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Protein

Protein ECM21

Gene

ECM21

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell wall organization and biogenesis.

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • ubiquitin-dependent endocytosis Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-28985-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ECM21
Alternative name(s):
Extracellular mutant protein 21
Gene namesi
Name:ECM21
Ordered Locus Names:YBL101C
ORF Names:YBL0814
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL101C.
SGDiS000000197. ECM21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869171 – 1117Protein ECM21Add BLAST1117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei115PhosphoserineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei286PhosphoserineCombined sources1
Modified residuei527PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Cross-linki577Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki651Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki712Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei775PhosphoserineCombined sources1
Cross-linki794Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources1 Publication
Cross-linki807Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1024Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei1035PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP38167.
PRIDEiP38167.
TopDownProteomicsiP38167.

PTM databases

iPTMnetiP38167.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399402EBI-21359,EBI-16219

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi32602. 41 interactors.
DIPiDIP-791N.
IntActiP38167. 7 interactors.
MINTiMINT-628659.

Structurei

3D structure databases

ProteinModelPortaliP38167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi490 – 511Ser-richAdd BLAST22

Sequence similaritiesi

Belongs to the CSR2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000067002.
HOGENOMiHOG000000708.
InParanoidiP38167.
KOiK20060.
OMAiKLRHYEV.
OrthoDBiEOG092C2P4Q.

Family and domain databases

InterProiIPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFITSRPVA KNSSHSLSET DLNQSKGQPF QPSPTKKLGS MQQRRRSSTI
60 70 80 90 100
RHALSSLLGG ANVHSPAVLN NTTKGGNNNG NIRSSNTDAQ LLGKKQNKQP
110 120 130 140 150
PPNARRHSTT AIQGSISDSA TTTPRSSTSD TNRRTSGRLS VDQEPRISGG
160 170 180 190 200
RYSQIEEDST VLDFDDDHNS SAVVSSDLSS TSLTRLANSK KFNEQFLIEY
210 220 230 240 250
LTARGLLGPK TVLSNEYLKI SISTSGESVF LPTISSNDDE YLSRLNGLND
260 270 280 290 300
GTDDAEADFF MDGIDQQEGN TPSLATTAAA TESGGSINEN RDTLLRENNS
310 320 330 340 350
GDHPGSGSEL NTRSVEIDSS MVSYSIAVIV SVKKPTRFTD MQLELCSRVK
360 370 380 390 400
VFWNTGVPPT KTFNEEFYNA ASMKWNLNDE NFDLFVPLSI SPDDQMIENN
410 420 430 440 450
SNDRQMRLFK NIPTEERLYL DKTKTKASLL NAIDVNKTHL YQPGDYVFLV
460 470 480 490 500
PVVFSNHIPE TIYLPSARVS YRLRLATKAI NRKGFYRQDS NSPQPIVSPD
510 520 530 540 550
SSSSLSSTTS SLKLTETESA QAHRRISNTL FSKVKNHLHM SSHQLKNEES
560 570 580 590 600
GEEDIFAEYP IKVIRTPPPV AVSTANKPIY INRVWTDSLS YEISFAQKYV
610 620 630 640 650
SLNSEVPIKI KLAPICKNVC VKRIHVSITE RVTFVSKGYE YEYDQTDPVA
660 670 680 690 700
KDPYNPYYLD FASKRRKERS VSLFEIRTKE KGTRALREEI VENSFNDNLL
710 720 730 740 750
SYSPFDDDSD SKGNPKERLG ITEPIIIETK LKFPKYEDLD KRTAKIIPPY
760 770 780 790 800
GIDAYTSIPN PEHAVANGPS HRRPSVIGFL SGHKGSKSHE ENEKPVYDPK
810 820 830 840 850
FHQTIIKSNS GLPVKTHTRL NTPKRGLYLD SLHFSNVYCR HKLEIMLRIS
860 870 880 890 900
KPDPECPSKL RHYEVLIDTP IFLVSEQCNS GNMELPTYDM ATMEGKGNQV
910 920 930 940 950
PLSMNSDFFG NTCPPPPTFE EAISVPASPI VSPMGSPNIM ASYDPDLLSI
960 970 980 990 1000
QQLNLSRTTS VSGPSGYSDD AGVPNVNRNS ISNANAMNGS ISNSAFVSGN
1010 1020 1030 1040 1050
SGQGVARARA TSVNDRSRFN NLDKLLSTPS PVNRSHNSSP TNGLSQANGT
1060 1070 1080 1090 1100
VRIPNATTEN SKDKQNEFFK KGYTLANVKD DEEQEGIVSS SSADSLLSHG
1110
NEPPRYDEIV PLMSDEE
Length:1,117
Mass (Da):123,610
Last modified:March 1, 2005 - v2
Checksum:i7DE365C1625B8BA9
GO

Sequence cautioni

The sequence CAA55995 differs from that shown. Reason: Frameshift at positions 8, 964 and 967.Curated
The sequence CAB39760 differs from that shown. Reason: Frameshift at positions 8, 964 and 967.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti964 – 967PSGY → HPDT (PubMed:7502586).Curated4
Sequence conflicti964 – 967PSGY → HPDT (PubMed:7813418).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA55995.1. Frameshift.
Z35862 Genomic DNA. Translation: CAB39760.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07022.1.
PIRiS45395.
RefSeqiNP_009449.1. NM_001178341.1.

Genome annotation databases

EnsemblFungiiYBL101C; YBL101C; YBL101C.
GeneIDi852173.
KEGGisce:YBL101C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA55995.1. Frameshift.
Z35862 Genomic DNA. Translation: CAB39760.1. Frameshift.
BK006936 Genomic DNA. Translation: DAA07022.1.
PIRiS45395.
RefSeqiNP_009449.1. NM_001178341.1.

3D structure databases

ProteinModelPortaliP38167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32602. 41 interactors.
DIPiDIP-791N.
IntActiP38167. 7 interactors.
MINTiMINT-628659.

PTM databases

iPTMnetiP38167.

Proteomic databases

MaxQBiP38167.
PRIDEiP38167.
TopDownProteomicsiP38167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL101C; YBL101C; YBL101C.
GeneIDi852173.
KEGGisce:YBL101C.

Organism-specific databases

EuPathDBiFungiDB:YBL101C.
SGDiS000000197. ECM21.

Phylogenomic databases

GeneTreeiENSGT00530000067002.
HOGENOMiHOG000000708.
InParanoidiP38167.
KOiK20060.
OMAiKLRHYEV.
OrthoDBiEOG092C2P4Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-28985-MONOMER.

Miscellaneous databases

PROiP38167.

Family and domain databases

InterProiIPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECM21_YEAST
AccessioniPrimary (citable) accession number: P38167
Secondary accession number(s): D6VPQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.