3
Ordered Locus Names:YBL079W
ORF Names:YBL0725
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL079W.
SGDiS000000175. NUP170.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear pore Source: SGD
  • nuclear pore inner ring Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048541 – 1502Nucleoporin NUP170Add BLAST1502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38181.
PRIDEiP38181.

PTM databases

iPTMnetiP38181.

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEH1 and SEC1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof. During mitosis NUP53 changes its binding partner within the NPC from NUP170 to NIC96, exposing a high affinity binding site for the karyopherin PSE1, and retaining it in the NPC.

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP53Q037905EBI-11756,EBI-27321
SIR4P119783EBI-11756,EBI-17237
STH1P325973EBI-11756,EBI-18410

GO - Molecular functioni

  • protein complex binding Source: SGD

Protein-protein interaction databases

BioGridi32624. 179 interactors.
DIPiDIP-2450N.
IntActiP38181. 22 interactors.
MINTiMINT-2788627.

Structurei

Secondary structure

11502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1001 – 1015Combined sources15
Helixi1022 – 1032Combined sources11
Helixi1045 – 1056Combined sources12
Helixi1060 – 1075Combined sources16
Helixi1079 – 1086Combined sources8
Beta strandi1089 – 1093Combined sources5
Helixi1095 – 1114Combined sources20
Helixi1146 – 1149Combined sources4
Beta strandi1150 – 1152Combined sources3
Helixi1155 – 1167Combined sources13
Helixi1171 – 1176Combined sources6
Helixi1182 – 1188Combined sources7
Helixi1196 – 1201Combined sources6
Helixi1203 – 1206Combined sources4
Helixi1210 – 1221Combined sources12
Beta strandi1222 – 1225Combined sources4
Helixi1229 – 1242Combined sources14
Helixi1262 – 1264Combined sources3
Helixi1265 – 1281Combined sources17
Beta strandi1283 – 1285Combined sources3
Helixi1287 – 1299Combined sources13
Helixi1304 – 1310Combined sources7
Turni1311 – 1316Combined sources6
Helixi1318 – 1327Combined sources10
Helixi1333 – 1350Combined sources18
Helixi1357 – 1378Combined sources22
Turni1382 – 1384Combined sources3
Helixi1387 – 1401Combined sources15
Helixi1404 – 1406Combined sources3
Turni1409 – 1412Combined sources4
Helixi1413 – 1419Combined sources7
Helixi1423 – 1435Combined sources13
Helixi1442 – 1458Combined sources17
Helixi1460 – 1463Combined sources4
Helixi1469 – 1472Combined sources4
Turni1479 – 1481Combined sources3
Helixi1483 – 1491Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I5PX-ray3.20A980-1502[»]
3I5QX-ray2.20A/B1253-1502[»]
ProteinModelPortaliP38181.
SMRiP38181.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP38181.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 261Leucine-zipperSequence analysisAdd BLAST29

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP38181.
KOiK14312.
OMAiPIWTERV.
OrthoDBiEOG092C06XC.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 3 hits.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQSFFHNNG PAAAGETFSD SRSYPLTNHQ EVPRNGLNEL ASSATKAQQQ
60 70 80 90 100
PTHILNSYPI TGSNPLMRAS AMGATSGSIN PNMSNMNEHI RVSGMGTSKP
110 120 130 140 150
LDLAGKYIDH LQHKDSNTPV LDERSYYNSG VDYNFSREKN GLGAFTPFEK
160 170 180 190 200
QDVFNIPDEI LHEFSTSQTK TDMGIFPELN RCWITIDNKL ILWNINNDNE
210 220 230 240 250
YQVVDDMKHT IQKVALVRPK PNTFVPAVKH LLLISTTMEL FMFAISLDKA
260 270 280 290 300
TNELSVFNTH LSVPVQGIDV IDIVSHERSG RIFFAGQASG LNIWELHYSG
310 320 330 340 350
SDDWFNSKCS KVCLTKSALL SLLPTNMLSQ IPGVDFIQAL FEDNSNGNGG
360 370 380 390 400
FSQETITQLT IDQQRGIIYS LSSKSTIRAY VITEKSLEGP MSIEPAYISR
410 420 430 440 450
IIGTTTARAA PILGPKYLKI VKISSVAPEE NNNLFLVALT VGGVRLYFNG
460 470 480 490 500
SMGRFNIEAL RLESIKFPPS SVTPEVIQQE LLHQQQEQAK RSFPFFSNLM
510 520 530 540 550
SSEPVLLKFQ KKSSVLLETT KASTIISPGI FFSAVIKSSQ QTHQQEKKEN
560 570 580 590 600
SSVTGTTATA GSKTVKQQPV TLQHKLFVSV PDYGILKTHG KYVENATFLE
610 620 630 640 650
TAGPVQQIIP LSGLFNATTK PQGFANEFAT QYTSETLRVA VLTSTSIEIY
660 670 680 690 700
KYRTPDEIFE DLIDNPLPFV LNYGAAEACS TALFVTCKSN KSEKLRSNAL
710 720 730 740 750
TFLTMGIPGV VDIKPVYNRY SVSTVSSLLS KPTLSTATTN LQQSITGFSK
760 770 780 790 800
PSPANKEDFD LDDVILSPRF YGIALLITRL LRDIWGRHVF MTFTDNRVTS
810 820 830 840 850
HAFISSSDPI TPSINNLKSD EISQNRNIIS KVSISKDCIE YYLSSINILN
860 870 880 890 900
EFFITYGDSI SQISAPYVLA NNSNGRVIDK TEEVANQAES IAINAMIKMV
910 920 930 940 950
QSIKEGLSFL NVLYEESEVE GFDNQYLGFK DIISFVSLDV QKDLVKLDFK
960 970 980 990 1000
DLFAPNDKTK SLIREILLSI INRNITKGAS IEYTATALQE RCGSFCSASD
1010 1020 1030 1040 1050
ILGFRAIEHL RRAKEIGLRN YDSLNYHLKN ATALLEQIVD DLSIEKLKEA
1060 1070 1080 1090 1100
VSMMLSVNYY PKSIEFLLNI ANSMDKGKLA CQYVANGFLE NDDRKQYYDK
1110 1120 1130 1140 1150
RILVYDLVFD TLIKVDELAE KKQSSKTQNQ ISISNDDEVK LRQKSYEAAL
1160 1170 1180 1190 1200
KYNDRLFHYH MYDWLVSQNR EEKLLDIETP FILPYLMEKA GSSLKISNIL
1210 1220 1230 1240 1250
WVYYSRRSKF FESAEILYRL ATSNFDITLF ERIEFLSRAN GFCNSVSPLS
1260 1270 1280 1290 1300
QKQRIVQLAS RIQDACEVAG IQGDILSLVY TDARIDSAIK DELIKTLDGK
1310 1320 1330 1340 1350
ILSTSELFND FAVPLSYHEI ALFIFKIADF RDHEVIMAKW DELFQSLRME
1360 1370 1380 1390 1400
FNNTGKKEDS MNFINLLSNV LIKIGKNVQD SEFIFPIFEL FPIVCNFFYE
1410 1420 1430 1440 1450
TLPKEHIVSG SIVSIFITAG VSFNKMYYIL KELIETSDSD NSVFNKEMTW
1460 1470 1480 1490 1500
LIHEWYKSDR KFRDIISYND IIHLKEYKID NDPIEKYVKN SGNNLGICFY

KE
Length:1,502
Mass (Da):169,475
Last modified:October 1, 1994 - v1
Checksum:i3BEA65DAA2A5F99A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56029.1.
Z35840 Genomic DNA. Translation: CAA84900.1.
BK006936 Genomic DNA. Translation: DAA07044.1.
PIRiS45429.
RefSeqiNP_009474.1. NM_001178319.1.

Genome annotation databases

EnsemblFungiiYBL079W; YBL079W; YBL079W.
GeneIDi852199.
KEGGisce:YBL079W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56029.1.
Z35840 Genomic DNA. Translation: CAA84900.1.
BK006936 Genomic DNA. Translation: DAA07044.1.
PIRiS45429.
RefSeqiNP_009474.1. NM_001178319.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I5PX-ray3.20A980-1502[»]
3I5QX-ray2.20A/B1253-1502[»]
ProteinModelPortaliP38181.
SMRiP38181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32624. 179 interactors.
DIPiDIP-2450N.
IntActiP38181. 22 interactors.
MINTiMINT-2788627.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

PTM databases

iPTMnetiP38181.

Proteomic databases

MaxQBiP38181.
PRIDEiP38181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL079W; YBL079W; YBL079W.
GeneIDi852199.
KEGGisce:YBL079W.

Organism-specific databases

EuPathDBiFungiDB:YBL079W.
SGDiS000000175. NUP170.

Phylogenomic databases

GeneTreeiENSGT00390000016532.
HOGENOMiHOG000246581.
InParanoidiP38181.
KOiK14312.
OMAiPIWTERV.
OrthoDBiEOG092C06XC.

Enzyme and pathway databases

BioCyciYEAST:G3O-28970-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP38181.
PROiP38181.

Family and domain databases

InterProiIPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR004870. Nucleoporin_Nup155.
[Graphical view]
PANTHERiPTHR10350. PTHR10350. 3 hits.
PfamiPF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU170_YEAST
AccessioniPrimary (citable) accession number: P38181
Secondary accession number(s): D6VPS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.