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P38176 (AVT5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar amino acid transporter 5
Gene names
Name:AVT5
Ordered Locus Names:YBL089W
ORF Names:YBL0703
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable amino acid transporter of unknown specificity. Ref.4

Subcellular location

Vacuole membrane; Multi-pass membrane protein Ref.4.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Transport
   Cellular componentMembrane
Vacuole
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processamino acid transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Vacuolar amino acid transporter 5
PRO_0000093838

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane33 – 5321Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane364 – 38421Helical; Potential
Transmembrane386 – 40621Helical; Potential
Transmembrane434 – 45421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P38176 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 8D3D533A63CD190D

FASTA45950,892
        10         20         30         40         50         60 
MPSNVRSGVL TLLHTACGAG VLAMPFAFKP FGLMPGLITL TFCGICSLCG LLLQTRIAKY 

        70         80         90        100        110        120 
VPKSENASFA KLTQLINPSI SVVFDFAIAV KCFGVGVSYL IIVGDLVPQI VQSIFYRNDD 

       130        140        150        160        170        180 
NMSGSQEHHM FLDRRLYITL IIVFVISPLC FKRSLNSLRY ASMIAIVSVA YLSGLIIYHF 

       190        200        210        220        230        240 
VNRHQLERGQ VYFMVPHGDS QSHSPLTTLP IFVFAYTCHH NMFSVINEQV DKSFKVIRRI 

       250        260        270        280        290        300 
PIFAIVLAYF LYIIIGGTGY MTFGENIVGN ILTLYPNSIS TTIGRLAMLL LVMLAFPLQC 

       310        320        330        340        350        360 
HPCRSSVKNI IIFIENFRKG KLYDNRASFI PLDNFNSEDP QEAPTQQNNE EPNLRSESLR 

       370        380        390        400        410        420 
HINIITLCIL LFSYLLAISI TSLAKVLAIV GATGSTSISF ILPGLFGYKL IGSEFTGTNE 

       430        440        450 
RVPTSIKIFK YLSLSLFIWG IAVMVASLSA IVFLGTSSH

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II."
Obermaier B., Gassenhuber J., Piravandi E., Domdey H.
Yeast 11:1103-1112(1995) [PubMed: 7502586] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A family of yeast proteins mediating bidirectional vacuolar amino acid transport."
Russnak R., Konczal D., McIntire S.L.
J. Biol. Chem. 276:23849-23857(2001) [PubMed: 11274162] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed: 12748633] [Abstract]
Cited for: IDENTIFICATION OF PROBABLE INITIATION SITE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X79489 Genomic DNA. Translation: CAA56013.1.
Z35850 Genomic DNA. Translation: CAA84910.1.
BK006936 Genomic DNA. Translation: DAA07035.1.
PIRS45413.
RefSeqNP_009464.2. NM_001178329.1.

3D structure databases

ProteinModelPortalP38176.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-2846N.
IntActP38176. 1 interaction.
MINTMINT-505746.
STRINGP38176.

Protein family/group databases

TCDB2.A.18.6.10. amino acid/auxin permease (AAAP) family.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYBL089W; YBL089W; YBL089W.
GeneID852189.
KEGGsce:YBL089W.
NMPDRfig|4932.3.peg.150.

Organism-specific databases

CYGDYBL089w.
SGDS000000185. AVT5.

Phylogenomic databases

eggNOGfuNOG04087.
GeneTreeEFGT00050000001667.
HOGENOMHBG332582.
OrthoDBEOG4GMZ5X.

Gene expression databases

ArrayExpressP38176.
GenevestigatorP38176.
GermOnlineYBL089W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio970664.

Entry information

Entry nameAVT5_YEAST
AccessionPrimary (citable) accession number: P38176
Secondary accession number(s): D6VPR5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

SIMILARITY comments

Index of protein domains and families

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