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Protein

Tricarboxylate transport protein

Gene

CTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transport of citrate across inner mitochondrial membrane.

GO - Molecular functioni

  • tricarboxylate secondary active transmembrane transporter activity Source: SGD

GO - Biological processi

  • mitochondrial citrate transport Source: SGD
  • transmembrane transport Source: SGD
  • tricarboxylic acid transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29210-MONOMER.
ReactomeiR-SCE-70263. Gluconeogenesis.
R-SCE-75105. Fatty Acyl-CoA Biosynthesis.

Protein family/group databases

TCDBi2.A.29.7.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein
Alternative name(s):
Citrate transport protein
Short name:
CTP
Gene namesi
Name:CTP1
Ordered Locus Names:YBR291C
ORF Names:YBR2039
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR291C.
SGDiS000000495. CTP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei66 – 8621Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei174 – 19320Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Tricarboxylate transport proteinPRO_0000090653Add
BLAST

Proteomic databases

MaxQBiP38152.

PTM databases

iPTMnetiP38152.

Interactioni

Protein-protein interaction databases

BioGridi32985. 73 interactions.
DIPiDIP-5645N.
IntActiP38152. 12 interactions.
MINTiMINT-502540.

Structurei

3D structure databases

ProteinModelPortaliP38152.
SMRiP38152. Positions 16-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati10 – 9788Solcar 1Add
BLAST
Repeati109 – 19991Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074856.
HOGENOMiHOG000168307.
InParanoidiP38152.
KOiK15100.
OMAiCAMQIWK.
OrthoDBiEOG7ZGXD7.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKATKSDV DPLHSFLAGS LAGAAEACIT YPFEFAKTRL QLIDKASKAS
60 70 80 90 100
RNPLVLIYKT AKTQGIGSIY VGCPAFIIGN TAKAGIRFLG FDTIKDMLRD
110 120 130 140 150
SETGELSGTR GVIAGLGAGL LESVAAVTPF EAIKTALIDD KQSATPKYHN
160 170 180 190 200
NGRGVVRNYS SLVRDKGFSG LYRGVLPVSM RQAANQAVRL GCYNKIKTLI
210 220 230 240 250
QDYTDSPKDK PLSSGLTFLV GAFSGIVTVY STMPLDTVKT RMQSLDSTKY
260 270 280 290
SSTMNCFATI FKEEGLKTFW KGATPRLGRL VLSGGIVFTI YEKVLVMLA
Length:299
Mass (Da):32,173
Last modified:December 6, 2005 - v3
Checksum:iE0A9749704BA1405
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971M → L in AAC48984 (PubMed:7876161).Curated
Sequence conflicti101 – 1011S → R in AAC48984 (PubMed:7876161).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17503 mRNA. Translation: AAC48984.1.
X76053 Genomic DNA. Translation: CAA53655.1.
Z36160 Genomic DNA. Translation: CAA85256.1.
BK006936 Genomic DNA. Translation: DAA07406.1.
PIRiS44554.
RefSeqiNP_009850.1. NM_001178639.1.

Genome annotation databases

EnsemblFungiiYBR291C; YBR291C; YBR291C.
GeneIDi852594.
KEGGisce:YBR291C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17503 mRNA. Translation: AAC48984.1.
X76053 Genomic DNA. Translation: CAA53655.1.
Z36160 Genomic DNA. Translation: CAA85256.1.
BK006936 Genomic DNA. Translation: DAA07406.1.
PIRiS44554.
RefSeqiNP_009850.1. NM_001178639.1.

3D structure databases

ProteinModelPortaliP38152.
SMRiP38152. Positions 16-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32985. 73 interactions.
DIPiDIP-5645N.
IntActiP38152. 12 interactions.
MINTiMINT-502540.

Protein family/group databases

TCDBi2.A.29.7.3. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP38152.

Proteomic databases

MaxQBiP38152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR291C; YBR291C; YBR291C.
GeneIDi852594.
KEGGisce:YBR291C.

Organism-specific databases

EuPathDBiFungiDB:YBR291C.
SGDiS000000495. CTP1.

Phylogenomic databases

GeneTreeiENSGT00550000074856.
HOGENOMiHOG000168307.
InParanoidiP38152.
KOiK15100.
OMAiCAMQIWK.
OrthoDBiEOG7ZGXD7.

Enzyme and pathway databases

BioCyciYEAST:G3O-29210-MONOMER.
ReactomeiR-SCE-70263. Gluconeogenesis.
R-SCE-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

NextBioi971763.
PROiP38152.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae."
    Kaplan R.S., Mayor J.A., Gremse D.A., Wood D.O.
    J. Biol. Chem. 270:4108-4114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 200358 / YNN 295.
  2. "The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae."
    Holmstroem K., Brandt T., Kallesoe T.
    Yeast 10:S47-S62(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiTXTP_YEAST
AccessioniPrimary (citable) accession number: P38152
Secondary accession number(s): D6VQT6, Q02507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.