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P38148

- PPS1_YEAST

UniProt

P38148 - PPS1_YEAST

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Protein

Dual specificity protein phosphatase PPS1

Gene

PPS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei725 – 7251Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: SGD
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: SGD
  2. nuclear cell cycle DNA replication Source: SGD
  3. protein dephosphorylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

BioCyciYEAST:G3O-29197-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase PPS1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:PPS1
Ordered Locus Names:YBR276C
ORF Names:YBR2013
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR276c.
SGDiS000000480. PPS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Dual specificity protein phosphatase PPS1PRO_0000094921Add
BLAST

Proteomic databases

MaxQBiP38148.
PaxDbiP38148.
PeptideAtlasiP38148.

Expressioni

Gene expression databases

GenevestigatoriP38148.

Interactioni

Protein-protein interaction databases

BioGridi32971. 20 interactions.
DIPiDIP-6546N.
IntActiP38148. 2 interactions.
MINTiMINT-702219.
STRINGi4932.YBR276C.

Structurei

3D structure databases

ProteinModelPortaliP38148.
SMRiP38148. Positions 646-777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni593 – 807215CatalyticAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000115673.
InParanoidiP38148.
KOiK04459.
OrthoDBiEOG7R5725.

Family and domain databases

Gene3Di3.90.190.10. 3 hits.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38148-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLEVPSITP GELHDLMRLH QDAEWPECKK MFPWAHDISF GQPPDFPHSL
60 70 80 90 100
AIVKSQSDAN NSALLRNSLE VNDIFQSWKV RTSFHREGDT CETGNDSNGF
110 120 130 140 150
QYPNNTKELL NLLKFQIRQL ELQVDDVALE NAATYCHNHS ILPFLKVDPR
160 170 180 190 200
GLSLELKRYS RNKVGSNTTL KRSGQDVWGR RGLFRRFDLQ CAKMIEMVDN
210 220 230 240 250
IVIYCSRTGG STDMQTESAP ACSHEGNCPN CTTLALLLQI CLMFVQKGYV
260 270 280 290 300
GSGGSLYKTN LFICTYQNFN TDIPQTLIGT PLLDNEFFKN NTPLNLCSSP
310 320 330 340 350
SEIVCFNNVD KNMVLCEKLE LNKLTSATRL EETGLICGNT TDWHNYQIIK
360 370 380 390 400
KNNISLTHRF EENTSIVNLK SLNYDTDNPT TSISQLYNIP NTKEVWKLII
410 420 430 440 450
KCTSNSQMPS LTKIRTYLDL LLDDDASKSQ EHLHLTFPAS GSIGLGNLNI
460 470 480 490 500
QSVEILLNVC YLIFQVSQVQ ELLTFMYCED GYTETSLLLT AYIIFHFNIP
510 520 530 540 550
LQDALLRIHP RPFFLFPSDL QILGHLQPVL REFSPQNGSN LKLYANALKF
560 570 580 590 600
RDKSFQLHIS SELFSSIFFM KIPLESNFVN LKGPLPSRIL RHLYLGSLDH
610 620 630 640 650
AQNPALLKSL GITHIVSVGE VVSWTLNKDK IAHPVRPHRA ITMTNTNEVA
660 670 680 690 700
GNTTCNKSRN RADTVVSDKQ ENGSNVVISE NSGFQICQIE NLDDNGKDPL
710 720 730 740 750
FHQIDKVLDF ISNSEATGGK VLVHCMVGVS RSATVCIAEC MRYLQCDLAS
760 770 780 790 800
AYLFVRVRRL NVIIQPNLFF VYELFKWWKK HYNREKDKTM DWHIICRGIA

EVNMKYT
Length:807
Mass (Da):91,685
Last modified:October 1, 1994 - v1
Checksum:i17840CF7256EF785
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76053 Genomic DNA. Translation: CAA53639.1.
Z36145 Genomic DNA. Translation: CAA85239.1.
BK006936 Genomic DNA. Translation: DAA07392.1.
PIRiS44538.
RefSeqiNP_009835.3. NM_001178624.3.

Genome annotation databases

EnsemblFungiiYBR276C; YBR276C; YBR276C.
GeneIDi852579.
KEGGisce:YBR276C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76053 Genomic DNA. Translation: CAA53639.1 .
Z36145 Genomic DNA. Translation: CAA85239.1 .
BK006936 Genomic DNA. Translation: DAA07392.1 .
PIRi S44538.
RefSeqi NP_009835.3. NM_001178624.3.

3D structure databases

ProteinModelPortali P38148.
SMRi P38148. Positions 646-777.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32971. 20 interactions.
DIPi DIP-6546N.
IntActi P38148. 2 interactions.
MINTi MINT-702219.
STRINGi 4932.YBR276C.

Proteomic databases

MaxQBi P38148.
PaxDbi P38148.
PeptideAtlasi P38148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR276C ; YBR276C ; YBR276C .
GeneIDi 852579.
KEGGi sce:YBR276C.

Organism-specific databases

CYGDi YBR276c.
SGDi S000000480. PPS1.

Phylogenomic databases

eggNOGi COG2453.
HOGENOMi HOG000115673.
InParanoidi P38148.
KOi K04459.
OrthoDBi EOG7R5725.

Enzyme and pathway databases

BioCyci YEAST:G3O-29197-MONOMER.

Miscellaneous databases

NextBioi 971721.

Gene expression databases

Genevestigatori P38148.

Family and domain databases

Gene3Di 3.90.190.10. 3 hits.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae."
    Holmstroem K., Brandt T., Kallesoe T.
    Yeast 10:S47-S62(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle."
    Ernsting B.R., Dixon J.E.
    J. Biol. Chem. 272:9332-9343(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPPS1_YEAST
AccessioniPrimary (citable) accession number: P38148
Secondary accession number(s): D6VQS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 29, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3