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Reviewed, UniProtKB/Swiss-Prot P38143 (GPX2_YEAST)

Last modified November 3, 2009. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione peroxidase 2
    EC=1.11.1.9
Gene names
Name: GPX2
Ordered Locus Names: YBR244W
ORF Names: YBR1632
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May constitute a glutathionine peroxidase-like protective system against oxidative stresses By similarity.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Miscellaneous

Present with 2010 molecules/cell in log phase SD medium. Ref.3

Sequence similarities

Belongs to the glutathione peroxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 162162Glutathione peroxidase 2
PRO_0000066642

Sites

Active site371 By similarity

Amino acid modifications

Modified residue21Phosphothreonine Ref.5
Modified residue41Phosphoserine Ref.5
Modified residue1131Phosphoserine Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P38143-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: BD02E7E6D38527A6

FASTA16218,406
        10         20         30         40         50         60 
MTTSFYDLEC KDKKGESFKF DQLKGKVVLI VNVASKCGFT PQYKELEELY KKYQDKGFVI 

        70         80         90        100        110        120 
LGFPCNQFGK QEPGSDEQIT EFCQLNYGVT FPIMKKIDVN GSNADSVYNY LKSQKAGLLG 

       130        140        150        160 
FKGIKWNFEK FLVDSNGKVV QRFSSLTKPS SLDQEIQSLL SK

« Hide

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References

« Hide 'large scale' references
[1]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[4]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, MASS SPECTROMETRY.
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2 AND SER-4, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z36113 Genomic DNA. Translation: CAA85207.1.
AY557641 Genomic DNA. Translation: AAS55967.1.
PIRS46121.
RefSeqNP_009803.1.

3D structure databases

HSSPHSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:8180N.
IntActP38143. 24 interactions.
STRINGP38143.

Protein family/group databases

PeroxiBase3741. SceGPx02.

Proteomic databases

PeptideAtlasP38143.

Genome annotation databases

EnsemblYBR244W; YBR244W; YBR244W; Saccharomyces cerevisiae. [Genome view]
GeneID852546.
GenomeReviewsGene locus YBR244W in contig Y13134_GR.
KEGGsce:YBR244W.
NMPDRfig|4932.3.peg.518.

Organism-specific databases

CYGDYBR244w.
SGDS000000448. GPX2.

Phylogenomic databases

HOGENOMP38143.
OMALECKDKK.

Enzyme and pathway databases

BRENDA1.11.1.9. 250.

Gene expression databases

ArrayExpressP38143.
GenevestigatorP38143.
GermOnlineYBR244W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR000889. Glutathione_peroxidase.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971625.

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Entry information

Entry nameGPX2_YEAST
AccessionPrimary (citable) accession number: P38143
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 3, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents