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Protein

Lethal(2) giant larvae protein homolog SRO77

Gene

SRO77

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.2 Publications

GO - Molecular functioni

GO - Biological processi

  • establishment of cell polarity Source: GO_Central
  • exocytosis Source: SGD
  • Golgi to plasma membrane transport Source: SGD
  • regulation of exocytosis Source: GO_Central
  • regulation of protein secretion Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-28990-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(2) giant larvae protein homolog SRO77
Alternative name(s):
Sodium protection protein 2
Suppressor of RHO3 protein 77
Gene namesi
Name:SRO77
Synonyms:SNI2, SOP2
Ordered Locus Names:YBL106C
ORF Names:YBL0806
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL106C.
SGDiS000000202. SRO77.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512211 – 1010Lethal(2) giant larvae protein homolog SRO77Add BLAST1010

Proteomic databases

MaxQBiP38163.
PRIDEiP38163.

PTM databases

iPTMnetiP38163.

Interactioni

Subunit structurei

Interacts with SEC9.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32597. 41 interactors.
DIPiDIP-2947N.
IntActiP38163. 11 interactors.
MINTiMINT-583073.

Structurei

3D structure databases

ProteinModelPortaliP38163.
SMRiP38163.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 80WD 1Add BLAST34
Repeati87 – 122WD 2Add BLAST36
Repeati127 – 163WD 3Add BLAST37
Repeati182 – 215WD 4Add BLAST34
Repeati240 – 275WD 5Add BLAST36
Repeati299 – 364WD 6Add BLAST66
Repeati372 – 407WD 7Add BLAST36
Repeati431 – 504WD 8Add BLAST74
Repeati518 – 595WD 9Add BLAST78
Repeati602 – 637WD 10Add BLAST36
Repeati649 – 700WD 11Add BLAST52
Repeati709 – 763WD 12Add BLAST55
Repeati768 – 815WD 13Add BLAST48
Repeati829 – 852WD 14Add BLAST24

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated
Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiP38163.
KOiK08518.
OMAiYSSICCF.
OrthoDBiEOG092C096J.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKSRHLKN VSNAIKSARV HDVSNGINSK FFDTKKICTY GINGRITVTT
60 70 80 90 100
FDYTQSLLAV ATTAGEIHVY GQKQIEVVFT LKNRPQIKHM RFIKGIYLIA
110 120 130 140 150
VDEKSNIIVL SVHSKQILTT VFCPNSITCI ETDPSLDWML IGLESGSILI
160 170 180 190 200
YDVDRNQMSK LKIENFQKSV FLPKERLSPV ISIQWNPRDI GTILISYEHI
210 220 230 240 250
TVIYSFIDYK VKQHFFYQLE PYAPGGDLST NIEKKRTPKV IQSLYHPNSL
260 270 280 290 300
HILTVHEDNS LVFWDVNSGK LIHARSIFET HVNFPNPALK DCSFTETPAI
310 320 330 340 350
FKVSWLCQRN PEYTSLLIAT KATENPCLPQ EITMIDLGGT PMYSVTSFDA
360 370 380 390 400
MSKYYAKPVQ QKLFSLIGKA PLINFLPLPK ASPYFGGCHD TNLILLLLED
410 420 430 440 450
GELETLIYPA GSFSSKASIF PRSLAWVRPT VTTCIAQSVQ KNLWLGMMTI
460 470 480 490 500
AQSESFLKGG IPATRNIRRH ETRSALLTGH SNGSVRIWDA SHSEVTDNAV
510 520 530 540 550
FEVNTAKVLN RATNLAIKNI SFASETLELA VSSEVGDVIL FKFETNKFYG
560 570 580 590 600
QLPKSDALQL KFSRFSLDDS KTILVDVSDR GPTNVKQGFI PSTVIHAKKG
610 620 630 640 650
AVSAIMNSNI GFVAVGFIEG TLIILDRRGP AIIFNENIRV ISKAGSSYVS
660 670 680 690 700
TVHFCVMEYG DDGFSSILML CGTDIGELMT FKILPATNGR FEVKFTDATK
710 720 730 740 750
TNNQGKILGI NSFAKDTGYS CSATISKMQG LSKGIAIPGF VTISGANDIR
760 770 780 790 800
LVSPGKSKDT HALFKYPIAT SGLSFIPIID GKGERKLSTI MIVLLINGDI
810 820 830 840 850
KVLTVPELKE VKNLRCPVPL SAQYVENSSI LENGDIVIRT GKFQASLISV
860 870 880 890 900
LNESATGTNH TADISQHTPI DTLYNPDLKI GYRPQVNSLQ WARGTIYCTP
910 920 930 940 950
YQLDELLGGI ERPESKYEES AIARGCISSS SSNAARKLPP GTEDHRYARP
960 970 980 990 1000
VRSSGRSNGY GVLKSVSRAI ETRLDTVETT INDYATTMGQ TMNDAMEETG
1010
RDMMKSAVGF
Length:1,010
Mass (Da):111,623
Last modified:July 27, 2011 - v2
Checksum:i3547845334179A40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130I → F in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti130I → F in CAA84933 (PubMed:7813418).Curated1
Sequence conflicti135S → P in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti135S → P in CAA84933 (PubMed:7813418).Curated1
Sequence conflicti260S → A in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti260S → A in CAA84933 (PubMed:7813418).Curated1
Sequence conflicti834G → V in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti834G → V in CAA84933 (PubMed:7813418).Curated1
Sequence conflicti858T → S in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti858T → S in CAA84933 (PubMed:7813418).Curated1
Sequence conflicti943E → K in CAA55989 (PubMed:7502586).Curated1
Sequence conflicti943E → K in CAA84933 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA55989.1.
Z35867 Genomic DNA. Translation: CAA84933.1.
BK006936 Genomic DNA. Translation: DAA07017.2.
PIRiS45389.
RefSeqiNP_009444.2. NM_001178346.2.

Genome annotation databases

EnsemblFungiiYBL106C; YBL106C; YBL106C.
GeneIDi852168.
KEGGisce:YBL106C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79489 Genomic DNA. Translation: CAA55989.1.
Z35867 Genomic DNA. Translation: CAA84933.1.
BK006936 Genomic DNA. Translation: DAA07017.2.
PIRiS45389.
RefSeqiNP_009444.2. NM_001178346.2.

3D structure databases

ProteinModelPortaliP38163.
SMRiP38163.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32597. 41 interactors.
DIPiDIP-2947N.
IntActiP38163. 11 interactors.
MINTiMINT-583073.

PTM databases

iPTMnetiP38163.

Proteomic databases

MaxQBiP38163.
PRIDEiP38163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL106C; YBL106C; YBL106C.
GeneIDi852168.
KEGGisce:YBL106C.

Organism-specific databases

EuPathDBiFungiDB:YBL106C.
SGDiS000000202. SRO77.

Phylogenomic databases

GeneTreeiENSGT00510000052145.
InParanoidiP38163.
KOiK08518.
OMAiYSSICCF.
OrthoDBiEOG092C096J.

Enzyme and pathway databases

BioCyciYEAST:G3O-28990-MONOMER.

Miscellaneous databases

PROiP38163.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR013905. Lgl_C_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08596. Lgl_C. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRO77_YEAST
AccessioniPrimary (citable) accession number: P38163
Secondary accession number(s): D6VPP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.