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Protein

AP-3 complex subunit mu

Gene

APM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole.3 Publications

Miscellaneous

Present with 3410 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • Golgi to vacuole transport Source: SGD
  • protein targeting to vacuole Source: SGD

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29207-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu
Mu-adaptin 3A
Mu3-adaptin
Gene namesi
Name:APM3
Synonyms:YKS6
Ordered Locus Names:YBR288C
ORF Names:YBR2035
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR288C
SGDiS000000492 APM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937941 – 483AP-3 complex subunit muAdd BLAST483

Proteomic databases

MaxQBiP38153
PaxDbiP38153
PRIDEiP38153

PTM databases

iPTMnetiP38153

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32982, 218 interactors
DIPiDIP-4965N
IntActiP38153, 36 interactors
MINTiP38153
STRINGi4932.YBR288C

Structurei

3D structure databases

ProteinModelPortaliP38153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini211 – 482MHDPROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000033979
InParanoidiP38153
KOiK12398
OMAiYIYDEHN
OrthoDBiEOG092C222B

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
SUPFAMiSSF49447 SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

P38153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLSFYITDT KNKLIFQYLL GATAPSFKHL WTRVQSTCPQ LLEDSSSDDY
60 70 80 90 100
LDHSMVGRDL EVYKYFSVIN KLNYWCLAST SKSKGPLDCF TFLETIDRIL
110 120 130 140 150
LEYFDKDKLS IKKIVNNYDR ISLIFNCCVE AGEPNVSDML YVNKIKEAVP
160 170 180 190 200
ERSDLSKFIS STAHNLQQAV QLPQQRQQQL QQNQISRGSN SLIENEEIVP
210 220 230 240 250
WRTSRASKHE NNELYVDLLE TFHVVFEKKK SHLRLLTGSI HGIVDVRSYL
260 270 280 290 300
NDNPLVAVKL NTMGNDIGIP SLHDCVEIND GVFSPSNITF IPPDGKFRLL
310 320 330 340 350
EYSVDLSSQV KQSGVRMNSI GLMSLHFQNG LGKDSDEFEL SLNIENFKKV
360 370 380 390 400
SQVDDLKIDL QFNVENADPN EIAYKIKILR NTHGRFENSI IMGQGQWIFD
410 420 430 440 450
KSTATGTVPV LRGCIEYENT GPNFTKKVDL QTVSLEYSYI GQSASGIYVE
460 470 480
AIDIVSGLTI GKNTKLYKGA KYKTQTGNFQ VRL
Length:483
Mass (Da):54,837
Last modified:July 27, 2011 - v2
Checksum:iAAD5A7EA305C63CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35 – 36QS → RT in CAA53651 (PubMed:8091861).Curated2
Sequence conflicti35 – 36QS → RT in CAA85253 (PubMed:7813418).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76053 Genomic DNA Translation: CAA53651.1
Z36157 Genomic DNA Translation: CAA85253.1
BK006936 Genomic DNA Translation: DAA07403.2
PIRiS44550
RefSeqiNP_009847.4, NM_001178636.4

Genome annotation databases

EnsemblFungiiYBR288C; YBR288C; YBR288C
GeneIDi852591
KEGGisce:YBR288C

Similar proteinsi

Entry informationi

Entry nameiAP3M_YEAST
AccessioniPrimary (citable) accession number: P38153
Secondary accession number(s): D6VQT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health