P38157 (MAL33_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Maltose fermentation regulatory protein MAL33

Gene names

Name:	MAL33
Synonyms:	MAL3R
Ordered Locus Names:	YBR297W
ORF Names:	YBR2115

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Regulates the coordinate transcription of structural MAL3S (maltase) and MAL3T (maltose permease) genes.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the MAL13 family. Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.

Ontologies

Keywords
Biological process	Maltose metabolism Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from sequence or structural similarity PubMed 2549370. Source: SGD maltose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: GOC
Cellular_component	nucleus Inferred from sequence or structural similarity PubMed 10447589. Source: SGD
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity PubMed 10447589. Source: SGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Maltose fermentation regulatory protein MAL33		PRO_0000114957
Regions
	DNA binding	8 – 34	27	Zn(2)-C6 fungal-type
	Motif	41 – 49	9	Nuclear localization signal Potential

Sequences

	Sequence		Length	Mass (Da)
	P38157 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: EA8674EFEC56E5E9	FASTA	468	54,194
	10 20 30 40 50 60 MTLVKYACDY CRVRRVKCDG KKPCSRCIEH NFDCTYQQPL KKRGSKPIGT RSLKYIPKAK 70 80 90 100 110 120 MFIDNKSCTA AAEILMKVPK KVIDQCLRLY HDNLYVIWPL LSYDDLHKLL DEEYNDHYVY 130 140 150 160 170 180 WFLVALSAAN LSDLQSELES EGGFSFTGKQ LAVLCMSSRQ QFDDLSGRDI FRIMTYYCLL 190 200 210 220 230 240 RCFSQSSDVR NSYRLCREAI GLVIVAGLHR EKAYESLSFR EQQLLRKVYY LLLLTERYYS 250 260 270 280 290 300 VYVHCVTSLD TTIAPPQPEF VTDPRLSLDS FFEMIRVFTV PGKCFFDALA TESTSGSCTE 310 320 330 340 350 360 DSLKKIWKEL HTASLEIEPW SYGYVDISFS RHWIRALAWK LVFQMNGTKF FSNANNAHIL 370 380 390 400 410 420 VEIAKDMLDD IFLTPNNLYD VHGPGIPMKS LEVANALVDI VNKYDHNMKL EAWNILCDVS 430 440 450 460 KFVFSLKHCN HKMFQRFSTK CQSALIDLPI SRPLRLNDDS KDEDDIIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36166 Genomic DNA. Translation: CAA85262.1. AY692789 Genomic DNA. Translation: AAT92808.1. BK006936 Genomic DNA. Translation: DAA07412.1.
PIR	S46179.
RefSeq	NP_009856.3. NM_001178645.3.
3D structure databases
ProteinModelPortal	P38157.
SMR	P38157. Positions 6-37.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YBR297W.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR297W; YBR297W; YBR297W.
GeneID	852600.
KEGG	sce:YBR297W. sce:YBR301W.
Organism-specific databases
CYGD	YBR297w.
SGD	S000000501. MAL33.
Phylogenomic databases
eggNOG	NOG77115.
GeneTree	ENSGT00390000003136.
HOGENOM	HOG000113469.
OMA	IANGMAD.
Gene expression databases
Genevestigator	P38157.
GermOnline	YBR297W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	4.10.240.10. 1 hit.
InterPro	IPR020448. Maltose_ferment_reg_DNA-bd. IPR007219. Transcription_factor_fun. IPR001138. Zn2-C6_fun-type_DNA-bd. [Graphical view]
Pfam	PF04082. Fungal_trans. 1 hit. PF00172. Zn_clus. 1 hit. [Graphical view]
PRINTS	PR00054. FUNGALZNCYS.
SMART	SM00066. GAL4. 1 hit. [Graphical view]
SUPFAM	SSF57701. Fungi_TrN. 1 hit.
PROSITE	PS00463. ZN2_CY6_FUNGAL_1. 1 hit. PS50048. ZN2_CY6_FUNGAL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971778.

Entry information

Entry name

MAL33_YEAST

Accession

Primary (citable) accession number: P38157
Secondary accession number(s): D6VQU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program