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Protein

Tricarboxylate transport protein

Gene

CTP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transport of citrate across inner mitochondrial membrane.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial citrate transmembrane transport Source: SGD
  • mitochondrial transport Source: GO_Central
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29210-MONOMER
ReactomeiR-SCE-70263 Gluconeogenesis
R-SCE-75105 Fatty acyl-CoA biosynthesis

Protein family/group databases

TCDBi2.A.29.7.3 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein
Alternative name(s):
Citrate transport protein
Short name:
CTP
Gene namesi
Name:CTP1
Ordered Locus Names:YBR291C
ORF Names:YBR2039
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR291C
SGDiS000000495 CTP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei113 – 133Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei174 – 193Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei272 – 291Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906531 – 299Tricarboxylate transport proteinAdd BLAST299

Proteomic databases

MaxQBiP38152
PaxDbiP38152
PRIDEiP38152

PTM databases

iPTMnetiP38152

Interactioni

Protein-protein interaction databases

BioGridi32985, 173 interactors
DIPiDIP-5645N
IntActiP38152, 12 interactors
MINTiP38152
STRINGi4932.YBR291C

Structurei

3D structure databases

ProteinModelPortaliP38152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 97Solcar 1Add BLAST88
Repeati109 – 199Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074856
HOGENOMiHOG000168307
InParanoidiP38152
KOiK15100
OMAiLTFWSGA
OrthoDBiEOG092C3ST0

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

P38152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKATKSDV DPLHSFLAGS LAGAAEACIT YPFEFAKTRL QLIDKASKAS
60 70 80 90 100
RNPLVLIYKT AKTQGIGSIY VGCPAFIIGN TAKAGIRFLG FDTIKDMLRD
110 120 130 140 150
SETGELSGTR GVIAGLGAGL LESVAAVTPF EAIKTALIDD KQSATPKYHN
160 170 180 190 200
NGRGVVRNYS SLVRDKGFSG LYRGVLPVSM RQAANQAVRL GCYNKIKTLI
210 220 230 240 250
QDYTDSPKDK PLSSGLTFLV GAFSGIVTVY STMPLDTVKT RMQSLDSTKY
260 270 280 290
SSTMNCFATI FKEEGLKTFW KGATPRLGRL VLSGGIVFTI YEKVLVMLA
Length:299
Mass (Da):32,173
Last modified:December 6, 2005 - v3
Checksum:iE0A9749704BA1405
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97M → L in AAC48984 (PubMed:7876161).Curated1
Sequence conflicti101S → R in AAC48984 (PubMed:7876161).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17503 mRNA Translation: AAC48984.1
X76053 Genomic DNA Translation: CAA53655.1
Z36160 Genomic DNA Translation: CAA85256.1
BK006936 Genomic DNA Translation: DAA07406.1
PIRiS44554
RefSeqiNP_009850.1, NM_001178639.1

Genome annotation databases

EnsemblFungiiYBR291C; YBR291C; YBR291C
GeneIDi852594
KEGGisce:YBR291C

Similar proteinsi

Entry informationi

Entry nameiTXTP_YEAST
AccessioniPrimary (citable) accession number: P38152
Secondary accession number(s): D6VQT6, Q02507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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