Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P38148

- PPS1_YEAST

UniProt

P38148 - PPS1_YEAST

Protein

Dual specificity protein phosphatase PPS1

Gene

PPS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei725 – 7251Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: SGD
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: SGD
    2. nuclear cell cycle DNA replication Source: SGD
    3. protein dephosphorylation Source: SGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29197-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase PPS1 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:PPS1
    Ordered Locus Names:YBR276C
    ORF Names:YBR2013
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR276c.
    SGDiS000000480. PPS1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 807807Dual specificity protein phosphatase PPS1PRO_0000094921Add
    BLAST

    Proteomic databases

    MaxQBiP38148.
    PaxDbiP38148.
    PeptideAtlasiP38148.

    Expressioni

    Gene expression databases

    GenevestigatoriP38148.

    Interactioni

    Protein-protein interaction databases

    BioGridi32971. 20 interactions.
    DIPiDIP-6546N.
    IntActiP38148. 2 interactions.
    MINTiMINT-702219.
    STRINGi4932.YBR276C.

    Structurei

    3D structure databases

    ProteinModelPortaliP38148.
    SMRiP38148. Positions 586-783.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni593 – 807215CatalyticAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000115673.
    KOiK04459.
    OrthoDBiEOG7R5725.

    Family and domain databases

    Gene3Di3.90.190.10. 3 hits.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P38148-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLEVPSITP GELHDLMRLH QDAEWPECKK MFPWAHDISF GQPPDFPHSL    50
    AIVKSQSDAN NSALLRNSLE VNDIFQSWKV RTSFHREGDT CETGNDSNGF 100
    QYPNNTKELL NLLKFQIRQL ELQVDDVALE NAATYCHNHS ILPFLKVDPR 150
    GLSLELKRYS RNKVGSNTTL KRSGQDVWGR RGLFRRFDLQ CAKMIEMVDN 200
    IVIYCSRTGG STDMQTESAP ACSHEGNCPN CTTLALLLQI CLMFVQKGYV 250
    GSGGSLYKTN LFICTYQNFN TDIPQTLIGT PLLDNEFFKN NTPLNLCSSP 300
    SEIVCFNNVD KNMVLCEKLE LNKLTSATRL EETGLICGNT TDWHNYQIIK 350
    KNNISLTHRF EENTSIVNLK SLNYDTDNPT TSISQLYNIP NTKEVWKLII 400
    KCTSNSQMPS LTKIRTYLDL LLDDDASKSQ EHLHLTFPAS GSIGLGNLNI 450
    QSVEILLNVC YLIFQVSQVQ ELLTFMYCED GYTETSLLLT AYIIFHFNIP 500
    LQDALLRIHP RPFFLFPSDL QILGHLQPVL REFSPQNGSN LKLYANALKF 550
    RDKSFQLHIS SELFSSIFFM KIPLESNFVN LKGPLPSRIL RHLYLGSLDH 600
    AQNPALLKSL GITHIVSVGE VVSWTLNKDK IAHPVRPHRA ITMTNTNEVA 650
    GNTTCNKSRN RADTVVSDKQ ENGSNVVISE NSGFQICQIE NLDDNGKDPL 700
    FHQIDKVLDF ISNSEATGGK VLVHCMVGVS RSATVCIAEC MRYLQCDLAS 750
    AYLFVRVRRL NVIIQPNLFF VYELFKWWKK HYNREKDKTM DWHIICRGIA 800
    EVNMKYT 807
    Length:807
    Mass (Da):91,685
    Last modified:October 1, 1994 - v1
    Checksum:i17840CF7256EF785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76053 Genomic DNA. Translation: CAA53639.1.
    Z36145 Genomic DNA. Translation: CAA85239.1.
    BK006936 Genomic DNA. Translation: DAA07392.1.
    PIRiS44538.
    RefSeqiNP_009835.3. NM_001178624.3.

    Genome annotation databases

    EnsemblFungiiYBR276C; YBR276C; YBR276C.
    GeneIDi852579.
    KEGGisce:YBR276C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76053 Genomic DNA. Translation: CAA53639.1 .
    Z36145 Genomic DNA. Translation: CAA85239.1 .
    BK006936 Genomic DNA. Translation: DAA07392.1 .
    PIRi S44538.
    RefSeqi NP_009835.3. NM_001178624.3.

    3D structure databases

    ProteinModelPortali P38148.
    SMRi P38148. Positions 586-783.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32971. 20 interactions.
    DIPi DIP-6546N.
    IntActi P38148. 2 interactions.
    MINTi MINT-702219.
    STRINGi 4932.YBR276C.

    Proteomic databases

    MaxQBi P38148.
    PaxDbi P38148.
    PeptideAtlasi P38148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR276C ; YBR276C ; YBR276C .
    GeneIDi 852579.
    KEGGi sce:YBR276C.

    Organism-specific databases

    CYGDi YBR276c.
    SGDi S000000480. PPS1.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000115673.
    KOi K04459.
    OrthoDBi EOG7R5725.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29197-MONOMER.

    Miscellaneous databases

    NextBioi 971721.

    Gene expression databases

    Genevestigatori P38148.

    Family and domain databases

    Gene3Di 3.90.190.10. 3 hits.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae."
      Holmstroem K., Brandt T., Kallesoe T.
      Yeast 10:S47-S62(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "The PPS1 gene of Saccharomyces cerevisiae codes for a dual specificity protein phosphatase with a role in the DNA synthesis phase of the cell cycle."
      Ernsting B.R., Dixon J.E.
      J. Biol. Chem. 272:9332-9343(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPPS1_YEAST
    AccessioniPrimary (citable) accession number: P38148
    Secondary accession number(s): D6VQS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1994
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3