Reviewed, UniProtKB/Swiss-Prot P38149 (YB9X_YEAST)

Names and origin

Protein names

Recommended name:
    WD repeat-containing protein YBR281C

Gene names

Ordered Locus Names:	YBR281C
ORF Names:	YBR2018

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	878 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	Present with 1940 molecules/cell in log phase SD medium. Ref.3
Sequence similarities	Contains 6 WD repeats.

Ontologies

Keywords
Domain	Repeat WD repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutathione catabolic process Inferred from mutant phenotype. Source: SGD proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: SGD nucleus Inferred from direct assay. Source: SGD
Molecular function	metallopeptidase activity Inferred from electronic annotation. Source: InterPro omega peptidase activity Inferred from genetic interaction. Source: SGD protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SAS10	Q12136	1	EBI-21176,EBI-36084

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 878	878	WD repeat-containing protein YBR281C		PRO_0000051469
Regions
	Repeat	18 – 57	40	WD 1
	Repeat	68 – 107	40	WD 2
	Repeat	235 – 274	40	WD 3
	Repeat	282 – 322	41	WD 4
	Repeat	362 – 405	44	WD 5
	Repeat	608 – 651	44	WD 6
Amino acid modifications
	Modified residue	200	1	Phosphoserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P38149-1 [UniParc]. Last modified October 1, 1994. Version 1. Checksum: A24C10BB4E94C344	FASTA	878	98,071
	10 20 30 40 50 60 MYDSRGVALH SELIHRWNHA FSILSIVAFP KKRLLFAGSQ DSKILVFDLP TYNLIHTIRL 70 80 90 100 110 120 GESQEETHTR SSVLCLTGSE DENFLFSGGA DSLVRIWSIG EKTIRDDFLP VTEIATVYSV 130 140 150 160 170 180 TDIGDIFSLA YLDSLETIVF GCQNASLLYV ENLIQKIEKK SSDGVENINK LPHRRYDKFF 190 200 210 220 230 240 DSLGPTGYSS NSLSQTSLTS LQENCGAAII EVPSENIIKY AHYGFIYSIN KLCPRFNQLL 250 260 270 280 290 300 EKSSRTSGAE HIISSAGDGI SKLWEFSKDK GQNTVKISLI NDKIDNEDSV ISQTIEFPFL 310 320 330 340 350 360 YCGLTDGIIK IWDLNTQQII STLKTKHESD VISISVYMDH VFAIDESGIT HFYQNQVNHW 370 380 390 400 410 420 NPQQGKILSS EIFSKSNAGS VSLLTGGSDG SLTLWDITSL LSAVPLSSNS PINASSTLQT 430 440 450 460 470 480 TNLWAAYQSA SLNNEEMLNT LRELISFQTV SQSKDTTNTL SLRRCAIYLQ QLFLKFGATN 490 500 510 520 530 540 SQLFPLPDGG NPVVFAYFQG NGKVSQVKGA KKKRILWYGH YDVISSGNTF NWNTDPFTLT 550 560 570 580 590 600 CENGYLKGRG VSDNKGPLVS AIHSVAYLFQ QGELVNDVVF LVEGSEEIGS ASLKQVCEKY 610 620 630 640 650 660 HDIIGKDIDW ILLSNSTWVD QEHPCLNYGL RGVINAQIKV WSDKPDGHSG LNGGVYDEPM 670 680 690 700 710 720 VNLVKIVSKL QNEQNEIMIP NFYSPLKDLT EEEYQRFQKI TELANIDENT TVQDLITNWT 730 740 750 760 770 780 KPSLSMTTVK FSGPGNITVI PKSVTMGISI RLVPEQSVEQ VKRDLKAYLE ESFKQLKSQN 790 800 810 820 830 840 HLEIKVLNEA EGWLGDPTNH AYQILKDEIT TAWDVEPLLV REGGSISCLR MLERIFDAPA 850 860 870 VQIPCGQSTD NGHLANENLR IKNWSNLTEI LSKVFNRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae." Holmstroem K., Brandt T., Kallesoe T. Yeast 10:S47-S62(1994) [PubMed: 8091861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X76053 Genomic DNA. Translation: CAA53644.1. Z36150 Genomic DNA. Translation: CAA85245.1.
PIR	S44543.
RefSeq	NP_009840.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:1612N.
IntAct	P38149. 5 interactions.
Proteomic databases
PeptideAtlas	P38149.
PRIDE	P38149.
Genome annotation databases
Ensembl	YBR281C. Saccharomyces cerevisiae. [Contig view]
GeneID	852584.
GenomeReviews	Gene locus YBR281C in contig Y13134_GR.
KEGG	sce:YBR281C.
NMPDR	fig|4932.3.peg.556.
Organism-specific databases
CYGD	YBR281c.
SGD	S000000485. YBR281C.
Yeast-GFP	Search...
Phylogenomic databases
HOGENOM	P38149.
OMA	P38149. AEPWLGD.
Gene expression databases
ArrayExpress	P38149.
GermOnline	YBR281C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR017149. GSH_degradosome_DUG2. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
PIRSF	PIRSF037237. Peptidase_WD_repeats_DUG2. 1 hit.
SMART	SM00320. WD40. 4 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	971733.

Entry information

Entry name

YB9X_YEAST

Accession

Primary (citable) accession number: P38149

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	October 1, 1994
Last modified:	June 16, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)