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Protein

Condensin complex subunit 2

Gene

BRN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.2 Publications

GO - Molecular functioni

  • chromatin binding Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA unwinding involved in DNA replication Source: SGD
  • mitotic chromosome condensation Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • tRNA gene clustering Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-28983-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 2
Alternative name(s):
Barren homolog
CAPH homolog
Gene namesi
Name:BRN1
Ordered Locus Names:YBL097W
ORF Names:YBL0830
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL097W.
SGDiS000000193. BRN1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication
  • Chromosome 1 Publication

  • Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear condensin complex Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950471 – 754Condensin complex subunit 2Add BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245PhosphoserineCombined sources1
Modified residuei548PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP38170.
PRIDEiP38170.

PTM databases

iPTMnetiP38170.

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRN1, YCS4 and YCG1/YCS5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SMC2P389892EBI-4792,EBI-17412

Protein-protein interaction databases

BioGridi32608. 38 interactors.
DIPiDIP-4662N.
IntActiP38170. 11 interactors.
MINTiMINT-539913.

Structurei

3D structure databases

ProteinModelPortaliP38170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CND2 (condensin subunit 2) family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000004149.
HOGENOMiHOG000246707.
InParanoidiP38170.
KOiK06676.
OMAiEHWKVRN.
OrthoDBiEOG092C0XD0.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.

Sequencei

Sequence statusi: Complete.

P38170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQLRYENN DDDERVEYNL FTNRSTMMAN FEEWIKMATD NKINSRNSWN
60 70 80 90 100
FALIDYFYDL DVLKDGENNI NFQKASATLD GCIKIYSSRV DSVTTETGKL
110 120 130 140 150
LSGLAQRKTN GASNGDDSNG GNGEGLGGDS DEANIEIDPL TGMPISNDPD
160 170 180 190 200
VNNTRRRVYN RVLETTLVEF ETIKMKELDQ ELIIDPLFKK ALVDFDEGGA
210 220 230 240 250
KSLLLNTLNI DNTARVIFDA SIKDTQNVGQ GKLQRKEEEL IERDSLVDDE
260 270 280 290 300
NEPSQSLIST RNDSTVNDSV ISAPSMEDEI LSLGMDFIKF DQIAVCEISG
310 320 330 340 350
SIEQLRNVVE DINQAKDFIE NVNNRFDNFL TEEELQAAVP DNAEDDSDGF
360 370 380 390 400
DMGMQQELCY PDENHDNTSH DEQDDDNVNS TTGSIFEKDL MAYFDENLNR
410 420 430 440 450
NWRGREHWKV RNFKKANLVN KESDLLEETR TTIGDTTDKN TTDDKSMDTK
460 470 480 490 500
KKHKQKKVLE IDFFKTDDSF EDKVFASKGR TKIDMPIKNR KNDTHYLLPD
510 520 530 540 550
DFHFSTDRIT RLFIKPGQKM SLFSHRKHTR GDVSSGLFEK STVSANHSNN
560 570 580 590 600
DIPTIADEHF WADNYERKEQ EEKEKEQSKE VGDVVGGALD NPFEDDMDGV
610 620 630 640 650
DFNQAFEGTD DNEEASVKLD LQDDEDHKFP IRENKVTYSR VSKKVDVRRL
660 670 680 690 700
KKNVWRSINN LIQEHDSRKN REQSSNDSET HTEDESTKEL KFSDIIQGIS
710 720 730 740 750
KMYSDDTLKD ISTSFCFICL LHLANEHGLQ ITHTENYNDL IVNYEDLATT

QAAS
Length:754
Mass (Da):86,216
Last modified:July 27, 2011 - v3
Checksum:i7B30373738D4AE7A
GO

Sequence cautioni

The sequence CAA56003 differs from that shown. Reason: Frameshift at position 25.Curated
The sequence CAA84919 differs from that shown. Reason: Frameshift at position 25.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti517G → A in CAA56003 (PubMed:7502586).Curated1
Sequence conflicti517G → A in CAA84919 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56003.1. Frameshift.
Z35858 Genomic DNA. Translation: CAA84919.1. Frameshift.
AY558077 Genomic DNA. Translation: AAS56403.1.
BK006936 Genomic DNA. Translation: DAA07028.2.
PIRiS45403.
RefSeqiNP_009455.3. NM_001178337.2.

Genome annotation databases

EnsemblFungiiYBL097W; YBL097W; YBL097W.
GeneIDi852180.
KEGGisce:YBL097W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA56003.1. Frameshift.
Z35858 Genomic DNA. Translation: CAA84919.1. Frameshift.
AY558077 Genomic DNA. Translation: AAS56403.1.
BK006936 Genomic DNA. Translation: DAA07028.2.
PIRiS45403.
RefSeqiNP_009455.3. NM_001178337.2.

3D structure databases

ProteinModelPortaliP38170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32608. 38 interactors.
DIPiDIP-4662N.
IntActiP38170. 11 interactors.
MINTiMINT-539913.

PTM databases

iPTMnetiP38170.

Proteomic databases

MaxQBiP38170.
PRIDEiP38170.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL097W; YBL097W; YBL097W.
GeneIDi852180.
KEGGisce:YBL097W.

Organism-specific databases

EuPathDBiFungiDB:YBL097W.
SGDiS000000193. BRN1.

Phylogenomic databases

GeneTreeiENSGT00390000004149.
HOGENOMiHOG000246707.
InParanoidiP38170.
KOiK06676.
OMAiEHWKVRN.
OrthoDBiEOG092C0XD0.

Enzyme and pathway databases

BioCyciYEAST:G3O-28983-MONOMER.
ReactomeiR-SCE-2514853. Condensation of Prometaphase Chromosomes.

Miscellaneous databases

PROiP38170.

Family and domain databases

InterProiIPR022816. Condensin_barren_su2.
[Graphical view]
PfamiPF05786. Cnd2. 1 hit.
[Graphical view]
PIRSFiPIRSF017126. Condensin_H. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCND2_YEAST
AccessioniPrimary (citable) accession number: P38170
Secondary accession number(s): D6VPQ8, Q6Q5G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 704 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.