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Protein

Glutathione peroxidase 2

Gene

GPX2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37By similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: SGD
  • phospholipid-hydroperoxide glutathione peroxidase activity Source: SGD

GO - Biological processi

  • cellular response to oxidative stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciYEAST:YBR244W-MONOMER.

Protein family/group databases

PeroxiBasei3741. SceGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Gene namesi
Name:GPX2
Ordered Locus Names:YBR244W
ORF Names:YBR1632
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR244W.
SGDiS000000448. GPX2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • extrinsic component of mitochondrial inner membrane Source: SGD
  • extrinsic component of mitochondrial outer membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666421 – 162Glutathione peroxidase 2Add BLAST162

Proteomic databases

MaxQBiP38143.
PRIDEiP38143.

PTM databases

iPTMnetiP38143.

Interactioni

Protein-protein interaction databases

BioGridi32939. 47 interactors.
DIPiDIP-8180N.
IntActiP38143. 11 interactors.
MINTiMINT-385855.

Structurei

3D structure databases

ProteinModelPortaliP38143.
SMRiP38143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiP38143.
KOiK00432.
OMAiTSLGEYD.
OrthoDBiEOG092C4H0P.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P38143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSFYDLEC KDKKGESFKF DQLKGKVVLI VNVASKCGFT PQYKELEELY
60 70 80 90 100
KKYQDKGFVI LGFPCNQFGK QEPGSDEQIT EFCQLNYGVT FPIMKKIDVN
110 120 130 140 150
GSNADSVYNY LKSQKAGLLG FKGIKWNFEK FLVDSNGKVV QRFSSLTKPS
160
SLDQEIQSLL SK
Length:162
Mass (Da):18,406
Last modified:October 1, 1994 - v1
Checksum:iBD02E7E6D38527A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36113 Genomic DNA. Translation: CAA85207.1.
AY557641 Genomic DNA. Translation: AAS55967.1.
BK006936 Genomic DNA. Translation: DAA07360.1.
PIRiS46121.
RefSeqiNP_009803.3. NM_001178592.3.

Genome annotation databases

EnsemblFungiiYBR244W; YBR244W; YBR244W.
GeneIDi852546.
KEGGisce:YBR244W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36113 Genomic DNA. Translation: CAA85207.1.
AY557641 Genomic DNA. Translation: AAS55967.1.
BK006936 Genomic DNA. Translation: DAA07360.1.
PIRiS46121.
RefSeqiNP_009803.3. NM_001178592.3.

3D structure databases

ProteinModelPortaliP38143.
SMRiP38143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32939. 47 interactors.
DIPiDIP-8180N.
IntActiP38143. 11 interactors.
MINTiMINT-385855.

Protein family/group databases

PeroxiBasei3741. SceGPx02.

PTM databases

iPTMnetiP38143.

Proteomic databases

MaxQBiP38143.
PRIDEiP38143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR244W; YBR244W; YBR244W.
GeneIDi852546.
KEGGisce:YBR244W.

Organism-specific databases

EuPathDBiFungiDB:YBR244W.
SGDiS000000448. GPX2.

Phylogenomic databases

GeneTreeiENSGT00840000130500.
HOGENOMiHOG000277054.
InParanoidiP38143.
KOiK00432.
OMAiTSLGEYD.
OrthoDBiEOG092C4H0P.

Enzyme and pathway databases

BioCyciYEAST:YBR244W-MONOMER.

Miscellaneous databases

PROiP38143.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX2_YEAST
AccessioniPrimary (citable) accession number: P38143
Secondary accession number(s): D6VQP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.